Navigation Links
Different neuronal groups govern right-left alternation when walking
Date:6/30/2013

Scientists at Karolinska Institutet in Sweden have identified the neuronal circuits in the spinal cord of mice that control the ability to produce the alternating movements of the legs during walking. The study, published in the journal Nature, demonstrates that two genetically-defined groups of nerve cells are in control of limb alternation at different speeds of locomotion, and thus that the animals' gait is disturbed when these cell populations are missing.

Most land animals can walk or run by alternating their left and right legs in different coordinated patterns. Some animals, such as rabbits, move both leg pairs simultaneously to obtain a hopping motion. In the present study, the researchers Adolfo Talpalar and Julien Bouvier together with professor Ole Kiehn and colleagues, have studied the spinal networks that control these movement patterns in mice. By using advanced genetic methods that allow the elimination of discrete groups of neurons from the spinal cord, they were able to remove a type of neurons characterized by the expression of the gene Dbx1.

"It was classically thought that only one group of nerve cells controls left right alternation", says Ole Kiehn who leads the laboratory behind the study at the Department of Neuroscience. "It was then very interesting to find that there are actually two specific neuronal populations involved, and on top of that that they each control different aspect of the limb coordination."

Indeed, the researchers found that the gene Dbx1 is expressed in two different groups of nerve cells, one of which is inhibitory and one that is excitatory. The new study shows that the two cellular populations control different forms of the behaviour. Just like when we change gear to accelerate in a car, one part of the neuronal circuit controls the mouse's alternating gait at low speeds, while the other population is engaged when the animal moves faster. Accordingly, the study also show that whe
'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Do mens and womens hearts burn fuel differently?
2. Divide and define: Clues to understanding how stem cells produce different kinds of cells
3. Stem cell proliferation and differentiation observed within hydrogel
4. Men and women get sick in different ways
5. Antarctic and Arctic insects use different genetic mechanisms to cope with lack of water
6. Discovery may explain how prion diseases spread between different types of animals
7. BUSM study shows potential of differentiated iPS cells in cell therapy without immune rejection
8. Most-used diabetes drug works in different way than previously thought
9. Even in same vineyard, different microbes may create variations in wine grapes
10. Different genes behind same adaptation to thin air
11. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/18/2015)... , March 18, 2015 As mobile ... new revolutionary smart wallets and apps continue to be introduced ... entrenched in the mobile payment industry in focus today are:  ... Ltd. (NYSE: BABA ), Apple Inc. (NASDAQ: ... and Facebook Inc. (NASDAQ: FB ) ...
(Date:3/17/2015)... 17, 2015 Emotient, the leader in ... announced general availability of Emotient Analytics , ... analysis of facial expressions. The system analyzes videos ... products and services. It delivers audience response metrics ... - as derived from facial evidence of emotional ...
(Date:3/16/2015)... 16, 2015 Between 16 ... present groundbreaking innovations in biometric identification at the ... .      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ... is well at the forefront: the company,s all ... in Germany . BiometricGate is ...
Breaking Biology News(10 mins):Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3
... 4, 2008 Biologists examining ecosystems similar to those ... ago have made a surprising discovery: Viruses that infect ... in other regions of the globe. The finding, ... surprising because bacteria are ubiquitous on Earth. They,ve been ...
... is as much down to having the right genetic ... a recent study. Psychologists at the University of ... Research in Australia found that happiness is partly determined ... are largely hereditary. Using a framework which psychologists ...
... Zoos Conservation and Research Center in Front Royal, Va., is ... vanish from the planet. The oryx, along with ... Tunisia in December 2007 for an eventual reintroduction into the ... Oryx are a type of desert antelope that are mostly ...
Cached Biology News:Biologists surprised to find parochial bacterial viruses 2Biologists surprised to find parochial bacterial viruses 3National Zoo scimitar-horned oryx going into the wild 2
(Date:3/30/2015)... PARK, N.J. , March 30, 2015 /PRNewswire/ ... (PAMORA) under development by Shionogi & Co., Ltd., ... phase III study (COMPOSE I) for the treatment ... chronic non-cancer pain receiving opioid therapy. Study results ... daily) statistically significantly improved the frequency of spontaneous ...
(Date:3/29/2015)... 29, 2015  Caris Life Sciences® today ... small cell cervical cancer (SCCC) that shows ... the company,s panomic, comprehensive tumor profiling service, identified ... may explain sensitivities and resistance to common ... certain biomarkers may guide treatment strategies in ...
(Date:3/27/2015)... March 27, 2015 The consumption of ... of the recession and high prices in 2008. However, ... recovered and keeps on gaining momentum now. , To ... at more than 100,000 thousand tonnes. No considerable growth ... the global capacity rocketed during 2012-2013, registering 11% growth ...
(Date:3/27/2015)... , March 27, 2015  Peter Walter was ... Science for his pioneering work on how proteins are ... of a regulatory mechanism that cells use to handle ... Walter is a professor of biochemistry at the University ... for treating a range of human diseases related to ...
Breaking Biology Technology:Shionogi & Co., Ltd. Announces That Naldemedine Meets Primary Endpoint In A Phase 3 Study For The Treatment Of Opioid-Induced Constipation 2Shionogi & Co., Ltd. Announces That Naldemedine Meets Primary Endpoint In A Phase 3 Study For The Treatment Of Opioid-Induced Constipation 3Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling Identifies Potential Treatment Strategies for Small Cell Cervical Cancer 2Study Using Caris Molecular Intelligence Multiplatform Tumor Profiling Identifies Potential Treatment Strategies for Small Cell Cervical Cancer 3World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 2World NPK Fertilizers Market Keeps On Gaining Momentum, According to BAC Reports Study Available at MarketPublishers.com 3German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 3
... (Amex: ETC ) ("ETC" or the "Company") ... BARA-MED(R) XD Monoplace,Hyperbaric Chambers by Comprehensive Healthcare Solutions, ... Solutions a growing company,who focuses solely on initiating ... ETC prides itself on being the manufacturer ...
... 26 Insmed Inc. (Nasdaq:,INSM), a developer of ... requested a hearing before a Nasdaq Listing,Qualifications Panel ... the,Company,s common stock from the Nasdaq Global Market., ... Stock Market ("Nasdaq") on,December 20, 2007 indicating that ...
... N.J., Dec. 24 Genta,Incorporated (Nasdaq: GNTA ) ... Listing Qualifications Staff of The NASDAQ Stock Market,that it ... a minimum closing bid price of $1.00 per share. ... June 16, 2008 to regain,compliance, which requires a closing ...
Cached Biology Technology:Environmental Tectonics Corporation Announces Sale of Monoplace Hyperbaric Chambers 2Environmental Tectonics Corporation Announces Sale of Monoplace Hyperbaric Chambers 3Insmed to Appeal Delisting Notification From Nasdaq 2Genta Receives NASDAQ Non-Compliance Notice 2Genta Receives NASDAQ Non-Compliance Notice 3
... • Enzyme concentration - 5 units/µL ,• ... higher yields ,• Leaves an 'A' overhang ... polymerase which exhibits very high activity in ... To ensure the quality of the enzyme, ...
Our original highly-purified, robust Taq Polymerase which delivers consistently high yields and minimal background...
... AmpliTaq DNA Polymerase is the ... PCR process, a testimony to its overall ... profile makes it ideal for PCR applications. ... guarantee reproducible results. ,, AmpliTaq DNA ...
... Taq DNA Polymerase is a versatile and ... all PCR applications. GCpro Taq DNA Polymerase ... in E. coli, containing the DNA polymerase ... includes a highly processive 5'-3' DNA polymerase ...
Biology Products: