Navigation Links
Delivery of gene-therapy for heart disease boosted 100-fold; now in 100-patient trial
Date:5/16/2012

SAN DIEGO, CA May 16, 2012 Cardium Therapeutics (NYSE Amex: CXM) today announced a late-breaking poster presentation at the American Society of Gene & Cell Therapy (ASGCT) 15th Annual Meeting being held May 16-19, 2012 at the Pennsylvania Convention Center in Philadelphia, PA.

The new research findings demonstrate that cardiac ischemia plays an important role in adenovector gene transfection (delivery) in mammalian hearts. Based on this understanding, using a standard balloon angioplasty catheter, researchers have developed and tested a new method to induce transient ischemia during a non-surgical interventional cardiac procedure, which when coupled with the infusion of nitroglycerin, boosts the delivery (cell transfection) of an adenovector gene construct into heart cells. The increase in adenovector-based gene transfection with the new technique is over two orders of magnitude (>100 fold).

Cardium's new method of adenovector delivery takes advantage of the findings that transient ischemia appears to alter the permeability barrier of the vascular endothelium and may expose the blood to the coxsackie-adenovirus receptor mediating adenovector uptake by the heart. Balloon angioplasty catheters have been used for many years to dilate blocked coronary arteries, sometimes with use of a stent, and these catheters have also been used safely by cardiologists in patients with coronary artery disease to study the effects of brief ischemia. Cardium's new technique inflates the balloon in non-narrowed areas, and only enough to briefly interrupt flow using inflation pressure that is less than that used for performing angioplasty.

Cardium's recently initiated Russian-based ASPIRE Phase 3 / registration clinical study uses transient ischemia techniques during non-surgical percutaneous catheterization with a standard angioplasty catheter together with the intracoronary infusion of nitroglycerin with the Generx [Ad5FGF-4] product candidate
'/>"/>

Contact: Rex Graham
ragraham@sandiegobiotechnology.com
858-232-2706
San Diego Biotechnology Connection
Source:Eurekalert  

Page: 1 2

Related biology news :

1. ID Solutions Achieves Full-Production Delivery and Payment for Fingerprint Processing Software for TWIC
2. RNA molecules, delivery system improve vaccine responses, effectiveness
3. Depression during pregnancy can double risk of preterm delivery
4. Nanotechnology holds promise for STD drug delivery
5. Striata and CIC Launch Integrated eSignature, eDelivery, and eBilling for the Financial Services Industry
6. Striata and CIC Launch Integrated eSignature, eDelivery, and eBilling for the Financial Services Industry
7. New cancer drug delivery system is effective and reversible
8. UCSB scientists discover potential drug delivery system
9. U-Iowa improves delivery of cancer-fighting molecules
10. Encap agrees colonic drug delivery licensing deal
11. University of Iowa scientists use blood-brain barrier as therapy delivery system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Delivery of gene-therapy for heart disease boosted 100-fold; now in 100-patient trial
(Date:7/2/2015)... 2015 Research and ... the "Natural Language Processing Market by Type ... Pattern & Image Recognition) - Worldwide Forecast to ... The key vendors occupying the market are 3M, ... Corporation, NetBase Solutions, SAS Institute Inc., Verint Systems ...
(Date:7/2/2015)... , June 25, 2015 ... of the "Next Generation Biometrics Market by Application, ... report to their offering. The next ... by 2020, at a CAGR of 17.9% between 2015 ... leading application for the market. Safran SA ...
(Date:7/2/2015)... Sweden , July 2, 2015 ... sensors FPC1025, FPC1035, FPC1145 and FPC1155 from the distributor World ... one of FPC,s distributors in Asia . ... 2015. The sensors will be used by smartphone manufacturers in ... MSEK is included in the communicated revenue guidance of approximately ...
Breaking Biology News(10 mins):Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... Orangutans threatened with extinction could be brought back from ... Technology (QUT) statistician. Professor Kerrie Mengersen, from the ... to guide efforts for saving the Indonesian primate whose ... said the study had found a quarter of villagers ...
... Ore. An international group of scientists from the ... collaborating on a fascinating new climate modeling initiative ... create a network of digital power that surpasses that ... initial effort in 2003 and its "climateprediction.net" project has ...
... and neck cancer who have never smoked have much better ... of smoking, new research from UC Davis Cancer Center ... colleagues in the UC Davis radiation oncology and otolaryngology departments ... differences based on smoking history in patients with head and ...
Cached Biology News:Orangutans count on stats for survival 2OSU, Oxford, others launch citizen scientist climate modeling initiative 2OSU, Oxford, others launch citizen scientist climate modeling initiative 3Never-smokers fare far better than smokers after radiation therapy for head and neck cancer 2
(Date:7/3/2015)... Texas (PRWEB) , ... July ... ... biotechnology company providing industry-leading products for use in applications such as animal ... in wastewater treatment plants and restaurant kitchen settings, announced today that it ...
(Date:7/3/2015)... July 3, 2015 ... verkossa osoitteessa  http://www.openinnovationinscience.at Wienissä ... in Science" -jatkokoulutusohjelmaan 22.7.2015 asti.  ... (LBG) tekemän, kansainvälisiä tutkijoita ja ... kaksi suurinta haastetta ovat kannustimien ...
(Date:7/3/2015)... ... July 03, 2015 , ... The Alexander ... and professional service industries alike-- typically known for its consummate professionalism-- embarks each ... good cause and break from their day jobs. , "Our motto has always ...
(Date:7/3/2015)... ... ... global failure analysis market is expected to reach $7,147.0 million by 2020, at a ... at the highest CAGR of 8.46%; its growth is expected to be driven by ... for root cause analysis of failure. The market based on the geographic regions has ...
Breaking Biology Technology:DryLet to Highlight Benefits of Patented ManureMagic™ at North American Manure Expo in Chambersburg, PA July 14-15, 2015 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 3The Alexander Group Declares Their Independence with a Bit of Levity 2Failure Analysis Market to Grow at 7.52% CAGR to 2020 2Failure Analysis Market to Grow at 7.52% CAGR to 2020 3Failure Analysis Market to Grow at 7.52% CAGR to 2020 4Failure Analysis Market to Grow at 7.52% CAGR to 2020 5
... July 9 Human Genome Sciences, Inc. (Nasdaq: ... New England Journal of Medicine of the ... life-saving potential of the Company,s human monoclonal antibody drug raxibacumab ... which supported the use of raxibacumab in the event of ...
... gene that is essential for embryonic stem cells to ... may lead to a greater understanding of how cells ... efficiently reprogram mature cells back into the pluripotent state, ... crucial to a range of potential clinical treatments. ...
... July 8 Intellikine, Inc., a leader in the ... of cancer, inflammation and autoimmune diseases, announced today that ... Novartis Bioventures Ltd. led the financing in which ... FinTech Global Capital participated. Markus Goebel, M.D., Ph.D., ...
Cached Biology Technology:Data Published in The New England Journal of Medicine Support Use of Raxibacumab (ABthrax(TM)) for the Treatment of Inhalation Anthrax 2Data Published in The New England Journal of Medicine Support Use of Raxibacumab (ABthrax(TM)) for the Treatment of Inhalation Anthrax 3Data Published in The New England Journal of Medicine Support Use of Raxibacumab (ABthrax(TM)) for the Treatment of Inhalation Anthrax 4Data Published in The New England Journal of Medicine Support Use of Raxibacumab (ABthrax(TM)) for the Treatment of Inhalation Anthrax 5Stem cells' 'suspended' state preserved by key step, scientists report 2Stem cells' 'suspended' state preserved by key step, scientists report 3Intellikine Completes $51 Million Financing 2