Navigation Links
Discovery about DNA repair could lead to improved cancer treatments
Date:9/10/2013

Medical researchers at the University of Alberta have made a basic science discovery that advances the understanding of how DNA repairs itself. When DNA becomes too damaged it ultimately leads to cancer.

Faculty of Medicine & Dentistry researcher Mark Glover and his colleagues published their findings in the peer-reviewed journal, Structure (Cell Press), earlier this summer. For years, scientists thought two key proteins involved in DNA repair operated in exactly the same way. Glover's team discovered how the proteins operate and communicate is vastly different information that could lead to improved cancer treatments.

Glover explains that a protein known as BRCA1 acts like a hallway monitor constantly scanning DNA for damage. At the first sign of problems, this protein figures out what kind of help is needed, and "radios" in a cleanup crew of other proteins.

A second protein, known as TopBP1, ensures that DNA can copy itself when needed. When this process stalls due to DNA damage, this protein also calls in a cleanup crew. But Glover likens its method of communication to tweets, rather than radio.

"The two proteins may be related and look very similar, but their roles and the way they communicate are in fact very different, which was surprising to us," Glover says. "Each protein plays a role in recognizing damaged regions of DNA, but the problem they each solve is different.

"The question now is how can we use this information to try to improve cancer therapies? Could we temporarily knock out cancer DNA's ability to repair itself from radiation damage? Could we administer radiation at a point that prevents cancer DNA from copying itself? Could we inhibit the activity of proteins that are normally trying to run around and fix the damage?

"Maybe some of these ideas could ultimately translate into less radiation or chemotherapy needed for patients, if the treatment can be more targeted," says Glover, who works in the Department of Biochemistry.

His team is continuing its research in this area, and wants to learn more about the role of the TopBP1 protein and why it favours communicating with a specific protein. They also want to conduct tests in their lab to see if the use of certain medications could alter the way these proteins work in a way that could result in new or improved cancer treatments.

Glover's lab members make 3-D images of proteins, making it easier to understand and see how proteins work.


'/>"/>

Contact: Raquel Maurier
rmaurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Related biology news :

1. Discovery helps to unlock brains speech-learning mechanism
2. University of Hawaii Cancer Center researchers discovery
3. 4 projects awarded Discovery Transformation Grant funding by Minnesota Partnership
4. NOAA reports discovery of table coral, Acropora cytherea, off Oahu
5. UK researcher earns 2013 Discovery Award
6. Molecular discovery puts cancer treatment in a new perspective
7. Discovery of the Plastisphere -- a new marine ecological community
8. Unexpected discovery of the ways cells move could boost understanding of complex diseases
9. Discovery of how a gene that regulates factors involved in bacteria pathogenicity acts
10. Discovery of new material state counterintuitive to laws of physics
11. Discovery of the gene responsible for multiple intestinal atresia in newborns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/7/2017)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, is pleased to announce that the latest release ... flexible and award winning eClinical solution, is now available ... is a proven Software-as-a-Service (SaaS) clinical research technology platform ... also delivers an entire suite of eClinical tools to ...
(Date:2/6/2017)... 6, 2017 According to Acuity Market ... border authorities to continue to embrace biometric and ... 2143 Automated Border Control (ABC) eGates and 1436 ... more than 163 ports of entry across the ... achieving a combined CAGR of 37%. APC Kiosks ...
(Date:2/2/2017)... 2, 2017   TapImmune, Inc. (NASDAQ: ... specializing in the development of innovative peptide and ... cancer and metastatic disease, announced today it has ... of a second clinical lot of TPIV 200, ... alpha. The manufactured vaccine product will be used ...
Breaking Biology News(10 mins):
(Date:2/16/2017)... 2017  ArmaGen, Inc., a privately held biotechnology ... severe neurological disorders, today reported preliminary evidence of ... company,s investigational therapy for the treatment of Hurler ... I, or MPS I). The initial results from ... today at the 13 th annual WORLD ...
(Date:2/16/2017)... PALM BEACH, Florida , February 16, 2017 ... vastly improving with the infusion of innovative telemedicine ... patient monitoring services that are experiencing a boom ... evolve with the advancement of technologies, services and ... Technologies Inc. (OTC: RQHTF) (TSX-V: RHT), Cellectar Biosciences, ...
(Date:2/16/2017)... ... February 16, 2017 , ... ... Dr. Kingsley Chin, professor and Harvard trained surgeon, completed the procedure on Monday, ... on a 55-year-old practicing female physician suffering from degenerative disc disease with radiculomyelopathy, ...
(Date:2/16/2017)... ... February 16, 2017 , ... ... Inc. has further extended its industry leading Biochemistry Services specifically targeting the ... cGMP techniques and methods for the biochemical and biosimilar characterization , ...
Breaking Biology Technology: