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Enhanced NIST instrument enables high-speed chemical imaging of tissues
Date:7/22/2014

re very faint, so researchers have worked for years to develop enhanced methods for gathering these spectra.** "Coherent" Raman methods use specially tuned lasers to both excite the molecular vibrations and provide a bright source of probe photons to read the vibrations. This has partially solved the problem, but the coherent Raman methods developed to date have had limited ability to access most of the available spectroscopic information.

Most current coherent Raman methods obtain useful signal only in a spectral region containing approximately five peaks with information about carbon-hydrogen and oxygen-hydrogen bonds. The improved method described by the NIST team not only accesses this spectral region, but also obtains excellent signal from the "fingerprint" spectral region, which has approximately 50 peaksmost of the useful molecular ID information.

The NIST instrument is able to obtain enhanced signal largely by using excitation light efficiently. Conventional coherent Raman instruments must tune two separate laser frequencies to excite and read different Raman vibration modes in the sample. The NIST instrument uses ultrashort laser pulses to simultaneously excite all vibrational modes of interest. This "intrapulse" excitation is extremely efficient and produces its strongest signals in the fingerprint region. "Too much light will destroy cells," explains NIST chemist Marcus Cicerone, "So we've engineered a very efficient way of generating our signal with limited amounts of light. We've been more efficient, but also more efficient where it counts, in the fingerprint region."

Raman hyperspectral images are built up by obtaining spectra, one spatial pixel at a time. The hundred-fold improvement in signal strength for the NIST BCARS instrument makes it possible to collect individual spectral data much faster and at much higher quality than beforea few milliseconds per pixel for a high-quality spectrum versus tens of milliseconds for a
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Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

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