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Delivering drugs to the brain: New research into targeted treatment of Alzheimer's
Date:12/7/2010

lthy organs or systems and reduce side effects. It could also open up the opportunity for entirely new drugs, according to Karande.

"What is beneficial to the brain may in fact be toxic to other organs within the body," he said. "We could target just the brain with these techniques." Such targeted treatment might also allow pharmaceutical companies to reinvestigate drugs that were dropped during the drug discovery process due to toxicity to the rest of the body.

Karande will begin his research by using high-throughput cell cultures to study how different chemicals change the structure of the Velcro-like interfaces within cells. He will also continue his investigation of how different natural molecules such as the Herpes virus and bacterial toxins cross the blood-brain barrier.


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Contact: Gabrielle DeMarco
demarg@rpi.edu
518-956-0701
Rensselaer Polytechnic Institute
Source:Eurekalert

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