Navigation Links
Despite countless changes, original HIV infection lurks within
Date:6/29/2010

Scientists have been surprised to learn that, despite thousands of changes that viruses like HIV undergo in rapid fashion to evade the body's immune system, the original version that caused the infection is still present in the body months later.

The finding, published in the June issue of the Journal of Virology, is the result of an uncommonly detailed look at the cat-and-mouse action that takes place in an organism shortly after infection. The work is aimed at understanding the earliest stages of infection by HIV more thoroughly, to help scientists develop ways either to quash the infection outright or to develop a vaccine to prevent infection.

The research, which was conducted by scientists at the University of Rochester Medical Center, is based on an analysis of more than 100,000 genetic snippets of a virus known as SIV, or simian immunodeficiency virus, which infects monkeys and is a close cousin of HIV.

While HIV has flummoxed scientists for nearly three decades, that's certainly not because our immune system fails to respond. Rather, within two or three weeks of infection, the onslaught of immune cells puts the virus on the run to such an extent that the virus must mutate rapidly to evade the body's defenses.

HIV changes quickly and continually, creating thousands and thousands of mutated versions of itself in a process called "viral escape." The virus changes; the immune cells hunting it down change in response; and the virus changes again, and so on, in a kind of molecular arms race.

"Viral escape is a significant phenomenon in HIV it's what allows HIV to elude the immune system," said Ha Youn Lee, Ph.D., the assistant professor in the Department of Biostatistics and Computational Biology who led the project.

"The dynamics in the earliest stage of infection by HIV are incredibly complex, and understanding what happens is crucial for developing a vaccine," Lee added.

To do the study
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Pesky aphid thrives despite weak immune system
2. Despite risk, older African-Americans more likely than others to avoid flu vaccine
3. Despite claims, UK did not gas Iraqis in the 1920s, new research finds
4. Birds in Flint Hills of Kansas, Oklahoma face population decline despite large habitat
5. Organic soils continue to acidify despite reduction in acidic deposition
6. Despite peacenik reputation, bonobos hunt and eat other primates too
7. Despite awareness of global warming Americans concerned more about local environment
8. CITES caviar export quotas remain steady for beluga sturgeon despite threat of extinction
9. River delta areas can provide clue to environmental changes, Texas A&M prof says
10. River delta areas can provide clue to environmental changes, Texas A&M prof says
11. Aboriginal hunting and burning increase Australias desert biodiversity, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... BOSTON, Mass , March 23, 2015 SoundView ... shipment of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView ... world user feedback on their experience with the Wocket in ... experience at CVS, Whole Foods and other retailers, making both ... Kris Tuttle also says, "If the company meets ...
(Date:3/20/2015)... DUBLIN , Mar. 20, 2015 Research ... announced the addition of the "India Sensors ... their offering. The sensor market is ... through 2020 Consumer electronics, automotive, industrial ... for sensors in the country. In addition, adoption ...
(Date:3/19/2015)... Conn. , March 19, 2015  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, announces ... in a news clip that aired this week on ... ) . In a segment "The Next Great ... wallet ,a new way to pay, and ,a really big ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3
... Although the human brain is skilled at facial recognition ... suggests that the brain may not have developed a ... same kind of pattern recognition techniques to distinguish between ... other groups of objects, such as plants, animals and ...
... of our genetic code that may soon be as important ... is concerned with, not how genes work, but how small ... degree to "turn on." As part of this effort, researchers ... vast human DNA code to reveal for the first time ...
... that could help control an invasive mollusk that has ... pipes, virtually wiping out some native mussels species and ... microcapsules, which contain toxins that dissolve within a zebra ... of eliminating one of the world's "most important economic ...
Cached Biology News:Is the brain wired for faces? 2Is the brain wired for faces? 3Study finds 60 new genes controlled by DNA snippet 2Study finds 60 new genes controlled by DNA snippet 3Study finds 60 new genes controlled by DNA snippet 4Study finds 60 new genes controlled by DNA snippet 5'Biobullets' fight harmful mussels 2
(Date:3/25/2015)... The surging prevalence of internet use ... media growth, with over 50% of the world’s ... Insurance companies are making use of social media ... a diversity of their services and products. , ... networking services as part of sales and marketing, ...
(Date:3/25/2015)... An increase of awareness related to benefits of ... nutrients, regulatory changes and concerns related to consumer safety ... natural astaxanthin over the past few years. Producers of ... to satisfy the rising demand. , The global ... in nutraceuticals, aqua feed, food and beverages and cosmetics) ...
(Date:3/25/2015)... ST LOUIS and the HAGUE, ... publication of two-year results of LES Stimulation therapy for ... of the journal Surgery [ Surgery ... and efficacy of its minimally-invasive therapy. ... an average duration of 11 years and taking prescribed ...
(Date:3/25/2015)... 25, 2015 Proove Biosciences , ... excited to announce the success of their commercially supported ... to Optimize the Management of Pain, at the ... National Harbor, Maryland on Thursday, March 19th, 2015. ... AAPM President Lynn Webster , M.D., former Florida ...
Breaking Biology Technology:Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3Global Astaxanthin Market to Reach Value of USD 1.1 billion by 2020, Expects Industry Experts in New Report Available at MarketPublishers.com 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 3Proove Biosciences Hosts Symposium on Incorporating Genetic Testing to Optimize the Management of Pain 2
... September 9, 2011 PharmaVentures Limited, ... announce that they have been engaged by leading ... buyer for an established full service CMC (chemistry, ... California. The engagement will utilise PharmaVentures, asset divestment ...
... Va. The discovery that low-intensity, pulsed ultrasound ... circuits holds promise for engineering rapid-response medical devices. ... William "Jamie" Tyler, an assistant professor with the ... an in-depth article detailing this approach, which may ...
... Enterologics, Inc  ( ELGO.OB ) announced today that ... and its subsidiary BioBalance LLC from New York Health ... first probiotic biotherapeutic product, E. coli M17, or Probactrix®. ... Investigational New Drug application (IND) with the ...
Cached Biology Technology:Neuroscientists produce guide for ultrasound use to treat brain disorders in clinical emergencies 2Neuroscientists produce guide for ultrasound use to treat brain disorders in clinical emergencies 3Enterologics Completes Acquisition of BioBalance Corp and Probiotic Product From New York Health Care, Inc 2Enterologics Completes Acquisition of BioBalance Corp and Probiotic Product From New York Health Care, Inc 3Enterologics Completes Acquisition of BioBalance Corp and Probiotic Product From New York Health Care, Inc 4
...
Mouse monoclonal antibody raised against a partial recombinant ZNF155. NCBI Entrez Gene ID = ZNF155...
... are macroporous polystyrene beads for hydrophobic interaction ... for adsorbing organics of molecular weight less ... are useful for the adsorption of nonpolar ... the removal of detergents such as Triton ...
... : Fusion protein corresponding to ... human Mi-2 Formulation: 0.7M Tris-glycine, ... sodium azide, containing 30% glycerol ... immunoblot on Hela nuclear extract ...
Biology Products: