Navigation Links
Diabetes linked to male infertility; excess sugars in the body have direct effect on sperm quality
Date:7/9/2008

e in the expression of a protein called ornithine decarboxylase, which is responsible for the production of spermine and spermidine, compounds responsible for cell growth that help stabilise the structure of DNA. We also found that spermatogenesis 20, a factor unique to the testis and whose function remains unknown, was greatly increased. Taken together, these factors indicate clearly that having diabetes has a direct influence on the health of semen."

Sperm DNA quality is known to be associated with decreased embryo quality, low embryo implantation rates, higher miscarriage rates, and some serious childhood diseases, in particular some childhood cancers. Over the years possible causes for sperm DNA fragmentation have been suggested but to date the exact mechanism for the damage remains unknown, say the scientists.

"We found a class of compounds known as advanced glycation end products (AGEs) in the male reproductive tract. These are formed as the result of glycation (the addition of sugar)," said Dr. Mallidis, "and accumulate during normal ageing. They are dependent on life style diet, smoking etc and in many diabetic complications are centrally implicated in DNA damage. We believe that they play a similar role in the male reproductive system."

The scientists intend to follow up their work by trying to determine how AGEs cause and contribute to DNA damage. They believe that they may have uncovered a new role for AGEs, and that their influence goes far beyond diabetes and its complications.

"We must now try to develop strategies to protect sperm, and to diminish the accumulation of AGEs," said Dr. Mallidis. Such strategies could involve changes in diet, disrupting a step in the formation of AGEs, or increasing the body's protection against AGEs, possibly through the use of dietary supplements.

"Finally, there is spermatogenesis 20. What does it do, how does it do it, under what circumstances and why? Why is it
'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
34-932-308-810
European Society for Human Reproduction and Embryology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Moores UCSD Cancer Center study links vitamin D, type 1 diabetes
2. Mouse model developed at UT Southwestern mimics hyperglycemia, aids in diabetes research
3. Natural compounds in cocoa tied to blood flow improvements for adults with type 2 diabetes
4. People with diabetes may have all natural citrus supplement
5. Stem cell breakthrough offers diabetes hope
6. Michigan Tech researchers link 11 genetic variations to type 2 diabetes
7. Major collaboration uncovers surprising new genetic clues to diabetes
8. Major international collaboration offers new clues to genetics of type 2 diabetes
9. Potential association of type 2 diabetes genes with prostate cancer
10. Diabetes makes it hard for blood vessels to relax
11. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2015)... , June 18, 2015 NXT-ID, Inc. (NASDAQ: ... focused on the growing mobile commerce market announces that its ... segment on "Money on the Mark", scheduled to air on ... June 20 th . The broadcast ... from 7:00 to 8:00pm EST. NXT-ID, Inc.,s CEO Gino ...
(Date:6/16/2015)... , June 16, 2015 /CNW Telbec/ - ... partnership centralized around the incorporation of handyem,s HPC-150 ... diagnostic laboratory, the Mo-POD™. This unprecedented model of ... International Conference at the Pennsylvania ... from June 15 th to 18 th ...
(Date:6/15/2015)... A new report [ 1 ... of US consumers using mobile banking applications want their mobile ... and voiceprint, instead of having to prove who they are ... Mobile Identity   -   The Fusion of Financial Services, ... the primary channel used by Gen X and Gen Y ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4
... consumption in birds and mammals was limited by resource levels, ... while food was plentiful and produce as many offspring as ... shown that, even when food is abundant, energy intake reaches ... as lactating females. Scientists at the Research Institute of Wildlife ...
... familiar with the fact that cognitive function declines as we ... kind of daily activities we engage in during the course ... decline. A team of researchers from Technische Universitt Berlin are ... learning performance as they age. Surprisingly, they have found that, ...
... halo surrounding highly-publicized marketing campaigns regarding sweetener reformulations ... Starbucks and other brands that they will remove ... being called into question in news articles by ... have poked holes in companies, marketing efforts and ...
Cached Biology News:Key to evolutionary fitness: Cut the calories 2A young brain for an old bee 2Recent news reports of sweetener reformulations raise questions about motivations 2
(Date:7/1/2015)... , ... July 01, 2015 , ... It is now ... (TBI) using single photon emission computed tomography (SPECT) according to researchers from ... which examined over 20,000 brain scans and is believed to be the largest brain ...
(Date:7/1/2015)... ... ... The next-generation sequencing (NGS) clinical market is poised for huge growth as it prepares ... in its new report that the market drivers of this vibrant industry include increased ... diagnostics as part of a molecular diagnostics trend. , The global market is forecast ...
(Date:7/1/2015)... , July 1, 2015  Axovant Sciences Ltd. ... on the treatment of dementia, today announced that ... July 22 at 5:45 p.m. EDT following its ... Association International Conference 2015 (AAIC). ... , Dr. Lawrence Friedhoff , Chief ...
(Date:7/1/2015)... InferMed , s ... will augment ... s olutions suite   Elsevier , ... and services, announced today the acquisition of  InferMed , a ... company. InferMed,s Arezzo technology supports clinicians in choosing ...
Breaking Biology Technology:Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 2Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 4
... to the Menomonee Valley, Gov. Jim Doyle announced ... budget for the new Wisconsin Venture Center. , ,Doyle said ... will connect entrepreneurs with sources of capital, and serve as ... Wisconsin. , ,The concept was announced in December of 2006 ...
... and investors who are trying to come up with the ... relocate here have a fight on their hands. , ,And ... of Aruna Biomedical , an Athens, Ga. business that ... to move from research to production. , ,Last week, the ...
... has served as vice president of Quintessence Biosciences ... and chief operating officer of the Madison-based biopharmaceutical company. ... board of directors and announced at the company's annual ... from the University of Wisconsin-Madison , brings a ...
Cached Biology Technology:Doyle proposes $2M for venture capital center 2Wisconsin won't get Georgia biotech without a fight 2Wisconsin won't get Georgia biotech without a fight 3
...
... Custom Synthesis Service provides you ... to knockdown any gene. We ... base pairs with terminal dT ... other lengths of your choice. ...
...
...
Biology Products: