Navigation Links
Engineering cells for more efficient biofuel production
Date:2/19/2013

CAMBRIDGE, Mass. In the search for renewable alternatives to gasoline, heavy alcohols such as isobutanol are promising candidates. Not only do they contain more energy than ethanol, but they are also more compatible with existing gasoline-based infrastructure. For isobutanol to become practical, however, scientists need a way to reliably produce huge quantities of it from renewable sources.

MIT chemical engineers and biologists have now devised a way to dramatically boost isobutanol production in yeast, which naturally make it in small amounts. They engineered yeast so that isobutanol synthesis takes place entirely within mitochondria, cell structures that generate energy and also host many biosynthetic pathways. Using this approach, they were able to boost isobutanol production by about 260 percent.

Though still short of the scale needed for industrial production, the advance suggests that this is a promising approach to engineering not only isobutanol but other useful chemicals as well, says Gregory Stephanopoulos, an MIT professor of chemical engineering and one of the senior authors of a paper describing the work in the Feb. 17 online edition of Nature Biotechnology.

"It's not specific to isobutanol," Stephanopoulos says. "It's opening up the opportunity to make a lot of biochemicals inside an organelle that may be much better suited for this purpose compared to the cytosol of the yeast cells."

Stephanopoulos collaborated with Gerald Fink, an MIT professor of biology and member of the Whitehead Institute, on this research. The lead author of the paper is Jose Avalos, a postdoc at the Whitehead Institute and MIT.

Historically, researchers have tried to decrease isobutanol production in yeast, because it can ruin the flavor of wine and beer. However, "now there's been a push to try to make it for fuel and other chemical purposes," says Avalos, the paper's lead author.

Yeast typically produce isobut
'/>"/>

Contact: Caroline McCall
cmccall5@mit.edu
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers analyse rock dissolving method of geoengineering
2. NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability
3. UTSA engineer Hai-Chao Han named Fellow of Medical and Biological Engineering Institute
4. Engineering alternative fuel with cyanobacteria
5. Geo-engineering against climate change
6. Association of Environmental Engineering and Science Professors name Environmental Engineering Science as its official journal
7. University of Tennessee engineering professor looks to whirligig beetle for bio-inspired robots
8. Elsevier launches new open access journal -- Case Studies in Engineering Failure Analysis
9. OU research groups awarded NSF grants to expand research and training in science and engineering
10. Marc Travel Awards announced for the 2012 Biomedical Engineering Society Annual Meeting
11. International Life Sciences Conferences Address Advancements in High-Content Analysis, Sample Preparation, Clinical Trial Supply and Protein and Antibody Engineering
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... ply silent freeways, solar panels blanket rooftops and power ... howling winds and from the blazing desert sun. , ... and economically feasible to convert California,s all-purpose energy infrastructure ... Energy , the plan shows the way to ... that could create tens of thousands of jobs and ...
(Date:7/24/2014)... at Albert Einstein College of Medicine of ... J. Fox Foundation for Parkinson,s Research to translate a ... This drug discovery project will test chemical compounds on ... a drug that acts on an underlying cause of ... help many people manage their symptoms, we are eager ...
(Date:7/24/2014)... hazard in the United States, wildland managers often utilize ... suppressed trees (ladder fuels). These cuttings and other ... fire danger in order to dispose of the material. ... managers often cover all or part of the debris ... agricultural plastic, in order to keep water out. A ...
Breaking Biology News(10 mins):Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4Albert Einstein College of Medicine receives grant from the Michael J. Fox Foundation to fund drug discovery project targeting Parkinson's 2Albert Einstein College of Medicine receives grant from the Michael J. Fox Foundation to fund drug discovery project targeting Parkinson's 3Study gives new perspective on agricultural plastic, debris burning, and air quality 2
... the National Consortium for Data Science (NCDS) aims to ... and data science research, a move that will help ... the data-driven global economy. The consortium, ... University of North Carolina at Chapel Hill, unites data ...
... reveals that age matters when it comes to adapting to ... insight and understanding of the likely impact of predicted environmental ... the journal Global Change Biology scientists from British ... the Alfred Wegener Institute reveal that when it comes to ...
... An international team of researchers has decoded the genome ... and illuminating: the African coelacanth. A sea-cave dwelling, five-foot ... thought to be extinct. A living coelacanth was discovered ... questions about these ancient-looking fish popularly known as ...
Cached Biology News:National consortium to lead North Carolina in big data innovation 2National consortium to lead North Carolina in big data innovation 3Age matters to Antarctic clams 2Coelacanth genome surfaces 2Coelacanth genome surfaces 3Coelacanth genome surfaces 4
(Date:7/24/2014)... , July 24, 2014  Spherix Incorporated (SPEX) -- ... and monetization of intellectual property, today announced that the ... ending June 30, 2014 on Monday, August 18, 2014 ... 10 a.m. ET on Monday, August 18, 2014 to ... by the company,s CEO, Anthony Hayes . ...
(Date:7/24/2014)... (PRWEB) July 24, 2014 As part ... numerous projects in the MENA region during 2014 with ... a preferred provider agreement with DZS to manage our ... region,” said Global VP of R&D and President of ... developed excellent operational practices with a focus on utilizing ...
(Date:7/23/2014)... Lyfebulb, the International Pemphigus Pemphigoid Foundation ... OMX First North Premier, Stockholm ... collaboration to increase awareness of unmet needs in ... attended by more than sixty patients, physicians, scientists ... and wellness company dedicated to serving the needs ...
(Date:7/23/2014)... Inc. (NASDAQ: SGMO ) today reported its ... For the second quarter ended June 30, 2014, ... or $0.10 per share, compared to a net loss ... same period in 2013. As of June 30, 2014, ... interest receivable of $236.7 million. Revenues for ...
Breaking Biology Technology:Spherix Schedules Shareholder Update Call 2SBI Pharmaceuticals Co. Ltd. Enters into Preferred Provider Agreement with DZS Clinical Services 2Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 2Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 4Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 5Sangamo BioSciences Reports Second Quarter 2014 Financial Results 2Sangamo BioSciences Reports Second Quarter 2014 Financial Results 3Sangamo BioSciences Reports Second Quarter 2014 Financial Results 4Sangamo BioSciences Reports Second Quarter 2014 Financial Results 5Sangamo BioSciences Reports Second Quarter 2014 Financial Results 6Sangamo BioSciences Reports Second Quarter 2014 Financial Results 7Sangamo BioSciences Reports Second Quarter 2014 Financial Results 8Sangamo BioSciences Reports Second Quarter 2014 Financial Results 9
... Microsoft chairman and chief software architect Bill Gates talked ... industry when he stopped in their classroom during his ... included in the tour, which is promoting greater youth ... Communications. Photo by Jeff Miller , ...
... Wis. - These are not your parents' generation ... "cool" was rarely heard to cross the lips of ... commodity. The problem is that Wisconsin doesn't yet have ... dozen representatives of business, civic, academic and arts groups ...
... Madison, Wis. - The 53 Wisconsin companies that ... Business Innovation Research (SBIR) and Small Business Technology Transfer ... recognized at an upcoming banquet in Madison. , ,The ... technology transfer workshop. The workshop will focus on SBIR/STTR ...
Cached Biology Technology:Gates displays software's future to UW-Madison students 2Gates displays software's future to UW-Madison students 3Gates displays software's future to UW-Madison students 4Tech leaders call for more creativity 2
Presenilin 2 Immunogen: Synthetic peptide corresponding to residues 31-47 of human Presenilin 2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Monoclonal Anti-Gα o purified immunoglobulin buffered aqueous solution Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide. partially purified bovine brain Gα O ...
Potassium Channel kv3.2...
... 2, Neuronal (GLYT2). The antiserum has been ... nervous system. The staining pattern obtained with ... in situ hybridization with probes to GLYT2 ... for glycinergic neurons. Preabsorption of the antiserum ...
Biology Products: