Navigation Links
Developmental neurobiology: How the brain folds to fit
Date:4/26/2013

During fetal development of the mammalian brain, the cerebral cortex undergoes a marked expansion in surface area in some species, which is accommodated by folding of the tissue in species with most expanded neuron numbers and surface area. Researchers have now identified a key regulator of this crucial process.

Different regions of the mammalian brain are devoted to the performance of specific tasks. This in turn imposes particular demands on their development and structural organization. In the vertebrate forebrain, for instance, the cerebral cortex which is responsible for cognitive functions is remarkably expanded and extensively folded exclusively in mammalian species. The greater the degree of folding and the more furrows present, the larger is the surface area available for reception and processing of neural information. In humans, the exterior of the developing brain remains smooth until about the sixth month of gestation. Only then do superficial folds begin to appear and ultimately dominate the entire brain in humans. Conversely mice, for example, have a much smaller and smooth cerebral cortex.

"The mechanisms that control the expansion and folding of the brain during fetal development have so far been mysterious," says Professor Magdalena Gtz, a professor at the Institute of Physiology at LMU and Director of the Institute for Stem Cell Research at the Helmholtz Center Munich. Gtz and her team have now pinpointed a major player involved in the molecular process that drives cortical expansion in the mouse. They were able to show that a novel nuclear protein called Trnp1 triggers the enormous increase in the numbers of nerve cells which forces the cortex to undergo a complex series of folds. Indeed, although the normal mouse brain has a smooth appearance, dynamic regulation of Trnp1 results in activating all necessary processes for the formation of a much enlarged and folded cerebral cortex.

Levels of Trnp1 control expans
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
0049-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. New genes contributing to autism and related neurodevelopmental disorders uncovered
2. Mice with big brains provide insight into brain regeneration and developmental disorders
3. MARC travel awards announced for the Society for Developmental Biology 71st Annual Meeting
4. Environmental estrogens affect early developmental activity in zebrafish
5. Distinct developmental patterns identified in children with autism during their first 3 years
6. Developmental bait and switch
7. Researchers find new genetic pathway behind neurodevelopmental disorders
8. Developmental biologist Arthur Lander named Donald Bren Professor
9. Researchers explain a key developmental mechanism for the first time in plants
10. UTSW molecular biologist Olson wins March of Dimes developmental biology prize
11. Developmental delays in children following prolonged seizures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2014)... NEW YORK , Nov. 13, 2014  While we ... of technology Doctor McCoy used in "Star Trek" to gain ... and tools designed to work with smartphones and tablets for ... corners of the healthcare world. This may seem a tad ... are ready to adopt some of these technological opportunities into ...
(Date:11/10/2014)... pods began appearing on U.S. store shelves in early ... ever since. The small packets can be tossed into ... a liquid or powder. The convenience, though, has come ... from researchers at Nationwide Children,s Hospital found that from ... of 17,230 children younger than 6 years of age ...
(Date:11/7/2014)... November 6, 2014 Leading Biometric companies ... mobile security revolutionizing online transactions.  Companies in focus today are: ... (NYSE: BABA ), Google Inc. (NASDAQ: ... Inc. (NASDAQ: EBAY ) and MasterCard Inc. (NYSE: ... and NXTDW), a biometric authentication company focused on the growing ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Study finds laundry detergent pods, serious poisoning risk for children 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6
... a year, researchers watched patiently as a few computer-simulated ... different shapes. In real time, this contortion takes only ... this suspended animation paid off, as the simulations uncovered ... , Howard Hughes Medical Institute (HHMI) scientists made ...
... dwelling at deep-sea hydrothermal vents opt for temperatures of ... choice of conditions, giving them the highest thermal preference ... for extreme temperatures may be the undersea worms' meal ... to access -- and feast on -- lush mats ...
... London shows that robot assisted knee surgery is ... team of surgeons tested whether Acrobot, a robotic ... partial knee replacement. Acrobot works by helping the ... with the existing bones. , The surgeons looked ...
Cached Biology News:Computer simulation hints at new HIV drug target 2Computer simulation hints at new HIV drug target 3Computer simulation hints at new HIV drug target 4Computer simulation hints at new HIV drug target 5Some like it hot: Worms at deep-sea vents favor a fiery 45-55°C 2Robot assisted surgery more accurate than conventional surgery 2
(Date:11/24/2014)... SOUTH SAN FRANCISCO, Calif. , Nov. 24, 2014 /PRNewswire/ ... announced that Bonnie H. Anderson , president and chief ... the Piper Jaffray 26 th Annual Healthcare Conference on ... New York . The live audio ... website at http://investor.veracyte.com . Please connect to the website ...
(Date:11/24/2014)... Nov. 24, 2014  Spherix Incorporated (Nasdaq: ... to the fostering and monetization of intellectual property, ... Telecommunications Ltd.,  Case No. 3:13-cv-03494-M and  Spherix v. ... both in the United States District Court for ... . On November 21, 2014 ...
(Date:11/22/2014)... 21, 2014 Prominent academics, leaders ... gather on December 3rd at Genetic Rx, a ... GeneticRx will take place at the Joseph B. ... will discuss the present and future of genetic ... and gene editing—as well as the treatment of ...
(Date:11/22/2014)... 2014 Respiratory therapy students will ... management of life-like respiratory ailments using the latest ... Grand Rapids-based, Michigan Instruments Inc. developers of the ... the respiratory simulation units to the pro-gram, which ... and Muskegon Community College are collaborating to offer ...
Breaking Biology Technology:Veracyte to Present at the Piper Jaffray 26th Annual Healthcare Conference 2Markman Hearing Held as Scheduled in VTech and Uniden Cases 2Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3
... Kent State University Professor of Physics Dr. Satyendra ... Foundation (NSF) with its Directors Award for Excellence ... review of interdisciplinary condensed matter physics proposals. In ... a ceremony held in Arlington, Va. , ...
... 21 Sequenom, Inc. (Nasdaq:,SQNM) today announced that a live ... analyst and investor briefing event,"Sequenom Today and Tomorrow." Details of ... ), What: Sequenom Today and ... 2007 at 4:15 p.m. Eastern time, Where: ...
... investor The Blackstone Group now represented on company,s ... ... Stiefel Laboratories, Inc.,today announced the appointment of two new members to the ... The Blackstone Group, which recently became a minority-share,investor in the company. ...
Cached Biology Technology:Sequenom to Webcast Analyst and Investor Briefing Presentation on September 24 2Stiefel Laboratories Appoints Two New Members to Board of Directors 2Stiefel Laboratories Appoints Two New Members to Board of Directors 3
...
... The Bioactive peptides are molecules of peptidic ... behaviour or activity which can be developed ... chemical and agro-food applications. In this way ... with superior properties for therapeutic applications. Primm ...
... immunospot) Kit analyzes interferon gamma (IFNγ) production ... forms at the site where secreted cytokine ... dissection microscope or automated ELISPOT reader) and ... added to the microplate. This allows the ...
... The Open Frame DNAscope is an ... flexible, customizable, and readily integrated into your ... configuration, or we can tailor the system ... DNAscopes patented optical scanning design has been ...
Biology Products: