Navigation Links
Drug resistance: 'Baby steps' can pay off big
Date:1/9/2013

ld accurately predict how specific mutations would affect E. coli resistance, Shamoo's team examined a gene called TetX2. The gene encodes an enzyme that inactivates the antibiotic minocycline. The researchers looked at the most likely mutations of the gene and found seven that led to increased antibiotic resistance. They then spent two years amassing a catalog of basic biochemical measurements for each mutant.

"If this organism were a car, then these enzymatic measurements would be the equivalent of things like the cubic displacement of the engine, the torque and so on," Shamoo said. "These are measurable variables, but by themselves they won't tell you the car's top speed or how fast it can accelerate from 0 to 60 (miles per hour)."

By measuring the performance improvements from each of the seven TetX2 mutants, the group was able to build a mathematical formula that accurately correlated the E. coli resistance with enzyme performance. To test the formula, the team measured the resistance of a new family of mutants and used the formula to calculate their enzyme performance metrics.

"Using the car analogy again, it's like we took one car and measured its top speed and acceleration using seven different engines," Shamoo said. "Then, we took the same car with an unknown engine and showed that we didn't have to open the hood and look to tell what kind of engine it had. We could tell that strictly by knowing its top speed and acceleration." By knowing how the car with the unknown engine performed on the race track, we could describe the engine without ever popping the hood and vice versa.

Shamoo said the research could lead to faster screening methods for resistant strains of bacteria, but the most immediate benefit is an improved understanding of how resistance develops.

"An example of that is this finding about the small steps," he said. "That was unexpected, and it tells us something fundamental about how re
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Grant funded to improve mothers nutrition before pregnancy and impact on baby
2. Eating well during pregnancy reduces babys obesity risk regardless of moms size
3. Male snails babysit for other dads
4. Lawson researcher sings the baby blues
5. A diet high in choline during pregnancy may mean less stress for baby
6. Warm, dry El Nino weather puts baby sea turtle at risk
7. A new method detects traces of veterinary drugs in baby food
8. U of I study: Lose body weight before gaining baby weight
9. Flying jewels spell death for baby spiders
10. Following in Marie Curies footsteps
11. Synthetic diamond steps closer to next generation of high performance electrochemical applications
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug resistance: 'Baby steps' can pay off big
(Date:3/18/2015)... March 18, 2015 As mobile payments ... revolutionary smart wallets and apps continue to be introduced into ... in the mobile payment industry in focus today are:  NXT-ID, ... (NYSE: BABA ), Apple Inc. (NASDAQ: ... Facebook Inc. (NASDAQ: FB ) NXT-ID, ...
(Date:3/17/2015)... , March 17, 2015  MecklerMedia Corporation (OTCQX: ... exhibition for service robots ever held in ... place on May 11-13, 2015 at the Javits ... for the event include: Acorn Product Development; Axis ... Infranor; Kinova Robotics; Littler; NewBotic Corporation; Neya Systems ...
(Date:3/12/2015)... , March 12, 2015 The mascots ... Brenner Children,s Hospital, part of Wake Forest Baptist Medical ... initiative for the 2015 ACC Men,s Basketball Tournament. Young ... with them and getting their autographs. Brenner ... Baptist. It is the only children,s hospital in northwest ...
Breaking Biology News(10 mins):Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2
... the parareptiles, a diverse group of bizarre-looking terrestrial vertebrates ... small, slender, agile and lizard-like creatures, while others attained ... and bony spikes on their skulls. The researchers ... by the end-Permian extinction than at any other point ...
... years ago, the understory of late Mesozoic forests was dominated ... Today, only one genus from this group, Equisetum ... a prime candidate for being the oldest extant genus of ... the evolutionary beginnings of the genus Equisetum . Molecular ...
... (SALT LAKE CITY) New findings from University of Utah School of ... in the blood of patients who have chronic fatigue syndrome (CFS). ... study that linked CFS to XMRV. The study, performed by ... Singh, M.D., Ph.D., associate professor of pathology, was published May 4, ...
Cached Biology News:Reptile 'cousins' shed new light on end-Permian extinction 2Newly discovered plant fossil reveals more than age 2Newly discovered plant fossil reveals more than age 3Newly discovered plant fossil reveals more than age 4Comprehensive study finds no link between XMRV retrovirus and chronic fatigue syndrome 2Comprehensive study finds no link between XMRV retrovirus and chronic fatigue syndrome 3
(Date:3/25/2015)... South San Francisco, CA (PRWEB) March 25, 2015 ... Trial Provide Support for Novel Mechanism of Action ... CA, March 25, 2015 – Cytokinetics, Incorporated (Nasdaq: ... to its fast skeletal muscle troponin activator tirasemtiv ... results from a Phase IIa “Evidence of Effect” ...
(Date:3/25/2015)...  The Technology Association of Georgia ... promotion and economic advancement of Georgia,s ... of its Top 40 Innovative Technology Companies in ... group at the 2015 Georgia Technology Summit (GTS) on ... TAG,S Top 40 Awards recognize Georgia ...
(Date:3/25/2015)... Proove Biosciences , a commercial ... announce the success of their commercially supported symposium, ... Optimize the Management of Pain, at the 31st Annual ... Maryland on Thursday, March 19th, 2015. , ... Lynn Webster , M.D., former Florida Society of ...
(Date:3/25/2015)... (PRWEB) March 25, 2015 ... segmented on the basis of products, technology, ... in this report are radar, laser, infra-red, ... encompassing video guidance systems, terrain mapping systems, ... market data Tables and 60 Figures spread ...
Breaking Biology Technology:Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 2Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 3Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 4Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 5Cytokinetics Announces Publication of Results from Phase II Trial of Tirasemtiv in Patients with Myasthenia Gravis 6Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 2Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 3Streamline Health, Inc. Named a TAG Top 40 Innovative Technology Company 4Proove Biosciences Hosts Symposium on Incorporating Genetic Testing to Optimize the Management of Pain 2Smart Weapons Market is Estimate to reach $6.1 Billion by 2020 Worth $6.1 Billion by 2020 - New Report by MarketsandMarkets 2Smart Weapons Market is Estimate to reach $6.1 Billion by 2020 Worth $6.1 Billion by 2020 - New Report by MarketsandMarkets 3
... May 25 /PRNewswire-Asia-FirstCall/ -- Biostar,Pharmaceuticals, Inc. (Nasdaq: BSPM ... Hepatitis B medicine,Xin Aoxing Oleanolic Acid Capsule ("Xin Aoxing"), and a ... assembly of its production line for its proprietary Zushima product. , ... ...
... NEW YORK , May 25, 2010 ... biosensor and microprocessor technologies for use in,portable monitoring devices, ... the overall daily activity level of an individual and ... overweight or obese. The bracelet,designed both for children and ...
... May 25, 2010 t2cure GmbH, a biopharmaceutical,company developing and marketing ... t2c001 has been,certified by the European Medicines Agency (EMA). , ... t2c001 is the ... Therapy Medicinal Products (ATMPs). It is a somatic,cell therapy product derived from ...
Cached Biology Technology:Biostar Pharmaceuticals, Inc. Begins Assembly of New Production Line 2Biostar Pharmaceuticals, Inc. Begins Assembly of New Production Line 3Biostar Pharmaceuticals, Inc. Begins Assembly of New Production Line 4SPO Medical Announces Innovative Wellness Bracelet 2SPO Medical Announces Innovative Wellness Bracelet 3SPO Medical Announces Innovative Wellness Bracelet 4SPO Medical Announces Innovative Wellness Bracelet 5t2cure First Company to Have Quality of Cellular Therapeutic Certified by EMA 2t2cure First Company to Have Quality of Cellular Therapeutic Certified by EMA 3t2cure First Company to Have Quality of Cellular Therapeutic Certified by EMA 4
... This antibody recognizes murine IRF7 ... with other related IRF proteins. ... murine IRF7 protein was confirmed ... the 293T cells transfected with ...
Sprague-Dawley rats, 7-8 weeks old, mixed gender; tissue is collected fresh, frozen on dry ice within minutes of sacrifice and stored at -20C; individual tissue weight approx. 0.05 gram....
...
Contains L-glutamine...
Biology Products: