Navigation Links
Embryonic stem cell strategy advanced with UCSF finding
Date:9/11/2007

UCSF scientists are reporting what they say is a significant improvement in the technique for genetically reprogramming mouse cells to their embryonic state, a process that transforms the cells, in essence, into embryonic stem cells.

The finding, published on-line as an immediate early publication in Cell Stem Cell (Sept. 6, 2007), builds on the strategic breakthrough reported by Shinya Yamanaka, MD, PhD, in 2006, and confirmed in the spring of 2007 both by Yamanakas team and, in independent studies, by scientists at MIT, Harvard and UCLA.

The advance by the UCSF team should accelerate research aimed at improving the original strategy, the team says, and increase its potential use for studying disease development and creating patient-specific stem-cell based therapies.

The work is the result of a collaboration between the labs of Miguel Ramalho-Santos, PhD, and Robert Blelloch, MD, PhD, of the UCSF Institute for Regeneration Medicine.

The new technique removes a major technical hurdle that has likely discouraged many labs around the world from carrying out studies on the strategy, says senior author Ramalho-Santos, a UCSF Fellow and a member of the Diabetes Center. For separate reasons, he says, removal of the hurdle increases the techniques potential use in developing patient-specific cellular therapies.

Now, laboratories will be able to use the approach to study a broad range of normal and diseased cells of interest, says the first author of the study, Blelloch, an assistant professor of urology. There will be a much greater ability to precisely dissect the mechanisms of reprogramming and to identify the genes that will be most effective in transforming adult cells.

Yamanakas strategy -- over-expressing certain genes in mouse skin cells to initiate reprogramming relied on the insertion of a foreign drug resistance gene into the mouse skin cells. This gene would switch on in those cells that successfully
'/>"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Priming embryonic stem cells to fulfill their promise
2. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
3. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
4. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
5. Researchers devise way to mass-produce embryonic stem cells
6. Protein helps regulate the genes of embryonic stem cells
7. Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers
8. Vitamin As paradoxical role in influencing symmetry during embryonic development revealed
9. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
10. Canadas first embryonic stem cell lines
11. Researchers make embryonic-like stem cells from umbilical cord blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... Philadelphia, PA, October 30, 2014 – Bacteria in ... are critical for digestion. Yet, these same bacteria ... system if they penetrate the gut and enter ... natural response to protect the body, chronic or ... diseases. Prior research has established the involvement of ...
(Date:10/29/2014)... who lose their hair as a consequence of chemotherapy ... improve the scalp cooling technology that prevents hair loss. ... being pioneered by global scalp cooling manufacturing company, Paxman ... biology department of the University of Huddersfield. , The ... who has a background in the pharmacology of cancer ...
(Date:10/29/2014)... to make their food, but they also need protection from ... a group of molecules in plants that shields them from ... of the American Chemical Society , one team reports on ... Timothy Zwier and colleagues at Purdue University note that the ... serious damage to plant DNA and, as a result, hinder ...
Breaking Biology News(10 mins):Breakdown in gut barriers to bacteria may promote inflammation and craving in alcoholics 2New technology on the way to aid cancer suffers who lose their hair after chemotherapy 2
... in healthy foods are invited to a day-long conference ... findings on connections between fruit and vegetable production and ... include presentations by researchers, producers, allied produce industry leaders ... 20th anniversary of Texas A&M University,s Vegetable and Fruit ...
... plants has been found in honeybees and could help ... and Beijing, China report their findings in mBio ... for Microbiology. The routine screening of bees for ... of Tobacco Ringspot Virus, or TRSV, and prompted an ...
... blowing across the Pacific Ocean is often caused by the ... according to findings by UC Irvine and other researchers published ... Sciences . The study is the first to quantify ... the production in China of cellphones, televisions and other consumer ...
Cached Biology News:US food industry leaders to convene for health talks in Texas 2US food industry leaders to convene for health talks in Texas 3Pathogenic plant virus jumps to honeybees 2Made in China for us: Air pollution tied to exports 2
(Date:10/30/2014)... The report “Fragrance Ingredients Market by Type (Essential Oils ... Soaps & Detergents) & by Geography - Global Trends ... Fragrance Ingredients Market with analyses and projection of the ... has been segmented on the basis of major regions ... Rest of the World (ROW); and their value has ...
(Date:10/30/2014)... Global polyvinyl chloride (PVC) demand registered a significant ... especially in North America and Europe. However, the global ... a growing trend. , The largest chunk of the ... segment. In 2013, the key PVC application spheres included ... film. Moreover, the PVC was consumed in the production ...
(Date:10/30/2014)... SoundConnect , an industry leading ... end users the key to turning this already ... adding voice enablement and hybrid audio conferencing. , ... communication tool that includes presence, instant messaging and ... becomes a comprehensive unified communications solution. Adding the ...
(Date:10/30/2014)... 2014 Spartan Bioscience announced today that ... System . It detects CYP2C19 genetic mutations in less ... The Spartan RX CYP2C19 System is the first near-patient ... in Canada. Due to the system’s ease of use, ... by healthcare professionals such as doctors, nurses, pharmacists, and ...
Breaking Biology Technology:Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 4Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 5Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 2Global Polyvinyl Chloride Demand Is on Upward Trend Now, Says Merchant Research & Consulting in Its Topical Study 3SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3
... Madison, Wis . - It's been a long time since Wisconsin ... , ,The U.S. Forest Products Laboratory came to Madison ... U.S. Forest Service , was pioneering scientific forestry. The National ... back in the news as scientists there engage in a race ...
... months! The major stock indices looked pretty lackluster at the ... the second quarter with the Dow Jones going from ... for the first half. Not far behind was the NASADQ ... and 7% growth for the half year. , ,Unfortunately, the main ...
... controversy over its proposed overhaul of the state's healthcare system ... pare back additional funding for the Act 255 tax credit ... Joint Committee on Finance. , ,The caucus voted to delete ... investment and early-stage seed investment tax credits. , ,According ...
Cached Biology Technology:Federal bioenergy lab will give Wisconsin a chance to shine 2Federal bioenergy lab will give Wisconsin a chance to shine 3Federal bioenergy lab will give Wisconsin a chance to shine 4Midwest life science stocks kept sizzling in Q2 2Midwest life science stocks kept sizzling in Q2 3Midwest life science stocks kept sizzling in Q2 4Midwest life science stocks kept sizzling in Q2 5Midwest life science stocks kept sizzling in Q2 6Senate Democrats strip additional Act 255 funding from budget 2
... Sample Preparation for Membrane Proteins ,Contains ... membrane,protein extracts for 2-D gel analysis ... Extraction Kit , (contains sufficient ... a packed cell weight of 10 mg ...
...
Rabbit polyclonal to MCP2 ( Abpromise for all tested applications). entrezGeneID: 6355 SwissProtID: P49873...
... polystyrene with frosted labeling surfaces, volume ... counting. 100% integrity tested. Linkage: This ... number, created to easily match Cornings ... yet, please order under the old ...
Biology Products: