Navigation Links
Ebola virus disarmed by excising a single gene
Date:1/21/2008

MADISON - The deadly Ebola virus, an emerging public health concern in Africa and a potential biological weapon, ranks among the most feared of exotic pathogens.

Due to its virulent nature, and because no vaccines or treatments are available, scientists studying the agent have had to work under the most stringent biocontainment protocols, limiting research to a few highly specialized labs and hampering the ability of scientists to develop countermeasures.

Now, however, a team of researchers from the University of Wisconsin-Madison has figured out a way to genetically disarm the virus, effectively confining it to a set of specialized cells and making the agent safe to study under conditions far less stringent than those currently imposed.

"We wanted to make biologically contained Ebola virus," explains Yoshihiro Kawaoka, a professor of pathobiological sciences in the UW-Madison School of Veterinary Medicine and the senior author of a paper describing the system for containing the virus published today (Jan. 21, 2008) in the Proceedings of the National Academy of Sciences. "This is a great system."

The Ebola virus first emerged in 1976 with outbreaks in Sudan and Zaire. There are several strains of the virus, which causes hemorrhagic fever and during outbreaks kills anywhere from 50-90 percent of its human victims.

At present, research on live Ebola virus is confined to the very highest level of biosafety, known as Biosafety Level 4 (BSL 4). Because such laboratories are rare, small and very expensive, basic research that is the basis for any potential drugs or vaccines to thwart the virus has been limited to perhaps half a dozen labs worldwide. The system devised by Kawaoka and his colleagues could provide a way to greatly expand studies of the pathogen and speed the development of countermeasures.

Taming Ebola virus, according to the new study, depends on a single gene known as VP30. Like most viruses, Ebo
'/>"/>

Contact: Yoshihiro Kawaoka
kawaokay@svm.vetmed.wisc.edu
608-265-4925
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Features of replication suggest viruses have common themes, vulnerabilities
2. First all-African GM crop is resistant to maize streak virus
3. Carnegie Mellon scientist uses mass spectrometer to weigh virus particle, von Willebrand factor
4. Gamma globulin effective in treating eye infections caused by adenoviruses
5. Discovery may help defang viruses
6. Who will recover spontaneously from hepatitis C virus infection
7. Prions and retroviruses -- an unholy alliance?
8. Scientists learn structure of enzyme in unusual virus
9. UGA Odum School of Ecology professor receives grant to study West Nile Virus in NYC
10. New field-deployable biosensor detects avian influenza virus in minutes instead of days
11. Depression, aging, and proteins made by a virus may all play role in heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 31 juillet 2015 La 10e Conférence ... sera organisée par le BGI du 22 au ... en Chine. La conférence célèbre ... en 2006, l,ICG est devenue l,une des réunions ... des « omiques » et c,est aussi la plus dynamique, ...
(Date:7/31/2015)... 31. Juli 2015 Die 10. internationale Konferenz zu ... veranstaltet und findet vom 22. bis 25. Oktober ... statt. Die Konferenz feiert in ... 2006 ist die ICG weltweit zu einem der ... ist eines der dynamischsten, enthusiastischsten und angenehmsten wissenschaftlichen ...
(Date:7/31/2015)... , July 31, 2015 The 10 th ... held by BGI from October 22-25, 2015, in Shenzhen ... The conference is celebrating its 10 th anniversary this year. ... the world,s most influential annual meetings in the ,omics, fields, ... scientific gatherings. ICG-10 focuses on recent breakthroughs ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3The 10th International Conference on Genomics (ICG-10) to Open in October 2
... and Harvard Medical School have shown how a key ... triggering other changes that allow the AIDS virus to ... Feb. 24 issue of the journal Nature, offer clues ... Researchers led by Howard Hughes Medical Institute Investigator Stephen ...
... human embryonic,stem cells have been contaminated with a ... human subjects,according to research by investigators at the ... and the Salk Institute in La Jolla,California.,In a ... journal Nature,Medicine, the researchers found that human embryonic ...
... available. However, a,similar and equally dangerous addiction, alcoholism, ... be? Researchers from the University of,California in San ... addiction in rodents. We can only hope that ... close future; it would help fix a,problem that ...
Cached Biology News:Elusive HIV shape change revealed; Key clue to how virus infects cells 2Current human embryonic stem cell lines contaminated UCSD/Salk team finds 2Current human embryonic stem cell lines contaminated UCSD/Salk team finds 3Current human embryonic stem cell lines contaminated UCSD/Salk team finds 4Controversial drug shown to act on brain protein to cut alcohol use 2Controversial drug shown to act on brain protein to cut alcohol use 3
(Date:8/3/2015)... At the 11th hour, ... the shortfall of Jude Liversage,s campaign so ... first time.      (Photo: http://photos.prnewswire.com/prnh/20150803/254228 ... The Selective Dorsal Rhizotomy (SDR) procedure reduced ... out his wish to kick a ball around like ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... Benzene is processed to get such derivatives as ethylbenzene, a precursor to styrene, ... used within the automotive industry for the production of tyres and other components. ...
(Date:8/3/2015)... ... August 03, 2015 , ... Nine field days to promote practices ... Hosted by the Soil Health Partnership , the field days will demonstrate how ... potentially increasing farm productivity and income. , Brent Bible has practiced no-till farming and ...
(Date:8/3/2015)... , August 3, 2015 ... the commercialization of its Bio-electrical Signal Therapy device ("BST ... treatment of hard to heal chronic wounds, today announced ... with Chemipal, an Israeli distributor specializing in medical devices, ... Chemipal is a 70 years old, sales, ...
Breaking Biology Technology:Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 2Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 3World Benzene Market to Surpass 46 MMT by 2020, According to TechSci Research Report Published at MarketPublishers.com 2World Benzene Market to Surpass 46 MMT by 2020, According to TechSci Research Report Published at MarketPublishers.com 3Soil Health Field Days Kick Off Throughout Midwest 2Soil Health Field Days Kick Off Throughout Midwest 3E-QURE Corp Signs Second Distribution Agreement in Israel 2E-QURE Corp Signs Second Distribution Agreement in Israel 3
... 18 NeurogesX, Inc. (Nasdaq: NGSX ), ... pain management therapies, today announced plans to pursue a ... include patients with painful HIV-associated neuropathy (HIV-AN, also referred ... Following a recent meeting with the U.S. Food and ...
... in London five years ago - the 7/7 transit attacks ... the Study of Terrorism and Responses to Terrorism (START), based ... rise in the number of new terror groups and a ... usually far more lethal. The report is based on START,s ...
... Park, MD (July 20, 2010) -- Recently, academic debate ... mechanical effects in the most ubiquitous of phenomena, including ... chemical energy. In particular, physicists have suggested that entanglement ... photons, electrons, or atoms that are separated in physical ...
Cached Biology Technology:NeurogesX to Pursue Expanded U.S. Label for Qutenza® (capsaicin) 8% Patch in HIV-Associated Neuropathy 2NeurogesX to Pursue Expanded U.S. Label for Qutenza® (capsaicin) 8% Patch in HIV-Associated Neuropathy 3NeurogesX to Pursue Expanded U.S. Label for Qutenza® (capsaicin) 8% Patch in HIV-Associated Neuropathy 4Rise in new terror groups globally, fewer coordinated attacks, report finds 2
Rat monoclonal [HK5.3] to B7 RP1 (Biotin) ( Abpromise for all tested applications). entrezGeneID: 23308 SwissProtID: O75144...
... monoclonal [YPF19] to Yersinia pestis ... Yersinia pestis . Immunogen: ... Yersinia pestis vaccine strain EV76. ... recognises Y.pestis F1 capsular antigen. There ...
Phospho-SEK1/MKK4 (Thr261) Antibody...
Rabbit polyclonal to Leucyl tRNA synthetase ( Abpromise for all tested applications). Antigen: L930-H1176 denatured human recombinant LRS. Entrez Gene ID: 3926 Swiss Protein ID: Q9P2J5...
Biology Products: