Navigation Links
Discovering cell surface proteins' behavior
Date:2/12/2013

A Simon Fraser University chemist is the lead author on a new paper that advances scientific understanding of the structure and function of glycoproteins, in particular the number and positioning of sugars on them. PLOS ONE, an international, peer-reviewed, open-access, online, scientific research journal, has just published the paper, N-glycoproteome of E14.Tg2a Mouse Embryonic Stem Cells.

Glycoproteins are membrane proteins and are often involved in human diseases. They facilitate communication between cells, and interactions with pathogens, such as viruses and bacteria, and communication with external environments.

SFU chemist Bingyun Sun and her colleagues have discovered how nature can vary the amount of a dominant sugar type (N-Glycan) on membrane proteins on a cell surface. The variation helps stabilize these proteins and facilitate their functioning. The researchers verified their observation of a correlation between the number of sugars on a glycoprotein and its function in five animal species worms, flies, fish, mice and humans. This led to their realization that the correlation has been conserved through evolution.

To obtain the number of N-Glycans on proteins, the researchers used proteomics a combination of mass spectrometry (MS) and high-performance liquid chromatography (HPLC). In less than an hour, high-throughput technique identifies the exact place where N-Glycans attach on hundreds of glycoproteins.

The scientists analyzed cell surface glycoproteins in one type of mouse embryonic stem cells by genetically shutting down the Hypoxanthine Phosphoribosyltransferase (HPRT) gene in the cells. As an aside, HPRT deficiency causes Lesch-Nyhan syndrome in humans, a metabolic disorder characterized by mental retardation and self-mutilation.

Sun says this deeper understanding of the correlation between sugars' positioning on glycoproteins and the proteins' functions will benefit medical researchers and the pharmaceutica
'/>"/>

Contact: Carol Thorbes
cthorbes@sfu.ca
778-782-3035
Simon Fraser University
Source:Eurekalert

Page: 1 2

Related biology news :

1. KIT: Processes at the surface of catalysts
2. NASA satellite measurements imply Texas wind farm impact on surface temperature
3. Secret soil cracks linger, despite surface sealing
4. Proteomic analysis of immunocamouflaged surfaces
5. The most contaminated surfaces in hotel rooms
6. Wrinkled surfaces could have widespread applications
7. Sea surface temperatures reach record highs on Northeast continental shelf
8. Professor publishes on first-ever imaging of cells growing on spherical surfaces
9. 3dMD Transitions Anatomical Research from 3D-Static to 4D-Movement Surface Imaging
10. Ancient microbes found living beneath the icy surface of Antarctic lake
11. Surface analysis techniques for advanced materials enhance Mazovias research potential
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Wake Forest Baptist ... education building for its School of Medicine. Funding for ... larger capital campaign that will be publicly launched next ... be located in the former 60 series R.J. Reynolds ... Innovation Quarter. Construction will begin immediately with plans to ...
(Date:12/5/2014)... PROVO, Utah , Dec. 4, 2014  Tute ... has raised $2.3 million in Series A1 funding led ... angel investors also participated in the investment round. ... as the healthcare community adopts next-generation sequencing and seeks ... disease," said Reid Robison , MD MBA, and ...
(Date:11/21/2014)... , Nov. 19, 2014  Earlier this year ... York College, and one of the most prolific inventors ... that are transmitted from Smartphones to third party agencies. ... and has one of the earliest known patents in ... usage in the military, child care, elder care and ...
Breaking Biology News(10 mins):Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... competing demands on a mother,s physiology: Her body wants to produce ... own health. Some of the genes that she passes on to ... demands from her child. These so-called "imprinted genes" inherited from the ... is to get as many resources for the fetus as possible. ...
... People aren,t the only living things that suffer from ... from a lack of water or too much water, from ... climate. Helping trees and crops adapt to stress quickly and ... Now research led by Michigan Technological University scientists has identified ...
... disparities among women, socioeconomic status and social context may ... by researchers at the Johns Hopkins Bloomberg School of ... authors examined race disparities in obesity among black and ... similar income and compared these estimates to national data. ...
Cached Biology News:Gender-specific disease risks start in the womb 2Gender-specific disease risks start in the womb 3Feeling stressed? So is the poplar 2Social context may be a better indicator of obesity disparities than race 2
(Date:12/19/2014)... 19, 2014 BioPlus Specialty Pharmacy ... announces the promotion of Nick Maroulis, Pharm.D. to the ... Services. , In this position, Dr. Maroulis will ... managing the directors of our multi-site pharmacies as the ... 1997 and during that time he has served in ...
(Date:12/19/2014)... , Dec. 19, 2014 Decision Resources ... will grow at a 12 percent compound annual growth ... of the aging population and the increasing adoption of ... America will also spur demand for dental ... dental implant and periodontal treatments. Other key ...
(Date:12/19/2014)... LayerBio is an MIT spin-off developing novel ... National Eye Institute (NEI) at the National Institutes of ... grant to develop a drug-eluting intraocular lens (IOL) for ... of vision loss in people over age 40 and ... Ken Mandell, LayerBio’s Founder and CEO, "There is a ...
(Date:12/19/2014)... In contrast to traditional LED lights where ... Valoya uses proprietary LED technology to incorporate their spectra ... which is critical in low proximity installations. The Valoya ... its lifetime which is up to four times longer ... investment cost was clearly higher when compared to traditional ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2
... knows networks. The University of Wisconsin-Madison professor of computer ... the early international channels of the Internet. He also has ... all about finding the right applications to harness increased computing ... D.C., where he works for the National Science Foundation ...
... at the atomic scale. Source: Imago The ... for nanotechnology research, said it has commissioned an instrument ... , ,NANO officials said they were pleased with the ... the University of Sydney. , ,Imago makes tools to ...
... First-of-year columns are ripe for prognostication and this one is ... coaster, the technology industry has been laboring up, up, up the ... will offer a bit of payback, a little joy ride. And ... a few playful loops, not the white-knuckled death plummet we have ...
Cached Biology Technology:Landweber on networks, open source, and NSF budget cuts 2Landweber on networks, open source, and NSF budget cuts 3Landweber on networks, open source, and NSF budget cuts 4Year ahead offers payoff for hard work 2Year ahead offers payoff for hard work 3
...
... Human CD66 acd Recognizes human ... neutrophils and cells in some cases ... with transfectants containing BGPa, NCA and ... Immunogen: Human ...
Request Info...
... GOAT ANTI-MOUSE IgG+IgA+IgM (H+L) ... with highly purified horseradish ... antibody has been absorbed ... fetal bovine, horse, goat, ...
Biology Products: