Navigation Links
European Research Council supports search for regulators of tissue damage
Date:1/27/2012

There is more to fighting infection than just clearing the body of pathogens. As important as resisting infection, is limiting damage to the host's tissue caused, very frequently, by toxins produced by pathogens or by components of the host immune response that clears those pathogens. Indeed, it is the damage inflicted to different tissues and organs that, if uncontrolled, can lead to the lethal outcome of some infectious diseases.

The in-built capacity that an infected individual has to limit the extent of tissue damage caused by different pathogens, a phenomenon known as 'tolerance to infection', has fascinated Miguel Soares, a group Leader at the Instituto Gulbenkian de Cincia (IGC) in Portugal, for several years. Now, the European Research Council (ERC) has awarded his team an Advanced Grant of just over 2,2 million Euros, to investigate the mechanisms involved in this protective response. This line of research should identify and pave the way to the development of new therapeutic interventions, to quell the clinical outcome of various diseases.

Miguel Soares and his research team have already identified a restricted number of mechanisms, regulated by specific genetic programmes that control tissue damage in response to different types of infection. They have shown that these protective mechanisms are active for example against severe forms of malaria and severe sepsis. The researchers believe, however, that other protective mechanisms controlled by groups of so-called "protective genetic programmes" can act in a similar manner in the context of different diseases. Their aim is to identify these protective mechanisms, and describe how the genetic programs act, so that these may be targeted to treat a whole range of infectious diseases.

Says Miguel Soares, "Infectious diseases such as malaria and severe sepsis remain medical challenges today, acting as major killers across the globe. Our data suggest that one of the reasons for
'/>"/>

Contact: Ana Godinho
agodinho@igc.gulbenkian.pt
351-214-407-959
Instituto Gulbenkian de Ciencia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. European Geosciences Union General Assembly, April 22-27, 2012, Vienna, Austria
2. Cell Therapeutics, Inc. Expects That the European Medicines Agencys (EMA) Committee for Medicinal Products for Human Use (CHMP) May Issue an Opinion on the Marketing Authorization Application ("MAA") on Pixuvri™ in Mid-February
3. European mountain vegetation shows effects of warmer climate
4. DTU is participating in a European network on measurement of greenhouse gases
5. Register now for the European Congress on Osteoporosis & Osteoarthritis in Bordeaux
6. UK invests £75 million in European research infrastructure to support knowledge-based economy
7. EMBO awards Installation Grants to 7 European scientists
8. How does a plant survive with few mates or pollinators? A European herb has figured out its own way
9. New European project launched to address shortcomings in climate data
10. Misleading morphology: 3 European parasitoid wasp species are seasonal forms of just 1
11. Genomatix to partner in $41 million European epigenomics consortium
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
European Research Council supports search for regulators of tissue damage
(Date:8/22/2014)... French . NAIROBI ... African soils looming as a major threat to food security ... over the last five years, 1.7 million African farmers in ... million hectares and helped them double or even triple crop ... Revolution in Africa (AGRA) focuses on intensive efforts initiated five ...
(Date:8/22/2014)... release is available in German . ... substances, in PCFs proteins are fixated in a way ... crystals. Next, the HZB and Fudan University researchers are ... as functional materials. Their findings are being published today ... 10.1038/ncomms5634). , Proteins are sensitive molecules. Everyone knows that ...
(Date:8/22/2014)... birds and the bees. But that old expression ... The fertilization process for flowering plants is particularly ... and female reproductive cells. New research from an ... and including Carnegie,s Wolf Frommer, David Ehrhardt, and ... process that guides flowering plant fertilization. It is ...
Breaking Biology News(10 mins):Effort to confront Africa's soil health crisis helps millions of farmers triple yields 2Effort to confront Africa's soil health crisis helps millions of farmers triple yields 3Effort to confront Africa's soil health crisis helps millions of farmers triple yields 4Proteins: New class of materials discovered 2Calcium and reproduction go together 2
... (Nov. 4, 2010) Columbia University Medical Center has ... in Cardiovascular Research, with the 2010 Lewis Katz Visiting ... renowned heart failure expert from University of Texas Southwestern ... winners of the 2010 Lewis Katz Cardiovascular Research Prize ...
... Nov. 4, 2010 BIO-key International, Inc. (OTC Bulletin ... biometric identification solutions, today announced plans to release third ...  In conjunction with the release, BIO-key has scheduled a ... Internet on Thursday, November 11, 2010 at 10:00 a.m. ...
... amount of water flowing in streams and rivers has ... that were assessed in a new nationwide USGS study. ... river ecosystems and loss of native species. ... to date of stream flow alteration," said Bill Werkheiser, ...
Cached Biology News:Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research 2Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research 3Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research 4Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research 5BIO-key® Announces Third Quarter 2010 Earnings Release and Conference Call Schedule 2Most river flows across the US are altered by land and water management 2
(Date:8/22/2014)... IN (PRWEB) August 22, 2014 The ... community and its members in Alaska that Alaska Governor ... Concurrent Resolution 15, further defining public use of Unmanned ... Systems Task Force. House Bill 255states that it is, ... to images captured by an unmanned aircraft system.” It ...
(Date:8/21/2014)... 21, 2014 DNA vaccine pioneer ... its development of JRC-LAMP-vax, an innovative and safe potential ... IC studies began this month in Hawaii, moving the ... , The Japanese red cedar releases pollen that causes ... Mountain Cedar pollen wreaks similar havoc in Colorado, New ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 His Majesty ... Opening , The Court of His Majesty Willem-Alexander, King ... attend the Grand Opening of POET-DSM Advanced Biofuels’ Project ... Sept. 3. , The King will take part in ... activity, scheduled for 11 a.m.-12:20 p.m. and tour the ...
(Date:8/21/2014)... 21, 2014 OTC Markets Group ... a biotechnology company, on its approval to list ... on OTCQX®, the best marketplace for established U.S. ... Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO ... execution of its growth strategy and achievement of ...
Breaking Biology Technology:State of Alaska Signs Unmanned Aircraft Systems Bill 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2
... CALGARY, Feb. 11 /PRNewswire-FirstCall/ - SemBioSys Genetics ... of therapeutic,proteins for metabolic and cardiovascular diseases, today ... of the Company, will be,presenting a corporate update ... on Wednesday, February 13, 2008 at the Waldorf ...
... Fla., Feb. 11 Further to Phlo,Corporation,s ("Phlo"") (OTC: ... Roll Out to Metropolitan New York City Account,Base," an ... distributor in Metropolitan New York City has sold and ... key account base,as part of such roll out. AQISS(TM) ...
... Feb. 11 Santaris Pharma, the,Danish biopharmaceutical company ... McCullagh, President and Chief Executive,Officer, will be presenting ... for,2008 at the Biotechnology Industry Organisation,s 10th Annual ... February 11th at 12:30 pm,US Eastern Standard Time ...
Cached Biology Technology:SemBioSys to present at the 10th Annual BIO CEO & Investor Conference 2Phlo Affiliate Reports Progress in New York City Metropolitan Area Roll-Out 2Santaris Pharma to Present at 10th Annual Biotechnology Industry Organisation CEO & Investor Conference - February 11th, 2008 2
MagSi uniform silica particles coated with a carboxyl group containing polymer, covalently attached to the bead surface....
MAb to Vasopressin Preservative: NaN3...
Mouse monoclonal [1C6/2] to Rad17 ( Abpromise for all tested applications). entrezGeneID: 5884 SwissProtID: Q9UPF5...
... glycoprotein. distributed in colon and rectum, ... lung and salivary gland tissues. ... and MUC2. Epitope: Tandem repeats ... MUC3 tandem repeat peptide Positive ...
Biology Products: