Navigation Links
Different neuronal groups govern right-left alternation when walking
Date:6/30/2013

Scientists at Karolinska Institutet in Sweden have identified the neuronal circuits in the spinal cord of mice that control the ability to produce the alternating movements of the legs during walking. The study, published in the journal Nature, demonstrates that two genetically-defined groups of nerve cells are in control of limb alternation at different speeds of locomotion, and thus that the animals' gait is disturbed when these cell populations are missing.

Most land animals can walk or run by alternating their left and right legs in different coordinated patterns. Some animals, such as rabbits, move both leg pairs simultaneously to obtain a hopping motion. In the present study, the researchers Adolfo Talpalar and Julien Bouvier together with professor Ole Kiehn and colleagues, have studied the spinal networks that control these movement patterns in mice. By using advanced genetic methods that allow the elimination of discrete groups of neurons from the spinal cord, they were able to remove a type of neurons characterized by the expression of the gene Dbx1.

"It was classically thought that only one group of nerve cells controls left right alternation", says Ole Kiehn who leads the laboratory behind the study at the Department of Neuroscience. "It was then very interesting to find that there are actually two specific neuronal populations involved, and on top of that that they each control different aspect of the limb coordination."

Indeed, the researchers found that the gene Dbx1 is expressed in two different groups of nerve cells, one of which is inhibitory and one that is excitatory. The new study shows that the two cellular populations control different forms of the behaviour. Just like when we change gear to accelerate in a car, one part of the neuronal circuit controls the mouse's alternating gait at low speeds, while the other population is engaged when the animal moves faster. Accordingly, the study also show that whe
'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Do mens and womens hearts burn fuel differently?
2. Divide and define: Clues to understanding how stem cells produce different kinds of cells
3. Stem cell proliferation and differentiation observed within hydrogel
4. Men and women get sick in different ways
5. Antarctic and Arctic insects use different genetic mechanisms to cope with lack of water
6. Discovery may explain how prion diseases spread between different types of animals
7. BUSM study shows potential of differentiated iPS cells in cell therapy without immune rejection
8. Most-used diabetes drug works in different way than previously thought
9. Even in same vineyard, different microbes may create variations in wine grapes
10. Different genes behind same adaptation to thin air
11. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/26/2015)... PUNE, India , August 26, 2015 ... (Two, Three, Four, and Five Factor), Application (Travel & ... and Geography - Global Forecast to 2020", published by ... 9.60 Billion by 2020, growing at a CAGR of ... 71 Tables and 82 F igures spread through ...
(Date:8/24/2015)... MOUNTAIN VIEW, Calif. , Aug. 24, 2015  Based ... & Sullivan recognizes DERMALOG with the 2015 African Biometrics Company ... manufacturer and has achieved substantial commercial success in ... Nigeria , where it has implemented one of ... equipped 23 banks as well as the Central Bank of ...
(Date:8/20/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market and creator of the ... Card Alliance and the EMV Migration Forum.  ... Card Alliance Latin America (SCALA) Chapter provides NXT-ID, Inc. ... leaders promoting adoption of smart card technology. ...
Breaking Biology News(10 mins):Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 6NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4
... in the Siberian arctic to get water and sediment ... Lake Tahoe or digging quagga mussels out of Lake ... Chandra, assistant professor of limnology and conservation ecology at ... work in Nevada lakes, including his prolific record of ...
... release is available in Spanish . , ... project to fine-tune computer models that can indicate when ... The results will help pinpoint the effectiveness of trees ... temperatures and global climate change. ARS ...
... known recurrent genetic cause of schizophrenia impairs communications between ... memory deficits, according to a study in mice. ... animal model that shows us how genetics affects brain ... a learning and memory deficit linked to schizophrenia," explained ...
Cached Biology News:University of Nevada, Reno, professor receives exclusive American Fisheries Award of Excellence 2University of Nevada, Reno, professor receives exclusive American Fisheries Award of Excellence 3Model predicts shifts in carbon absorption by forest canopies 2Impaired brain connections traced to schizophrenia mutation 2
(Date:8/31/2015)... , Aug. 31, 2015 Research and Markets ... "Argentina Biomedical Sensors Market - Growth, Trends & ... The Argentina Biomedical Sensors market is estimated at ... over the period 2014-2020 The near future ... genetic formulation of each individual. These sensors can be ...
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cbgl72/middle_east_and ) has ... Africa Biomedical Sensors Market - Growth, Trends & Forecasts ... The Middle East & Africa ... 2018 at a CAGR of 3.26% over the period ... sensors that are adaptable to the genetic formulation of ...
(Date:8/31/2015)... , Aug. 31, 2015  RXi Pharmaceuticals ... focused on discovering and developing innovative therapies primarily ... announced that the 30-day review period following the ... for ocular indications with the U.S. Food and ... is now active. Logo -  ...
(Date:8/31/2015)... SOUTH SAN FRANCISCO, Calif. , Aug. 31, 2015 ... on the discovery and development of novel cancer immunotherapies, ... , M.D., Ph.D., as Chief Executive Officer and ... Drs. Wong and Ho join an experienced management team ... company: Jordan Fridman , Ph.D., Chief Scientific Officer; ...
Breaking Biology Technology:Argentina Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts 2014-2020 2Middle East & Africa Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts to 2020 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 3RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 4FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 3FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 4
... owners enforce their patent rights against potential infringers by ... stop the infringing activity. Thanks to a recent Federal ... , ,Typically, the patent owner would do this by ... party agree to pay for a license and then ...
... - It would be impressive enough if the ... St. Louis Park, Minn., had won a national championship ... that their competitors were seasoned college students. , ,Led ... competed against graduate-level college students in the 2005 U.S. ...
... debate is squarely in front of the nation again, and myriads ... of these opinions, we see they are driven by an almost ... terms used in this debate. , ,A recent article ... gives us a good example to use to examine one small ...
Cached Biology Technology:Patent licensing: For enforcing companies, the rules have changed 2Patent licensing: For enforcing companies, the rules have changed 3Silver linings in the cloud: America's dearth of STEM students 2Silver linings in the cloud: America's dearth of STEM students 3Silver linings in the cloud: America's dearth of STEM students 4Misconceptions dominate the immigration debate 2Misconceptions dominate the immigration debate 3Misconceptions dominate the immigration debate 4Misconceptions dominate the immigration debate 5
Rabbit polyclonal to Kallikrein 1 ( Abpromise for all tested applications). Antigen: Full length native kallikrein from tissue (Human) Entrez Gene ID: 3816 Swiss Protein ID: P06870...
PSGL-1 (215)...
Mouse Anti-human CD11b/Mac-1alpha, clone LM2/1, Monoclonal Antibody...
Mouse monoclonal [MLM544] to cardiac Myosin light chain 1 ( Abpromise for all tested applications). entrezGeneID: 4634 SwissProtID: P08590...
Biology Products: