Navigation Links
Early-stage gene transcription creates access to DNA
Date:10/6/2008

CHESTNUT HILL, MA (October 6, 2008) A gene contained in laboratory yeast has helped an international team of researchers uncover new findings about the process by which protein molecules bind to control sequences in genes in order to initiate gene expression, according to findings reported in the journal Nature.

Previously thought to be inert carriers of the genetic instructions from DNA, so-called non-coding RNAs turn out to reveal a novel mechanism for creating access to DNA required by transcriptional activation proteins for successful gene expression, according to Boston College Biology Professor Charles Hoffman, a co-author of the study with researchers from two Japanese universities.

The team focused on transcription, the first step in gene expression, whereby the blueprint of a cell's DNA is first communicated and paves the way for RNA to deliver their specific pieces of protein-synthesizing genetic coding essentially flicking the switch that activates the gene.

Hoffman and his colleagues examined how the yeast cell senses its cellular environment and makes decisions about whether or not to express a gene, in this case fbp1, which encodes an enzyme. What they found was a preliminary transcription phase with a flurry of switches flicked "on" and then "off" as seen by the synthesis of non-coding RNA before the final "on" switch is tripped.

The non-coding RNAs initiate over one thousand base pairs of nucleotides along the DNA away from the known start site for this gene. The group discovered that the process of transcribing non-coding RNAs is required for the eventual production of the protein-encoding RNA. The transient synthesis of these non-coding RNAs serves to unfurl the tightly wound DNA, essentially loosening the structure to allow for gene expression.

"This is a novel identification of one of the many ways gene expression can be regulated," said Hoffman. "It's a surprising discovery of why there
'/>"/>

Contact: Ed Hayward
ed.hayward@bc.edu
617-552-4826
Boston College
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cleveland Clinic leading clinical program to improve early-stage lung cancer detection
2. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
3. NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness
4. Research sheds light on the mechanics of gene transcription
5. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
6. MIT creates new material for fuel cells
7. Novel living system recreates predator-prey interaction
8. Using evolution, UW team creates a template for many new therapeutic agents
9. Auto immune response creates barrier to fertility; could be a step in speciation
10. MIT creates 3-D images of living cell
11. Parente Randolph Secures Access to New Corporate Headquarters With BIO-key(R) Biometric Identification
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2015)... Conn. , June 18, 2015 NXT-ID, Inc. ... authentication company focused on the growing mobile commerce market announces ... a featured segment on "Money on the Mark", scheduled to ... City June 20 th . ... will be from 7:00 to 8:00pm EST. NXT-ID, Inc.,s CEO ...
(Date:6/17/2015)... June 17, 2015  Crossmatch™, a leading provider ... its U.are.U ® 4500 fingerprint readers have ... Eateries, Inc., a San Jose, CA ... increase security, improve accountability and reduce fraud at ... non-repudiable identity confirmation for employee sign in and ...
(Date:6/16/2015)... GOTHENBURG, Sweden , June 16, 2015 ... 2015 from previously communicated that it will amount to at ... 390 MSEK. Due to the rapid increase in market growth ... from the previously communicated guidance that revenue for 2015 will ... 2015 will amount to approximately 2,200 MSEK. Due ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3
... . , The daily consumption of cannabis ... those episodes of psychosis which are fruit of this ... and in the clinical presentation of the psychosis. This ... "Neurodevelopment and environmental stress in initial psychosis: transversal analysis ...
... to manipulate the proportion of females and males in ... entire genome of a bacterium that infects a close ... PNAS, reveal extremely high frequencies of gene exchange within ... hoped that it will be possible to use sex-manipulating ...
... of Medicine, New Orleans, Louisiana have discovered that ... included in highly active antiretroviral therapy (HAART) regimen ... effects on insulin secretion mediated through the oxidative ... the levels of the antioxidants, cytosolic superoxide dismutase ...
Cached Biology News:Daily consumption of cannabis predisposes to the appearance of psychosis and schizophrenia 2Gene exchange common among sex-manipulating bacteria 2HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection 2
(Date:7/1/2015)... ... ... The next-generation sequencing (NGS) clinical market is poised for huge growth as ... Research reveals in its new report that the market drivers of this vibrant industry ... for better diagnostics as part of a molecular diagnostics trend. , The global market ...
(Date:7/1/2015)... 2015 Isagenix International, a leading global health ... three Silver, and three Bronze Stevie® Awards at the ... Chicago this month.The American Business ... program in the U.S. "Winning is ... developing leaders, cultivating talent, creating a unified team, and ...
(Date:7/1/2015)... ... July 01, 2015 , ... NEMA 4 (IP66) Medical ... new Medical Joysticks have an impermeable molecular barrier protection against bio-hazardous agents. ... that will increase healthcare worker safety and reduce financial costs. , CTI Electronics ...
(Date:6/30/2015)... , June 30, 2015 /PRNewswire/ - Resverlogix Corp. ... common shares of Resverlogix have approved the resolutions ... Capital Limited of 5,600,000 units at a price ... each unit being comprised of one common share ... proceeds of approximately CAD$15 million; and (ii) the ...
Breaking Biology Technology:NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3Isagenix Earns Nine American Business Awards 2Isagenix Earns Nine American Business Awards 3Sanitized Medical Joysticks for a Safer and Healthier Work Environment 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 3
... Diagnostics Limited, the decentralised and point-of-care molecular diagnostics company, announced ... the Veterinary Laboratories Agency to evaluate the performance of the ... to be one of the main threats to cattle (1), ... is closely related to classical swine fever virus, a serious ...
... HAVEN, Conn., June 30 Rib-X Pharmaceuticals, Inc., a development ... antibiotics for the treatment of antibiotic resistant infections, announced today ... been appointed to the Company,s Board of Directors. Rib-X,s ... "We are extremely pleased that Russell Greig has joined the ...
... ... The Northern Irish packaging machinery manufacturer, Sepha Ltd. is breaking into ... leak testing and de-blistering machines for the first ... 1-3 July. Ahead of its presence at Interphex, Sepha has ...
Cached Biology Technology:Enigma Diagnostics Announces Successful Evaluation of the Enigma FL by the UK's Veterinary Laboratories Agency 2Enigma Diagnostics Announces Successful Evaluation of the Enigma FL by the UK's Veterinary Laboratories Agency 3Rib-X Pharmaceuticals, Inc. Appoints Dr. Russell Greig to Board of Directors 2Rib-X Pharmaceuticals, Inc. Appoints Dr. Russell Greig to Board of Directors 3Asia Debut for Money-Saving Pharma-Packaging Machines from Ireland 2Asia Debut for Money-Saving Pharma-Packaging Machines from Ireland 3