Navigation Links
Disarming specialized stem cells might combat deadly ovarian cancer
Date:1/27/2010

Eliminating cancer stem cells (CSCs) within a tumor could hold the key to successful treatments for ovarian cancer, which has been notoriously difficult to detect and treat, according to new findings published this week in the journal Oncogene by Yale School of Medicine researchers.

"We found that stopping the expression of two genesLin28 and Oct4reduces ovarian cancer cell growth and survival," said Yingqun Huang, M.D., assistant professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine.

Ovarian cancer has been challenging to treat because it tends to recur frequently and develop resistance to treatment. The poor outcome for women with ovarian cancer has been associated with subtle and nonspecific symptomsearning it the moniker the "disease that whispers."

"This recurrence and drug resistance may be due to the presence of CSCs within the tumors that have the capacity to reproduce and to differentiate into non-CSC tumor cells that repopulate the tumor mass," said Huang, who is a member of Yale Stem Cell Center and Yale Cancer Center. "Eliminating these CSCs may be key to successful treatments."

While in the process of studying the functions of stem cell proteins in human embryonic stem cells, Huang and her colleagues unexpectedly discovered that a sub-population of ovarian cancer cells express stem cell proteins Lin28 and Oct4. They also found that the two proteins appear to act together in ovarian cancer tissue cells to produce more advanced tumors. Inhibiting their combined expression led to a significant decrease in the growth and survival of cancer cells. A larger-scale ovarian cancer study is currently underway to confirm the significance of the findings.

"We hope we will soon be able to apply this new information to improve outcomes, perhaps by developing better diagnostic markers and treatment strategies that may be useful in customizing treatment for ov
'/>"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
Source:Eurekalert

Page: 1 2

Related biology news :

1. UB specialized exercise regimen shown to relieve prolonged concussion symptoms
2. Asthma and other allergies tied to absence of specialized cells
3. Mice use specialized neurons to detect carbon dioxide in the air
4. March of Dimes awards $250,000 prize to scientist who discovered how to reprogram human cells
5. Grant to study how cells sense electric fields
6. NYSCF Fellow lead author on study that creates blood vessel cells from stem cells
7. New way to generate abundant functional blood vessel cells from human stem cells discovered
8. Update on pluripotent stem cells (hESC and iPS)
9. Excess DNA damage found in cells of patients with Friedreichs ataxia
10. Mutations in different cells cooperate to set the stage for cancer
11. Study shows that delivering stem cells improves repair of major bone injuries in rats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... Some manufacturers are turning away from using triclosan as ... over health concerns. And now scientists are reporting new ... published in the ACS journal Chemical Research in ... commercial substance called octylphenol, promoted the growth of human ... tumors in mice. , Kyung-Chul Choi and colleagues note ...
(Date:4/23/2014)... Exeter researcher has shed light on how an estimated ... remote outback have become reviled as pests and culled ... Environment and Sustainability Institute at the University of Exeter,s ... Australia, from their historic role helping to create the ... "invader." , The deserts of the Australian outback are ...
(Date:4/23/2014)... think one can argue that if we were to follow ... that we canthen we can solve the climate problem without ... foremost climate researchers, in the current issue of Bulletin ... take significant action on climate change now makes it more ... problem, Wigley explains in an exclusive Bulletin interview. ...
Breaking Biology News(10 mins):In lab tests, the antimicrobial ingredient triclosan spurs growth of breast cancer cells 2How Australia got the hump with 1 million feral camels 2How Australia got the hump with 1 million feral camels 3Is nuclear power the only way to avoid geoengineering? 2
... Kam Tang of the Virginia Institute of Marine Science ... play an important role in carrying hitchhiking bacteria to ... "Bacteria dispersal by hitchhiking on zooplankton," appeared in the ... National Academy of Sciences . It was co-authored by ...
... variant which increases susceptibility to tuberculosis (TB) in African ... (GWA) study. This is the first novel disease variant ... demonstrates that such studies are viable in African populations, ... Over the past few years, GWA studies, such as ...
... Joseph Nadeau, PhD, of Case Western Reserve University School ... Health (NIH) Director,s Pioneer Award. One of ... will investigate transgenerational genetic effects, where the biological features ... to depend as much on the genetics of ancestral ...
Cached Biology News:Study shows that hitchhiking bacteria can go against the flow 2Study shows that hitchhiking bacteria can go against the flow 3Genome study identifies genetic variant linked to TB susceptibility in Africans 2Genome study identifies genetic variant linked to TB susceptibility in Africans 3Case Western Reserve geneticist receives prestigious NIH Director's Pioneer Award 2
(Date:1/15/2014)... 2014  Bill Jacobs Automotive, a group of car dealerships headquartered ... the Heartland Blood Center and offering free oil change coupons ... place Saturday, Jan. 18 at the Bill Jacobs Cadillac and ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill Jacobs ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Cynvenio, a ... management through the genomic analysis of tumor cells in ... Finder™, a web-based cancer decision support application powered by ... with Cynvenio’s ClearID™ genomic test, Therapy Finder will provide ...
(Date:1/15/2014)... January 15, 2014 A study has been ... the Formula 1 track could help to tackle the problem ... (MAT), Stowhealth (a GP surgery based in Stowmarket) and academics ... Simplyhealth. Telemetry technology, which is inspired by equipment ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased ... Life Science organizations who need document translations. Clients will ... their documents in advance with a selection of nearly 50 ... often a critical factor in clinical and scientific fields, and ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2
... Critical Path Immunology created to discover and develop ... for immune system-related diseases -, SAN FRANCISCO, March 31 ... with Beckman Coulter, Inc. to,establish a Center for Critical Path ... disease. This facility, which will be managed by,ITI and located ...
... (PHPG) today reported its consolidated, audited, financial,results for its ... in fiscal year 2007 were a record at $15,100,000 ... the year was our,highest ever at $17,802,000 as was ... 2006, respectively., Pre-tax income for the year was ...
... 31 BioMarin,Pharmaceutical Inc. (Nasdaq and SWX: BMRN) ... and distribution partner in Japan, has,received approval for ... Ministry of Health, Labour and Welfare,(MHLW) for the ... "We are proud to work with AnGes ...
Cached Biology Technology:The Immune Tolerance Institute Announces Collaboration with Beckman Coulter Establishing a Multiplatform Immunophenotyping/Immunogenotyping Laboratory 2The Immune Tolerance Institute Announces Collaboration with Beckman Coulter Establishing a Multiplatform Immunophenotyping/Immunogenotyping Laboratory 3Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 2Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 3Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 4Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 5Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 6Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 7Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 8Photonic Products Group, Inc. Reports Record Financial Results for FY 2007 9Naglazyme Approved by Japanese Ministry of Health 2Naglazyme Approved by Japanese Ministry of Health 3Naglazyme Approved by Japanese Ministry of Health 4
... BioGenex Super Sensitive Polymer-HRP ... a novel product based ... polymeric technology. This system ... to noise ratio and ...
... unit is an inexpensive personal or mini thermal ... process. Lightweight, with a small footprint, it can ... the researcher's desk. , The Gene Cycler thermal ... not have access to a large laboratory thermal ...
... Leu-CMK FLISP Assay with SR-101 ... Em=620 nm) • Accurately measure serine ... or permeabilization • B-Bridge's FLISP Kits ... serine proteases (FLISPs) to measure chymotrypsin-like ...
... He biolistic system enables 7-10 times more cells ... fits into the shocking chamber of the PDS-1000 ... wave over 7 microcarriers. By uniformly spreading the ... area, the system maximizes the number of cells ...
Biology Products: