Navigation Links
Drug resistance: 'Baby steps' can pay off big
Date:1/9/2013

HOUSTON -- (Jan. 9, 2013) -- Rice University scientists have found that mutations of small effect can turn out to be game changers in the bacterial fight against antibiotic drugs.

The discovery came during an exhaustive, three-year effort to create a mathematical model that could accurately predict how specific mutations allow bacteria like E. coli to adapt to antibiotics like minocycline. The findings are detailed in a Dec. 10 study in the Proceedings of the National Academy of Sciences.

"As biologists, we tend to focus on big effects that result from big changes, but this study shows that bacteria don't have to solve the problem of antibiotic resistance in one giant step," said Rice University biochemist Yousif Shamoo, the lead researcher on a new study. "We were surprised to see that small mutations could make a big difference. In some cases, we saw that minor molecular changes could boost resistance by as much as 500 percent."

Despite the remarkable success of antibiotics, bacterial infections remain a leading cause of death, and antibiotic resistance among bacterial pathogens is a significant threat to public health.

Shamoo, professor of biochemistry and cell biology and director of Rice's Institute of Biosciences and Bioengineering, said the study of antibiotic resistance offers opportunities to both examine complex cellular phenomena and address the "genotype to phenotype problem," one of modern biology's major challenges.

"We've sequenced hundreds of genomes, and we're finding that it's one thing to read the blueprint, and it's another thing to predict how the DNA in that blueprint will affect change in a living cell," Shamoo said.

Shamoo said that because a single antibiotic resistance gene can make big changes in whether a cell lives or dies, it is possible to make the connection between the gene and the cell's fitness to its environment.

To show that a mathematical model cou
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Grant funded to improve mothers nutrition before pregnancy and impact on baby
2. Eating well during pregnancy reduces babys obesity risk regardless of moms size
3. Male snails babysit for other dads
4. Lawson researcher sings the baby blues
5. A diet high in choline during pregnancy may mean less stress for baby
6. Warm, dry El Nino weather puts baby sea turtle at risk
7. A new method detects traces of veterinary drugs in baby food
8. U of I study: Lose body weight before gaining baby weight
9. Flying jewels spell death for baby spiders
10. Following in Marie Curies footsteps
11. Synthetic diamond steps closer to next generation of high performance electrochemical applications
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Drug resistance: 'Baby steps' can pay off big
(Date:12/3/2014)... GLENDALE, Ariz. , Dec. 2, 2014 ... biometric hand readers, Inception Technologies is pleased to announce ... it easier for customers to collect the workforce data ... the problems that have been left by existing readers. ... to user interface, connectivity and modern technology. Older models ...
(Date:11/21/2014)... NEW YORK , Nov. 19, 2014  Earlier ... Board at New York College, and one of the ... for biosensor signals that are transmitted from Smartphones to ... there were Smartphones and has one of the earliest ... are discussing its usage in the military, child care, ...
(Date:11/21/2014)... , Nov. 20, 2014 C-Labs LLC, ... the Internet of Things (IoT), today announced the appointment ... chief operating officer. Previously a strategic advisor to the ... and operations. Mr. Traynor is based out of the ... He reports to Chris Muench , Chief Executive ...
Breaking Biology News(10 mins):Inception Technologies to Release New Biometric Reader 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... doesn,t end with the event itself. Blockage of blood flow ... With transplants scarce, half the people who live through a ... address this problem by engineering cardiac tissue to patch up ... Feiner under the supervision of Dr. Tal Dvir of ...
... September 23, 2013 It is often said that ... eliminate their attraction to the abused substance. New findings ... even long-term abstinence from cocaine does not result in ... currently trying to answer some of the ,chicken and ...
... Alliance, a nonprofit organization that focuses on local conservation and ... million award to address land use alteration as a significant ... The funding for the new program was awarded by ... (RDMA). Over 60 percent of emerging infectious diseases over ...
Cached Biology News:Putting the spring back in broken hearts 2Addiction: Can you ever really completely leave it behind? 2EcoHealth Alliance announces new award from USAID to combat disease emergence and climate change 2
(Date:12/17/2014)... 2014 CASI Pharmaceuticals, Inc. (Nasdaq: ... development and commercialization of innovative therapeutics addressing cancer and ... a primary commercial focus on China ... Type C meeting with the U.S. Food and Drug ... in February 2015.  During this meeting the Company will ...
(Date:12/17/2014)... Dec. 17, 2014   Synageva BioPharma Corp. ... therapeutic products for rare disorders, announced today its presentation ... in San Francisco, CA. ... Executive Officer, will present on Monday, January 12, 2015, ... will be webcast live and may be accessed from ...
(Date:12/15/2014)... Israel , Dec. 15, 2014  BrainStorm ... leading developer of adult stem cell technologies for neurodegenerative ... Ltd. was awarded a grant of approximately $1.1 million ... Chief Scientist (OCS).  This is the eighth year that ... the Office of the Chief Scientist, which is part ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
Breaking Biology Technology:CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 2BrainStorm Receives $1,100,000 for its 8th Annual Non-Dilutive Grant from Israel's Chief Scientist Office 3AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3
... -- WuXi PharmaTech (NYSE:,WX), a leading pharmaceutical, biotechnology ... operations in China and the United,States, today announced ... the Vice,President of Strategy., (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ... Dr. Yu worked at Pfizer Inc., where,she co-led ...
... Practices for Long-term Jatropha Development', the critical ... November 2007 position paper 'Sustainable Biodiesel Feedstock: ... It emphasizes the need to develop sustainability ... as a viable alternative energy source. Key ...
... BANNOCKBURN, Ill., July 10 Pinnacle Biologics, a,private, ... has entered into an agreement with pharmexx to ... in Western Europe. Terms of the,agreement were not ... Inc. stated, "We are,pleased to conclude this agreement ...
Cached Biology Technology:WuXi PharmaTech (NYSE: WX) Appoints Dr. Debra Yu as VP of Strategy 2Comprehensive Jatropha Standards Mandatory in Optimum Long-term Biofuel Efficacy 2Comprehensive Jatropha Standards Mandatory in Optimum Long-term Biofuel Efficacy 3Comprehensive Jatropha Standards Mandatory in Optimum Long-term Biofuel Efficacy 4Pinnacle Biologics Announces Agreement With pharmexx to Expand Sales Support Activities in Key European Markets 2
... uses include large-scale colony-counting and plaque-lifting, microbial ... TM automated colony picking and gridding ... product number, created to easily match Cornings ... please order under the old Sigma-Aldrich number ...
Mouse Anti-Human Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4 Monoclonal Antibody Family: New...
BD BioCoat Laminin 150 mm Culture Dishes...
...
Biology Products: