Navigation Links
European Research Council supports search for regulators of tissue damage
Date:1/27/2012

There is more to fighting infection than just clearing the body of pathogens. As important as resisting infection, is limiting damage to the host's tissue caused, very frequently, by toxins produced by pathogens or by components of the host immune response that clears those pathogens. Indeed, it is the damage inflicted to different tissues and organs that, if uncontrolled, can lead to the lethal outcome of some infectious diseases.

The in-built capacity that an infected individual has to limit the extent of tissue damage caused by different pathogens, a phenomenon known as 'tolerance to infection', has fascinated Miguel Soares, a group Leader at the Instituto Gulbenkian de Cincia (IGC) in Portugal, for several years. Now, the European Research Council (ERC) has awarded his team an Advanced Grant of just over 2,2 million Euros, to investigate the mechanisms involved in this protective response. This line of research should identify and pave the way to the development of new therapeutic interventions, to quell the clinical outcome of various diseases.

Miguel Soares and his research team have already identified a restricted number of mechanisms, regulated by specific genetic programmes that control tissue damage in response to different types of infection. They have shown that these protective mechanisms are active for example against severe forms of malaria and severe sepsis. The researchers believe, however, that other protective mechanisms controlled by groups of so-called "protective genetic programmes" can act in a similar manner in the context of different diseases. Their aim is to identify these protective mechanisms, and describe how the genetic programs act, so that these may be targeted to treat a whole range of infectious diseases.

Says Miguel Soares, "Infectious diseases such as malaria and severe sepsis remain medical challenges today, acting as major killers across the globe. Our data suggest that one of the reasons for
'/>"/>

Contact: Ana Godinho
agodinho@igc.gulbenkian.pt
351-214-407-959
Instituto Gulbenkian de Ciencia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. European Geosciences Union General Assembly, April 22-27, 2012, Vienna, Austria
2. Cell Therapeutics, Inc. Expects That the European Medicines Agencys (EMA) Committee for Medicinal Products for Human Use (CHMP) May Issue an Opinion on the Marketing Authorization Application ("MAA") on Pixuvriâ„¢ in Mid-February
3. European mountain vegetation shows effects of warmer climate
4. DTU is participating in a European network on measurement of greenhouse gases
5. Register now for the European Congress on Osteoporosis & Osteoarthritis in Bordeaux
6. UK invests £75 million in European research infrastructure to support knowledge-based economy
7. EMBO awards Installation Grants to 7 European scientists
8. How does a plant survive with few mates or pollinators? A European herb has figured out its own way
9. New European project launched to address shortcomings in climate data
10. Misleading morphology: 3 European parasitoid wasp species are seasonal forms of just 1
11. Genomatix to partner in $41 million European epigenomics consortium
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
European Research Council supports search for regulators of tissue damage
(Date:11/18/2014)... Nov. 17, 2014 The Parenteral Drug Association (PDA) ... agencies will speak and at least seven more will participate ... the Omni Shoreham Hotel in Washington D.C. ... to have significant support from the regulatory agencies in ... in our effort to help advance the use ...
(Date:11/10/2014)... on U.S. store shelves in early 2010, and people ... small packets can be tossed into a washing machine ... powder. The convenience, though, has come with risks for ... Nationwide Children,s Hospital found that from 2012 through 2013, ... younger than 6 years of age swallowing, inhaling, or ...
(Date:11/6/2014)... yet progress in preventing and treating migratory cancer ... challenging to design drugs that work against metastasis," ... at Harvard Medical School. , "Unfortunately, many ... , Gujral and colleagues have now identified a ... how metastasis begins. Their findings may also inform ...
Breaking Biology News(10 mins):FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Study finds laundry detergent pods, serious poisoning risk for children 2Migration negation 2Migration negation 3
... 15, 2013  Medbox, Inc. (OTC Markets: MDBX) ( www.medboxinc.com ... and patented systems to various medical and retail related ... corporate governance and transparency in the mushrooming legal marijuana industry and ... the status of past, present, and future projects. ...
... 15, 2013   Evolution Marketing Research , a leading supplier ... three new industry professionals. Ian Fureman ... as Associate Methodologist; and Shannon Sesa ... Fureman brings to Evolution more than 14 years of ...
... 14, 2013) Through a collaborative genome-wide study on ... are associated with heart rate. Since heart rate ... provide a better understanding of genetic regulation of heart ... for new drugs to treat cardiovascular disease. The ...
Cached Biology News:Medbox Positions Itself as the Leader on Wall Street in the Legalized Marijuana Industry 2Medbox Positions Itself as the Leader on Wall Street in the Legalized Marijuana Industry 3Medbox Positions Itself as the Leader on Wall Street in the Legalized Marijuana Industry 4Medbox Positions Itself as the Leader on Wall Street in the Legalized Marijuana Industry 5Evolution Marketing Research Grows its Practice with Addition of Three Key Industry Professionals 2Evolution Marketing Research Grows its Practice with Addition of Three Key Industry Professionals 3Mount Sinai study identifies new gene variations associated with heart rate 2
(Date:11/24/2014)... November 24, 2014 2014 Deep ... Industry is a professional and in-depth research report ... Dihydrazide information, like its definition, classification, application, and ... This report covers the international market analysis, including ... as the US, Europe, Asia, China, Japan etc. ...
(Date:11/22/2014)... and London (PRWEB) November 21, 2014 Two ... will explore what comes next for ALS research and how ... , After the Ice Bucket Challenge: Where Does the ... Date: Tuesday, 2 December 2014, Time: 1:30pm ET, ... , Join expert speaker Dr. Merit Cudkowicz, Julianne Dorn Professor ...
(Date:11/22/2014)... IL (PRWEB) November 21, 2014 On ... competitors at the 2014 Emerging Medical Technologies Summit in ... Innovator Awards. Widely regarded among Silicon Valley investors ... medical device innovation, the win also positions Briteseed ... MedTech Innovator competition in 2015 and compete with other ...
(Date:11/21/2014)... -- , Todd Martensen se ... Mariano Rodríguez es elegid vicepresidente senior de desarrollo empresarial y ... marcha para comenzar de forma rápida la comercialización de su ... en Europa   , KLOX Technologies ... siguientes nombramientos: Todd Martensen ha sido ...
Breaking Biology Technology:Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 3DrugDev Webinars in December to Explore What Comes Next for ALS Research and How We Can Make Life Easier for Clinical Sites 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 3KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5
... - Human neural stem cells, exposed in a lab dish ... rates, suggesting that the hormone may play a role in ... study published this week in the online editions of the ... new work, conducted by a team of scientists at the ...
... Lands End, Inc., , Wisconsin-based online clothing retailer, introduced Thursday ... effort to take the guesswork out of online shopping. , ... men and women find clothes that fit correctly by modeling ... more life-like model that closely resembles the customer. , ,Our ...
... and Chemicon International, Inc. announced today ... and apply Madison-based Promegas DNA-directed, RNA interference (ddRNAi) ... division of Serologicals Corporation, will have the right ... ddRNAi-based products and reagents for life science research. ...
Cached Biology Technology:DHEA Boosts Growth Rate of Human Neural Stem Cells 2DHEA Boosts Growth Rate of Human Neural Stem Cells 3
... two-position, three-way universal digital valve, just 8 mm ... its functional features in a single glass-reinforced, PBT ... only 8mm in width. , Meets a range ... 100 psi. , Satisfies a 0.016 sccm leakage ...
... Series offers high performance miniature stepper motors ... and 34 frame sizes. These space-efficient 1.8 ... science applications, including medical instrumentation, medical devices, ... systems., Meets a wide range of ...
... been designed to save time and provide ... in eliminating the recycling and resterilizing necessary ... packaged, RNase/DNase free, non-pyrogenic and antistatic. Linkage: ... number, created to easily match Cornings product ...
... PBL's bioassays for interferons are cytopathic effect ... antiviral assays. The neutralization assay measures ... activity of the cytokine. Sample types include; ... In these assays, one unit is ...
Biology Products: