Navigation Links
Dividing cells 'feel' their way out of warp
Date:9/10/2009

Every moment, millions of a body's cells flawlessly divvy up their genes and pinch perfectly in half to form two identical progeny for the replenishment of tissues and organs even as they collide, get stuck, and squeeze through infinitesimally small spaces that distort their shapes.

Now Johns Hopkins scientists, working with the simplest of organisms, have discovered the molecular sensor that lets cells not only "feel" changes to their neat shapes, but also to remodel themselves back into ready-to-split symmetry. In a study published September 15 in Current Biology, the researchers show that two force-sensitive proteins accumulate at the sites of cell-shape disturbances and cooperate first to sense the changes and then to resculpt the cells. The proteins myosin II and cortexillin I monitor and correct shape changes in order to ensure smooth division.

"What we found is an exquisitely tuned mechanosensory system that keeps the cells shipshape so they can divide properly," says Douglas N. Robinson, Ph.D., an associate professor of Cell Biology, Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine.

Faulty cell division can put organisms, including people, on the pathway to diseases such as cancer, Robinson notes, and a better understanding of how cells respond to mechanical stress on their shapes could present new targets for both diagnosing and treating such diseases.

Working with hardy, single-celled protozoa that move and divide similarly to human cells, the scientists watched through microscopes while they deformed the cells' shapes with a tiny instrument that, like a soda straw, sucks in on the cell surface and creates distorted shapes.

"This particular method, based on a very old principle that dates back to Archimedes, enables us to deform cells without killing them, much in the same way that natural processes in the body constantly assault them, Robinson says."


'/>"/>
Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Carbon nanotubes could make efficient solar cells
2. Size of fat cells and waist size predict type 2 diabetes in women
3. Pandemic flu can infect cells deep in the lungs, says new research
4. Individual cells isolated from biological clock can keep daily time, but are unreliable
5. Researchers find first evidence of virus in malignant prostate cells
6. Liposuction leftovers easily converted to IPS cells, Stanford study shows
7. Making more efficient fuel cells
8. UT Southwestern researchers examine mechanisms that help cancer cells proliferate
9. Lower-cost solar cells to be printed like newspaper, painted on rooftops
10. Glow-in-the-dark red blood cells made from human stem cells
11. When cells run out of fuel
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Dividing cells 'feel' their way out of warp
(Date:4/23/2014)... announced Sophie Martin of the University of Lausanne, Switzerland, ... The award acknowledges her work to understand the molecular ... cell. , Martin has been working for the past ... way in which the spatial organization of cells contributes ... 11 years, she has been using fission yeast, which ...
(Date:4/23/2014)... new study by a University of Exeter researcher has ... of wild camels thriving in Australia,s remote outback have ... scale. , Sarah Crowley, of the Environment and Sustainability ... the history of the camel in Australia, from their ... to their current status as unwelcome "invader." , The ...
(Date:4/23/2014)... a technique used to read quickly. It involves ... non-essential words and/ or sentences. Similarly to humans, ... quickly "read" genetic information. Genes that need to ... smaller the encoding message, the easier it will ... Instituto Gulbenkian de Cincia (IGC, Portugal) and Centre ...
Breaking Biology News(10 mins):EMBO Gold Medal 2014 awarded to Sophie Martin 2How Australia got the hump with 1 million feral camels 2How Australia got the hump with 1 million feral camels 3Cell division speed influences gene architecture 2
... from North Carolina State University, the University of Washington ... most diverse collections of prehistoric non-native animal remains in ... find contributes to our understanding of culture in the ... may have been more important than previously thought. ...
... The Saint Louis Zoo,s Ron Goellner Center for ... on Nov. 30, 2011, that Ozark hellbenders have been ... subspecies of hellbender. This decade-long collaboration has yielded ... Nov. 15, and currently there are approximately 120 additional ...
... COPENHAGEN, DENMARK/ROCKVILLE, MD, USA Statens Serum Institut and Aeras ... trial of a new candidate TB vaccine designed to protect ... The trial is being conducted by the South African ... in the Western Cape province of South Africa. Dr. Hassan ...
Cached Biology News:Archaeologists find new evidence of animals being introduced to prehistoric Caribbean 2World's first captive breeding of Ozark hellbenders at Saint Louis Zoo 2World's first captive breeding of Ozark hellbenders at Saint Louis Zoo 3Vaccine targeting latent TB enters clinical testing 2
(Date:1/15/2014)... 2014 AudioNotch is the internet's leading ... the treatment of tinnitus. Patients listen to sound therapy ... a period of weeks to months, their tinnitus volume decreases. ... forms: Notched Music and Notched White Noise. Now, AudioNotch is ...
(Date:1/14/2014)... January 14, 2014 Date: Friday, April 11, ... Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... organization solely dedicated to finding a cure for hepatitis B ... will host its annual Crystal Ball on Friday, April 11 ...
(Date:1/14/2014)... 2014 Histogen, Inc., a regenerative medicine ... grown under simulated embryonic conditions, today announced that they ... Medical, Inc. for physician-dispensed aesthetic products containing Histogen’s proprietary ... agreement is an amendment to the existing license between ...
(Date:1/14/2014)... BURLINGAME, Calif. , Jan. 14, 2014 As pet owners ... no doubt many of them wrote: "Take better care of my ... and even designer clothes and top-brand carrying cases to take the ... Pet parents might also feel compelled to buy some pricey toys ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... a regulatory framework to guide the approval of the ... providing more affordable treatment for millions of Americans suffering ... chairman and CEO of Medco Health Solutions, Inc. (NYSE: ... and innovation over a period of many years has ...
... CASTLE, Del., March 12 -- Arkion(R) Life Sciences has ... AV-1011 Liquid Rice Seed Treatment in Louisiana and Missouri ... The EPA approval means that rice growers in these ... grackles. The new bird repellent effectively stops birds ...
... States, long the beneficiary of talented immigrants, must act ... pursue expanding opportunities in their home countries, according to ... Science and Technology .In A Reverse Brain Drain ... Harvard Law School, writes that immigrant scientists and engineers, ...
Cached Biology Technology:Biogenerics Legislation Provides Critical Pathway to Affordable Access for Patients with Chronic and Complex Conditions 2Biogenerics Legislation Provides Critical Pathway to Affordable Access for Patients with Chronic and Complex Conditions 3AV-1011 Bird Repellent to Protect Rice Seed Approved for Use in Louisiana and Missouri 2U.S. Risks Losing Highly Skilled Immigrants 2U.S. Risks Losing Highly Skilled Immigrants 3
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation of endotoxins for research purposes. sensitivity 0.05-0.1 EU/mL...
... The Label IT siRNA Tracker Intracellular Localization ... directly label and deliver siRNA, of your ... for in vitro tracking experiments. Subcellular localization ... can be monitored following introduction of the ...
... MW: 60kDa (A) and 36kDa (C) ... pH 7.5, 500mM NaCl, 60mM 2-mercaptoethanol, ... 1mM DTT, and 0.1mg/ml serum albumin ... of proteins. Purification: DEAE chromatography, aminohexyl-agarose ...
... The Label IT siRNA Tracker Intracellular ... to directly label and deliver siRNA, of ... manner, for in vitro tracking experiments. Subcellular ... expression can be monitored following introduction of ...
Biology Products: