Navigation Links
European Research Council supports search for regulators of tissue damage
Date:1/27/2012

There is more to fighting infection than just clearing the body of pathogens. As important as resisting infection, is limiting damage to the host's tissue caused, very frequently, by toxins produced by pathogens or by components of the host immune response that clears those pathogens. Indeed, it is the damage inflicted to different tissues and organs that, if uncontrolled, can lead to the lethal outcome of some infectious diseases.

The in-built capacity that an infected individual has to limit the extent of tissue damage caused by different pathogens, a phenomenon known as 'tolerance to infection', has fascinated Miguel Soares, a group Leader at the Instituto Gulbenkian de Cincia (IGC) in Portugal, for several years. Now, the European Research Council (ERC) has awarded his team an Advanced Grant of just over 2,2 million Euros, to investigate the mechanisms involved in this protective response. This line of research should identify and pave the way to the development of new therapeutic interventions, to quell the clinical outcome of various diseases.

Miguel Soares and his research team have already identified a restricted number of mechanisms, regulated by specific genetic programmes that control tissue damage in response to different types of infection. They have shown that these protective mechanisms are active for example against severe forms of malaria and severe sepsis. The researchers believe, however, that other protective mechanisms controlled by groups of so-called "protective genetic programmes" can act in a similar manner in the context of different diseases. Their aim is to identify these protective mechanisms, and describe how the genetic programs act, so that these may be targeted to treat a whole range of infectious diseases.

Says Miguel Soares, "Infectious diseases such as malaria and severe sepsis remain medical challenges today, acting as major killers across the globe. Our data suggest that one of the reasons for
'/>"/>

Contact: Ana Godinho
agodinho@igc.gulbenkian.pt
351-214-407-959
Instituto Gulbenkian de Ciencia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. European Geosciences Union General Assembly, April 22-27, 2012, Vienna, Austria
2. Cell Therapeutics, Inc. Expects That the European Medicines Agencys (EMA) Committee for Medicinal Products for Human Use (CHMP) May Issue an Opinion on the Marketing Authorization Application ("MAA") on Pixuvri™ in Mid-February
3. European mountain vegetation shows effects of warmer climate
4. DTU is participating in a European network on measurement of greenhouse gases
5. Register now for the European Congress on Osteoporosis & Osteoarthritis in Bordeaux
6. UK invests £75 million in European research infrastructure to support knowledge-based economy
7. EMBO awards Installation Grants to 7 European scientists
8. How does a plant survive with few mates or pollinators? A European herb has figured out its own way
9. New European project launched to address shortcomings in climate data
10. Misleading morphology: 3 European parasitoid wasp species are seasonal forms of just 1
11. Genomatix to partner in $41 million European epigenomics consortium
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
European Research Council supports search for regulators of tissue damage
(Date:5/18/2015)... 18, 2015 Fingerprint Cards (FPC) has ... FPC1145, FPC1155 and FPC1035 from one if its module partners. ... including Q3 2015 and the sensors will be used by ... values for 2015 hereby amount to 740 MSEK to date. ... 140 MSEK and a number of smaller orders not separately ...
(Date:5/11/2015)... Ohio , May 11, 2015  Through a well-rounded ... Ohio had a strong showing at AUVSI,s Unmanned ... These representatives of Ohio,s UAS industry ... and abroad from all points along the UAS ecosystem. ... Development Coalition,s (DDC) Vice President for Aerospace Rich Knoll ...
(Date:5/7/2015)... , May 7, 2015 ... sensors, FPC1022 and FPC1035, FPC,s smallest touch fingerprint ... are mainly considered for integration on the backside ... smartphone OEMs increased possibilities to integrate touch fingerprint ... size also improves possibilities for module manufacturers to ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2
... the European Society for Clinical and Economic Aspects of ... an outstanding scientific programme for the upcoming IOF WCO- ... Italy from May 5-8, 2010. Complete programme ... on www.iofwco-ecceo10.org . IOF WCO-ECCEO10 ...
... 1, 2009, St. Louis, MO Micronutrients such as ... in maintaining health. As older adults tend to reduce ... that deficits in these micronutrients lead to medical problems. ... of the Journal of the American Dietetic Association ...
... - Amyris Biotechnologies has announced the publication of an ... toward the production of amorphadiene, a precursor of the ... of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, ... ONE , an open-access journal from the Public Library ...
Cached Biology News:World Congress on Osteoporosis 2010 presents outstanding scientific program 2Many middle-aged and older Americans not getting adequate nutrition 2Milestone achieved toward production of malaria treatment using synthetic biology and fermentation 2
(Date:5/21/2015)... May 21, 2015  CytRx Corporation (NASDAQ: ... specializing in oncology, today announced positive updated results ... aldoxorubicin for the treatment of unresectable glioblastoma multiforme ... open-label, multisite trial is designed to investigate the ... whose tumors have progressed following prior treatment with ...
(Date:5/21/2015)... DUBLIN , May 20, 2015 Research ... announced the addition of the "2015 Global ... to their offering. The primary goal ... of flow cytometry instruments and reagents. Key information ... drive the selection of flow cytometers, predominantly used ...
(Date:5/21/2015)... Kingston, Ontario (PRWEB) May 21, 2015 ... entered into an exclusive North American distribution agreement ... microbiology testing system. , With more than 160 ... of products and services for laboratory and production ... choice, operational excellence and differentiated services to enable ...
(Date:5/20/2015)... Calif. , May 20, 2015 ... today presented preliminary data demonstrating the ability of ... pulmonary fibrosis (IPF) from other interstitial lung diseases ... suggest the classifier,s potential to help thousands of ... resolve ambiguity in IPF diagnosis – a frequent ...
Breaking Biology Technology:CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7Global Survey on Flow Cytometry Adoption Trends 2015 2Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 2Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 3Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 4Veracyte Presents Preliminary Data Demonstrating Ability of Molecular Classifier to Improve Non-Surgical IPF Diagnosis Using Bronchoscopy Samples 5
... option for asthma patients not fully controlled on other ... ... Dey, L.P., an,affiliate of Merck KGaA of Darmstadt, Germany, announced ... partner, Critical Therapeutics, Inc. (Nasdaq: CRTX ). ZYFLO CR(TM),offers twice-daily, ...
... ADVENTRX Pharmaceuticals,Inc. (Amex: ANX ), a ... proprietary product candidates for the treatment,of cancer ... from,preclinical studies of ANX-514 (docetaxel emulsion) will ... Research (AACR), National Cancer,Institute (NCI) and European ...
... Sept. 26 The National,Alliance for Thrombosis and Thrombophilia ... totaling $1.35 million that will serve as,building blocks for ... year to nearly one million Americans who develop a ... for Disease Control and Prevention (CDC),grants to "launch a ...
Cached Biology Technology:Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma 2Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma 3ADVENTRX to Present ANX-514 Preclinical Data at 2007 AACR-NCI-EORTC International Conference 2ADVENTRX to Present ANX-514 Preclinical Data at 2007 AACR-NCI-EORTC International Conference 3ADVENTRX to Present ANX-514 Preclinical Data at 2007 AACR-NCI-EORTC International Conference 4CDC Awards NATT Funding to Improve Blood Clot Awareness 2CDC Awards NATT Funding to Improve Blood Clot Awareness 3
... The Gene Pulser Xcell ... V, 50-60 Hz, is used ... This system includes the main ... (25-3,275 microfarad range) or square-wave ...
AVOID FREEZE/THAW CYCLES. Recognizes the ~5 kDa thymosin beta4 protein....
... Accurate To score SNPs, ... sequencing, the gold standard in DNA analysis. ... The polymorphic locus can be confirmed by ... DNA sequencing also provides sequence context information, ...
... PowerPac basic power supply are used for submerged ... gels. The mini format cell includes a buffer ... bubble. The PowerPac basic power supply, 100-120 and ... mA, and 75 W. Power cord and instructions ...
Biology Products: