Navigation Links
Developing microbial cell factories by employing synthetic small regulatory RNAs
Date:1/20/2013

Biotechnologists have been working hard to address the climate change and limited fossil resource issues through the development of sustainable processes for the production of chemicals, fuels and materials from renewable non-food biomass. One promising sustainable technology is the use of microbial cell factories for the efficient production of desired chemicals and materials. When microorganisms are isolated from nature, the performance in producing our desired product is rather poor. Metabolic engineering is performed to improve the metabolic and cellular characteristics to achieve enhanced production of desired product at high yield and productivity. Since the performance of microbial cell factory is very important in lowering the overall production cost of the bioprocess, many different strategies and tools have been developed for the metabolic engineering of microorganisms.

One of the big challenges in metabolic engineering is to find the best platform organism and to find those genes to be engineered so as to maximize the production efficiency of the desired chemical. Even Escherichia coli, the most widely utilized simple microorganism, has thousands of genes, the expression of which is highly regulated and interconnected to finely control cellular and metabolic activities. Thus, the complexity of cellular genetic interactions is beyond our intuition and thus it is very difficult to find effective target genes to engineer. Together with gene amplification strategy, gene knockout strategy has been an essential tool in metabolic engineering to redirect the pathway fluxes toward our desired product formation. However, experiment to engineer many genes can be rather difficult due to the time and effort required; for example, gene deletion experiment can take a few weeks depending on the microorganisms. Furthermore, as certain genes are essential or play important roles for the survival of a microorganism, gene knockout experiments cannot be p
'/>"/>

Contact: Lan Yoon
hlyoon@kaist.ac.kr
82-423-502-295
The Korea Advanced Institute of Science and Technology (KAIST)
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Developing second skin military fabric to repel chemical and biological agents
2. Inspired: Canada funds 68 bold, inventive ways to improve health, save lives in developing countries
3. Watching the developing brain, scientists glean clues on neurological disorder
4. Cilia guide neuronal migration in developing brain
5. First-ever 3-D stress map of developing embryonic heart sheds light on why defects form
6. The role of stem cells in developing new drugs
7. Sam Houston state developing lab test for bath salts
8. Purple corn compound may aid in developing future treatments for Type 2 diabetes, kidney disease
9. Risk of developing diabetes higher in neighborhoods that arent walk-friendly: Study
10. Students create low-cost biosensor to detect contaminated water in developing nations
11. UC Riverside developing biofuel formulations for California
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/12/2015)... 12, 2015  Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring, announced the ... electronically capture, analyze and identify participants of a ... This system can: , ... and subsequent sign-on process is actually the person ...
(Date:6/10/2015)... 10, 2015 According to ... by Technology (Ultrasound, TOF, Structured Light, Stereo Vision), ... Automotive) and by Geography - Trends & Forecast ... market is expected to reach $3,319.71 Million by ... 2015 and 2020. Browse 71 market ...
(Date:6/9/2015)... DUBLIN , June 09, 2015 ... the addition of the "Gesture Recognition & ... Application (Consumer Electronics, Automotive, & Others), Product (Biometric ... Forecast to 2020" report to their offering. ... sensing market is expected to reach $ 23.55 ...
Breaking Biology News(10 mins):Securus Announces Patent Issued for Authorized Presence Verification During Video Visitation 23D Sensor Market Worth $3,319.71 Million by 2020 23D Sensor Market Worth $3,319.71 Million by 2020 33D Sensor Market Worth $3,319.71 Million by 2020 4Global Gesture Recognition & Touchless Sensing (Technology, Application & Products) Market 2015-2020 2
... of folic acid around the time of conception and throughout ... one day deserve a spot on the obstetrician,s list of ... choline a nutrient found in eggs and meat ... such as mental health disturbances, and chronic conditions, like hypertension, ...
... floating islands containing papyrus plants to help protect the ... Kenya. The German REWE Group is funding a ... grower Finlays and Dr David Harper, a Senior Lecturer ... the water-cleansing services of papyrus as artificial floating islands. ...
... Sept. 20, 2012 Novetta Solutions, LLC (Novetta), ... announced the acquisition of International Biometric Group, LLC ... to customers within the National Security community and ... Novetta was established in March 2012 through the ...
Cached Biology News:Nutrient in eggs and meat may influence gene expression from infancy to adulthood 2Nutrient in eggs and meat may influence gene expression from infancy to adulthood 3Novel plastic-and-papyrus restoration project 2Novel plastic-and-papyrus restoration project 3Novetta Solutions Acquires International Biometric Group, LLC 2Novetta Solutions Acquires International Biometric Group, LLC 3
(Date:7/7/2015)... ... , ... CSM, a leading clinical trial supply company, today announced that Michael ... extensive background in financial management and accounting, bringing over 20 years of experience in ... will oversee all financial areas of the company to both strengthen CSM’s financial strategy ...
(Date:7/6/2015)... ... July 06, 2015 , ... A study ... insights into how virulent fungi adapt through genetic modifications to fight back against ... leaves them temporarily weakened. These insights may provide clues to new ways to ...
(Date:7/6/2015)... Wellesley, Mass. (PRWEB) , ... July 06, 2015 ... ... development of simpler and cheaper molecular diagnostic tests are key drivers of the ... projected growth of personalized medicine and the introduction of new companion diagnostic tests ...
(Date:7/6/2015)... -- ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") (NYSE MKT: IMUC) today ... Clinical (Novella), to conduct the phase 3 registration ... Novella is a full-service, global clinical research organization (CRO) ... companies. The ICT-107 phase 3 trial will include approximately ... and Canada , and ...
Breaking Biology Technology:CSM Appoints Michael Morse as Vice President of Finance 2Worcester Polytechnic Institute Co-directs Study That Provides New Insights into the Genetics of Drug-Resistant Fungal Infections 2Worcester Polytechnic Institute Co-directs Study That Provides New Insights into the Genetics of Drug-Resistant Fungal Infections 3Worcester Polytechnic Institute Co-directs Study That Provides New Insights into the Genetics of Drug-Resistant Fungal Infections 4Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 2Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 3ImmunoCellular Therapeutics Establishes Agreement with Novella Clinical to Conduct ICT-107 Phase 3 Registration Trial in Glioblastoma 2
... on a poultry farm in Texas. Soon, there are reports ... and New Jersey. How can health officials be mobilized to ... humans? , ,That process may well begin at the All-Emergency ... Services Secretary Tommy Thompson to keep tabs on the range ...
... , today announced the addition of two new members ... Weis. , ,The Madison-based media communications company hopes to ... its board of directors with the appointments. Peercy and ... meeting, at which time they will stand for election. ...
... intranets are frustrated. In a recent Moreover survey, 58 ... information resource at work, but only 11 percent considered ... Given all the money and effort that has gone ... value in them? , ,By 1998, companies were already ...
Cached Biology Technology:Federal command center is at the front line of defense for public health emergencies 2Federal command center is at the front line of defense for public health emergencies 3The unfilled promise of corporate intranets 2The unfilled promise of corporate intranets 3
Homo sapiens postsynaptic protein CRIPT Antigen: Recombinant Protein...
... quadrupole 1200L sets the new standard ... - incorporating the latest technologies and ... chromatography analytical needs. The Atmospheric ... Transmission Quadrupole Analyzer provide superior selectivity ...
Human Legumain Affinity Purified Polyclonal Ab...
Mouse Endoglin/CD105 Fluorescein MAb (Clone 209701)...
Biology Products: