Navigation Links
Drug resistance: 'Baby steps' can pay off big
Date:1/9/2013

ld accurately predict how specific mutations would affect E. coli resistance, Shamoo's team examined a gene called TetX2. The gene encodes an enzyme that inactivates the antibiotic minocycline. The researchers looked at the most likely mutations of the gene and found seven that led to increased antibiotic resistance. They then spent two years amassing a catalog of basic biochemical measurements for each mutant.

"If this organism were a car, then these enzymatic measurements would be the equivalent of things like the cubic displacement of the engine, the torque and so on," Shamoo said. "These are measurable variables, but by themselves they won't tell you the car's top speed or how fast it can accelerate from 0 to 60 (miles per hour)."

By measuring the performance improvements from each of the seven TetX2 mutants, the group was able to build a mathematical formula that accurately correlated the E. coli resistance with enzyme performance. To test the formula, the team measured the resistance of a new family of mutants and used the formula to calculate their enzyme performance metrics.

"Using the car analogy again, it's like we took one car and measured its top speed and acceleration using seven different engines," Shamoo said. "Then, we took the same car with an unknown engine and showed that we didn't have to open the hood and look to tell what kind of engine it had. We could tell that strictly by knowing its top speed and acceleration." By knowing how the car with the unknown engine performed on the race track, we could describe the engine without ever popping the hood and vice versa.

Shamoo said the research could lead to faster screening methods for resistant strains of bacteria, but the most immediate benefit is an improved understanding of how resistance develops.

"An example of that is this finding about the small steps," he said. "That was unexpected, and it tells us something fundamental about how re
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Grant funded to improve mothers nutrition before pregnancy and impact on baby
2. Eating well during pregnancy reduces babys obesity risk regardless of moms size
3. Male snails babysit for other dads
4. Lawson researcher sings the baby blues
5. A diet high in choline during pregnancy may mean less stress for baby
6. Warm, dry El Nino weather puts baby sea turtle at risk
7. A new method detects traces of veterinary drugs in baby food
8. U of I study: Lose body weight before gaining baby weight
9. Flying jewels spell death for baby spiders
10. Following in Marie Curies footsteps
11. Synthetic diamond steps closer to next generation of high performance electrochemical applications
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug resistance: 'Baby steps' can pay off big
(Date:10/14/2014)... (Oct. 14, 2014)—It,s been millions of years since ... team led by Ohio University scientists is breathing life ... airflow through dinosaur snouts. The research has important implications ... breathe but to enhance the sense of smell and ... animals," said Ohio University doctoral student Jason Bourke, lead ...
(Date:10/14/2014)... October 14, 2014 – High doses of fish oil supplements, ... a common type of irregular heartbeat in which the heart ... results of the AFFORD trial led by the Montreal Heart ... College of Cardiology on October 7th. , For the ... therapy were randomly assigned to 4 grams of fish oil ...
(Date:10/14/2014)... likely takes between 10 and 20 years to ... window" of intervention if detected early, which may ... say Australian clinical researchers. , Dr Jeremy ... Institute of Medical Research, analysed medical histories and ... pancreatic cancer patients, operated on between 1994 and ...
Breaking Biology News(10 mins):Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Early detection window when pancreatic cancer is in the family 2
... of Chicago scientists have successfully used geometrically patterned surfaces ... approach is a departure from that of many stem-cell ... proteins in controlling the fate of stem cells. ... both cases it,s the shape alone that,s dictating whether ...
... This release is available in French . ... on an extremely important process for the proper functioning ... transportation pathway of ,cargo, to and from the surface ... have severe consequences, leading to numerous diseases such as ...
... release is available in French . ... in contact with bacteria, inducing an inflammatory response that is ... and this can lead to inflammatory bowel disease that may ... the mechanism of inflammation, has long been believed to be ...
Cached Biology News:Getting turned on 2Getting turned on 3Could regulating intestinal inflammation prevent colon cancer? 2
(Date:10/20/2014)... OncLive® is pleased ... at Thomas Jefferson University has joined its Strategic ... Alliance Partnership program, the Sidney Kimmel Cancer Center ... awareness of the Center’s cutting-edge research programs, comprehensive ... and other health care professionals from the Sidney ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Local veterinary ... in an investigational study of donor stem cells for ... stem cell therapy and has performed clinical stem cell ... study is to determine if a single injection of ... joints can help reduce pain and inflammation in the ...
(Date:10/19/2014)... OCTOBER 20-22, 2014: The 9th Annual ... take place at the Congress Center Basel, ... now available at http://www.abim.ch . ... from all over the globe will exchange ... products and developments on the world market. ...
(Date:10/19/2014)... 2014 The Asia-Pacific Bromine Market ... Asia-Pacific with analysis and forecast of revenue. , ... Bromine Market report, to get an idea of ... glimpse of the segmentation in the Asia-Pacific bromine ... figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine ...
Breaking Biology Technology:Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3
... , , , ... the leading systems biology tools company, announced today that it ... cells with global pharmaceutical companies and leading academic centers as ... base" on development and biology of different types of stem ...
... ... Trial (NLST). , ... 31, 2009 -- The Honolulu-based Pacific Health Research Institute (PHRI) has received $2.8 million ... Trial (NLST), a major lung cancer screening study in Hawaii, for two more years. ...
... September 1 According to a new,market research report, ... the total global,biomaterials market is expected to be worth ... from 2009 to 2014. The U.S. market is expected ... biomaterials market today has,already crossed $28 billion. , ...
Cached Biology Technology:GeneGo Kicks Off The MetaMiner Stem Cell Project With Industry and Academics 2Pacific Health Research Institute Awarded $2.8 Million in Research Funding 2Pacific Health Research Institute Awarded $2.8 Million in Research Funding 3Global Biomaterials Market Worth US$58.1 Billion by 2014 2Global Biomaterials Market Worth US$58.1 Billion by 2014 3
... This marking pen has been designed to provide a ... the specimen on a slide. This barrier creates ... within the target area on the slide. PAP ... alcohol and acetone. It can be removed, if ...
Mouse monoclonal antibody to QDPR - quinoid dihydropteridine reductase...
...
Anti-Conjugated Quinaldic Acid...
Biology Products: