Navigation Links
Engineering a protein to prevent brain damage from toxic agents
Date:7/30/2014

Research at New York University is paving the way for a breakthrough that may prevent brain damage in civilians and military troops exposed to poisonous chemicalsparticularly those in pesticides and chemical weapons.

An article in the current issue of the journal ChemBioChem outlines the advancement in detoxifying organophosphates, which are compounds commonly used in pesticides and warfare agents. The patent-pending process was developed by NYU School of Engineering Associate Professor of Chemical and Biological Engineering Jin Kim Montclare, along with Richard Bonneau, an associate professor in NYU's Department of Biology and a member of the computer science faculty at NYU's Courant Institute of Mathematical Sciences.

Their work centers on proteins called phosphotriesterases, which have the unique capability of degrading chemicals in a class known as organophosphates, which are found in everything from industrial pesticides to the sarin gas used in chemical warfare.

Organophosphates permanently bond to neurotransmitters in the brain, interfering with their ability to function and causing irreversible damage. The ability of phosphotriesterases to detoxify organophosphates has been previously documented; however, applications using the protein for this purpose have been limited by its short half-life and instability at high temperatures.

Montclare and her colleagues devised a method of re-engineering phosphotriesterases by incorporating an artificial fluorinated amino acid and computational biology. The result: a thermo-stable protein with a longer half-life that retains all the detoxification capabilities of the original version.

"Organophosphates pose tremendous danger to people and wildlife, and sadly it's not unusual for humans to come into contact with these compounds, whether through exposure to pesticide or an intentional chemical warfare attack," explained Montclare. "We've known that phosphotr
'/>"/>

Contact: Kathleen Hamilton
kathleen.hamilton@nyu.edu
718-260-3792
New York University Polytechnic School of Engineering
Source:Eurekalert

Page: 1 2

Related biology news :

1. ACS Biomaterials Science & Engineering: Brand-new journal launches in 2015, names editor
2. University of Houston researcher publishes textbook on tissue engineering
3. New professorship in tissue engineering links molecular engineering, marine biology
4. NJIT engineering professor spurs interest in sanitary landfills throughout Asia
5. Exquisitely engineered human vision featured in Optical Engineering
6. Climate engineering cant erase climate change
7. Engineering a better way to rebuild bone inside the body
8. UH awarded $2 million for new engineering professor
9. Elsevier selected publish official journal: Engineering in Agriculture, Environment & Food
10. Having problems with your engineering project? This book will be your lifesaver
11. UH petroleum engineering director wins SPE Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)...   Guidepoint , a leading global research services ... Management TRACKER, part of the Guidepoint TRACKER ... medical device and therapeutics markets. The Post-Surgical Pain Management ... market share, and adoption rates across three major modalities ... The Post-Surgical Pain Management TRACKER will provide ...
(Date:3/24/2015)... WASHINGTON , March 24, 2015   NexID ... applications with critical security-authentication needs, today announced the beginning ... fake-finger-detection (FFD) solution. The company, based in ... announcement at the three-day Connect:ID Expo, which began here ... NexID said version 2.0 of its SDK boosts ...
(Date:3/23/2015)... OXFORD, Conn. , Mar. 23, 2015 NXT-ID, Inc. ... authentication company focused on the growing mobile commerce market, announces ... a new advertising campaign on CNBC television starting March 30 ... ads will commence airing in New York ... Executive Officer said: "We are excited about our new ad ...
Breaking Biology News(10 mins):Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3
... Expertise in fluid mechanics at The University of Akron has ... physicians better diagnose and treat an unusual cause of pain ... a disorder of the neurologic system caused in part by ... are able to probe the "hydraulics behind the headaches" and ...
... Plant and animal scientists are working together to meet the ... Society for experimental Biology on 28th June will demonstrate innovative ... food security issues, crop yields and diminishing fish stocks. ... yields of the world,s four most important crops has fallen ...
... of the basic elements of cognition―the ability to estimate quantities―grows ... a person,s life, according to researchers supported by the National ... called an approximate number sense, or ANS, is tied to ... found. Previously, the researchers have reported that ninth ...
Cached Biology News:When does a headache need an engineer to fix it? 2When does a headache need an engineer to fix it? 3Ability to estimate quantity increases in first 30 years of life 2Ability to estimate quantity increases in first 30 years of life 3
(Date:5/4/2015)... 2015 /PRNewswire/ - Fluorinov Pharma (Fluorinov), a FACIT ... of Dr. Roger J Garceau, to its Board ... in matters including corporate development and clinical strategy, ... significant regulatory expertise as Fluorinov transitions to clinical ... years of pharmaceutical development experience to Fluorinov and ...
(Date:5/4/2015)... May 04, 2015 Achieved primarily through ... slides that boast 10 to 100x better detail than ... capabilities of all existing light microscopy methods, it needed ... were chosen as the frame of reference because it ... , The goal from the earliest discovery days of ...
(Date:5/4/2015)... 4, 2015   Tocagen Inc. , a ... from Tocagen,s ongoing investigational studies were presented at ... American Association of Neurological Surgeons (AANS)/Congress of Neurological ... 2015, in Washington, D.C. ... meeting with FDA and continues to advance towards ...
(Date:5/1/2015)... Md. , May 1, 2015  Northwest Biotherapeutics ... company developing DCVax® personalized immune therapies for solid tumor ... the $28.5 million second tranche of a $40 million ... Woodford first invested $25 million in NW ... Woodford entered into an agreement with the Company for ...
Breaking Biology Technology:Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 2Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 3Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 2Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 3Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 4Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 5NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 3
... Colo., Oct. 19 The Davis Phinney Foundation ( ... provide information and tools that help people to live ... a new exercise DVD: " Exercise and Parkinson,s: Questions ... a panel of movement disorder experts in the fields ...
... SAINT PAUL, Minn., Oct. 19 Cellectis plant ... of Cellectis (Alternext: ALCLS), announced today that it ... Inc. for plant transformation technologies. The agreement provides ... Midwest,s Aerosol Beam Injector (ABI) technology for precise ...
... Reportlinker.com announces that a new market ... Global Automated And Rapid ... http://www.reportlinker.com/p092467/Global-Automated-And-Rapid-Microbiological-Tests-Industry.html This report analyzes ... Microbiological Tests in US$ Million by the ...
Cached Biology Technology:Davis Phinney Foundation Launches Exercise-Focused Tools to Help People Live Well With Parkinson's Disease 2Davis Phinney Foundation Launches Exercise-Focused Tools to Help People Live Well With Parkinson's Disease 3Davis Phinney Foundation Launches Exercise-Focused Tools to Help People Live Well With Parkinson's Disease 4Cellectis Plant Sciences Licenses Plant Transformation Technology From Midwest Oilseeds 2Cellectis Plant Sciences Licenses Plant Transformation Technology From Midwest Oilseeds 3Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 2Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 3Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 4Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 5Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 6Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 7Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 8Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 9Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 10Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 11Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 12Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 13Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 14Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 15Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 16Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 17Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 18Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 19Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 20Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 21Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 22Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 23Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 24Reportlinker Adds Global Automated And Rapid Microbiological Tests Industry 25
... Ion Chromatography requirements, IonQuest will ... The newly developed conductivity detector ... exceptionally ultra-low drift . The ... creates even higher sensitivities for ...
... Provides a fast and easy ... enriched mitochondrial fraction from mammalian tissues. ... contain inner and outer membranes. The ... functional studies and proteome profiling. Also ...
... PYREX low form culture flask is designed for culturing ... This flask has a heavy beaded rim to protect ... neck O.D. is 38mm and takes a No. 6.5 ... on a heat source smaller than the base of ...
... DNA transformation can be difficult to achieve ... presence of one or more restriction and ... that is recognized as "foreign". TypeOne™ Restriction ... transformation efficiencies in bacterial strains with type ...
Biology Products: