Navigation Links
Engineering excitable cells for studies of bioelectricity and cell therapy
Date:7/19/2011

DURHAM, N.C. By altering the genetic makeup of normally "unexcitable" cells, Duke University bioengineers have turned them into cells capable of generating and passing electrical current.

This proof-of-concept advance could have broad implications in treating diseases of the nervous system or the heart, since these tissues rely on cells with the ability to communicate with adjacent cells in order to function properly. This communication is achieved through the passage of electrical impulses, known as action potentials, from cell to cell.

The researchers achieved this transformation by introducing genes into the cells that result in the formation of ion channels which are openings, or gates, on the surface of cells. Ion channels allow the flow of electrically charged molecules, or ions, to exit or enter the cell thus enabling the transfer of electric current from one cell to its neighbor.

"By introducing only three specific ion channels, we were able to give normally electrically inactive cells the ability to become electrically excitable," said Rob Kirkton, graduate student in the laboratory of senior investigator Nenad Bursac, associate professor of biomedical engineering at Duke's Pratt School of Engineering.

"We also demonstrated proof-of-concept experiments in which these modified cells were able restore large electrical gaps within and between rat heart cells," Kirkton continued. "This approach to genetically engineering electrical excitability may stimulate the development of new cell or gene-based therapies for excitable tissue repair."

The results of the Duke experiments were published in the journal Nature Communications. The researchers are supported by the National Science Foundation, the American Heart Association and the National Institutes of Health.

"We believe that our approach opens the door to a wide range of novel studies involving electrical communication between cells and may al
'/>"/>

Contact: Richard Merritt
richard.merritt@duke.edu
919-660-8414
Duke University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. BGI and National Wolfberry Engineering Research Center launch Chinese wolfberry genome project
2. NJIT receives second part of $1M gift to chemical engineering department
3. Engineering blue-hued flowers
4. UA engineering college lands national support for equipment used in unique research
5. U.S. Biomedical Leaders Present a New National Device Innovation Strategy Based on "Value-driven Engineering"
6. Progress in tissue engineering to repair joint damage in osteoarthritis
7. Environmental engineering students and faculty study Passaic River pollution
8. Engineering new weapons in the fight against juvenile diabetes
9. Columbia Engineering team makes major step in improving forecasts of weather extremes
10. Stevens biomedical engineering students fight hypothermia on the battlefield
11. Yale scientists discover new method for engineering human tissue regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... 2015 Research and Markets ( ... "Global Biometrics Market (2014-2020): Market Forecast By ... report to their offering. , ... is anticipated to overtake North ... government spending towards IT security, government biometric based ...
(Date:1/22/2015)... Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the leading source of ... of its new website design. "When we launched ... says Peter O,Neill , founder and CEO of FindBiometrics. ... needs involvement from the key players on a very broad ...
(Date:1/22/2015)... , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... commerce market, reports on the recent success of the Wocket™ smart wallet ... Wocket smart wallet was named as one of the "11 Hot ... "5 Best Products Launched At CES So Far" by Newseveryday.com and "The ...
Breaking Biology News(10 mins):Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 3Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... tumor cell growth also plays a key role in aging. ... p16INK4a in older cells; these aging cells worked poorly compared ... from old mice to young mice. The cells of mice ... aged and continued to function in a manner more similar ...
... researchers has received a four-year, $1 million grant from ... biological separations. Led by Ravi Kane, the Merck Associate ... Institute, the group plans to develop nanoscale surfaces that ... eventually lead to more efficient separation tools for genomics ...
... Cincinnati (UC) environmental health researchers have determined that firefighters ... of cancer than workers in other fields. , Their ... in the past didn't do a good job in ... profession, the researchers say. , The researchers found, ...
Cached Biology News:Studies find general mechanism of cellular aging 2Studies find general mechanism of cellular aging 3Researchers to develop active nanoscale surfaces for biological separations 2Firefighters face increased risk for certain cancers 2
(Date:2/27/2015)... Scotia (PRWEB) February 27, 2015 ... vaccine and immunotherapy company, today announced that the ... application for Fast Track designation and Phase I ... in conjunction with the mutual co-development agreement signed ... obtained Fast Track designation for the DPX-Survivac. , ...
(Date:2/27/2015)... San Francisco, CA (PRWEB) February 27, 2015 ... is joining forces on February 28 with patients and ... to raise awareness for Rare Disease Day®. Rare ... rare diseases and calling attention to the special challenges ... community around them. , “Cytokinetics is proud to stand ...
(Date:2/26/2015)... Calif. , Feb. 26, 2015  23andMe, the ... Kate Black as Privacy Officer and Corporate ... and state privacy laws as well as health care ... team, she will be responsible for reviewing, updating and ... in the U.S. and abroad. She joined the company ...
(Date:2/26/2015)... Fla. , Feb. 26, 2015 DuPont ... growth priorities driven by key research advancements and product ... at today,s Bank of America Merrill Lynch 2015 Global ... the challenge of building grain supplies the last two ... continue at the pace of the last decade, when ...
Breaking Biology Technology:Immunovaccine Inc. (TSX: IMV) receives Fast Track and Phase I trial approval for Ebola and Anthrax vaccine programs, signs co-development agreement with Gilead Sciences 2Immunovaccine Inc. (TSX: IMV) receives Fast Track and Phase I trial approval for Ebola and Anthrax vaccine programs, signs co-development agreement with Gilead Sciences 3Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 2Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 3Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 4Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 5Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 623andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 3DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 4DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 5
... YORK, Nov. 3 NeoStem, Inc. (Amex: ... and long-term,storage of adult stem cells for future ... acquire a Hong Kong corporation, whose wholly-owned,subsidiary, Beijing ... contracts with Shandong New Medicine Research Institute of,Integrated ...
... VINELAND, ON, Nov. 3 /PRNewswire/ - Vineland ... established to create a,world-class centre for horticultural ... Dr. Isabelle Lesschaeve to the new role ... "As the Research Chair, Sensory and Consumer ...
... 3 Nile Therapeutics,Inc., (Nasdaq: NLTX ), announced ... the following upcoming investor conferences:, -- Rodman & ... the Kennedy II room on Monday, November 10, 2008 ... Lazard Capital Markets 5th Annual Healthcare Conference at 9:00 ...
Cached Biology Technology:NeoStem, Inc. to Enter the Regenerative Medicine Market in Asia 2NeoStem, Inc. to Enter the Regenerative Medicine Market in Asia 3NeoStem, Inc. to Enter the Regenerative Medicine Market in Asia 4Vineland Welcomes Dr. Isabelle Lesschaeve as Research Chair, Sensory and Consumer Sciences 2Nile Therapeutics to Present at Two Upcoming Investor Conferences 2
... kit contains 5 ml CELLection Dynabeads (4.5 ... the human epithelial antigen EpCAM and DNase ... log enrichment of epithelial tumour cells directly ... cells clumps can be enriched from bone ...
Recombinant Human CCL21/6Ckine (Mucin Stalk Chimera)...
Recombinant Human Erythropoietin (Tissue Culture Grade)...
Acrylamide PAGE 40% Solution, 1 l. Category: Electrophoresis Systems & Standards & Reagents, Electrophoresis Standards and Reagents, Gel Casting Chemicals....
Biology Products: