Navigation Links
Discovery points toward anti-inflammation treatment for blinding disease
Date:1/14/2010

stick to the endothelial cells lining blood vessels of the retina, which slows blood flow. The white blood cells also start producing inflammatory and vascular growth factors that cause blood vessel walls to leak and thicken, further constricting blood flow. Retinal cells start dying from the reduced blood and oxygen supplies that result. In response, the body prompts growth of new blood vessels, presumably to help but instead causing more vision impairment.

If the trigger, high glucose, was temporary, these natural responses might help clear damaged cells and protect the eye. "Inflammation is a compensatory mechanism that gets activated as a survival mechanism," Dr. Rojas said. "If it continues, the effect is bad."

"We have known for along time if patients keep their blood sugar under perfect control, they don't have these problems, but that's hard," Dr. Caldwell adds. "That is why it's such a difficult disease."

To examine interleukin-6's role in the destruction, the researchers injected angiotensin II into the vitreous portion of the eyes of mice missing the gene for the inflammatory factor as well as normal mice. The extra angiotensin did little to the retinal vessels of mice lacking interleukin-6 but vessels in the normal mouse retina mimicked the inflammatory reaction found in diabetic retinopathy. When they reintroduced interleukin-6 to the genetically altered mice, the damage mimicked that of the normal mice. "So when we knock out interleukin-6, we can block the effects of angiotensin II," Dr. Caldwell said.

The scientists want to see whether the interleukin-6 antibody can be used to prevent damage by giving it shortly after the onset of diabetes in rodents and as a treatment by using it later in the disease process.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Discovery at JGH opens door to new treatments for prostate, brain and skin cancers
2. Discovery of a new molecular mechanism that guides visual nerves towards the brain
3. New discovery by Harvard scientists aims to correct cellular defects leading to diabetes
4. New year, new vitamin C discovery: It cures mice with accelerated aging disease
5. Emerald BioStructures announces discovery of small molecule modulators of PDE4
6. UGA researchers lead team in discovery involving devastating freshwater fish parasite, Ich
7. Discovery makes brain tumor cells more responsive to radiation
8. Discovery of the Jekyll-and-Hyde factors in coral bleaching
9. Rocket science leads to new whale discovery
10. A year after discovery, Congos mother lode of gorillas remains vulnerable
11. Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery points toward anti-inflammation treatment for blinding disease
(Date:11/5/2014)... biology in the UTSA College of Sciences, is ... to receive a two-year $300,00 National Science Foundation ... The funding supports President Obama,s BRAIN Initiative, a ... technology that will demystify complex brain processes. ... are broken into the interactions of multiple components, ...
(Date:11/5/2014)... Brazil -Individuals show great diversity in their ability to ... females greatly differ in their perceptual evaluation of odors, ... tests. , Sex differences in olfactory detection ... may be connected to one,s perception of smell, which ... women,s olfactory superiority has been suggested to be cognitive ...
(Date:11/4/2014)... amount of death at the right time might actually ... research that could help in understanding animal populations, pest ... a paper in the journal Trends in Ecology ... colleagues conclude that the kind of positive population effect ... or mortality, depends on the size and developmental stage ...
Breaking Biology News(10 mins):UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3The female nose always knows: Do women have more olfactory neurons? 2When less is more: Death in moderation boosts population density in nature 2
... featuring lab tours and scientific presentations on a variety ... medical countermeasures, vaccine adjuvant safety, and salmonella. Tailor your ... story ideas and spot news announcements on both days ... Margaret A. Hamburg, M.D., FDA Chief Scientist Jesse Goodman, ...
... , Johns Hopkins researchers have created a synthetic protein that, ... within the body where cancer, arthritis and other serious medical ... a new type of diagnostic imaging technology and may someday ... the body where signs of disease have been found. In ...
... mood for food can be changed by a restaurant,s choice ... calorie intake, according to a new study., "When we did ... music and lighting led diners to eat 175 fewer calories ... Wansink, professor of marketing and director of Cornell University,s Food ...
Cached Biology News:FDA's 2012 Science Writers Symposium 2Collagen-seeking synthetic protein could lead doctors to tumor locations 2Collagen-seeking synthetic protein could lead doctors to tumor locations 3
(Date:11/26/2014)... OH (PRWEB) November 25, 2014 Miles ... has joined the Graphel Carbon Products team as Sales/Marketing ... sales, marketing, and customer service for the graphite industry. ... Miles to our team,” stated Dave Trinkley, VP of ... “His wide range of experience in the graphite industry, ...
(Date:11/26/2014)... Dallas, Texas (PRWEB) November 26, 2014 ... Acid Industry is an in-depth research report on ... analysis, the report introduces Palmitic Acid, basic information, ... overview, policy analysis, and news analysis, etc. ... report analyzes Palmitic Acid market in ...
(Date:11/26/2014)... Theravalues Corporation annuncia con orgoglio il lancio di Theracurmin® ... Europe 2014 (dal 2 al 4 dicembre, ... con la maggiore biodisponibilità di sempre, con una combinazione ... norme europee. La curcumina è un pigmento ... longa ) che è stata associata con attività antiossidanti, ...
(Date:11/24/2014)... UAE, November 24, 2014 Five ... Bin Rashid Al Maktoum Awards for Medical Sciences", in ... Dubai, United Arab Emirates , on 15 December ... , The Carter Center which won the ... actively involved in numerous programs that aim to improve ...
Breaking Biology Technology:Miles Holder Joins Graphel Corporation as Sales/Marketing Manager 2Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 2Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 3La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3Five US Winners Among Recipients of Hamdan Medical Awards 2
... Strategic Fund L.P. invests $10 million in Radius-, ... ("Radius"),announced today that it has granted Novartis (NYSE: ... worldwide license (except Japan) to develop and,commercialize all ... a proprietary analog of hPTHrP (human parathyroid,hormone-related protein) ...
... ultraviolet laser light has been used for years to ... extent of their thermal motion. Now, applying a different ... the National Institute of Standards and Technology (NIST) have ... miniature mechanical oscillator containing more than a quadrillion atoms, ...
... ST. LOUIS, Sept. 14 Sigma-Aldrich Corporation,(Nasdaq: SIAL ... Life Sciences,Conference on Tuesday, September 25th at 1:00 PM ... via live audio broadcast over the,Internet available at ... this file. For the webcast on, http://ir.sigmaaldrich.com users ...
Cached Biology Technology:Radius Grants Major Pharmaceutical Company Exclusive Option to License BA058 for Osteoporosis 2'Radio wave cooling' offers new twist on laser cooling 2
Collected from animals of U.S. origin.Collected from animals of U.S. origin. *Can be used in cell growth studies and immunoassays. *Sterility tested, * Mycoplasma tested upon request, *Endoto...
...
Mouse monoclonal [Ley 37D/G6] to LKB1 ( Abpromise for all tested applications). entrezGeneID: 6794 SwissProtID: Q15831...
... reagent for Virus isolation ... unique water insoluble Elastomeric ... and chaotropes; Engineered to ... viruses while preserving infectivity; ...
Biology Products: