Navigation Links
Diabetes Research Institute develops oxygen-generating biomaterial
Date:3/1/2012

Miami, FL March 1, 2012 -- Scientists at the Diabetes Research Institute have developed a revolutionary technique to provide critical oxygen for maintaining the survival of insulin-producing cells. This is the first time that scientists have been able to successfully deliver oxygen locally to beta cells using a biomaterial. The results of the study, which represents a major step toward the goal of developing an alternative site to house insulin-producing cells, were just published in the prestigious journal Proceedings of the National Academy of Sciences (PNAS).

One of the major problems with the transplantation of cells, particularly beta cells, is meeting the high nutrient demand of these cells following transplantation. During the initial days of implantation, these cells do not have a functioning vascular network feeding oxygen to the cells, thus cells become starved and large cell loss occurs.

The DRI team, led by Dr. Cherie Stabler, developed a novel oxygen-generating material (termed PDMS-CaO2), which has the capacity to generate this critical element when exposed to water. This spontaneous generation of oxygen creates a nutrient-rich environment with sustained oxygen supplementation for more than six weeks. With this unique biomaterial system, the duration and amount of oxygen generated can be elegantly controlled, thereby providing the ideal environment for the cells. The potential of this technique to enhance beta cell survival with the use of this material was illustrated by incubating beta cells and islets in conditions that mimic the native pancreas.

"We have been working to create an optimal environment for housing transplanted islets that mimics the native pancreas, akin to a 'mini organ,' and this study represents a significant step toward that goal," says Dr. Cherie Stabler. "This oxygen-generating biomaterial provides the supplemental oxygen needed by the islets and serves as a bridge until the vascular bed (blo
'/>"/>

Contact: Lori Weintraub
Lweintraub@drif.org
954-964-4040
Diabetes Research Institute Foundation
Source:Eurekalert

Page: 1 2

Related biology news :

1. VTT searches for novel biomarkers and targets for preventing or treating Type 2 diabetes
2. Diabetes risk factors in young Sri Lankans much higher than previously thought
3. Largest-ever gene study of Type 2 diabetes finds variants across many ethnic groups
4. Body clock receptor linked to diabetes in new genetic study
5. Genetic regulation of metabolomic biomarkers - paths to cardiovascular diseases and type 2 diabetes
6. La Jolla Institute scientist takes quest to conquer Type 1 diabetes to the next level
7. La Jolla Institute researchers identify pivotal immune cell in Type 1 diabetes in humans
8. UCSF, Sanofi collaborate to find new diabetes cures
9. How poor maternal diet can increase risk of diabetes -- new mechanism discovered
10. How poor maternal diet can increase risk of diabetes - new mechanism discovered
11. Study finds air pollution linked to diabetes and hypertension in African-American women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... German . Why ... order to reproduce? And why are there two sexes anyway? ... issue of the research journal Molecular Human Reproduction ... from Bielefeld University Bielefeld has compiled this special issue on ... female to copulate with several males in quick succession – ...
(Date:10/16/2014)... have a new synthesis of recent research findings to ... in the two states. , The Ecology and ... Washington: A Synthesis of the Relevant Biophysical Science and ... published by the U.S. Forest Service,s Pacific Northwest Research ... managers for a synthesis of the large body of ...
(Date:10/16/2014)... 2014 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market ... Wocket™, the Smart Wallet, at the 13 th ... leading global conference on the intersection of technology and ... Anderson , founder and publisher of the Strategic News ...
Breaking Biology News(10 mins):Sperm wars 2New report synthesizes best available science on management of moist mixed-conifer forests 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
... racking your brain on a Monday morning to remember where ... those keys, you can thank the hippocampus, a brain region ... that room where your keys were hiding in an unusual ... Biological Studies have helped explain how the brain keeps track ...
... A dysfunction of a certain Calcium channel, the so called ... cause different motor diseases as well as a special type ... Dr. Melanie Mark and Prof. Dr. Stefan Herlitze from the ... of the P/Q-type in the modulatory input neurons of the ...
... compared water quality trends in forested streams across the country ... changes. The study, which draws on decades, worth of ... Rico, underscores the value of long-term data in understanding the ... rivers. It is published in the current issue of the ...
Cached Biology News:The neuroscience of finding your lost keys 2The neuroscience of finding your lost keys 3Dysfunction in cerebellar Calcium channel causes motor disorders and epilepsy 2Study explores long-term water quality trends in near-pristine streams 2
(Date:10/22/2014)... October 22, 2014 Grace Century, a ... healthcare projects, announces the addition of Dr. Yousef ... its advisory team. Dr. Siddiqui will provide further healthcare ... A graduate of University College Medical School ... in medicine in 2001. With further certification as a ...
(Date:10/22/2014)...   Synthetic Biologics, Inc. (NYSE MKT: SYN), ... infections and diseases, announced today that the U.S. Patent ... for a composition of matter patent application that covers ... SYN-004. This is Synthetic Biologics, first allowed patent application ... to the Company,s extensive C. difficile patent ...
(Date:10/22/2014)... 22, 2014 Research and Markets  has ... by Material, by Application, Geography - Global Analysis and ... Organic electronics, also called as polymer ... science which deals with small conductive molecules and electrically ... molecules and polymers are carbon based, made using synthetic ...
(Date:10/20/2014)... 2014 Mapp Biopharmaceutical,s valiant effort to ... to fight the Ebola outbreak will make the ... production of pharmaceuticals can be, according to Kalorama ... while some may be taken aback by the ... industry knowledge are well aware of the complex ...
Breaking Biology Technology:Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3
... on powerful computational tools and a state-of-the-art scanning ... Wisconsin-Madison and Iowa State University materials science and ... structure in solid metallic materials known as metallic ... Physical Review Letters , the findings fill ...
... May 11, 2012   Synthetic Biologics, Inc. (NYSE Amex: ... and innovative disease-modifying medicines for serious illnesses, announced today ... Board, it has split the roles of Chairman and ... serve as its independent, non-executive Chairman of the Board. ...
... ORLANDO, Fla., May 10, 2012   GeneLink, Inc. ... leading consumer genomics biotech company, reports financial results for the ... Results: , The Company reached an agreement ... Life Sciences, Inc. to Capsalus Corp (OTCBB:WELL.OB, or "Capsalus"). Capsalus ...
Cached Biology Technology:In metallic glasses, researchers find a few new atomic structures 2In metallic glasses, researchers find a few new atomic structures 3Synthetic Biologics Appoints Jeffrey J. Kraws as Independent Chairman 2Synthetic Biologics Appoints Jeffrey J. Kraws as Independent Chairman 3GeneLink Reports 2011 Financial Results 2GeneLink Reports 2011 Financial Results 3
... CultureWell cell culture systems provide an ... for staining and imaging. Each system ... standard optical-quality coverslips in cell culture ... sterile and ready to use. Individual ...
RECOMBINANT EQUINE IL-4 Product Type: Recombinant Protein...
RECOMBINANT EQUINE TNF ALPHA Product Type: Recombinant Protein...
Request Info...
Biology Products: