Navigation Links
Different neuronal groups govern right-left alternation when walking
Date:6/30/2013

Scientists at Karolinska Institutet in Sweden have identified the neuronal circuits in the spinal cord of mice that control the ability to produce the alternating movements of the legs during walking. The study, published in the journal Nature, demonstrates that two genetically-defined groups of nerve cells are in control of limb alternation at different speeds of locomotion, and thus that the animals' gait is disturbed when these cell populations are missing.

Most land animals can walk or run by alternating their left and right legs in different coordinated patterns. Some animals, such as rabbits, move both leg pairs simultaneously to obtain a hopping motion. In the present study, the researchers Adolfo Talpalar and Julien Bouvier together with professor Ole Kiehn and colleagues, have studied the spinal networks that control these movement patterns in mice. By using advanced genetic methods that allow the elimination of discrete groups of neurons from the spinal cord, they were able to remove a type of neurons characterized by the expression of the gene Dbx1.

"It was classically thought that only one group of nerve cells controls left right alternation", says Ole Kiehn who leads the laboratory behind the study at the Department of Neuroscience. "It was then very interesting to find that there are actually two specific neuronal populations involved, and on top of that that they each control different aspect of the limb coordination."

Indeed, the researchers found that the gene Dbx1 is expressed in two different groups of nerve cells, one of which is inhibitory and one that is excitatory. The new study shows that the two cellular populations control different forms of the behaviour. Just like when we change gear to accelerate in a car, one part of the neuronal circuit controls the mouse's alternating gait at low speeds, while the other population is engaged when the animal moves faster. Accordingly, the study also show that whe
'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Do mens and womens hearts burn fuel differently?
2. Divide and define: Clues to understanding how stem cells produce different kinds of cells
3. Stem cell proliferation and differentiation observed within hydrogel
4. Men and women get sick in different ways
5. Antarctic and Arctic insects use different genetic mechanisms to cope with lack of water
6. Discovery may explain how prion diseases spread between different types of animals
7. BUSM study shows potential of differentiated iPS cells in cell therapy without immune rejection
8. Most-used diabetes drug works in different way than previously thought
9. Even in same vineyard, different microbes may create variations in wine grapes
10. Different genes behind same adaptation to thin air
11. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... from strains of influenza virus increases with the latest ... complacent that the most substantial threats have been identified, ... arise when a new virus strain – against which ... in the human population. There have been five such ... which – the 1918 Spanish Flu – cost 50 ...
(Date:10/15/2014)... bacterial pneumonia in female mice to an enzyme activated ... naturally more resistant to respiratory infections than males. Now, ... resistance to bacterial pneumonia in female mice is linked ... also show that this enzyme is ultimately activated by ... The team, lead by Professor Lester Kobzik at the ...
(Date:10/14/2014)... cancer tumors scavenge and hoard copper that is an ... be a fatal weakness. , Researchers at Duke ... cells by delivering a trove of copper along with ... with the mineral, leaving non-cancer cells healthy. , The ... for other uses, could soon be tested in clinical ...
Breaking Biology News(10 mins):Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Prostate cancer's penchant for copper may be a fatal flaw 2
... as the insects and plants in the network are ... question is difficult to answer because there is no ... or insects first appeared and almost none follow both ... Knight and her then postdoctoral research associate Laura Burkle ...
... on the challenge of providing the first insights into how ... with scientists from the John Innes Centre on a project ... Society and 2000 from the British Society for Plant Pathology., ... to Take-all, one of the most serious fungal diseases of ...
... everyone,s skin, yet one in five people is lucky enough ... In a boon for teenagers everywhere, a UCLA study conducted ... Los Angeles Biomedical Research Institute has discovered that acne bacteria ... may protect the skin. The findings, published ...
Cached Biology News:Walking in the footsteps of 19th and 20th century naturalists 2Walking in the footsteps of 19th and 20th century naturalists 3Walking in the footsteps of 19th and 20th century naturalists 4Walking in the footsteps of 19th and 20th century naturalists 5Growing talent -- schools to provide vital knowledge for food security 2New study could explain why some people get zits and others don't 2New study could explain why some people get zits and others don't 3
(Date:10/18/2014)... The Asian arthroscopic devices report defines and ... forecast of revenue. The arthroscopic devices market in Asia ... at a CAGR of 6.5% from 2013 to 2018. ... devices market, to get an idea of the in-depth ... segmentation of arthroscopic devices market in the same region, ...
(Date:10/18/2014)... 18, 2014 The Biomass Power ... the five years to 2014. The industry's expansion has ... tax credits that encouraged the use of biomass power. ... standards (RPSs), which require local utilities to generate electricity ... energy portfolio. Increased campaigning for green technology also influenced ...
(Date:10/17/2014)... a $451,781 Air Force Office of Scientific Research grant ... nano-scale level that will provide clues for predicting fatigue ... Aerospace Engineering, said the new technology and process would ... an aircraft,s wing., "We,ll be able to determine metal ... it on this scale," Huang said. "Certain patterns of ...
(Date:10/17/2014)... Horsham, PA (PRWEB) October 17, 2014 ... is being called upon by health facilities around ... exposed patients are being treated. Among the many ... used includes Texas Health Presbyterian Hospital Dallas and ... Center. The state-of-the-art vapor-producing robots have been utilized ...
Breaking Biology Technology:The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3UT Arlington project to detect possible damages in aircraft parts early in process 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 3Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 5Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 6
... 2 Onyx,Pharmaceuticals, Inc. (Nasdaq: ONXX ) ... Healthcare Conference on Monday, January 7, at 11:30 ... webcast of the,presentation at:, http://www.metameetings.com/webcasts/jpmorgan/healthcare08 , ... 15 minutes early in order to,register and download ...
... CARLOS, Calif., Jan. 2 Nektar,Therapeutics, (Nasdaq: NKTR ... corporate presentation at the upcoming JPMorgan 26th Annual Healthcare,Conference ... California on,Tuesday, January 8, 2008, at 4:30 p.m. Pacific ... live audio and slideshow,webcast through a link posted on ...
... PRINCETON, N.J., Dec. 31 Pharmasset, Inc.,(Nasdaq: ... to,discovering, developing and commercializing novel drugs to treat ... year ended,September 30, 2007. Pharmasset reported a net ... $0.46 per share, as compared to a net ...
Cached Biology Technology:Pharmasset Reports Fiscal Year End 2007 Financial Results 2Pharmasset Reports Fiscal Year End 2007 Financial Results 3Pharmasset Reports Fiscal Year End 2007 Financial Results 4Pharmasset Reports Fiscal Year End 2007 Financial Results 5Pharmasset Reports Fiscal Year End 2007 Financial Results 6Pharmasset Reports Fiscal Year End 2007 Financial Results 7Pharmasset Reports Fiscal Year End 2007 Financial Results 8Pharmasset Reports Fiscal Year End 2007 Financial Results 9
... timer, SB3, Fully adjustable mixing angle, Variable ... to hold a number of different sized ... for aerating cultures, keeping biological samples in ... rotator can be used in incubators up ...
...
Fingerprinting II database sharing tools is an optional module for the Fingerprinting II Basic software package that enables peer-to-peer data exchange over the internet and provides external databas...
Fingerprinting II cluster analysis is an optional module that adds dendrogram and phylogenetic tree construction, cluster and group significance, and congruence of techniques functions to the Fingerp...
Biology Products: