Navigation Links
European Research Council supports search for regulators of tissue damage
Date:1/27/2012

There is more to fighting infection than just clearing the body of pathogens. As important as resisting infection, is limiting damage to the host's tissue caused, very frequently, by toxins produced by pathogens or by components of the host immune response that clears those pathogens. Indeed, it is the damage inflicted to different tissues and organs that, if uncontrolled, can lead to the lethal outcome of some infectious diseases.

The in-built capacity that an infected individual has to limit the extent of tissue damage caused by different pathogens, a phenomenon known as 'tolerance to infection', has fascinated Miguel Soares, a group Leader at the Instituto Gulbenkian de Cincia (IGC) in Portugal, for several years. Now, the European Research Council (ERC) has awarded his team an Advanced Grant of just over 2,2 million Euros, to investigate the mechanisms involved in this protective response. This line of research should identify and pave the way to the development of new therapeutic interventions, to quell the clinical outcome of various diseases.

Miguel Soares and his research team have already identified a restricted number of mechanisms, regulated by specific genetic programmes that control tissue damage in response to different types of infection. They have shown that these protective mechanisms are active for example against severe forms of malaria and severe sepsis. The researchers believe, however, that other protective mechanisms controlled by groups of so-called "protective genetic programmes" can act in a similar manner in the context of different diseases. Their aim is to identify these protective mechanisms, and describe how the genetic programs act, so that these may be targeted to treat a whole range of infectious diseases.

Says Miguel Soares, "Infectious diseases such as malaria and severe sepsis remain medical challenges today, acting as major killers across the globe. Our data suggest that one of the reasons for
'/>"/>

Contact: Ana Godinho
agodinho@igc.gulbenkian.pt
351-214-407-959
Instituto Gulbenkian de Ciencia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. European Geosciences Union General Assembly, April 22-27, 2012, Vienna, Austria
2. Cell Therapeutics, Inc. Expects That the European Medicines Agencys (EMA) Committee for Medicinal Products for Human Use (CHMP) May Issue an Opinion on the Marketing Authorization Application ("MAA") on Pixuvriâ„¢ in Mid-February
3. European mountain vegetation shows effects of warmer climate
4. DTU is participating in a European network on measurement of greenhouse gases
5. Register now for the European Congress on Osteoporosis & Osteoarthritis in Bordeaux
6. UK invests £75 million in European research infrastructure to support knowledge-based economy
7. EMBO awards Installation Grants to 7 European scientists
8. How does a plant survive with few mates or pollinators? A European herb has figured out its own way
9. New European project launched to address shortcomings in climate data
10. Misleading morphology: 3 European parasitoid wasp species are seasonal forms of just 1
11. Genomatix to partner in $41 million European epigenomics consortium
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
European Research Council supports search for regulators of tissue damage
(Date:8/1/2014)... Scripps Research Institute (TSRI) have identified a signaling pathway ... fat cells. , The study, which is reported ... Proceedings of the National Academy of Sciences , sheds ... which is of great interest to medical researchers because ... against diabetes. , "This finding offers new possibilities for ...
(Date:8/1/2014)... 1, 2014  LiveScan Service Provider Binary Biometrics is pleased to ... result, Binary Biometrics will improve its mobile service capabilities and add more daily ... and service several new cities such as, but not limited to, ... DeLand , Deltona , Edgewater , ... New Smyrna Beach , Oak Hill , ...
(Date:7/31/2014)... United States, natural-gas production from shale rock has ... Yet scientists still do not fully understand the ... a report in the journal Frontiers in ... extraction continues to vastly outpace scientific examination, a ... and institutions, including Princeton University, concluded that determining ...
Breaking Biology News(10 mins):Scripps Research Institute scientists find new calorie-burning switch in brown fat 2Scripps Research Institute scientists find new calorie-burning switch in brown fat 3Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 2'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 3
... had been suggested that the origin of pumpkins and cucumbers ... confirmed on the basis of genetic analyses performed by German ... access journal PhytoKeys . Vegetables are ... India but around the globe. Compared to grains and pulses, ...
... at Uppsala University, Sweden, has been granted funding for digitising ... make the valuable plants available to the whole world, online. ... Carl Thunberg travelled with the Dutch East India Company to ... he collected almost 28,000 plants on his journey, of which ...
... about ground-level ozone in American cities. While dangerous ozone ... emissions from vehicles and industry, a new study from ... predict the impact of remediation efforts has been too ... even beyond what was anticipated by cutting emissions of ...
Cached Biology News:New genetic study confirms Indian origins of pumpkins and cucumbers 2Carl Thunberg's Japanese plants to be digitized 2Ground-level ozone falling faster than model predicted 2
(Date:8/1/2014)... 2014 As one of the 10 largest ... Meeting & Clinical Lab Expo is the place where ... introduced to the healthcare world. This year, many of ... will include the latest diagnostic technology in the field ... and biosensors have enabled the development of "labs-on-a-chip" that ...
(Date:8/1/2014)... , Aug. 1, 2014 Research and ... "Global Single Nucleotide Polymorphism (SNP) Genotyping and Analysis Market ... http://photos.prnewswire.com/prnh/20130307/600769 Single Nucleotide Polymorphism ... variations of SNPs in the genome of various species. ... SNP genotyping and analysis technology can analyze thousands of ...
(Date:8/1/2014)... (PRWEB) August 01, 2014 Testing ... led to a better understanding embryonic development. ... reorganize into structurally and functionally distinct tissues is ... defects. Prof. Todd McDevitt, Melissa Kinney, and ... signals interact with biochemical cues to control many ...
(Date:7/31/2014)... There,s a good reason people over 60 are not ... ages and weakens with time, making the elderly prone ... San Francisco research team now has discovered a reason ... for the inability of blood-forming cells to maintain blood ... identified molecular defects that could be restored for rejuvenation ...
Breaking Biology Technology:Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 3Global Single Nucleotide Polymorphism (SNP) Genotyping and Analysis Market 2014-2018 2Study Links Biomechanics and Gene Expression in Stem Cells 2Key to aging immune system is discovered 2
... , , , SADDLE RIVER, ... a leading provider of sales and marketing support to U.S. pharmaceutical companies, today ... highlights include: , , , Four new ... Signed agreement with The Medical Affairs Company (TMAC(R)) to enhance our ...
... SAN DIEGO, Aug. 5 Orexigen(R) Therapeutics, Inc. (Nasdaq: ... announced that the Company will be speaking at the 29th Annual Canaccord ... , , Date: Thursday, ... Location: InterContinental Boston, London Room, Speaker: Michael ...
... DIEGO, Aug. 5 ADVENTRX Pharmaceuticals, Inc. (NYSE Amex: ... on Wednesday, August 12, 2009 at 1:30 p.m. Pacific (4:30 p.m. ... an update on its business. , , Individuals ... dialing (866) 305-6438 for domestic callers, or (706) 679-7161 for international ...
Cached Biology Technology:PDI Reports 2009 Second Quarter Financial Results 2PDI Reports 2009 Second Quarter Financial Results 3PDI Reports 2009 Second Quarter Financial Results 4PDI Reports 2009 Second Quarter Financial Results 5PDI Reports 2009 Second Quarter Financial Results 6PDI Reports 2009 Second Quarter Financial Results 7PDI Reports 2009 Second Quarter Financial Results 8PDI Reports 2009 Second Quarter Financial Results 9
Mouse Anti-Human Methyl-CpG binding domain protein 2 (MBD2 Monoclonal Antibody Family: Other Applications: Western Blot...
... and rocking for maximal fluid movement. This unit ... steel or acrylic platform, it is perfect for ... platform angle is easily adjusted from 0 to ... rotation speed of platform is adjusted from 0 ...
...
Monoclonal Anti-Cystatin A tissue culture supernatant Solution containing 15 mM sodium azide human cystatin A ...
Biology Products: