Navigation Links
Digital communication technology helps clear path to personalized therapies
Date:1/9/2009

LA JOLLA, Calif., January 9, 2009 -- Researchers at the Burnham Institute for Medical Research (Burnham) have shown that search algorithms used in digital communications can help scientists identify effective multi-drug combinations. The study, led by Giovanni Paternostro, M.D., Ph.D., was published in the December 26, 2008, issue of PLoS Computational Biology.

Using the stack sequential algorithm, which was developed for digital communications, the team of scientists searched for optimal drug combinations. This algorithm can integrate information from different sources, including biological measurements and model simulations. This differs from the classic systems biology approach by having search algorithms rather than explicit quantitative models as the central element. The variability of biological systems is the fundamental motivation for this strategy.

"Combination therapies have demonstrated efficacy in treating complex diseases such as cancer and hypertension, but it is difficult to identify safe and effective combination treatment regimens using only trial and error," said Dr. Paternostro. "As personalized medicine moves from the present emphasis on diagnosis and prognosis to therapy, the problem of searching for optimal drug combinations uniquely suited to the genetic and molecular profile of each patient will need to be solved. This research is a first step in that direction."

Current methodology for identifying effective combination therapies involves exhaustive testing. However, the exponential expansion of possibilities precludes exploring large combinations using this approach. For example, many chemotherapy regimens include six drugs from a pool of 100. A study that included all combinations (including partial combinations containing only some of these compounds) at three different doses would have to digest 8.9 x 10^11 possibilities. The problem requires a new approach rather than more efficient screening techno
'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Burnham Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Entrust Digital Signatures Help Secure More Than 18 Million U.S. ePassports
2. Book is the first high-resolution digital mouse brain atlas designed for Web applications
3. FEBS Letters Structured Digital Abstracts experiment
4. Vobile Launches VideoDNA Live; Enables Real-Time Digital Content Protection for Live Broadcast Events
5. Fixing the education digital disconnect one video game at a time
6. Digital cameras, remote satellites measure crop water demand
7. Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
8. DigitalPersona Places Identity Protection at Peoples Fingertips
9. The birds of Spain, in a digital ornithological encyclopedia
10. A private bandwidth for communication in bats: Evidence from insular horseshoe bats
11. Communication Intelligence Corporation Reports Second Quarter 2007 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... SHELTON, Conn. , October 16, 2014 ... ("NXT-ID" or the "Company"), a biometric authentication company focused ... present its leading edge technologies including Wocket™, the Smart ... Review® (FiRe) Conferenece. FiRe is a leading global conference ... Hosted by Mark Anderson , founder ...
(Date:10/15/2014)... book ,Models of Life, is a non-traditional biophysics textbook ... The book is a journey of discovery into biological ... life and biological regulation. It is about how our ... communication between the billions of cells in an organism. ... relationships between principles, which can be found on both ...
(Date:10/15/2014)... pneumonia in female mice to an enzyme activated by ... more resistant to respiratory infections than males. Now, an ... to bacterial pneumonia in female mice is linked to ... show that this enzyme is ultimately activated by the ... team, lead by Professor Lester Kobzik at the Harvard ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3New book about life as seen from physics 2
... the regressiveness of pollution taxes can be offset by ... labor tax, that approach may not work, and also ... overall real net wages, according to research by a ... a finance professor and former deputy assistant secretary of ...
... Feb. 22, 2011 Reportlinker.com announces that a ... catalogue: Global Bioinformatics Industry ... This report analyzes the worldwide markets for ... Software, Hardware, and Biocontent. The report provides separate ...
... in the global carbon cycle, helping sequester significant amounts ... so numerous, that they discolor coastal waters and reduce ... ecosystem. Previously known as "red tide," the term "harmful ... note accumulation of algal biomass can sometimes also turn ...
Cached Biology News:Pollution tax rebates little help for low-income workers 2Reportlinker Adds Global Bioinformatics Industry 2Brown tide culprit sequenced: Genome of the first of algal bloom species 2Brown tide culprit sequenced: Genome of the first of algal bloom species 3Brown tide culprit sequenced: Genome of the first of algal bloom species 4
(Date:10/22/2014)... DUBLIN , Oct. 22, 2014 ... "Organic Electronics Market by Material, by Application, Geography ... report to their offering. Organic electronics, ... a branch of material science which deals with small ... as organic because small molecules and polymers are carbon ...
(Date:10/20/2014)... 2014 Convey Computer , the ... from Iowa State University won first place in the ... Convey HC-2ex, the team’s solution achieved the highest overall ... the second place finisher. , Experts from all segments ... month long challenge, using a variety of design tools, ...
(Date:10/20/2014)... Oct. 20, 2014  GenVec, Inc. (NASDAQ: GNVC ... , Ph.D., from its board of directors effective on October ... 2003, and served as its chairman from June 2006 to ... Nominating and Corporate Governance and Audit Committees of the board.  ... a decade of dedicated service to GenVec, and its stockholders," ...
(Date:10/20/2014)... Tigard, OR (PRWEB) October 20, 2014 ... to participate in an investigational study of donor stem ... nationally in stem cell therapy and has performed clinical ... of this study is to determine if a single ... arthritically affected joints can help reduce pain and inflammation ...
Breaking Biology Technology:Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... Up Online Simplifies the Donor Designation Process and Saves ... donation,groups today formally unveiled a Web portal that will ... rather than waiting until their driver,s,license or photo ID ... license,center in person. The Web portal, http://www.donatelife-pa.org, ...
... The Center for Molecular,Medicine (CMM) today said it ... nursing mothers for codeine risks cited in a Friday ... Late Friday, the FDA issued an advisory noting new ... nursing infants whose mothers are,taking codeine and are also ...
... Early Detection ... Hypertension in the UK, NEW YORK and MILTON KEYNES, ... INCR), and Omron Healthcare (UK),Ltd., a wholly owned subsidiary of ... hypertension diagnostics and,therapies in the professional and pharmacy healthcare markets. ...
Cached Biology Technology:Web Portal Makes Organ Donation Easy 2Center for Molecular Medicine Only Regional Provider of Test Suggested in FDA Alert on Prescribing Codeine to Nursing Mothers 2InterCure and Omron Healthcare (UK) Ltd. Announce Marketing Collaboration for Hypertension Market in United Kingdom 2InterCure and Omron Healthcare (UK) Ltd. Announce Marketing Collaboration for Hypertension Market in United Kingdom 3InterCure and Omron Healthcare (UK) Ltd. Announce Marketing Collaboration for Hypertension Market in United Kingdom 4
...
... This CLS number is a ... match Cornings product number. If showing ... the old Sigma-Aldrich number (R4276) or ... Material: cap polystyrene (expanded surface, easy ...
... Custom Peptide Services offer a full range ... research needs. Services include: Peptide synthesis, ... Peptide synthesis, purified product (70-95% pure) ... amidation, biotinylation, fluorescein, myristylation, phosphorylation, and rhodamine) ...
... Endogens Bovine IFNγ ELISPOT (enzyme-lined immunospot) ... the single cell level. A spot forms ... bound, is counted (either using a dissection ... compared to the number of cells added ...
Biology Products: