Navigation Links
Discovery by UC Riverside entomologists could shrink dengue-spreading mosquito population
Date:12/2/2010

RIVERSIDE, Calif. Each year, dengue fever infects as many as 100 million people while yellow fever is responsible for about 30,000 deaths worldwide. Both diseases are spread by infected female Aedes aegypti mosquitoes, which require vertebrate blood to produce eggs. The blood feeding and the egg development are tightly linked to how the mosquito transmits the disease-causing virus.

Now a team of entomologists at the University of California, Riverside has identified a microRNA (a short ribonucleic acid molecule) in female Aedes aegypti mosquitoes that when deactivated disrupts the mosquito's blood digestion and egg development a discovery that could help control the spread of not only dengue and yellow fever but potentially all vector-borne diseases.

MicroRNAs do not code for protein products but play powerful regulatory roles in development and cell growth; their mis-regulation leads to defects, including cancer. The researchers asked if microRNAs were involved in essential functions in female mosquitoes such as blood feeding and egg maturation. These functions are required not only for successful reproduction, but also serve as a foundation for the mosquito's ability to transmit pathogens of devastating human diseases.

In their experiments in the lab, the researchers were screening a number of microRNAs in female Aedes aegypti mosquitoes to study their behavior during blood feeding and reproduction, when they found one microRNA, "miR-275," was highly elevated during egg development.

Next, the researchers developed a method for specific deactivation of miR-275 in Aedes aegypti females and fed these mosquitoes with blood to analyze what effects occur when female mosquitoes no longer have this microRNA at their disposal.

They found that the blood these mosquitoes had fed on remained undigested in their guts. Further, the overall volume of the engorged blood was unusua
'/>"/>

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Strange discovery: Bacteria built with arsenic
2. Mystery dissolves with calcium pump discovery
3. In new novel, secret discovery threatens company and damages love affair
4. New sleep cycle discovery explains why fatty diets during pregnancy make kids obese
5. Gene discovery suggests way to engineer fast-growing plants
6. TB-drugome provides new targets for anti-tuberculosis drug discovery
7. Discovery of an anti-inflammatory substance
8. A discovery could be important for the therapy of lymphoma and leukemia
9. AACR announces new journal, Cancer Discovery
10. Swan song of space shuttle Discovery to carry 2 payloads built by CU-Boulder
11. Discovery of taste receptors in the lungs could help people with asthma breathe easier
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery by UC Riverside entomologists could shrink dengue-spreading mosquito population
(Date:10/15/2014)... non-traditional biophysics textbook and it describes how life functions ... discovery into biological systems and provides an understanding of ... about how our genes make proteins that control the ... in an organism. It quantifies the principles of life ... found on both large and small scales. The book ...
(Date:10/15/2014)... 44th Rosenstiel Award for Distinguished Work in Biomedical Science ... mechanisms of genomic instability and its implications for the ... alumnus to win the Rosenstiel Award; the first, Rod ... is the Charles A. Janeway Professor of Pediatrics and ... investigator at the Howard Hughes Medical Institute at Boston ...
(Date:10/14/2014)... have sequenced the house fly genome for the first ... from an insect that thrives in pathogen-rich dung piles ... in the journal Genome Biology , will increase ... how flies quickly adapt to resist insecticides, which could ... (Musca domestica) carry and transmit more than 100 human ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2House fly genome reveals expanded immune system 2
... Stacia Sower, professor of biochemistry and director of ... University of New Hampshire, has received a $420,000 grant ... brain and pituitary hormones and receptors. With ... of NSF-funded research in the fields of hormonal genomics ...
... YORK (March 12, 2009) New software developed with ... researchers to rapidly identify individual animals by creating a ... The software, described in an issue of the journal ... origin of tigers from confiscated skins. The new software, ...
... (Mar. 12, 2009) Researchers from DaVinci Biosciences, Costa ... Ecuador, have determined that injecting a patient,s own bone ... column using multiple routes can be an effective treatment ... of life for SCI patients without serious adverse events. ...
Cached Biology News:Major NSF grant boosts UNH research on hormonal genomics 2Tracking tigers in 3-D 2Multiple route bone marrow stem cell injections show promise to treat spinal cord injury 2
(Date:10/20/2014)... Calif. , Oct. 20, 2014 ... that the Company has signed a Notice of ... Regenerative Medicine (CIRM), effective October 1, 2014.  The ... Development payments and the release of additional grant ... CIRM grant award for clinical development of Asterias, ...
(Date:10/20/2014)... 20, 2014  GenVec, Inc. (NASDAQ: GNVC ) ... Ph.D., from its board of directors effective on October 24, ... and served as its chairman from June 2006 to November ... and Corporate Governance and Audit Committees of the board.  ... decade of dedicated service to GenVec, and its stockholders," said ...
(Date:10/20/2014)... Earle Martin , Chief ... that Ellen Teplitzky, an experienced attorney specializing in ... industry, has joined the firm as Director of ... practice. NDA Partners provides legal services, including ... to top law firms and their clients in ...
(Date:10/19/2014)... October 20, 2014 OCTOBER ... Meeting (ABIM). ABIM will take place ... information about ABIM 2014 is now available ... Delegates representing companies and organizations from all ... obtain information on the latest products and ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Zola P. Horovitz To Retire From GenVec Board 2NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2
... , ... Sinovac Biotech Ltd. ( SVA),a leading developer and provider ... (JV) agreement to establish Sinovac (Dalian) Vaccine,Technology Co., Ltd. ... human-use vaccines. Sinovac will contribute its expertise,and experience in ...
... This release is available in German . ... tags (Radio Frequency Identification) are increasingly finding their way into ... goods and identify them automatically by radio frequency. The appropriate ... label. Smart labels can be affixed to goods under production ...
... ... has agreed an AU$6.7 mil convertible note private placement with a U.S. institutional investor. ... advisor. , ... York (PRWEB) November 23, 2009 -- The independent New York investment bank KTA Capital, ...
Cached Biology Technology:Sinovac Establishes Joint Venture to Expand Human-Use Vaccine Development and Manufacturing Capabilities 2Sinovac Establishes Joint Venture to Expand Human-Use Vaccine Development and Manufacturing Capabilities 3Intelligence inside metal components 2KTA Capital Arranges an AU$6.7 Million Private Placement by Neuren Pharmaceuticals 2
... Supercoiled DNA Ladder is suitable ... 2 to 16 kb by ... bands can be visualized by ... also be detected on Southern ...
CREB-2 (H-290)...
... Dynabeads Tosylactivated (4.5 m). Hydrophobic naked ... coupling of antibodies for cell applications. Proteins ... covalent binding of primary amine groups (NH ... Coupling reactions can be performed at neutral ...
cysteine and glycine-rich protein 2,...
Biology Products: