Navigation Links
Delivering drugs to the brain: New research into targeted treatment of Alzheimer's
Date:12/7/2010

opening these pathways into the brain can be found within the natural world. He will utilize this new research funding to investigate how certain natural pathogens cross the blood-brain barrier, and how he can develop synthetic small molecules that mimic the same blood-brain breech.

The end goal of the research is to develop small molecules that act as "chemical wedges," which "sit" on the Velcro junction points within the brain's blood vessels to prevent them from closing and gently allowing drugs to move through the system. His research seeks to develop a chemical method to open the blood-brain barrier that is gentle, but also quickly reversible.

The new technique would not be without risk, but the payoff of such a therapy would be broad, according to Karande.

"The most important challenge is going to be how we control this," he said. "We want to gently open the junctions in the brain, allow them to stay open for a short period of time during the delivery of a drug, and then reseal before any other potentially harmful materials can cross the barrier."

The result would be a much more targeted delivery of drugs to the brain. Currently, some of the most widely administered drugs used for people with brain illness do cross the blood-brain barrier, but only when large concentrations of chemicals are administered into the body to ensure that just a small fraction of the drug will bypass the tight blood-brain barrier. An example of this is the common Parkinson's drug L-DOPA, which is used to successfully treat thousands of people, but at the cost of substantial side effects due to the significant levels of the drug required to make it into the brain, according to Karande. He hopes his research success will allow drugs like L-DOPA and others to be more efficiently used within the body.

"We want to saturate the brain with a drug treatment," he said. Such saturation in the brain would reduce the presence of the drug in other hea
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-956-0701
Rensselaer Polytechnic Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Molecules delivering drugs as they walk
2. Conserving nature and dollars: Delivering cost-effective biodiversity protection
3. Study shows that delivering stem cells improves repair of major bone injuries in rats
4. Delivering medicine directly into a tumor
5. Synthetic cells shed biological insights while delivering battery power
6. Preventing ear infections in the future: Delivering vaccine through the skin
7. HIV drugs interfere with blood sugar, lead to insulin resistance
8. Multiple sclerosis drug serves as model for potential drugs to treat botulism poisoning
9. Scientists learn more about how kidneys fail and how new drugs may intervene
10. Drugstore of the future -- new drugs from an old source
11. Video-game technology may speed development of new drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 15, 2015  BellBrook Labs, a leader in high ... launch of a TR-FRET (time resolved Forster resonance ... Assay, a high throughput screening assay for glycosyltransferases ... allow for sensitive detection of hundreds of human ...
(Date:1/22/2015)... OXFORD, Conn. , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: ... growing mobile commerce market, reports on the recent success of the Wocket™ ... Wocket smart wallet was named as one of the ... of the "5 Best Products Launched At CES So Far" by Newseveryday.com ...
(Date:1/22/2015)...  Analyst Report Issued by Small Cap IR. In 2011, Nilson ... transactions at merchants on the leading payment cards rose to ... debit, and prepaid cards reached 6.54 billion.  Eight million credit ... usage in 2012, and credit and debit card fraud resulted ...
Breaking Biology News(10 mins):BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2
... the future will be "soft". , "If I think of ... tentacles of an octopus or the trunk of an elephant ... inner workings of a watch. And if I think of ... The robots of the future will be increasingly like biological ...
... by Centennial Chair Professor of the Department of Chemical ... of an innovative DNA engineering technique to discover potentially ... was reported in a Nature Communications article ... of every bacterial species contains genes that can synthesize ...
... Bahamas spanning almost two decades shows that female lemon sharks ... birth to their own young, confirming this behavior for the ... has resulted in the capture, tagging, and release of more ... This article, published online on December 5 in the ...
Cached Biology News:'Soft' (and miniaturized) robots 2New method of DNA editing allows synthetic biologists to unlock secrets of a bacterial genome 2New method of DNA editing allows synthetic biologists to unlock secrets of a bacterial genome 3New finding shows that mother sharks 'home' to their birthplace to give birth, like salmon and sea turtles 2New finding shows that mother sharks 'home' to their birthplace to give birth, like salmon and sea turtles 3
(Date:3/5/2015)... , Mar. 05, 2015 Research and Markets ... the "Mature Biotech Outlook 2015: New Therapy Ventures ... offering. All biotech companies - Gilead ... in past year, have given a positive return and ... have been able to select therapy/niche indication where the ...
(Date:3/4/2015)... PDL BioPharma, Inc. (PDL) (NASDAQ: PDLI ) today ... , 3.75% Convertible Senior Notes due May 1, 2015 (May ... principal amount or approximately $5.72 per share, effective March 3, 2015. ... adjusted in connection with the regular quarterly dividend of $0.15 ... own shares of PDL on March 5, 2015, the record date. ...
(Date:3/4/2015)... , Mar. 04, 2015 Research and ... the addition of Jain PharmaBiotech,s new report ... their offering. This report follows ... characteristic that can be objectively measured and evaluated ... processes as well as pharmacological responses to a ...
(Date:3/4/2015)... , March 4, 2015 AcelRx Pharmaceuticals, ... pharmaceutical company focused on the development and commercialization ... and breakthrough pain, today announced that it will ... after market close on Monday, March 9th, 2015. ... at 4:30 p.m. Eastern Time (1:30 p.m. Pacific ...
Breaking Biology Technology:Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 2Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 3PDL BioPharma Announces Conversion Rate Adjustment for Convertible Note 2Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 2Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 3AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 3
... 2009 Senomyx, Inc. (Nasdaq: SNMX ), ... discover and develop novel flavor ingredients for the food, ... SA has selected a new flavor ingredient, which was ... for development activities and evaluation of commercial potential in ...
... -- American Oriental,Bioengineering, Inc. (NYSE: AOB ), ... manufacture and commercialization of,a broad range of prescription and ... Company,s participation in the following conferences: , , ... May 6-8 at the Ritz Carlton in, ...
... Breakthrough biotechnology research is providing new applications ... and diabetes, two leading health concerns among consumers. ... Advana Science, www.advanascience.com , will ... this dynamic consumer healthy category at VitaFoods International ...
Cached Biology Technology:SENOMYX ANNOUNCES NESTLE'S SELECTION OF A NEW FLAVOR INGREDIENT FOR EVALUATION OF COMMERCIAL POTENTIAL 2SENOMYX ANNOUNCES NESTLE'S SELECTION OF A NEW FLAVOR INGREDIENT FOR EVALUATION OF COMMERCIAL POTENTIAL 3Industry Expert Reveals Cutting Edge Biotechnology Science for Nutraceutical and Functional Food Applications 2
Rabbit polyclonal to Quinaldic Acid ( Abpromise for all tested applications). Antigen: Synthetic peptide Quinaldic Acid conjugated to a protein carrier....
... c-Jun N-terminal kinase (JNK) is one of ... luciferase has been used as a sensitive ... Luciferase provides a 1000-fold increase in sensitivity ... (CAT) assay. Firefly luciferase catalyzes the oxidative ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ID ...
Biology Products: