Navigation Links
Engineering excitable cells for studies of bioelectricity and cell therapy
Date:7/19/2011

DURHAM, N.C. By altering the genetic makeup of normally "unexcitable" cells, Duke University bioengineers have turned them into cells capable of generating and passing electrical current.

This proof-of-concept advance could have broad implications in treating diseases of the nervous system or the heart, since these tissues rely on cells with the ability to communicate with adjacent cells in order to function properly. This communication is achieved through the passage of electrical impulses, known as action potentials, from cell to cell.

The researchers achieved this transformation by introducing genes into the cells that result in the formation of ion channels which are openings, or gates, on the surface of cells. Ion channels allow the flow of electrically charged molecules, or ions, to exit or enter the cell thus enabling the transfer of electric current from one cell to its neighbor.

"By introducing only three specific ion channels, we were able to give normally electrically inactive cells the ability to become electrically excitable," said Rob Kirkton, graduate student in the laboratory of senior investigator Nenad Bursac, associate professor of biomedical engineering at Duke's Pratt School of Engineering.

"We also demonstrated proof-of-concept experiments in which these modified cells were able restore large electrical gaps within and between rat heart cells," Kirkton continued. "This approach to genetically engineering electrical excitability may stimulate the development of new cell or gene-based therapies for excitable tissue repair."

The results of the Duke experiments were published in the journal Nature Communications. The researchers are supported by the National Science Foundation, the American Heart Association and the National Institutes of Health.

"We believe that our approach opens the door to a wide range of novel studies involving electrical communication between cells and may al
'/>"/>

Contact: Richard Merritt
richard.merritt@duke.edu
919-660-8414
Duke University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. BGI and National Wolfberry Engineering Research Center launch Chinese wolfberry genome project
2. NJIT receives second part of $1M gift to chemical engineering department
3. Engineering blue-hued flowers
4. UA engineering college lands national support for equipment used in unique research
5. U.S. Biomedical Leaders Present a New National Device Innovation Strategy Based on "Value-driven Engineering"
6. Progress in tissue engineering to repair joint damage in osteoarthritis
7. Environmental engineering students and faculty study Passaic River pollution
8. Engineering new weapons in the fight against juvenile diabetes
9. Columbia Engineering team makes major step in improving forecasts of weather extremes
10. Stevens biomedical engineering students fight hypothermia on the battlefield
11. Yale scientists discover new method for engineering human tissue regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... robots could be much more useful in homes, if ... usually see the world with cameras and lasers, which ... that are hidden in clutter. A complementary way robots ... use of small ultra-high frequency radio-frequency identification (UHF RFID) ... allowing an RFID-equipped robot to search a room for ...
(Date:9/22/2014)... 2014 NXT-ID, Inc. (NASDAQ: NXTD ... mobile commerce market, issues the following corporate shareholder update ... Letter from the CEO : ... funding and joined the NASDAQ to support ramping of ... biometric and authentication products and services. This strategic achievement positions ...
(Date:9/21/2014)... September 22, 2014The story of cowpea (black-eyed peas) is ... world,s biggest problemseven more fascinating is the story of ... wrote Cowpea: The Food Legume of the 21st Century ... management, and use. The book was recently published by ... International Institute of Tropical Agriculture (IITA). , Singh has ...
Breaking Biology News(10 mins):New RFID technology helps robots find household objects 2New RFID technology helps robots find household objects 3NXT-ID Issues Shareholder Corporate Update 2NXT-ID Issues Shareholder Corporate Update 3NXT-ID Issues Shareholder Corporate Update 4
... Bellvitge Biomedical Research Institute (IDIBELL) have shown that breast ... higher level of the protein peroxiredoxin 2 (PRDX2). The ... this protein could be a new therapeutic strategy to ... in the online edition of the journal Oncogene ...
... Researchers have gained new insight into why 22% ... a folate concentration considered optimal for reducing the risk of ... of folate deficiency in the general Canadian population. When ... reason why some women are not achieving levels optimal for ...
... April 10, 2012 The neighborhoods in which children and ... whether or not they eat a healthy diet, get enough ... a special theme issue of the American Journal of ... uses the latest concepts and methods in geographic information systems ...
Cached Biology News:Geographic information systems demonstrate links between health and location 2
(Date:9/22/2014)... , Sept. 22, 2014 Research and ... "Global and Chinese Microcrystalline Cellulose Industry Report 2014" ... and Chinese Microcrystalline Cellulose Industry Report 2014 is a ... the global microcrystalline cellulose industry with a focus on ... basic overview of the industry including definitions, classifications, applications ...
(Date:9/22/2014)... TORONTO , Sept. 22, 2014 ... (OTCBB:GNBT) today announced that it has entered into ... to which UHN,s Centre for Molecular Design and ... refinement project.  The goal of the project is ... the Company,s proprietary buccal insulin spray product, thereby ...
(Date:9/22/2014)... Washington, D.C (PRWEB) September 22, 2014 ... the top privately held biotechnology companies of 2014. ... of companies before selecting this year’s winners. Those ... private biotechnology companies in the industry. , ... a new group of Fierce 15 companies," said Carroll. ...
(Date:9/22/2014)... The US markets on Friday, September 19, ... Jones Industrial Average finished at 17,279.74, up 0.08% and ... S&P 500 finished the session 0.05% lower at 2,010.40. ... finished on a positive note. The S&P 500 Health ... 0.10%, with the index gaining 6.95% in the previous ...
Breaking Biology Technology:Global and Chinese Microcrystalline Cellulose Industry Report 2014 2Generex Collaborates with University Health Network for Buccal Insulin Project 2Generex Collaborates with University Health Network for Buccal Insulin Project 3Generex Collaborates with University Health Network for Buccal Insulin Project 4FierceBiotech Announces Annual “Fierce 15” Winners of 2014 2Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 2Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 3Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 4Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 5
... Council has teamed with JobSightUSA , a top-ranked ... match job seekers with positions based on specific "skill ... that are considering locating or expanding in Wisconsin to ... Wisconsinite workers who may wish to return to the ...
... plugs, cut the cords, and can the cables as we ... for all the freedom and mobility, we are nowhere without ... the like. That fact alone has turned the average business ... most obscure corner of airports and coffee houses. Indeed, Im ...
... 2004, the New Venture Center at the Fitchburg ... in its first phase. , ,Ground-breaking will be held on ... tenant is another nanotech company, Imago Scientific . When it ... to staff up to 71 over the next eight months. , ...
Cached Biology Technology:Power for the people 2Fitchburg Technology Campus attracts nanotechnology firms 2
... and reliable automation for today's drug ... laboratories. Staccato Mini-Workstations offer the minimal ... liquid handling and material management tasks. ... Caliper's time proven CLARA™ assay development ...
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
... high experimental throughput, minimum input of ... 4 up to 16 culture vessels ... users with proven fermentation results when ... fungi or any other microbial application. ...
Experion HighSens chips are the microfluidic chips used to perform high-sensitivity RNA analysis (picogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to ru...
Biology Products: