Navigation Links
Effects of environmental toxicants reach down through generations
Date:3/2/2012

PULLMAN, Wash.A Washington State University researcher has demonstrated that a variety of environmental toxicants can have negative effects on not just an exposed animal but the next three generations of its offspring.

The animal's DNA sequence remains unchanged, but the compounds change the way genes turn on and offthe epigenetic effect studied at length by WSU molecular biologist Michael Skinner and expanded on in the current issue of the online journal PLoS ONE.

While Skinner's earlier research has shown similar effects from a pesticide and fungicide, this is the first to show a greater variety of toxicantsincluding jet fuel, dioxin, plastics, and the pesticides DEET and permethrinpromoting epigenetic disease across generations.

"We didn't expect them all to have transgenerational effects, but all of them did," Skinner told the technology website Gizmodo. "I thought hydrocarbon would be negative but it was positive too."

This tells researchers that the ability to promote transgenerational disease is "not simply a unique aspect for a unique compound" but a characteristic of many environmental compounds.

The field opens new ground in the study of how diseases develop. While toxicologists generally focus on animals exposed to a compound, Skinner's work further demonstrates that diseases can also stem from older, ancestral exposures that are then mediated through epigenetic changes in sperm.

The work also points the way to identify and diagnose exposures through the use of specific epigenetic molecular markers.

"In the future we might be able to use these epigenetic biomarkers to determine your ancestral and personnel exposure early in life, and to predict your susceptibility to get a disease later in life," Skinner says.

The study was funded by the U.S. Army to study pollutants that troops might be exposed to. Skinner and his colleagues exposed pregnant female rats to relatively high but non-lethal amounts of the compounds and tracked changes in three generations of offspring. The researchers saw females reaching puberty earlier, increased rates in the decay and death of sperm cells, and lower numbers of ovarian follicles that later become eggs. Future studies can use the molecular tools for risk assessment analysis.


'/>"/>

Contact: Michael Skinner
skinner@wsu.edu
509-335-1524
Washington State University
Source:Eurekalert

Related biology news :

1. Prolonged effects of a warming anomaly on grasslands
2. Effects of anthropogenic sound on marine mammals -- a research strategy
3. UC Riverside biochemists devise method for bypassing aluminum toxicity effects in plants
4. How to build crops that can beat aluminums toxic effects
5. Effects of climate change vary greatly across plant families
6. UNC, Yale partner to study effects of cocaine use on mother-infant relationships
7. Study reveals effects of unconscious exposure to advertisements
8. Climate change effects on imperiled Sierra frog examined
9. Ocean acidification could have broad effects on marine ecosystems
10. Stronger coastal winds due to climate change may have far-reaching effects
11. Chantix side effects no worse with depression history
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2017)... MOUNTAIN VIEW, Calif. , March 9, ... Simple," and 23andMe , the leading personal genetics ... choices.  Zipongo can now provide customers with personalized nutrition ... goals and biometrics, but also genetic markers impacting how ... Zipongo,s personalized food decision support platform uses biometrics ...
(Date:3/7/2017)... , March 7, 2017   HireVue , the ... global companies identify the best talent, faster, today announced ... Sales Officer (CSO) and Diana Kucer as ... out a seasoned executive team poised to drive continued growth ... on a year of record bookings in 2017. ...
(Date:3/2/2017)... March 2, 2017 Summary This report ... and its partnering interests and activities since 2010. ... Read the full ... Alliance since 2010 report provides an in-depth insight into the ... companies. On demand company reports are prepared upon ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... 28, 2017  Viking Therapeutics, Inc. ("Viking") (NASDAQ: VKTX), ... novel therapies for metabolic and endocrine disorders, today announced ... Ph.D., will deliver a corporate presentation at H.C. Wainwright ... being held April 3, 2017 at the St. Regis ... this presentation are as follows: ...
(Date:3/28/2017)... HOLLISTON, Mass. , March 28, 2017 ... "Company"), a biotechnology company developing bioengineered organ implants to ... bronchus and trachea, today announced that Jim McGorry, ... 3D Printing and BioEngineering panel at the ... 2017 at 2:30 PM ET in Cambrige, Massachussetts. The ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... and diminished effectiveness over time. A recent study published in STEM CELLS suggests ... stimulating subventricular zone (SVZ) stem cells to produce more neural cells. , ...
(Date:3/28/2017)... (PRWEB) , ... March 28, ... ... to launch its brand-new, fully-certified hygienic SWB805 MultiMountTM weigh modules. These weigh ... guidelines and certified by National Sanitation Foundation (NSF). , As fully integrated ...
Breaking Biology Technology: