Navigation Links
Enhanced NIST instrument enables high-speed chemical imaging of tissues
Date:7/22/2014

re very faint, so researchers have worked for years to develop enhanced methods for gathering these spectra.** "Coherent" Raman methods use specially tuned lasers to both excite the molecular vibrations and provide a bright source of probe photons to read the vibrations. This has partially solved the problem, but the coherent Raman methods developed to date have had limited ability to access most of the available spectroscopic information.

Most current coherent Raman methods obtain useful signal only in a spectral region containing approximately five peaks with information about carbon-hydrogen and oxygen-hydrogen bonds. The improved method described by the NIST team not only accesses this spectral region, but also obtains excellent signal from the "fingerprint" spectral region, which has approximately 50 peaksmost of the useful molecular ID information.

The NIST instrument is able to obtain enhanced signal largely by using excitation light efficiently. Conventional coherent Raman instruments must tune two separate laser frequencies to excite and read different Raman vibration modes in the sample. The NIST instrument uses ultrashort laser pulses to simultaneously excite all vibrational modes of interest. This "intrapulse" excitation is extremely efficient and produces its strongest signals in the fingerprint region. "Too much light will destroy cells," explains NIST chemist Marcus Cicerone, "So we've engineered a very efficient way of generating our signal with limited amounts of light. We've been more efficient, but also more efficient where it counts, in the fingerprint region."

Raman hyperspectral images are built up by obtaining spectra, one spatial pixel at a time. The hundred-fold improvement in signal strength for the NIST BCARS instrument makes it possible to collect individual spectral data much faster and at much higher quality than beforea few milliseconds per pixel for a high-quality spectrum versus tens of milliseconds for a
'/>"/>

Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Enhanced royal jelly produces jumbo queen bee larvae
2. Potential drug molecule shows enhanced anti-HIV activity
3. Discovery may pave way to genetically enhanced biofuel crops
4. Musicians who learn a new melody demonstrate enhanced skill after a nights sleep
5. Xyngular Announces the Launch of its New Xyng Enhanced Formula
6. Better broccoli, enhanced anti-cancer benefits with longer shelf life
7. 660 nm red light-enhanced BMSCs transplantation for hypoxic-ischemic brain damage
8. WHOI scientists/engineers partner with companies to market revolutionary new instruments
9. UNH labs receive 2 NSF grants totalling $1.35m for research instruments
10. Exclusive agreement to distribute Affinity Biosensors Archimedes system extends Malvern Instruments biopharma solutions
11. BiOptix to highlight new 404pi instrument at European symposia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Enhanced NIST instrument enables high-speed chemical imaging of tissues
(Date:4/8/2015)... , April 8, 2015  Infinisource, a ... and services, and Morpho, a leading supplier of ... to produce the market,s most advanced biometrically-enabled time ... iSolved NXG time clock is setting a bold, ... labor data for the small and mid-size employer. ...
(Date:4/2/2015)... 2015 At its 2015 ACMG Annual Clinical ... , the American College of Medical Genetics and Genomics ... its Board.  Members of the ACMG Board of Directors ... and advancing its policies and programs. ACMG is the ... "It,s an eventful time in medical genetics and genomics.  ...
(Date:4/1/2015)... Apr. 1, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces the ... wallets is underway to early access pre-order customers. ... usage at retail outlets including Walmart, Target, AT&T, Dunkin, ... Wocket was accepted at all outlets and very easy ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... European Alps suggests that population declines to be observed ... effects of recent climate warming on mountain plants. A ... Department of Conservation Biology, Vegetation and Landscape Ecology of ... to predict migration of mountain plants which explicitly takes ...
... LSU,s Mark Batzer, along with research associate Jerilyn Walker ... modern-day orangutans are host to ancient jumping genes called Alu, ... was done in collaboration with the Zoological Society of San ... is featured in the new open access journal Mobile ...
... requirement for efficient mosquito mass-rearing technology has been one ... of the Sterile Insect Technique (SIT) against mosquitoes. ... next issue of the Journal of Medical Entomology ... Organization (FAO) and the International Atomic Energy Agency (IAEA) ...
Cached Biology News:European mountain plant population shows delayed response to climate change 2LSU research finds orangutans host ancient jumping genes 2
(Date:4/16/2015)... , April 16, 2015  Schulman Associates IRB, Inc., ... has signed a long-term lease on Laboratory Drive in ... Carolina . The location will house review board ... provide high quality reviews and customer service to clients. ... represented Schulman in the deal, while Capital Associates ...
(Date:4/16/2015)... Streetsboro, Ohio (PRWEB) April 16, 2015 ... Safety Index, overexertion involving an outside source was ... injuries. This includes injuries related to lifting, pushing, ... $15.1 billion in direct costs. The David Round ... Round is committed to working hard to develop ...
(Date:4/16/2015)... The Council for Agricultural Science and ... CAST Communication Award goes to Dr. Channapatna Prakash, ... Alabama. Award nominees must demonstrate an ability to ... use of television, radio, or other social media. ... specialist in the field of plant genetics and ...
(Date:4/16/2015)... , April 16, 2015 /PRNewswire/ - Portage Biotech Inc. ... Securities Exchange: PBT.U), is pleased to announce that the ... on April 25, 2015 to be held in ... Gregory Bailey and Mr. James Mellon , ... an update on the key programs at its subsidiaries, ...
Breaking Biology Technology:Schulman IRB to Open Office in Research Triangle Park, N.C. 2The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2Portage to Present at Master Investor 2015 in London, UK 2Portage to Present at Master Investor 2015 in London, UK 3Portage to Present at Master Investor 2015 in London, UK 4
... NeoStem, Inc. (NYSE Amex: NBS ), which is ... stem cells for future medical need, announced today it has ... Managing Partner of Bernstein & Pinchuk LLP, to serve as ... Mr. Bernstein co-founded Bernstein & Pinchuk LLP (B&P) in 1983, ...
... Experience Daily Pain From Rheumatoid Arthritis Despite Current ... Rheumatism Annual Congress of Rheumatology , , ... Rheumatoid Arthritis: Insights, Strategies & Expectations (RAISE) survey ... throughout Europe and Canada revealed a majority of ...
... LONDON, June 9 /PRNewswire/ -- The Healthcare ... despite difficult economic times, renewals of Web of ... have even added new content to their portfolio of ... largest citation database, providing researchers, administrators, faculty and students ...
Cached Biology Technology:NeoStem, Inc. Appoints Financial Expert with Broad International Experience to the Board of Directors and to Serve as Chairman of the Company's Audit Committee 2NeoStem, Inc. Appoints Financial Expert with Broad International Experience to the Board of Directors and to Serve as Chairman of the Company's Audit Committee 3New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 2New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 3New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 4New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 5New Survey Reveals That More Than Half of Rheumatoid Arthritis Patients in Europe and Canada Feel Their Disease Controls Their Lives 6Web of Science(R) Renewals Remain Strong Despite Tough Economic Climate 2
Chicken Anti-Human Stomatin-like 2 (STOML2 Polyclonal AntibodyNew Applications: ELISA, Western Blot...
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
... Polyclonal Antibody to Asb-2 (Ankyrin repeat ... was raised against synthetic peptides containing amino ... protein. Human spleen lysate (Imgenex Catalog No. ... control. It should cross react with mouse ...
Monoclonal Anti-Gα o purified immunoglobulin buffered aqueous solution Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide. partially purified bovine brain Gα O ...
Biology Products: