Navigation Links
Early-stage gene transcription creates access to DNA
Date:10/6/2008

CHESTNUT HILL, MA (October 6, 2008) A gene contained in laboratory yeast has helped an international team of researchers uncover new findings about the process by which protein molecules bind to control sequences in genes in order to initiate gene expression, according to findings reported in the journal Nature.

Previously thought to be inert carriers of the genetic instructions from DNA, so-called non-coding RNAs turn out to reveal a novel mechanism for creating access to DNA required by transcriptional activation proteins for successful gene expression, according to Boston College Biology Professor Charles Hoffman, a co-author of the study with researchers from two Japanese universities.

The team focused on transcription, the first step in gene expression, whereby the blueprint of a cell's DNA is first communicated and paves the way for RNA to deliver their specific pieces of protein-synthesizing genetic coding essentially flicking the switch that activates the gene.

Hoffman and his colleagues examined how the yeast cell senses its cellular environment and makes decisions about whether or not to express a gene, in this case fbp1, which encodes an enzyme. What they found was a preliminary transcription phase with a flurry of switches flicked "on" and then "off" as seen by the synthesis of non-coding RNA before the final "on" switch is tripped.

The non-coding RNAs initiate over one thousand base pairs of nucleotides along the DNA away from the known start site for this gene. The group discovered that the process of transcribing non-coding RNAs is required for the eventual production of the protein-encoding RNA. The transient synthesis of these non-coding RNAs serves to unfurl the tightly wound DNA, essentially loosening the structure to allow for gene expression.

"This is a novel identification of one of the many ways gene expression can be regulated," said Hoffman. "It's a surprising discovery of why there
'/>"/>

Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cleveland Clinic leading clinical program to improve early-stage lung cancer detection
2. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
3. NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness
4. Research sheds light on the mechanics of gene transcription
5. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
6. MIT creates new material for fuel cells
7. Novel living system recreates predator-prey interaction
8. Using evolution, UW team creates a template for many new therapeutic agents
9. Auto immune response creates barrier to fertility; could be a step in speciation
10. MIT creates 3-D images of living cell
11. Parente Randolph Secures Access to New Corporate Headquarters With BIO-key(R) Biometric Identification
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... fears that reef biodiversity may not provide the level ... , In an international study published today, Professor David ... Reef Studies (Coral CoE) says we need to identify ... , In coral reefs, just as in any modern-day ... safe and functioning. , Professor Bellwood says, in ...
(Date:9/15/2014)... vision document, released today by the National Academy ... goals, objectives, and strategies for the program and ... next five years (2015-2020). In addition, the ... be funded in 2015, will include exploratory grants, ... , The $500 million, 30-year program to be ...
(Date:9/15/2014)... Conditions on Earth for the first 500 million years ... the present day, complete with oceans, continents and active ... geologic eon, called the Hadean, has gained substantial new ... that formed more than 4 billion years ago with ... as a possible geological analog for early Earth. , ...
Breaking Biology News(10 mins):Specialized species critical for reefs 2NAS Gulf Research Program announces strategic vision, initial opportunities 2NAS Gulf Research Program announces strategic vision, initial opportunities 3NAS Gulf Research Program announces strategic vision, initial opportunities 4Early Earth less hellish than previously thought 2Early Earth less hellish than previously thought 3
... and Matthew Champion from the University of Notre Dame,s ... to directly detect bacterial protein secretion, which could provide ... The Champions point out that bacteria ... beyond their cell membrane in order to interact with ...
... by several orders of magnitude. The molecular mechanism by which ... and thus slows cell growth is described by biophysicists at ... the Online Early Edition of the journal PNAS . ... showed that Ras puts a phosphate chain under tension to ...
... MA A new article published today in ... evidence to suggest the current obesity epidemic in the ... high fructose corn syrup (HFCS). The commentary concludes ... research, there is overwhelming evidence showing HFCS is nutritionally ...
Cached Biology News:Notre Dame research could provide new insights into tuberculosis and other diseases 2RUB researchers clarify catalysis mechanism of cell growth protein Ras 2RUB researchers clarify catalysis mechanism of cell growth protein Ras 3Scientists conclude high fructose corn syrup should not be blamed for obesity 2
(Date:9/15/2014)... 15, 2014 EnGeneIC, Ltd. , ... treatment of cancer through the targeted delivery of ... together with the Asbestos Disease Research Institute (ADRI), ... South Wales (NSW) Premier,s Award for Excellence in ... the hospitals that will be involved in the ...
(Date:9/15/2014)... researchers led by Northeastern University has developed a ... and a variety of nanocarbon structures in carbon ... scalable, which will allow the researchers to tailor ... in applications ranging from electronic devices to CNT-reinforced ... sports equipment. , Their findings were published in ...
(Date:9/15/2014)... , Sept. 15, 2014 The chemistry, taste, ... climate, says a new article published by the nonprofit American ... PhD, on climate change and its effects on the phytochemical ... an extensive study conducted by Dr. Ahmed in the ... and has implications for the future of medicinal ...
(Date:9/15/2014)... 2014  The second annual International Plasma Awareness ... joint initiative of the Plasma Protein Therapeutics Association ... is designed to: , Raise global awareness ... of plasma donors in saving and improving lives ... rare diseases Member companies are planning ...
Breaking Biology Technology:EnGeneIC Named a Recipient of the Cancer Institute NSW Premier's Award for Excellence in Translational Cancer Research 2EnGeneIC Named a Recipient of the Cancer Institute NSW Premier's Award for Excellence in Translational Cancer Research 3Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4International Plasma Awareness Week To Celebrate Donors And Spotlight Rare Diseases 2International Plasma Awareness Week To Celebrate Donors And Spotlight Rare Diseases 3
... June 1, 2011 VWR International, LLC, a ... announced today that it acquired the business of ... Founded in 1985, BioExpress is a well-respected ... segments, and offers over 200 well-known, multi-national brands, ...
... ( www.investoruprising.com ) has released "A Guide to Biotech ... Exchange Traded Funds (ETFs) and mutual funds, which is ... (Logo: http://photos.prnewswire.com/prnh/20110411/NY80781LOGO-a) "A Guide to ... the leading biotech mutual funds and ETFs. It explains ...
... Waters Corporation (NYSE: WAT ) ... System, the highest performing UPLC® system ever engineered ... level.  For scientists challenged by the most difficult ... system dispersion and lowest carryover in the industry ...
Cached Biology Technology:VWR International, LLC Acquires BioExpress Corp. 2Investor Uprising Publishes Free Biotech Investment Report 2Investor Uprising Publishes Free Biotech Investment Report 3Waters Introduces Highest Performing UPLC Ever Engineered - the New ACQUITY UPLC I-Class 2Waters Introduces Highest Performing UPLC Ever Engineered - the New ACQUITY UPLC I-Class 3Waters Introduces Highest Performing UPLC Ever Engineered - the New ACQUITY UPLC I-Class 4
For demonstration of Helicobacter pylori...
... efficient interfacing with mass spectrometry. Improved ... demands for benefits like these have ... routine applications. Standard HPLC systems, however, ... to operate with smaller bore columns ...
... The MitoPT kit is used in conjunction with ... culture and induce apoptosis according to your existing ... as a negative control). Once you have induced ... solution to each population and incubate the cells ...
Kit Components: Anti-Acetylated Histone H3 Salmon Sperm DNA/Protein A Agarose All necessary buffers. ...
Biology Products: