Navigation Links
Dominant cholesterol-metabolism ideas challenged by new research
Date:8/15/2007

A team of researchers investigating cholesterol and lipid transport has performed experiments that cast serious doubt on the dominant hypothesis of how the body rids its cells of "bad" cholesterol (LDL) and increases "good" cholesterol (HDL). Cholesterol metabolism is an area of intense inquiry because high levels of LDL cholesterol or total cholesterol put about half of all Americans at significant risk of heart disease.

The team was led by Robert A. Schlegel, Professor of Biochemistry and Molecular Biology at Penn State University, and Patrick Williamson, the Edward S. Harkness Professor of Biology at Amherst College. The paper by Schlegel, Williamson, and their colleagues will be published on Wednesday, 15 August 2007, in the on-line journal PLoS One.

A protein called ABCA1 is critical for producing "good" cholesterol: patients who lack the gene for this protein produce no HDL, and as a result, suffer from heart attacks at an early age. An important question is what ABCA1 does that is so important for producing HDL.

The most popular hypothesis was put forth in 2000 by Giovanna Chimini, Group Leader of a laboratory in the Centre d'Immunologie Marseille-Luminy in France, and colleagues. They suggested that the ABCA1 enzyme plays a major role in the transfer of a phospholipid called phosphatidylserine (PS) from the inside of the cell -- where it is normally concentrated -- across the cell membrane to the outer surface of the cell. This is a crucial first step in the mechanism by which excess lipids and cholesterol are eliminated from the body. Under normal conditions, there is a second important step. After the PS is expressed on the cell surface, the phospholipids and excess cholesterol can be loaded onto a circulating protein, apoA1, to generate an HDL cholesterol particle. HDL cholesterol carries the lipids through the blood stream to the liver, where they are dumped into the in
'/>"/>

Contact: Barbara K. Kennedy
science@psu.edu
814-863-4682
Penn State
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Past experience of pheromones induces dominant courtship behavior in fruit flies
2. Dominant meerkats render rivals infertile
3. Agriculture and tropical conservation: rethinking old ideas
4. Researchers discover way to make cells in the eye sensitive to light
5. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
6. Columbia research lifts major hurdle to gene therapy for cancer
7. Researchers find how protein allows insects to detect and respond to pheromones
8. Researchers Uncover Key Step In Manufacture of Memory Protein
9. Research advances quest for HIV-1 vaccine
10. Research on Worms Yields Clues on Aging
11. U of M researcher examines newly emerging deadly disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... the University of Texas Medical Branch at Galveston has gone ... can completely protect monkeys against a lethal dose of Ebola ... when the disease is severe. , Thomas Geisbert, professor of ... discussing advances in Ebola treatment research. The filoviruses known ... deadly of pathogens, with fatality rates of up to 90 ...
(Date:8/29/2014)... release is available in German . ... players in the natural nitrogen cycle on Earth and ... bacteria were thought to depend on nitrite as their ... by Holger Daims, a microbiologist at the University of ... hydrogen as an alternative source of energy. The oxidation ...
(Date:8/29/2014)... - In a cell,s nucleus, chromosomal DNA is ... an amalgam biologists call chromatin. Until about two ... "sidekick," the mere packing material around which the ... have developed a greater appreciation for how DNA/histone ... from multiple research institutions studying the sequence of ...
Breaking Biology News(10 mins):Leading Ebola researcher at UTMB says there's an effective treatment for Ebola 2Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 3
... vanilla smells like vanilla. But androstenone, a derivative of ... odor, can smell like either - depending on your ... androstenone, usually that of stale urine or strong sweat, ... cannot smell it at all. New research ...
... that plays a linchpin role in the ability of ... may lead to improved therapies for hormone-responsive breast cancers ... treatments. Estrogen causes hormone-responsive breast cancer cells to ... by cancer cells. Interfering with estrogen signaling is the ...
... sensor of voltage-gated ion channels is a conserved protein ... regulate ion permeation through the channel. A recently discovered ... not to an ion channel but to a phosphatidylinositide ... In a new paper published in The Journal ...
Cached Biology News:Gene determines whether male body odor smells pleasant 2Gene determines whether male body odor smells pleasant 3Linchpin gene may be useful target for new breast cancer therapies 2New insight into the mechanisms of voltage sensing and transduction in biological processes 2
(Date:8/28/2014)... New York, NY (PRWEB) August 28, 2014 ... has renewed its long term partnership with PTI ... to provide clients with state of the art leak ... state of the art instruments currently available. As part ... a new High Voltage Leak Detection Instrument ...
(Date:8/27/2014)... Austin, TX (PRWEB) August 27, 2014 ... $6 million in Series B funding and secured Otter ... and investment capital will accelerate commercialization of GGI’s Agriplier™ ... multiple crop types. , “Since our first meeting, ... commitment to the biological product space,” said Alan Sobba, ...
(Date:8/27/2014)... California (PRWEB) August 27, 2014 ... (LLNL), through Lawrence Livermore National Security LLC ... to develop and deliver a state-of-the-art laser system ... facility (ELI Beamlines), under construction in the Czech ... performance, the laser system, called the " High ...
(Date:8/27/2014)... Aug. 27, 2014   MSC , a healthcare ... today announced the appointment of Mary Beth Loesch ... 28 years of experience preparing companies for rapid growth ... Executive Vice President of Corporate Development and Healthcare. In ... business , as well as corporate strategy and marketing. ...
Breaking Biology Technology:Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3MSC names Mary Beth Loesch President and CEO 2
... an economic year in which some new investments were made, ... positioned itself to prosper in some emerging sectors. , ,With ... must remain warm and state policymakers need to turn a ... compete in the global marketplace. What's in store for the ...
... The Dow Jones Industrials had a fabulous year ... had a very solid year, by a large margin. The ... differently, mostly because the different composition of each. , ,The ... represents a greater spectrum of the biotech industry (larger and ...
... Wis. - The United States District Court for the ... damage verdict against Abbott Laboratories . , ,The Madison-based ... biopharmaceutical company based in Gent, Belgium, and rejected Abbott Labs' ... sued Abbott labs for infringing on a genotyping patent. Frank ...
Cached Biology Technology:Wisconsin's high-growth economy: '07 predictions 2Wisconsin's high-growth economy: '07 predictions 3Wisconsin's high-growth economy: '07 predictions 42006: A mixed blessing for Midwest life science companies 22006: A mixed blessing for Midwest life science companies 32006: A mixed blessing for Midwest life science companies 42006: A mixed blessing for Midwest life science companies 52006: A mixed blessing for Midwest life science companies 62006: A mixed blessing for Midwest life science companies 72006: A mixed blessing for Midwest life science companies 82006: A mixed blessing for Midwest life science companies 92006: A mixed blessing for Midwest life science companies 102006: A mixed blessing for Midwest life science companies 11
... a chemically modified form of AmpliTaq® DNA ... to the enzyme, the enzyme is inactive. ... thermal cycling (when the reaction is going ... inactive. The result is that mis-primed primers ...
A robust formulation of Taq Polymerase supplied with a 10X colored reaction buffer which allows Direct Gel-Loading...
Ps-Aeruginosa (IgG) -Ab EIA Sample Size: 100 l...
Ps-Aeruginosa (IgA) -Ab EIA Sample Size: 100 l...
Biology Products: