Navigation Links
Dysfunctional chemokine receptor promotes candidiasis
Date:11/1/2013

Candida albicans is one of the leading causes of hospital-acquired infections in immune compromised patients. The risk of both developing candidiasis and the clinical outcome of infection is variable among patients, and the host-dependent factors that contribute to patient susceptibility to C. albicans infection are poorly understood. In this issue of the Journal of Clinical Investigation, Michail Lionakis and colleagues at the National Institute of Allergy and Infectious Diseases demonstrated that the chemokine receptor CX3CR1 is required for the interaction of C. albicans and macrophages in the kidney. Mice lacking this receptor were prone to C. albicans-induced kidney failure; however, these mice did not have increased fungal burden in other organs. Furthermore, the authors found that patients with a mutation in the gene encoding CX3CR1 were at higher risk of candidiasis. This study identifies an important role for the interaction of C. albicans and macrophages in disease progression and outcome.


'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related biology news :

1. Has modern science become dysfunctional?
2. Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management
3. G protein-coupled receptor mediates the action of castor oil
4. BUSM study identifies receptors role in regulating obesity, type 2 diabetes
5. Cell receptor has proclivity for T helper 9 cells, airway inflammation
6. Steroid hormone receptor prefers working alone to shut off immune system genes
7. Jackson Laboratory researchers provide definitive proof for receptors role in synapse development
8. Dopamine-receptor gene variant linked to human longevity
9. How the tilt of a cell-surface receptor prevents cancer
10. Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury
11. Therapies for ALL and AML targeting MER receptor hold promise of more effect with less side-effect
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ... the "Global Iris Recognition Market 2015-2019" report ... Global Iris Recognition market to grow at a CAGR ... This report covers the present scenario and the growth ... period 2015-2019. To calculate the market size, the report ...
(Date:3/24/2015)... PALM BEACH GARDENS, Fla. , March 24, ... of biometric identity management solutions, today announced that ... enabling premium clothing accessory retailer Goorin Bros ... login. The Crossmatch biometrics-based solution secures access to ... customers from the increased risk of data breaches. ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 fiscal ... case conviction losses. This figure accounts for a fraction ... to The Nilson Report, exceeds $11 billion globally. The ... after a crime has occurred. Investor Mark Saint ... expert Joe Paolella partnered to administer the ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... Cigarette smoking, which causes over 8.6 million illnesses annually ... effects on a variety of orthopedic conditions. Studies have ... can undermine fracture and ligament repair following injury. In ... healing problems and bone infections and smoking has been ...
... team of scientists is calling for a targeted global ... for the world’s coastal ecosystems, according to an article ... of the American Institute of Biological Sciences (AIBS). , ... the critical role seagrasses play in coastal systems and ...
... Veterinary Medicine have discovered a unique evolutionary link between ... has survived in fish, to the more advanced, adaptive ... The finding, which appears in the online version of ... step for the mammalian immune system and offers a ...
Cached Biology News:The effects of smoking on fractures and ligament injuries 2Seagrass ecosystems at a 'global crisis' 2'Killer' B cells provide new link in the evolution of immunity 2
(Date:3/30/2015)...  Multiple new research abstracts suggest walnuts may have ... From their impact on colon cancer and certain aspects ... gut health and vascular health, the research findings presented ... of walnuts, inner workings. Running March 28 through April ... meeting attracts an international audience of over 14,000 leading ...
(Date:3/30/2015)... March 30, 2015  New Jersey Health Foundation, a ... the state of New Jersey , ... grant funding, announced James M. Golubieski , president. ... Research Grants program, an additional $500,000 will be available ... early stage research projects that demonstrate exciting potential and ...
(Date:3/30/2015)... , March 30, 2015 /CNW/ - A new ... on the salaries and demographic profiles of new graduates ... the Door – Building Careers for New Grads in ... Research-Based Pharmaceutical Companies (Rx&D) and features data ... Career Focus wage subsidy program from 2013 to 2015. ...
(Date:3/30/2015)... BELLINGHAM, Washington, USA (PRWEB) March 29, 2015 ... Europe and the United States and plenary talks by ... for SPIE Optics + Optoelectronics next month ... 700 technical presentations in 17 conferences alongside a two-day ... optics and photonics , the event will run 13-16 ...
Breaking Biology Technology:New Findings Support the Benefits of Eating Walnuts on Overall Health 2New Findings Support the Benefits of Eating Walnuts on Overall Health 3New Findings Support the Benefits of Eating Walnuts on Overall Health 4New Jersey Health Foundation Announces An Additional $1 Million To Fund Innovation and Research Grants in New Jersey 2New Report on Graduates in Canadian Biotech Industry Sheds Light on Hiring Practices 2New Report on Graduates in Canadian Biotech Industry Sheds Light on Hiring Practices 3New Report on Graduates in Canadian Biotech Industry Sheds Light on Hiring Practices 4Laser Energy Advances Among Reports Set for SPIE Optics + Optoelectronics 2Laser Energy Advances Among Reports Set for SPIE Optics + Optoelectronics 3
... Surgery ... Meeting, ... today that leading experts presented clinical evidence showing,that its EndoSurgical Operating ... reduce the size of the,gastric pouch and stoma in patients who,ve ...
... LOUISVILLE, Colo., June 23 Replidyne, Inc.,(Nasdaq: RDYN ... its license,agreement with Asubio Pharma Co., Ltd. for faropenem ... announced that it has,terminated its supply agreement with Asubio ... of faropenem. These decisions were made as a,result of ...
... sponsors easy-to-use tools to store, mine and ... base to ensure enrollment success, NEWTON, Mass., June ... announced the release of a new,product, "Center of Excellence," ... capabilities for clinical,trial sponsors. The goal is to standardize ...
Cached Biology Technology:Studies Show USGI Medical's EndoSurgical Operating System(TM) Enables Incisionless Surgery to Reduce Gastric Pouch and Stoma After Gastric Bypass 2Replidyne Terminates Faropenem Agreements 2Replidyne Terminates Faropenem Agreements 3TCN e-Systems Offers Trial Sponsors Solutions for Creating In-House Center of Excellence in Patient Recruitment 2TCN e-Systems Offers Trial Sponsors Solutions for Creating In-House Center of Excellence in Patient Recruitment 3TCN e-Systems Offers Trial Sponsors Solutions for Creating In-House Center of Excellence in Patient Recruitment 4
Umbilical cord blood neutrophils, For immunohistochemistry (IHC)...
...
Adjustable tilt angle 0 to 20 Adjustable speed of 3-25 RPM Load capacity: 2.7 kg (6 lbs.) Ambient temperature range 4C to 65C Low voltage power is supplied by wall mount transformer...
... spin filters allow for the rapid isolation of ... DNA gel slice in the spin filter, centrifuge ... DNA is recovered. There is no need to ... Spin filters can also be used for buffer ...
Biology Products: