Navigation Links
Engineering cells for more efficient biofuel production
Date:2/19/2013

CAMBRIDGE, Mass. In the search for renewable alternatives to gasoline, heavy alcohols such as isobutanol are promising candidates. Not only do they contain more energy than ethanol, but they are also more compatible with existing gasoline-based infrastructure. For isobutanol to become practical, however, scientists need a way to reliably produce huge quantities of it from renewable sources.

MIT chemical engineers and biologists have now devised a way to dramatically boost isobutanol production in yeast, which naturally make it in small amounts. They engineered yeast so that isobutanol synthesis takes place entirely within mitochondria, cell structures that generate energy and also host many biosynthetic pathways. Using this approach, they were able to boost isobutanol production by about 260 percent.

Though still short of the scale needed for industrial production, the advance suggests that this is a promising approach to engineering not only isobutanol but other useful chemicals as well, says Gregory Stephanopoulos, an MIT professor of chemical engineering and one of the senior authors of a paper describing the work in the Feb. 17 online edition of Nature Biotechnology.

"It's not specific to isobutanol," Stephanopoulos says. "It's opening up the opportunity to make a lot of biochemicals inside an organelle that may be much better suited for this purpose compared to the cytosol of the yeast cells."

Stephanopoulos collaborated with Gerald Fink, an MIT professor of biology and member of the Whitehead Institute, on this research. The lead author of the paper is Jose Avalos, a postdoc at the Whitehead Institute and MIT.

Historically, researchers have tried to decrease isobutanol production in yeast, because it can ruin the flavor of wine and beer. However, "now there's been a push to try to make it for fuel and other chemical purposes," says Avalos, the paper's lead author.

Yeast typically produce isobut
'/>"/>

Contact: Caroline McCall
cmccall5@mit.edu
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers analyse rock dissolving method of geoengineering
2. NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability
3. UTSA engineer Hai-Chao Han named Fellow of Medical and Biological Engineering Institute
4. Engineering alternative fuel with cyanobacteria
5. Geo-engineering against climate change
6. Association of Environmental Engineering and Science Professors name Environmental Engineering Science as its official journal
7. University of Tennessee engineering professor looks to whirligig beetle for bio-inspired robots
8. Elsevier launches new open access journal -- Case Studies in Engineering Failure Analysis
9. OU research groups awarded NSF grants to expand research and training in science and engineering
10. Marc Travel Awards announced for the 2012 Biomedical Engineering Society Annual Meeting
11. International Life Sciences Conferences Address Advancements in High-Content Analysis, Sample Preparation, Clinical Trial Supply and Protein and Antibody Engineering
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... stress and stress-related psychiatric disorders are associated ... the molecular mechanisms underlying this relation are ... the development of targeted preventive strategies and ... diseases. This work is presented at the ... Now an international group of researchers from ...
(Date:10/17/2014)... regarding Ebola is critical and pertinent for practicing physicians ... outbreak and epidemic. The Journal, Disaster Medicine and ... Ebola Virus and Public Health, to surround the public, ... critical societal moment. , On October 17, the ... . The primer was prepared by Dr. Eric Toner, ...
(Date:10/17/2014)... available in German . ... few drugs. When treating overdoses, doctors are often limited to ... if there is a combination of drugs involved. So what ... swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux from the ... an answer to this question. "The task was to develop ...
Breaking Biology News(10 mins):Researchers find why depression and aging linked to increased disease risk 2Emergency aid for overdoses 2Emergency aid for overdoses 3
... Miss. Treating chronic migraines with behavioral approaches ... can make financial sense compared to prescription-drug ... new study found. Longtime behavioral therapy researcher ... Medical Center professor of psychiatry, coauthored the study. ...
... Professor Michael Davies will tell the annual meeting of ... (Wednesday) that the "vanishing twin" phenomenon, in which only ... starts as a multiple pregnancy, is linked to a ... to a nearly three-fold risk of multiple malformations. ...
... German . FRANKFURT. A newly synthesized protein is ... into its correct three dimensional structure if it was not ... of membrane proteins chaperones do not only pre-vent their aggregation, ... membrane insertion. The underlying molecular mechanism of how a certain ...
Cached Biology News:Behavioral treatment for migraines a cost-effective alternative to meds, study finds 2Behavioral treatment for migraines a cost-effective alternative to meds, study finds 3'Vanishing twin' explains increased risk of birth defects 2'Vanishing twin' explains increased risk of birth defects 3'Vanishing twin' explains increased risk of birth defects 4A chaperone system guides tail-anchored membrane proteins to their destined membrane 2
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy is seeking ... stem cells for dogs with osteoarthritis. Dr. McCarthy has ... clinical stem cell therapy for 7 years. The ultimate ... single injection of donor stem cells into one or ... inflammation in the treated joints. , Candidates for ...
(Date:10/19/2014)... October 20, 2014 OCTOBER ... Meeting (ABIM). ABIM will take place ... information about ABIM 2014 is now available ... Delegates representing companies and organizations from all ... obtain information on the latest products and ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines and ... and forecast of revenue. , Browse through the ... to get an idea of the in-depth analysis ... segmentation in the Asia-Pacific bromine market, and is ... http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a volatile ...
(Date:10/19/2014)... The Asia-Pacific Speech Analytics market report ... with analysis and forecast of revenue. This market is ... $208 million by 2019, at a Compound Annual Growth ... Browse through the TOC of the Asia-Pacific Speech Analytics ... analysis provided. It also provides a glimpse of the ...
Breaking Biology Technology:Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4
... Webb Space Telescope is its new technology. Much of the ... built specifically to enable it to see farther back in ... innovations are being used to benefit humankind in many other ... observatory and successor to the Hubble Space Telescope. The most ...
... Syndax Pharmaceuticals, Inc. , an oncology company moving into ... studies, announced the appointment of Arlene M. Morris as ... president.  "Syndax is leading the field ... unmet needs in cancer due to the problem of ...
... 2012 The following is being released by SENS Foundation: ... debate on Wednesday, 25th April, 2012. The debate will begin ... Eastern) in the University of Oxford,s Sheldonian Theatre; doors open ... propose the motion "This house wants to defeat ageing entirely" ...
Cached Biology Technology:Webb Telescope spinoff technologies already seen in some industries 2Webb Telescope spinoff technologies already seen in some industries 3Webb Telescope spinoff technologies already seen in some industries 4Syndax Pharmaceuticals Appoints Arlene Morris as CEO 2Syndax Pharmaceuticals Appoints Arlene Morris as CEO 3Leading Scientists to Debate Views on Rejuvenation Biotechnologies 2
... in Refrigerated Vapor Trap Models RVT100, RVT400, ... Models UVS400, UVS400A and UVS800DDA., A non-corrosive, ... use for temperatures ranging from -105 to ... stability and does not evaporate. Far superior ...
... 10X Automation Buffer is a concentrated formulation ... autostainers employing capillary action technology, as well ... in collaboration with David Brigati M.D., Department ... OK. This buffer is recommended for all ...
... MALDI O-TOF creates a new category for ... platform that has been licensed to the ... Manitoba. , As the first single MALDI-TOF ... collisional cooling, the prOTOF 2000 represents a ...
... miVac DNA is an ideal small concentrator ... concentrator capable of removing water and organic ... including tubes, microplates, vials and round bottom ... for the busy lab. ,The built-in special ...
Biology Products: