Navigation Links
Engineering cells for more efficient biofuel production
Date:2/19/2013

CAMBRIDGE, Mass. In the search for renewable alternatives to gasoline, heavy alcohols such as isobutanol are promising candidates. Not only do they contain more energy than ethanol, but they are also more compatible with existing gasoline-based infrastructure. For isobutanol to become practical, however, scientists need a way to reliably produce huge quantities of it from renewable sources.

MIT chemical engineers and biologists have now devised a way to dramatically boost isobutanol production in yeast, which naturally make it in small amounts. They engineered yeast so that isobutanol synthesis takes place entirely within mitochondria, cell structures that generate energy and also host many biosynthetic pathways. Using this approach, they were able to boost isobutanol production by about 260 percent.

Though still short of the scale needed for industrial production, the advance suggests that this is a promising approach to engineering not only isobutanol but other useful chemicals as well, says Gregory Stephanopoulos, an MIT professor of chemical engineering and one of the senior authors of a paper describing the work in the Feb. 17 online edition of Nature Biotechnology.

"It's not specific to isobutanol," Stephanopoulos says. "It's opening up the opportunity to make a lot of biochemicals inside an organelle that may be much better suited for this purpose compared to the cytosol of the yeast cells."

Stephanopoulos collaborated with Gerald Fink, an MIT professor of biology and member of the Whitehead Institute, on this research. The lead author of the paper is Jose Avalos, a postdoc at the Whitehead Institute and MIT.

Historically, researchers have tried to decrease isobutanol production in yeast, because it can ruin the flavor of wine and beer. However, "now there's been a push to try to make it for fuel and other chemical purposes," says Avalos, the paper's lead author.

Yeast typically produce isobut
'/>"/>

Contact: Caroline McCall
cmccall5@mit.edu
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers analyse rock dissolving method of geoengineering
2. NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability
3. UTSA engineer Hai-Chao Han named Fellow of Medical and Biological Engineering Institute
4. Engineering alternative fuel with cyanobacteria
5. Geo-engineering against climate change
6. Association of Environmental Engineering and Science Professors name Environmental Engineering Science as its official journal
7. University of Tennessee engineering professor looks to whirligig beetle for bio-inspired robots
8. Elsevier launches new open access journal -- Case Studies in Engineering Failure Analysis
9. OU research groups awarded NSF grants to expand research and training in science and engineering
10. Marc Travel Awards announced for the 2012 Biomedical Engineering Society Annual Meeting
11. International Life Sciences Conferences Address Advancements in High-Content Analysis, Sample Preparation, Clinical Trial Supply and Protein and Antibody Engineering
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... , April 13, 2015 ... Research, "Global Biometrics Market Forecast & Opportunities, 2020", the ... CAGR of around 14% till 2020. The biometrics ... large scale implementation and review of biometric management ... of new products with greater efficiency, are resulting ...
(Date:4/9/2015)... Calif. , April 9, 2015 Synaptics ... interface solutions, announced today that it will report financial ... Thursday, April 23, 2015, after the close of market. ... analysts and investors at 2:00 p.m. PT (5:00 p.m. ... To participate on the live call, analysts ...
(Date:4/2/2015)... , April 2, 2015 ... tests DERMALOG by far outperforms the strongest competitors, ... maintaining high accuracy, the system is capable of ... the speed proves up to be ten times ... than its runner-up performance.      (Photo: ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2Synaptics to Report Third Quarter Results on April 23 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... harmful to wild fish, according to an essay in this ... Neil Frazer of the Department of Geology and Geophysics at ... cause nearby wild fish to decline. The foundation of his ... infection lowers the fitness of the fish. For ...
... The elevated carbon dioxide levels expected to be found in ... impairments of jumbo (or Humboldt) squid, according to research by ... study by Brad Seibel, URI assistant professor of biological sciences, ... the faculty at the University of Lisbon, Portugal, is reported ...
... a patient-centered, care management program utilizing nurse care managers ... coordination systems reduce the rate of deaths and hospitalizations ... based on a three-year study involving more than 3,400 ... University researcher David A. Dorr, M.D. appears to ...
Cached Biology News:Ocean fish farming harms wild fish, study says 2Ocean acidification from CO2 emissions will cause physiological impairment to jumbo squid 2Proactive care saves lives of seniors, study finds 2Proactive care saves lives of seniors, study finds 3
(Date:4/20/2015)... and Champaign, IL (PRWEB) April 20, 2015 ... the establishment of its 12th clinical research site: PMG ... Research has assumed operation of the clinical research department ... PMG’s footprint outside the Southeast to a second region ... a 150 multi-specialty physician practice enhances PMG’s access to ...
(Date:4/20/2015)... April 20, 2015  Eli Lilly and Company (NYSE: ... several targeted cancer therapies, reflecting Lilly,s diverse oncology pipeline, ... Meeting 2015, held April 18-22 in Philadelphia ... to Patients" is the theme of this year,s AACR ... to broadening its portfolio of therapies that accelerate the ...
(Date:4/20/2015)... 20, 2015 Sinovac Biotech Ltd. (Nasdaq: SVA), ... announced its unaudited financial results for the fourth quarter ... Fourth Quarter 2014 Financial Highlights(Compared to the fourth quarter ... a decrease of 11.4% from $22.9 million in the ... of H5N1 pandemic influenza vaccine of $0.1 million in ...
(Date:4/18/2015)... , April 18, 2015 ... CRIS ) will be presenting data at ... American Associate of Cancer Research Annual Meeting (April ...      (Logo: http://photos.prnewswire.com/prnh/20130418/608115 ) , ... proprietary Nicotinamide phosphoribosyltransferase (NAMPT) small molecule inhibitors program, ...
Breaking Biology Technology:PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 2PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 3Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 2Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 3Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 4Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 5Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 6Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 2Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 3Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 4Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 5Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 6Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 7Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 8Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 9Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 10Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 11Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 12Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 13Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 14Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 15Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 16Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 17Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 18Aurigene to Present its NAMPT and IRAK-4 Inhibitors Programs at AACR 2015 2
... 4 Imaging,Diagnostic Systems, Inc., (OTC Bulletin Board: ... systems, has shipped a CT Laser Mammography,(CTLM(R)) system ... Lumpur,Malaysia, the first such scanner in the country. ... CTLM system will be installed at UPM,s academic ...
... PHRM ) today announced that Erle Mast, the Company,s ... corporate overview at,the Bear Stearns 2007 Healthcare Conference in ... 4:00 p.m. (Eastern) on Monday,September 10, 2007 at the ... will be a live webcast of the presentation from ...
... and Advisor to ForSight ... ... Morgenthaler Ventures, (http://www.morgenthaler.com/ventures ), a leading venture capital firm focused ... Plain as partner in its Menlo Park office. Plain brings,significant entrepreneurial ...
Cached Biology Technology:Imaging Diagnostic Systems New Laser Breast Imaging Scanner Introduced in Malaysia 2Hank Plain Joins Morgenthaler Ventures as Partner 2Hank Plain Joins Morgenthaler Ventures as Partner 3
... are preactivated with carbonyl diimidazole chemistry that ... The PS10 array contains the same binding ... with an updated hydrophobic barrier coating. These ... mm diameter spots spatially compatible with one ...
... Second Mitochondria Derived Activator of Caspase/DIABLO ... mM HEPES, pH 7.5 AVOID FREEZE/THAW CYCLES. Amino ... with a carboxy terminal His•Tag ® sequence ... coli . Smac/DIABLO is released along with cytochrome ...
...
... Fixed clamp trays and universal ... Magnetic drive Shaking ... 25 mm amplitude ... to 2000 ml, including Fernbach flasks ...
Biology Products: