Navigation Links
Effects of environmental toxicants reach down through generations
Date:3/2/2012

PULLMAN, Wash.A Washington State University researcher has demonstrated that a variety of environmental toxicants can have negative effects on not just an exposed animal but the next three generations of its offspring.

The animal's DNA sequence remains unchanged, but the compounds change the way genes turn on and offthe epigenetic effect studied at length by WSU molecular biologist Michael Skinner and expanded on in the current issue of the online journal PLoS ONE.

While Skinner's earlier research has shown similar effects from a pesticide and fungicide, this is the first to show a greater variety of toxicantsincluding jet fuel, dioxin, plastics, and the pesticides DEET and permethrinpromoting epigenetic disease across generations.

"We didn't expect them all to have transgenerational effects, but all of them did," Skinner told the technology website Gizmodo. "I thought hydrocarbon would be negative but it was positive too."

This tells researchers that the ability to promote transgenerational disease is "not simply a unique aspect for a unique compound" but a characteristic of many environmental compounds.

The field opens new ground in the study of how diseases develop. While toxicologists generally focus on animals exposed to a compound, Skinner's work further demonstrates that diseases can also stem from older, ancestral exposures that are then mediated through epigenetic changes in sperm.

The work also points the way to identify and diagnose exposures through the use of specific epigenetic molecular markers.

"In the future we might be able to use these epigenetic biomarkers to determine your ancestral and personnel exposure early in life, and to predict your susceptibility to get a disease later in life," Skinner says.

The study was funded by the U.S. Army to study pollutants that troops might be exposed to. Skinner and his colleagues exposed pregnant female rats to relatively high but
'/>"/>

Contact: Michael Skinner
skinner@wsu.edu
509-335-1524
Washington State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Prolonged effects of a warming anomaly on grasslands
2. Effects of anthropogenic sound on marine mammals -- a research strategy
3. UC Riverside biochemists devise method for bypassing aluminum toxicity effects in plants
4. How to build crops that can beat aluminums toxic effects
5. Effects of climate change vary greatly across plant families
6. UNC, Yale partner to study effects of cocaine use on mother-infant relationships
7. Study reveals effects of unconscious exposure to advertisements
8. Climate change effects on imperiled Sierra frog examined
9. Ocean acidification could have broad effects on marine ecosystems
10. Stronger coastal winds due to climate change may have far-reaching effects
11. Chantix side effects no worse with depression history
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... School of Medicine announced today that it is ... by the Bill & Melinda Gates Foundation. ... and Reproductive Sciences; and Vice Chair of Research ... Medicine will pursue an innovative global health and ... Assess Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) funds ...
(Date:11/4/2014)... examining only marketing directed at children on the ... found that the majority of black, middle-income and ... tactics. , Authored by Arizona State University researcher ... the first to examine the use of child-directed ... food restaurants and its relationship to demographics. It ...
(Date:11/4/2014)... – (Nov. 4, 2014) – A majority of Madagascar,s ... that could have serious consequences for the rainforests they ... shows the positive impacts lemurs can have on rainforest ... their disappearance could have on the region,s rich biodiversity. ... have fruits eaten by lemurs. Lemurs in turn ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3
... calls for policymakers to reduce both nitrogen and phosphorus ... problems in fresh and coastal waters. In the ... argue that dual-nutrient reduction strategies are likely to be ... phosphorus in fresh and coastal water ecosystems. "If ...
... 2009 ― Protecting drinking water and preventing harmful ... many lakes, will require reducing both nitrogen and ... to the sea, management strategies should be implemented ... that focus only on one nutrient will fail. ...
... be exhausting. When fruit flies mate, the females, genes ... an immune reaction starts. This is shown in a ... the scientific publication, Journal of Evolutionary Biology .* ... genomic technology, so-called microarrays, researchers at Uppsala University can ...
Cached Biology News:Nutrient pollution chokes marine and freshwater ecosystems 2
(Date:11/21/2014)... 20, 2014 Polaris Group announced today ... its Phase 1 trial of ADI-PEG 20 in ... of malignant pleural mesothelioma (MPM) and non-squamous non-small ... trials on ADI-PEG 20, both as monotherapy and ... of several other indications, including breast cancer, melanomas, ...
(Date:11/18/2014)... , Nov. 18, 2014 Cord Blood Registry® ... of the 10th Annual World Stem Cell Summit, the largest ... The 2014 World Stem Cell Summit will be held December ... Texas . The World Stem ... of lifesaving cures and therapies, convening the most prominent figures ...
(Date:11/18/2014)... 17, 2014 Athena Signature Series: Turning Cancer ... Beverly Emerson, a professor in the Regulatory Biology Laboratory at ... recent discovery points to an “off switch” for drug resistance ... how her local research is making a global impact in ... and then join host Cheryl K. Goodman, CEO of Social ...
(Date:11/18/2014)... Texas (PRWEB) November 18, 2014 ... Polytetrahydrofuran (PTMEG) Industry is professional and in-depth ... gives Polytetrahydrofuran basic information, including its definition, ... also industry outline. This exploration covers the ... and worldwide industry examination covering macroeconomic environment ...
Breaking Biology Technology:Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 2PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 3
... Multiporator , , , , , , , , ... Protocol No. 4308 915.029 11/1999 , , , , , ... , Cell line , 293 T, human embryonal kidney, ... Plasmid pEGFP-N1 (in bidistilled H 2 O), , ...
... , , , , Multiporator / Electroporator 2510 , , , , ... Transformation Protocol , Protocol No. 4308 915.541 03/2002 , ... , , , , ... , Cell type , Bacteria, gram positive, ...
... Electroporator 2510 , , , , , , , , ... Protocol No. 4308 915.534 01/2002 , , , , ... , Microorganism , Staphylococcus epidermidis, ... Bacteria, gram positive, , , ...
Cached Biology Technology:293 T 2Streptococcus salivarius 2Staphylococcus epidermidis 2
Dedicated 29.5" X 18" platforms for Stackable shakers. These platforms are optimized for a particular flask clip size and are sold with a full load of flask clips....
... Reverse Transcriptase (RT) is an improved version ... is a DNA polymerase that synthesizes a ... or an RNA:DNA hybrid. This enzyme is ... mutations rather than a deletion in the ...
... SuperScript™ II RNase H- Reverse Transcriptase (RT) ... RNase H- RT. It is a DNA ... from single-stranded RNA DNA or an RNA:DNA ... the introduction of point mutations rather than ...
... (PNK) catalyzes the transfer of the ... of single- and double-stranded DNA, RNA, ... removes the 3'-phosphate from 3'-phosphoryl polynucleotides, ... to form a 3'-hydroxyl group. Storage ...
Biology Products: