Navigation Links
Developing microbial cell factories by employing synthetic small regulatory RNAs
Date:1/20/2013

Biotechnologists have been working hard to address the climate change and limited fossil resource issues through the development of sustainable processes for the production of chemicals, fuels and materials from renewable non-food biomass. One promising sustainable technology is the use of microbial cell factories for the efficient production of desired chemicals and materials. When microorganisms are isolated from nature, the performance in producing our desired product is rather poor. Metabolic engineering is performed to improve the metabolic and cellular characteristics to achieve enhanced production of desired product at high yield and productivity. Since the performance of microbial cell factory is very important in lowering the overall production cost of the bioprocess, many different strategies and tools have been developed for the metabolic engineering of microorganisms.

One of the big challenges in metabolic engineering is to find the best platform organism and to find those genes to be engineered so as to maximize the production efficiency of the desired chemical. Even Escherichia coli, the most widely utilized simple microorganism, has thousands of genes, the expression of which is highly regulated and interconnected to finely control cellular and metabolic activities. Thus, the complexity of cellular genetic interactions is beyond our intuition and thus it is very difficult to find effective target genes to engineer. Together with gene amplification strategy, gene knockout strategy has been an essential tool in metabolic engineering to redirect the pathway fluxes toward our desired product formation. However, experiment to engineer many genes can be rather difficult due to the time and effort required; for example, gene deletion experiment can take a few weeks depending on the microorganisms. Furthermore, as certain genes are essential or play important roles for the survival of a microorganism, gene knockout experiments cannot be p
'/>"/>

Contact: Lan Yoon
hlyoon@kaist.ac.kr
82-423-502-295
The Korea Advanced Institute of Science and Technology (KAIST)
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Developing second skin military fabric to repel chemical and biological agents
2. Inspired: Canada funds 68 bold, inventive ways to improve health, save lives in developing countries
3. Watching the developing brain, scientists glean clues on neurological disorder
4. Cilia guide neuronal migration in developing brain
5. First-ever 3-D stress map of developing embryonic heart sheds light on why defects form
6. The role of stem cells in developing new drugs
7. Sam Houston state developing lab test for bath salts
8. Purple corn compound may aid in developing future treatments for Type 2 diabetes, kidney disease
9. Risk of developing diabetes higher in neighborhoods that arent walk-friendly: Study
10. Students create low-cost biosensor to detect contaminated water in developing nations
11. UC Riverside developing biofuel formulations for California
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... BERLIN , March 12, 2015 ... IAM, a standardized identity and access management (IAM) ... reliable implementation schedule. With Beta System,s new IAM ... and best practices gleaned from multiple IAM implementations ... includes the software as well as any necessary ...
(Date:3/11/2015)... and Markets ( http://www.researchandmarkets.com/research/3p32qm/access_control ) has announced ... Product, Application & By Geography - Global Forecast & ... This report predicts that the access control ... with an estimated CAGR of 10.6%. The ... as contact cards & readers, contactless cards & readers, ...
(Date:3/10/2015)... March 10, 2015  Continuing its 167-year history of ... Schlemmer introduces The Eye Scanning Password Authenticator , ... access to secure websites or sensitive data. ... at international borders, the device has a small camera ... of the iris, converting them into an encrypted ID ...
Breaking Biology News(10 mins):Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2
... from the University of Wisconsin-Milwaukee, a Wisconsin biotech company ... in jellyfish is neuro-protective and may be effective in ... promising results, said Mark Y. Underwood of Quincy Bioscience ... professor at UW-Milwaukee, subjected brain cells to the "lab" ...
... predict where a bumblebee will carry its pollen next, you ... a foraging style that's been successful, they are more likely ... something new," says Rebecca Flanagan, a graduate student at the ... Jeffrey Karron, are studying the behaviors of bees as they ...
... five-year, $1 million grant from the National Cancer Institute, a ... improve the effectiveness of a drug that he developed ... Waldemar Debinski, M.D., Ph.D., pioneered a method to destroy cells ... The drug is currently being tested in clinical trials and ...
Cached Biology News:UWM brain research supports drug development from jellyfish protein 2Researchers find that bumblebees' flower choice matters 2Researchers find that bumblebees' flower choice matters 3Researchers find that bumblebees' flower choice matters 4Scientist works to improve treatment for brain tumors 2
(Date:3/29/2015)... As a symbol of its commitment to meet ... clients, Whitehouse Laboratories is excited to announce that is ... for the 2015 race season. Success on the race ... sense of precision and attention to detail. These are ... quality control testing laboratory. Sponsorship of the race car, ...
(Date:3/27/2015)... 2015  Peter Walter wurde als Gewinner ... seine bahnbrechende Arbeit ausgewählt, die sich damit ... sowie für die Entschlüsselung der Komponenten eines ... nutzen, der mit der Ansammlung von deformierten ... Biochemie an der University of California, San ...
(Date:3/27/2015)... YORK , March 27, 2015  Peter Walter ... Biomedical Science for his pioneering work on how proteins ... components of a regulatory mechanism that cells use to ... Dr. Walter is a professor of biochemistry at the ... groundwork for treating a range of human diseases related ...
(Date:3/27/2015)... Md. , March 27, 2015  CASI Pharmaceuticals, ... to the acquisition, development and commercialization of innovative therapeutics ... global market with a commercial focus on ... three and 12 months ended December 31, 2014.  ... ($1.6 million), or ($0.05) per share, for the three ...
Breaking Biology Technology:Whitehouse Laboratories Reaffirms Commitment to Speedy Results – Renews Sponsorship of Berkenstock Racing Team 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 3Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 4German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 2CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 4CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 5CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 6
... CRN says , CRN magazine ranked Laurie Benson, ... the top 25 executives in 2004. The magazine looked for ... Benson ranked among executives from IBM, Cisco, Intel, Sun and ... Infosecurity Conference , Milwaukee PKWare s ...
... cooperative that networks Wisconsin institutions, took different directions in ... eWeek last September, the magazine has reported. , ... than 30 respondents and choosing six for evaluation, eWeek ... enough to provide anti-spam services to all of WiscNets ...
... , ,Now what? Everyone thinks I have some cushy ... secretary at the Department of Health and Human Services, but ... don't realize that federal ethics rules basically keep Cabinet secretaries ... next would have meant staying inside the Bush administration. The ...
Cached Biology Technology:WiscNet members choose anti-spam products for different needs 2Reading Tommy Thompson's mind – life after public service 2Reading Tommy Thompson's mind – life after public service 3
RABBIT ANTI RHEB (IN) Immunogen: A 15 amino acid peptide located in the central region of human Rheb....
... Agarose Gel-Digesting Preparation contains a unique β-agarose ... quantitative recovery of intact DNA and RNA ... following electrophoresis in TAE, TBE, MOPS, or ... directly in the TAE, TBE, MOPS, and ...
... Agarose Gel-Digesting Preparation contains a unique β-agarose ... quantitative recovery of intact DNA and RNA ... following electrophoresis in TAE, TBE, MOPS, or ... directly in the TAE, TBE, MOPS, and ...
... is causing shortages in your laboratory or fellow ... unwanted distractions, problems and delays. • ... and endeavour! Bring us your idea and let ... We work under ISO 9001 quality assurance in ...
Biology Products: