Navigation Links
Drug studied as possible treatment for spinal injuries
Date:11/19/2009

searchers subjected spinal cord tissue to stresses that mimic what happens in a compression injury, which stretches nerves. Then they treated the damaged axons with 4-aminopyridine-3-methyl hydroxide.

The compound is a derivative of the drug 4-aminopyridine, used primarily as a research tool and also to manage symptoms of multiple sclerosis.

The axons of each nerve are sheathed in a thick insulating lipid layer, called myelin, which enables the transmission of signals without short circuiting, much like the insulation surrounding electrical wires. Spinal cord trauma damages the myelin sheath, exposing "fast potassium channels" that are embedded in the axons and are critical for transmitting nerve impulses.

The researchers confirmed previous circumstantial evidence suggesting injury causes the myelin insulation to recede, exposing the channels and impairing signal transmission. Laboratory and imaging techniques revealed the exposed channels in damaged axons.

The researchers also discovered that 4-aminopyridine-3-methyl hydroxide is a "potassium channel blocker," using a sophistic laboratory technique called "patch clamp" to measure signal conduction. Findings confirmed that the compound prevents the exposed channels from leaking electrical current and enhances nerve conduction in segments of the damaged spinal cord.

The compound could make it possible to sidestep spinal cord damage by enabling axons to transmit signals as though they were still sheathed in myelin, Shi said.

Nerves transmit signals through a series of rapid electrical pulses, or "action potentials." For proper nerve function, the time gap between pulses must be as brief as possible. However, 4-aminopyridine has been shown to lengthen the gap, or "refractory period," between pulses. The researchers found that 4-aminopyridine-3-methyl hydroxide restores function without affecting the refractory period. As a result, the damaged nerves perform more lik
'/>"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Feline virus, antiviral drug studied to understand drug resistance
2. Gulf of Mexico dead zone to be studied by University of Texas at Austin marine scientists
3. Silicons effect on sunflowers studied
4. Alternatives to ozone-depleting pesticide studied
5. New roadside beautification concept studied
6. Complex ocean behavior studied with artificial upwelling
7. Potential new herpes therapy studied
8. Hispanic women and breast cancer: An understudied group
9. Possible hepatitis C vaccine
10. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
11. Study reveals possible genetic risk for fetal alcohol disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug studied as possible treatment for spinal injuries
(Date:7/31/2015)... China , 31 de julho de 2015 /PRNewswire/ ... (ICG-10, www.icg-10.org ) será realizada pela BGI de 22-25 ... . A conferência está celebrando seu ... em 2006, a ICG se tornou uma das reuniões ... um dos encontros científicos mais dinâmicos, entusiastas e prazerosos. ...
(Date:7/31/2015)... July 31, 2015 The 10 th International ... by BGI from October 22-25, 2015, in Shenzhen ... conference is celebrating its 10 th anniversary this year. Since ... world,s most influential annual meetings in the ,omics, fields, and ... gatherings. ICG-10 focuses on recent breakthroughs and ...
(Date:7/23/2015)... , July 23, 2015 Research and ... of the "Global Outlook of the Biometrics ... The global biometrics market is ... and commercial applications owing to the uptake of ... a transformation that enhances the growth of biometrics ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3The 10th International Conference on Genomics (ICG-10) to Open in October 2Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3
... Good news for candy and chocolate lovers: they tend ... waist circumferences, and have decreased levels of risk factors for ... study(1) published in Nutrition Research . The findings ... RD, Louisiana State University Agricultural Center, cautions it is all ...
... from human blood be the key to creating cyborg interfaces? ... an electronic device, such as a robotic limb or artificial ... of biological components. Writing in the International Journal ... describes how a "memristor" can be made using human blood. ...
... Deepwater Horizon oil spill of 2010 devastated the Gulf of ... Conservation Letters reveals that the true impact of ... argues that fatality figures based on the number of recovered ... may be 50 times higher than believed. "The Deepwater ...
Cached Biology News:New study shows you can have your candy and eat it too -- without adverse health effects 2Blood simple circuitry for cyborgs 2Whale and dolphin death toll during Deepwater disaster may have been greatly underestimated 2Whale and dolphin death toll during Deepwater disaster may have been greatly underestimated 3
(Date:8/4/2015)... 2015   California Cryobank Stem Cell Services LLC ... Cryogenics, an east coast cord blood and reproductive tissue ... tristate area. LifeLine clients will maintain full access ... be honored. Since 1991, LifeLine has provided ... sperm, eggs, embryos, and cord blood stem cells. LifeLine Cryogenics ...
(Date:8/3/2015)... , Aug. 3, 2015  ArroGen Group, an ... new Fingerprint Molecular Identification™ (FMID) technology Aug. 2-8 ... in Sacramento, Calif. ... will enable law enforcement agents, district attorneys and ... criminal suspects. By analyzing chemical residues ...
(Date:8/3/2015)... London, UK (PRWEB) , ... August 03, 2015 ... ... largest consumer of benzene. Benzene is processed to get such derivatives as ethylbenzene, ... Ethylbenzene derivatives are principally used within the automotive industry for the production of ...
(Date:8/3/2015)... , Aug. 3, 2015  Aethlon Medical, Inc. (Nasdaq: ... devices to treat life-threatening diseases, today announced that it ... call and webcast on Thursday, August 13, 2015 at ... webcast will follow the release of fiscal 2016 first ... be available approximately two hours after the call at ...
Breaking Biology Technology:FamilyCord Announces Acquisition of LifeLine Cryogenics 2ArroGen Previews New Fingerprint Molecular Identification Technology 2World Benzene Market to Surpass 46 MMT by 2020, According to TechSci Research Report Published at MarketPublishers.com 2World Benzene Market to Surpass 46 MMT by 2020, According to TechSci Research Report Published at MarketPublishers.com 3Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2
... , EAST NORRITON, Pa. , Aug. 2 Tengion ... has appointed A. Brian Davis to the position of Chief ... Technologies, Inc., a biopharmaceutical company using enzymatic technologies to develop improved protein ... and research personnel at three sites.  , ...
... 2 Reportlinker.com announces that a new market research report is available in ... Asia Pacific Flexible ... , ... This research service ...
... represents one of the most fundamental processes in physics. ... in the summer due to the absorption of light ... or light-emitting diodes that convert electricity into light, we ... lives. Understanding the interactions between individual light particles ...
Cached Biology Technology:Tengion Appoints A. Brian Davis Chief Financial Officer 2Asia Pacific Flexible Alternating Current Transmission Equipment Markets 2Asia Pacific Flexible Alternating Current Transmission Equipment Markets 3Asia Pacific Flexible Alternating Current Transmission Equipment Markets 4Asia Pacific Flexible Alternating Current Transmission Equipment Markets 5Asia Pacific Flexible Alternating Current Transmission Equipment Markets 6Asia Pacific Flexible Alternating Current Transmission Equipment Markets 7One more step on the path to quantum computers 2
Request Info...
Human RUNX2/CBFA1 MAb (Clone 232902)...
... Streptavidin-Horseradish Peroxidase Conjugate, ... to reporter enzyme molecules ... and in situ hybridization ... Blotting & Labeling & ...
...
Biology Products: