Navigation Links
Drug resistance: 'Baby steps' can pay off big
Date:1/9/2013

HOUSTON -- (Jan. 9, 2013) -- Rice University scientists have found that mutations of small effect can turn out to be game changers in the bacterial fight against antibiotic drugs.

The discovery came during an exhaustive, three-year effort to create a mathematical model that could accurately predict how specific mutations allow bacteria like E. coli to adapt to antibiotics like minocycline. The findings are detailed in a Dec. 10 study in the Proceedings of the National Academy of Sciences.

"As biologists, we tend to focus on big effects that result from big changes, but this study shows that bacteria don't have to solve the problem of antibiotic resistance in one giant step," said Rice University biochemist Yousif Shamoo, the lead researcher on a new study. "We were surprised to see that small mutations could make a big difference. In some cases, we saw that minor molecular changes could boost resistance by as much as 500 percent."

Despite the remarkable success of antibiotics, bacterial infections remain a leading cause of death, and antibiotic resistance among bacterial pathogens is a significant threat to public health.

Shamoo, professor of biochemistry and cell biology and director of Rice's Institute of Biosciences and Bioengineering, said the study of antibiotic resistance offers opportunities to both examine complex cellular phenomena and address the "genotype to phenotype problem," one of modern biology's major challenges.

"We've sequenced hundreds of genomes, and we're finding that it's one thing to read the blueprint, and it's another thing to predict how the DNA in that blueprint will affect change in a living cell," Shamoo said.

Shamoo said that because a single antibiotic resistance gene can make big changes in whether a cell lives or dies, it is possible to make the connection between the gene and the cell's fitness to its environment.

To show that a mathematical model cou
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Grant funded to improve mothers nutrition before pregnancy and impact on baby
2. Eating well during pregnancy reduces babys obesity risk regardless of moms size
3. Male snails babysit for other dads
4. Lawson researcher sings the baby blues
5. A diet high in choline during pregnancy may mean less stress for baby
6. Warm, dry El Nino weather puts baby sea turtle at risk
7. A new method detects traces of veterinary drugs in baby food
8. U of I study: Lose body weight before gaining baby weight
9. Flying jewels spell death for baby spiders
10. Following in Marie Curies footsteps
11. Synthetic diamond steps closer to next generation of high performance electrochemical applications
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug resistance: 'Baby steps' can pay off big
(Date:2/5/2015)... , January 28, 2015 ... Analysis, Size And Segment Forecasts To 2020 has Been ... IR camera market is expected to reach USD 5.10 ... Grand View Research, Inc. IR cameras help identify the ... are expected to witness surging demand in medical imaging ...
(Date:1/22/2015)... and Markets ( http://www.researchandmarkets.com/research/4trb7t/biometrics_a ) has announced the ... report to their offering. , The ... individual is who she/he is claiming to be, and for ... unique physical characteristics, such as fingerprint, hand or palm print, ...
(Date:1/22/2015)...  BellBrook Labs, a leader in high throughput screening ... a TR-FRET (time resolved Forster resonance energy transfer) ... high throughput screening assay for glycosyltransferases and other ... sensitive detection of hundreds of human and microbial ...
Breaking Biology News(10 mins):IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 3Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2
... The effects of amphetamines on gene expression in ... BioMed Central,s open access journal Genome Biology , ... addiction by describing the nad zebrafish mutant, which does ... Katharine Webb, from the German Research ...
... Some people who are serious about wanting to reduce ... to them that may yield a large long-term benefit ... Oregon State University concluded that in the United States, the ... is almost 20 times more important than some of the ...
... program aimed at using platinum as an exploration guide for ... a time scale on the planet,s large-scale convection processes. The ... "Progressive mixing of meteoritic veneer into the early Earth,s deep ... Dr Stephen Barnes said the study group collected a large ...
Cached Biology News:Drug-proof zebrafish reveal secrets of addiction 2Family planning a major environmental impact 2Extraterrestrial platinum was 'stirred' into the Earth 2
(Date:2/27/2015)... , Feb. 27, 2015   PureTech , ... inventing and commercializing disruptive products and technologies in the ... Viehbacher , former CEO and Member of the Board ... "It,s has been a pleasure to ... excited that we will be working together more closely ...
(Date:2/26/2015)... /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the "Company") ... develops and commercializes proprietary technologies and products for advanced ... for the fiscal first quarter ended December  31, 2014. ... dollars (CAD), unless otherwise stated. "During ... from our existing customers and add to our sales ...
(Date:2/26/2015)... FT. LAUDERDALE, Fla. , Feb. 26, 2015 /PRNewswire/ ... discussed growth priorities driven by key research advancements ... Health segments at today,s Bank of America Merrill Lynch ... worldwide met the challenge of building grain supplies the ... expected to continue at the pace of the last ...
(Date:2/26/2015)... MOUNTAIN VIEW, Calif. , Feb. 26, 2015 ... you navigate this ever-changing arena, Frost & Sullivan will host ... Frost & Sullivan Executive MindXchange , March 8 to 10, ... San Diego, Calif. This event ... and connected healthcare leaders to discuss industry disruptions and how ...
Breaking Biology Technology:Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 3Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 4SQI Diagnostics Reports First Quarter Financial Results 2SQI Diagnostics Reports First Quarter Financial Results 3SQI Diagnostics Reports First Quarter Financial Results 4SQI Diagnostics Reports First Quarter Financial Results 5SQI Diagnostics Reports First Quarter Financial Results 6DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 3DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 4DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 5Embrace the Future of Medical Technologies with Frost & Sullivan 2Embrace the Future of Medical Technologies with Frost & Sullivan 3
... the University of Colorado at Boulder believe a dry ... for human clinical trials later this year in India ... ranging from tuberculosis to cervical cancer. The ... CU-Boulder chemistry and biochemistry Professor Robert Sievers, involves mixing ...
... novel wheat grain fraction with high levels of ... cereals and bread containing wheat aleurone have been ... beneficial compounds such as betaine, and decreased homocysteine ... disease risk. It is important for the ...
... PAULO , May 5 Twenty-two Brazilian companies and ... Convention 2010, held on May 3 to 6 , in ... Trade and Investment Promotion Agency (Apex- Brazil ). At the Convention ... products at the international level. Brazil will have a ...
Cached Biology Technology:New inhalable measles vaccine may lead to vaccines for other diseases 2New inhalable measles vaccine may lead to vaccines for other diseases 3New inhalable measles vaccine may lead to vaccines for other diseases 4Brazilian Biotechnology Present at BIO 2010 Is Looking for the Worldwide Market 2
... is obtained from non-demolished blood ... fasted donors. The donors are ... and are maintained on an ... Protein Concentration : 85 mg/ml ...
... Captiva 96-well Filter Plates are offered ... and 0.45 um depth filter plates are ... LC/MS analysis. Filtration is simple, versatile, and ... columns. The Captiva 10 um glass fiber ...
... CyScribe First-Strand cDNA Labeling System ... Kit, 50 reactions. For the generation ... cDNA.Optimized reagents are packaged together for ... optimized protocols can be used for ...
Collected from sexually mature, mixed sex, mixed breed dogs. Serum from specific breeds available by request....
Biology Products: