Navigation Links
Delivering drugs to the brain: New research into targeted treatment of Alzheimer's
Date:12/7/2010

Troy, N.Y. Pankaj Karande, a Rensselaer Polytechnic Institute assistant professor of chemical and biological engineering, is among a new generation of scientists and engineers developing exciting and novel new techniques to treat some of the most complex brain illnesses, including Alzheimer's disease, Parkinson's disease, traumatic brain injury, and brain cancer. His research has already attracted the interest of the Goldhirsh Foundation and now has garnered the support of the Alzheimer's Association with an additional $80,000 in research funding.

Karande's research seeks to open the natural and protective barriers that exist in the brain to allow for the targeted delivery of drugs into the brain. Such drug delivery systems could limit the side effects experienced by patients using existing drugs to treat brain illness, increase the effectiveness of current drug treatments, lead to the development of new drugs, and even allow drugs that previously failed in clinical trials to be reconsidered utilizing new delivery methods.

"You can have the best and most promising of drugs, but if it doesn't go where it is needed, then it won't be effective," Karande said. "There are a lot of new discoveries within the area of drug development, even related to treatment of Alzheimer's. There is not a drug discovery problem; drug delivery is really the challenge."

The problem with delivering drugs to the brain is that the brain is exceptionally good at keeping out foreign substances. The main obstacle to entry is called the blood-brain barrier. Blood vessels within the brain are lined with "Velcro-like" cells that interlock so tightly that very little is allowed to pass through into the system.

But entry is not impossible, according to Karande. "There are more blood vessels in the brain than anywhere else in the body. The supply lines are there, we simply need to understand how to open them."

Karande's hypothesis is that the key to
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-956-0701
Rensselaer Polytechnic Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Molecules delivering drugs as they walk
2. Conserving nature and dollars: Delivering cost-effective biodiversity protection
3. Study shows that delivering stem cells improves repair of major bone injuries in rats
4. Delivering medicine directly into a tumor
5. Synthetic cells shed biological insights while delivering battery power
6. Preventing ear infections in the future: Delivering vaccine through the skin
7. HIV drugs interfere with blood sugar, lead to insulin resistance
8. Multiple sclerosis drug serves as model for potential drugs to treat botulism poisoning
9. Scientists learn more about how kidneys fail and how new drugs may intervene
10. Drugstore of the future -- new drugs from an old source
11. Video-game technology may speed development of new drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... standards process, will be available soon and will improve ... in the OnlineFirst version of Nutrition in Clinical ... the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), ... misconnection that can be harmful and even fatal to ... medical devices, components, and accessories to deliver fluids or ...
(Date:8/20/2014)... a John and Rebecca Moores Professor of Biology and Biochemistry ... in the International Society for the Study of the Origin ... members two from the U.S., one from France and ... are elected every three years, and 36 have been named ... 20 countries, the ISSOL includes researchers from disciplines as varied ...
(Date:8/20/2014)... the University of Tbingen, Arizona State University, the Wellcome ... Health Institute (Swiss TPH) isolated Mycobacterium pinnipedii ... 1000 years old. The pathogen is a relative of ... causes disease in humans today. These researchers assume that ... coast. "The link to sea lions was unexpected" comments ...
Breaking Biology News(10 mins):New feeding tube connectors will improve patient safety 2UH professor named fellow by International Astrobiology Society 2
... the battle of the sexes, African electric fish couples ... also engage in a sort of dueling "electric duet." ... and behavioral displays in breeding and nonbreeding Brienomyrus brachyistius, ... electric fields from a batterylike organ in their tails ...
... brain consists of billions of nerve cells enabling to ... experience, touch, smell or fear, millions of neurons in ... each other by chemical and electrical impulses to compute ... regions. With 20,000 - 25,000 genes in our genome, ...
... Board: NRGX) today announced the publication in the June 23 ... the first ever gene therapy trial for Parkinson’s disease and ... own brain cells for any adult neurodegenerative disease. , ... with advanced Parkinson’s disease demonstrated both a lack of adverse ...
Cached Biology News:Turn-ons and turn-offs for neurons 2Gene therapy study shows safety and statistically significant improvement in Parkinson's disease 2Gene therapy study shows safety and statistically significant improvement in Parkinson's disease 3Gene therapy study shows safety and statistically significant improvement in Parkinson's disease 4
(Date:8/21/2014)... (PRWEB) August 21, 2014 Ontotext ... today by Ontotext . Now the same ... analysis of structured and unstructured data is available to ... cost of enterprise technology. Organizations that do not have ... data management can use S4 since there is no ...
(Date:8/21/2014)... 2014 On Wednesday of last week RENU ... Redox Signaling molecules, became available for purchase in Australia and ... way that RENU 28 works is, if you think about ... the rate of cellular renewal within your body. If you ... that rate of cellular renewal. What RENU 28 does is ...
(Date:8/20/2014)... American Indians largely were wiped out by diseases such ... to the New World by European explorers., One report ... in the Americas shortly before Europeans arrived, and roughly ... But new research led by anthropological geneticists Anne Stone ... University of Tubingen in Germany indicates the diagnosis of ...
(Date:8/20/2014)... 20, 2014 High performance computing ... the most complete climate and Earth system model ... change issues. , Eight national laboratories, including ... National Center for Atmospheric Research, four academic institutions ... Other participating national laboratories include Argonne, Brookhaven, Lawrence ...
Breaking Biology Technology:Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4RENU 28 Skin Care Now Available in Australia and New Zealand 2Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3
... Seahorse Bioscience, Inc., the leader in the design and ... In Vitro Technologies Pty Ltd as the new distributor ... New Zealand. Seahorse Extracellular Flux Analyzers ... the two major energy producing pathways - mitochondrial respiration ...
... Serono, Inc., an affiliate of Merck KGaA, Darmstadt, ... response letter (CRL) from the U.S. Food and ... (NDA) for Cladribine Tablets, EMD Serono,s proprietary investigational ... relapsing-remitting multiple sclerosis (MS). (Logo: ...
... very sharp object has put Canadian researchers at the National ... Guinness Book of World Records. Only one atom at ... the sharpest man-made object. It is made of Tungsten ... currently being evaluated for its commercial potential., "We did not ...
Cached Biology Technology:Seahorse Bioscience, Inc. Appoints In Vitro Technologies Pty Ltd as New Distributor in Australia and New Zealand 2EMD Serono Receives Complete Response Letter From FDA on Cladribine Tablets New Drug Application 2EMD Serono Receives Complete Response Letter From FDA on Cladribine Tablets New Drug Application 3EMD Serono Receives Complete Response Letter From FDA on Cladribine Tablets New Drug Application 4
Anti-human L-Ficolin, Clone GN4, Monoclonal Antibody...
CD45/CD34 combination 50 tests...
WASF2 Immunogen: WASF2 (NP_008921, 73 a.a. ~ 173 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Rabbit polyclonal to Lck (phospho Y192) ( Abpromise for all tested applications). entrezGeneID: 3932 SwissProtID: P06239...
Biology Products: