Navigation Links
Does the brain become unglued in autism?
Date:12/11/2012

Philadelphia, PA, December 11, 2012 A new study published in Biological Psychiatry suggests that autism is associated with reductions in the level of cellular adhesion molecules in the blood, where they play a role in immune function.

Cell adhesion molecules are the glue that binds cells together in the body. Deficits in adhesion molecules would be expected to compromise processes at the interfaces between cells, influencing tissue integrity and cell-to-cell signaling. In the brain, deficits in adhesion molecules could compromise brain development and communication between nerve cells.

Over the years, deficits in neural cell adhesion molecules have been implicated in schizophrenia and other psychiatric disorders. One adhesion molecule, neurexin, is strongly implicated in the heritable risk for autism.

Cell adhesion molecules also play a crucial role in regulating immune cell access to the central nervous system. Prior research provided evidence of immune system dysfunction in individuals diagnosed with autism spectrum disorder (ASD). This led scientists from the University of California, Davis to examine whether adhesion molecules are altered in children with ASD.

To conduct the study, they recruited 2-4 year old children, 49 of whom were diagnosed with an ASD and 31 of whom were typically developing. They measured blood plasma levels of multiple molecules, conducted behavioral assessments, and measured head circumference in all participants.

"For the first time, we show that levels of soluble sPECAM-1 and sP-selectin, two molecules that mediate leukocyte migration, are significantly decreased in young children with ASD compared with typically developing controls of the same age," explained the authors. "This finding is consistent with previous reports of decreased levels of both sPECAM-1 and sP-selectin in adults with high-functioning autism."

They also found that repetitive behavior scores and sPEC
'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. How the common cat parasite gets into the brain
2. Research shows immune system response is detrimental to novel brain cancer therapy
3. Musical duets lock brains as well as rhythms
4. Double duty: Immune system regulator found to protect brain from effects of stroke
5. University of Maryland School of Medicine, NIH study pinpoints brain areas role in learning
6. Multiple sclerosis immune exchange between brain and blood is uncovered
7. A 3-D light switch for the brain
8. Neurons made from stem cells drive brain activity after transplantation in laboratory model
9. Brain waves make waves
10. New brain gene gives us edge over apes, study suggests
11. Watching the developing brain, scientists glean clues on neurological disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... and can reduce free radical damage. Can ... stress? Jianbo Zhao and co-workers from the ... China discovered that green tea polyphenol effectively ... indicating green tea polyphenols play a protective ... stress. The relevant study has been published ...
(Date:8/22/2014)... 3β-Hydroxysteroid-Δ24 reductase (DHCR24) is a multifunctional ... reticulum and has neuroprotective and cholesterol-synthesizing ... apoptosis caused by amyloid β deposition. ... Liaoning University in China constructed two ... drive DHCR24 expression specifically in neuronal ...
(Date:8/22/2014)... will finally be able to purchase fuel cell cars ... vehicles, most of the cars will run on hydrogen ... to global warming. , Now scientists at Stanford University ... ordinary AAA battery to produce hydrogen by water electrolysis. ... electrodes that split liquid water into hydrogen and oxygen ...
Breaking Biology News(10 mins):Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3
... Disadvantaged urban preschoolers aren,t only at risk for failure in ... and athletic fields as well, research suggests. A new ... disadvantaged preschoolers from two urban areas showed significant developmental delays ... catching. That means that they are at risk of ...
... the sun,s rays through solar panels on their roofs used to ... order to help save the planet. But now there is no ... says a Spanish-German partnership, which has developed a virtually invisible solar ... don,t see the film at all it,s marvellous," says Francisco ...
... grapes slow what,s for many Americans a downhill sequence of ... and type 2 diabetes? Scientists at the University ... effect of grapes in reducing risk factors related to cardiovascular ... due to phytochemicals -- naturally occurring antioxidants that ...
Cached Biology News:86 percent of disadvantaged preschoolers lack basic motor skills 286 percent of disadvantaged preschoolers lack basic motor skills 3Roof integrated solar energy 2Roof integrated solar energy 3Grapes reduce risk factors for heart disease and diabetes, U-M animal study shows 2Grapes reduce risk factors for heart disease and diabetes, U-M animal study shows 3
(Date:8/22/2014)... August 22, 2014 The AMA is ... its members in Alaska that Alaska Governor Sean Parnell ... 15, further defining public use of Unmanned Aircraft Systems ... Force. House Bill 255states that it is, “An Act ... captured by an unmanned aircraft system.” It defines State ...
(Date:8/22/2014)... 2014 Nerium International, the go-to, ... the spotlight again. Nerium will showcase its signature ... Body Contouring Cream to Hollywood’s elite at the ... the 66th Primetime Emmy® Awards. , Developed from ... clinical trials show that NeriumAD night cream dramatically ...
(Date:8/22/2014)... 2014 The identification of protein-coding ... be accelerated by exome sequencing. Built on Roche ... custom SeqCap EZ Developer system has been a ... will additionally present how he achieved coverage statistics ... and mouse exome kits. With over 236,000 SNPs ...
(Date:8/22/2014)... August 22, 2014 “Our nation's ... is a national disgrace. Furthermore, every governmental and ... the current, deplorable state of unorganized dysfunction shares ... mistakes," to merely serve as a device to ... of colossal failure(s) that have accumulated through the ...
Breaking Biology Technology:State of Alaska Signs Unmanned Aircraft Systems Bill 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 25 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2
... Corporation, a spinal and orthopaedic implant and instrument company ... the launch of four new product offerings. The ... Valeo(®) C VBR, Valeo(®) Concise Cervical Plating System and ... American Spine Society (NASS) prepares to meet in San ...
... 10 Genoptix, Inc. (Nasdaq: GXDX ), a specialized ... Lazard Capital Management 6th Annual Healthcare Conference at The St. ... , Genoptix,s EVP and CFO, Doug Schuling, will ... at approximately 11:25 a.m. EST. He will provide an ...
... LOUIS, Nov. 10, 2009 The positive mix lift ... allows Monsanto Company (NYSE: MON ) to reconfirm ... 2012, Monsanto President and CEO Hugh Grant will tell ... Grant will indicate that accelerated launches for its Genuity(TM) ...
Cached Biology Technology:Amedica Announces New Product Offering 2Genoptix Announces Participation at Lazard Capital Management 6th Annual Healthcare Conference 2Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 2Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 3Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 4Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 5Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 6Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 7Monsanto Reconfirms 2010 Guidance and 2012 Financial Commitments on Strength of Larger Expected Launches for Blockbuster Products 8