Navigation Links
Early-stage gene transcription creates access to DNA
Date:10/6/2008

CHESTNUT HILL, MA (October 6, 2008) A gene contained in laboratory yeast has helped an international team of researchers uncover new findings about the process by which protein molecules bind to control sequences in genes in order to initiate gene expression, according to findings reported in the journal Nature.

Previously thought to be inert carriers of the genetic instructions from DNA, so-called non-coding RNAs turn out to reveal a novel mechanism for creating access to DNA required by transcriptional activation proteins for successful gene expression, according to Boston College Biology Professor Charles Hoffman, a co-author of the study with researchers from two Japanese universities.

The team focused on transcription, the first step in gene expression, whereby the blueprint of a cell's DNA is first communicated and paves the way for RNA to deliver their specific pieces of protein-synthesizing genetic coding essentially flicking the switch that activates the gene.

Hoffman and his colleagues examined how the yeast cell senses its cellular environment and makes decisions about whether or not to express a gene, in this case fbp1, which encodes an enzyme. What they found was a preliminary transcription phase with a flurry of switches flicked "on" and then "off" as seen by the synthesis of non-coding RNA before the final "on" switch is tripped.

The non-coding RNAs initiate over one thousand base pairs of nucleotides along the DNA away from the known start site for this gene. The group discovered that the process of transcribing non-coding RNAs is required for the eventual production of the protein-encoding RNA. The transient synthesis of these non-coding RNAs serves to unfurl the tightly wound DNA, essentially loosening the structure to allow for gene expression.

"This is a novel identification of one of the many ways gene expression can be regulated," said Hoffman. "It's a surprising discovery of why there are all these RNA molecules being made in cells that are not protein-encoding molecules. It is in fact the process of making these molecules that leads to the protein-encoding RNAs."

The paper was co-authored by Hoffman and RIKEN Advanced Science Institute scientists Kouji Hirota, Kazuto Kugou, Takehiko Shibata, Kunihiro Ohta and their colleague Tomoichiro Miyoshi at the University of Tokyo.

"I hope this leads others to find similar events occurring on other genes," said Hoffman. "A big part of this kind of work is understanding that there are other potential mechanisms for gene expression."


'/>"/>

Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert

Related biology news :

1. Cleveland Clinic leading clinical program to improve early-stage lung cancer detection
2. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
3. NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness
4. Research sheds light on the mechanics of gene transcription
5. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
6. MIT creates new material for fuel cells
7. Novel living system recreates predator-prey interaction
8. Using evolution, UW team creates a template for many new therapeutic agents
9. Auto immune response creates barrier to fertility; could be a step in speciation
10. MIT creates 3-D images of living cell
11. Parente Randolph Secures Access to New Corporate Headquarters With BIO-key(R) Biometric Identification
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2016)... SAN JOSE, Calif. , Jan. 20, 2016 ... leading developer of human interface solutions, today announced ... touch controller solution for wearables and small screen ... appliances such as printers. Supporting round and rectangular ... the S1423 offers excellent performance with moisture on ...
(Date:1/13/2016)... 2016 http://www.researchandmarkets.com/research/7h6hnn/india_biometrics ... the  "India Biometrics Authentication & Identification ...  report to their offering.  ... the addition of the  "India Biometrics ... & Forecast (2015-2020)"  report to ...
(Date:1/8/2016)... 2016 NXTD ), a company ... , a privately held leading direct seller of vacation ... 5000 fastest-growing company announced that on December 31, 2015, ... in Nxt-ID to develop a proprietary new wireless smart ... , a unique smart wallet that serves to securely ...
Breaking Biology News(10 mins):
(Date:2/6/2016)... ... February 06, 2016 , ... The Center for Excellence in ... and high school teachers on Wednesday February 10, 2016. This Bite of Science ... School of Conservation, located at 1500 Remount Road in Front Royal, VA from 5:00 ...
(Date:2/5/2016)... , Feb. 5, 2016  In the pharmaceutical ... for a host of launch activities including the identification ... this launch activity is especially high in the oncology ... Best Practices and the Role of Medical Affairs ... companies focused on oncology therapies find better ways to ...
(Date:2/5/2016)... Australian-US drug discovery and development company, Novogen Limited (ASX:NRT; NASDAQ: ... Chairman, Mr John O,Connor , and new Deputy Chairman, ... James Garner , has also been formally appointed to the ... Iain Ross , will resume his role on the ... , has also been formally appointed to the Board as ...
(Date:2/4/2016)... -- Sangamo BioSciences, Inc. (NASDAQ: SGMO ), the leader ... Lanphier , Sangamo,s president and chief executive officer, will ... Therapeutic ® development programs and an overview of ... Thursday, February 11, 2016, at the Leerink Partners 5 ... being held in New York . ...
Breaking Biology Technology: