Navigation Links
Drug resistance: 'Baby steps' can pay off big
Date:1/9/2013

ld accurately predict how specific mutations would affect E. coli resistance, Shamoo's team examined a gene called TetX2. The gene encodes an enzyme that inactivates the antibiotic minocycline. The researchers looked at the most likely mutations of the gene and found seven that led to increased antibiotic resistance. They then spent two years amassing a catalog of basic biochemical measurements for each mutant.

"If this organism were a car, then these enzymatic measurements would be the equivalent of things like the cubic displacement of the engine, the torque and so on," Shamoo said. "These are measurable variables, but by themselves they won't tell you the car's top speed or how fast it can accelerate from 0 to 60 (miles per hour)."

By measuring the performance improvements from each of the seven TetX2 mutants, the group was able to build a mathematical formula that accurately correlated the E. coli resistance with enzyme performance. To test the formula, the team measured the resistance of a new family of mutants and used the formula to calculate their enzyme performance metrics.

"Using the car analogy again, it's like we took one car and measured its top speed and acceleration using seven different engines," Shamoo said. "Then, we took the same car with an unknown engine and showed that we didn't have to open the hood and look to tell what kind of engine it had. We could tell that strictly by knowing its top speed and acceleration." By knowing how the car with the unknown engine performed on the race track, we could describe the engine without ever popping the hood and vice versa.

Shamoo said the research could lead to faster screening methods for resistant strains of bacteria, but the most immediate benefit is an improved understanding of how resistance develops.

"An example of that is this finding about the small steps," he said. "That was unexpected, and it tells us something fundamental about how re
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Grant funded to improve mothers nutrition before pregnancy and impact on baby
2. Eating well during pregnancy reduces babys obesity risk regardless of moms size
3. Male snails babysit for other dads
4. Lawson researcher sings the baby blues
5. A diet high in choline during pregnancy may mean less stress for baby
6. Warm, dry El Nino weather puts baby sea turtle at risk
7. A new method detects traces of veterinary drugs in baby food
8. U of I study: Lose body weight before gaining baby weight
9. Flying jewels spell death for baby spiders
10. Following in Marie Curies footsteps
11. Synthetic diamond steps closer to next generation of high performance electrochemical applications
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug resistance: 'Baby steps' can pay off big
(Date:11/6/2014)... from a team of Florida State University biologists could ... adapt to and survive environmental swings such as droughts ... issue of the journal The Plant Cell , ... and proteins) is organized in a cell and how ... turned on and others are turned off. , "If ...
(Date:11/6/2014)... November 6, 2014 - Insilico Medicine, Inc, a ... and age related diseases announced a research collaboration ... cancer, Champions Oncology, Inc (OTC: CSBR). , "There ... personalized medicine, but Champions Oncology,s TumorGraft technology is ... the chemotherapy regimen experimentally generating vast amounts of ...
(Date:11/5/2014)... show great diversity in their ability to identify scents ... differ in their perceptual evaluation of odors, with women ... , Sex differences in olfactory detection may play ... connected to one,s perception of smell, which is naturally ... superiority has been suggested to be cognitive or emotional, ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2The female nose always knows: Do women have more olfactory neurons? 2
... create autoimmune response , New research finds the human ... it to produce better antibodies in less time because ... attack the body's own tissues. The Rice University study ... for producing antibodies that are both effective against pathogens ...
... A Howard Hughes Medical Institute investigator from Albany, New ... Aires, Argentina have combined their expertise to identify two ... that causes Chagas disease. Their findings could help scientists ... whose cardiac complications kill up to 30 percent of ...
... Researchers at the Vaccine and Gene Therapy Institute (VGTI) ... diagnostic methods to better detect future monkeypox or smallpox ... 2003 monkeypox outbreak in the Midwest -- monkeypox is ... the 2003 outbreak was larger than the 72 cases ...
Cached Biology News:Immune system has evolved to prevent autoimmune disease 2Immune system has evolved to prevent autoimmune disease 3North & South American researchers find architectural abnormalities in T. cruzi ribosome 2North & South American researchers find architectural abnormalities in T. cruzi ribosome 3North & South American researchers find architectural abnormalities in T. cruzi ribosome 4Researchers develop new testing methods for potential monkeypox or smallpox outbreak 2Researchers develop new testing methods for potential monkeypox or smallpox outbreak 3
(Date:11/26/2014)... 2014 2014 Deep Research Report ... research report on the Global Palmitic Acid industry. ... Acid, basic information, including definition, classification, application, industry ... analysis, etc. , For international and China ... market in China and other countries or ...
(Date:11/26/2014)... 2014  Roka Bioscience, Inc. (NASDAQ: ROKA ), ... for the detection of foodborne pathogens, today announced that ... 26 th Annual Healthcare Conference on December 2, 2014 ... New York Palace in New York, NY ... the Company, its operations, strategies and prospects may be discussed. ...
(Date:11/24/2014)... , Nov. 24, 2014 VolitionRx Limited ... diagnostic tests for cancer and other conditions, today announced that ... at the Science for Business BioWin Day 2014, being held ... The data come from VolitionRx,s lung cancer pilot study, the ... the Centre Hospitalier Universitaire (CHU) de Liege in ...
(Date:11/24/2014)... Continental Clinical Solutions, LLC (Continental) focuses ... at its mid-Atlantic late-phase research facility, located in ... the idea of closing patient disparities in mind. ... advances," said Continental's CEO, Saleh Stevens . ... cell line of Henrietta Lacks, dubious ethical practices ...
Breaking Biology Technology:Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 2Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 3Roka Bioscience to Present at the Piper Jaffray Healthcare Conference 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3
... incorporates naturally occurring soil micro-organism proteins to protect ... Dow AgroSciences LLC, a wholly owned subsidiary of ... ), today announced that it has received regulatory ... Biosafety (CTNBio), for its WideStrike(TM) Insect Protection ...
... 19 CryoLife, Inc. (NYSE: CRY ), ... announced today that it will participate in the Sidoti & ... at The Grand Hyatt Hotel on Wednesday, March 25, 2009.D. ... financial officer of CryoLife, Inc., will present a corporate overview ...
... Records, Billing and Inventory, and JCAHO ComplianceOAKLAND, ... leading provider of fully integrated medical imaging ... collect interventional radiology procedural information at the ... data capture for both general and vascular ...
Cached Biology Technology:Dow AgroSciences Receives Approval for New Technology to Control Cotton Pests in Brazil 2CryoLife to Present at Sidoti's 13th Annual New York Emerging Growth Institutional Forum 2LUMEDX Launches New Interventional Radiology Software 2
CQCS kit for first KR 4i , (first unit)....
... Wellpro 384, compatible ... automated liquid handling system ... quickly and accurately prepares ... dilutions. The Wellpro ...
...
...
Biology Products: