Navigation Links
Developmental neurobiology: How the brain folds to fit
Date:4/26/2013

ion and folding

"Trnp1 is critical for the expansion and folding of the cerebral cortex, and its expression level is dynamically controlled during development," says Gtz. In the early embryo, Trnp1 is locally expressed in high concentrations. This promotes the proliferation of self-renewing multipotent neural stem cells and supports tangential expansion of the cerebral cortex. The subsequent fall in levels of Trnp1 is associated with an increase in the numbers of various intermediate progenitors and basal radial glial cells. This results in the ordered formation and migration of a much enlarged number of neurons forming folds in the growing cortex.

The findings are particularly striking because they imply that the same molecule Trnp1 controls both the expansion and the folding of the cerebral cortex and is even sufficient to induce folding in a normally smooth cerebral cortex. Trnp1 therefore serves as an ideal starting point from which to dissect the complex network of cellular and molecular interactions that underpin the whole process. Gtz and her colleagues are now embarking on the next step in this exciting journey - determination of the molecular function of this novel nuclear protein Trnp1 and how it is regulated.


'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
0049-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. New genes contributing to autism and related neurodevelopmental disorders uncovered
2. Mice with big brains provide insight into brain regeneration and developmental disorders
3. MARC travel awards announced for the Society for Developmental Biology 71st Annual Meeting
4. Environmental estrogens affect early developmental activity in zebrafish
5. Distinct developmental patterns identified in children with autism during their first 3 years
6. Developmental bait and switch
7. Researchers find new genetic pathway behind neurodevelopmental disorders
8. Developmental biologist Arthur Lander named Donald Bren Professor
9. Researchers explain a key developmental mechanism for the first time in plants
10. UTSW molecular biologist Olson wins March of Dimes developmental biology prize
11. Developmental delays in children following prolonged seizures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... The Parenteral Drug Association (PDA) today confirmed that ... and at least seven more will participate in the upcoming ... Hotel in Washington D.C. , Dec. 2-4. ... support from the regulatory agencies in the United ... our effort to help advance the use of metrics in ...
(Date:11/11/2014)... , Nov. 11, 2014  Forensicon, Inc., a ... firm, is pleased to announce the promotion of ... Director of Digital Forensics. In Schiff,s new role as ... the team of digital forensics examiners and provide leadership ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 ...
(Date:11/7/2014)... -- Leading Biometric companies aim to provide consumers ... transactions.  Companies in focus today are: NXT-ID, Inc. (NASDAQ: ... ), Google Inc. (NASDAQ: GOOG ), Microsoft Corporation ... EBAY ) and MasterCard Inc. (NYSE: MA) NXT-ID, ... authentication company focused on the growing mobile commerce is pleased ...
Breaking Biology News(10 mins):FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6
... sclerosis (MS), neuroradiologists and neurologists of the University hospitals ... inflammatory tissue damage, most of which had remained unrecognized ... contrast medium, Gadofluorine M, in magnetic resonance imaging. The ... of the renowned medical journal Brain . ...
... Germany have discovered that methadone, an agent used to ... against leukemia cells, including treatment resistant forms of the ... 1 issue of Cancer Research , a journal ... methadone holds promise as a new therapy for leukemia, ...
... hide their top mate choice, reveals a new study published ... Cell Press journal. They feign disinterest in females ... rival, the tricky males direct their first sexual advances toward ... known to copy other males, mate choices, the researchers noted. ...
Cached Biology News:Multiple Sclerosis: new MRI contrast medium enables early diagnosis in animal model 2Lab study shows methadone breaks resistance in untreatable forms of leukemia 2Male fish deceive rivals about their top mate choice 2
(Date:11/26/2014)... SonaCare Medical, a leading manufacturer ... recently participated in the American Urology Association’s (AUA) ... Key opinion leaders in urology presented on the ... renal masses while attendees had the opportunity to ... hands-on labs. Attendees at the Los Angeles, CA ...
(Date:11/26/2014)... ADDISON, TX (PRWEB) November 25, 2014 ... age-defying skincare products, earned three prestigious MarCom Awards for ... , Nerium received a Platinum MarCom Award, the organization’s ... Real Event in St. Louis held in April of ... for more than 14,000 attendees. Additionally, Nerium was awarded ...
(Date:11/26/2014)... Global biostimulants market is expected to reach $2,524.02 ... of 12.5%. In order to cater to the ... impacts, farmers are looking to adopt natural compounds ... effectively & efficiently. Biostimulants are consequently seen as ... investments. , Leading companies in the biostimulants market ...
(Date:11/26/2014)... SoundConnect , an award winning ... announce that Darren Suders has joined the team as ... drive the partner program through innovative offerings, ... , Darren brings more than 10-years of channel telecommunication ... channel operations, from policy development, to partner education and ...
Breaking Biology Technology:SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 4SoundConnect Appoints Director of Channel Development & Sales 2
... for Molecular Biology,(CMB) has received an $8.7 million ... support continued development of an avian influenza vaccine ... against,highly pathogenic avian influenza viruses of H5N1 subtype, ... , Dr. Vidadi Yusibov, ...
... ATHENS, Ga., Jan. 30 ArunA Biomedical, Inc., announced ... available to the research community in early 2009. ... lines, are offered as a normal, consistent population of ... never before offered to the research community. hN2 ...
... a company,developing enzymes for the chemical industry, announced today ... Officer. , "We are excited ... Bioscience," said Rudy Pandjaitan, Ph.D., CEO of EUCODIS Bioscience.,"His ... close relations,with the investment community will be a tremendous ...
Cached Biology Technology:Fraunhofer USA Center for Molecular Biotechnology Receives Gates Foundation Grant for Avian Influenza Vaccine Development 2ArunA Biomedical Announces Commercial Release of its Human Embryonic Stem Cell Derived Neural Cells 2EUCODIS Bioscience Appoints Thomas Fischer as Chief Financial Officer 2
... novel target for which no antibody exists? Having ... antibodies for a variety of pharmaceutical, biotech and ... put our technology and expertise in antibody generation ... our patented RabMAb development technology , High affinity ...
... were designed for full-length gene cloning and ... identify the desired cDNA clone. The first ... "Master Plate," where each well contains plasmid ... positive well(s) by gel electrophoresis of the ...
... The ProteoSpin CBED Micro Kit provides ... buffer exchange and desalting of protein samples. ... using Norgens patented protein resin as an ... KCl, CaCl2,LiCl, CsCl have poor affinities for ...
... Canine Endostatin. Canine Cytokine EIA ... include a line of enzyme-linked immunosorbent ... used for multiple research applications. The ... ultra-sensitive, quick and dependable assays. The ...
Biology Products: