Navigation Links
Delivering drugs to the brain: New research into targeted treatment of Alzheimer's
Date:12/7/2010

Troy, N.Y. Pankaj Karande, a Rensselaer Polytechnic Institute assistant professor of chemical and biological engineering, is among a new generation of scientists and engineers developing exciting and novel new techniques to treat some of the most complex brain illnesses, including Alzheimer's disease, Parkinson's disease, traumatic brain injury, and brain cancer. His research has already attracted the interest of the Goldhirsh Foundation and now has garnered the support of the Alzheimer's Association with an additional $80,000 in research funding.

Karande's research seeks to open the natural and protective barriers that exist in the brain to allow for the targeted delivery of drugs into the brain. Such drug delivery systems could limit the side effects experienced by patients using existing drugs to treat brain illness, increase the effectiveness of current drug treatments, lead to the development of new drugs, and even allow drugs that previously failed in clinical trials to be reconsidered utilizing new delivery methods.

"You can have the best and most promising of drugs, but if it doesn't go where it is needed, then it won't be effective," Karande said. "There are a lot of new discoveries within the area of drug development, even related to treatment of Alzheimer's. There is not a drug discovery problem; drug delivery is really the challenge."

The problem with delivering drugs to the brain is that the brain is exceptionally good at keeping out foreign substances. The main obstacle to entry is called the blood-brain barrier. Blood vessels within the brain are lined with "Velcro-like" cells that interlock so tightly that very little is allowed to pass through into the system.

But entry is not impossible, according to Karande. "There are more blood vessels in the brain than anywhere else in the body. The supply lines are there, we simply need to understand how to open them."

Karande's hypothesis is that the key to
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-956-0701
Rensselaer Polytechnic Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Molecules delivering drugs as they walk
2. Conserving nature and dollars: Delivering cost-effective biodiversity protection
3. Study shows that delivering stem cells improves repair of major bone injuries in rats
4. Delivering medicine directly into a tumor
5. Synthetic cells shed biological insights while delivering battery power
6. Preventing ear infections in the future: Delivering vaccine through the skin
7. HIV drugs interfere with blood sugar, lead to insulin resistance
8. Multiple sclerosis drug serves as model for potential drugs to treat botulism poisoning
9. Scientists learn more about how kidneys fail and how new drugs may intervene
10. Drugstore of the future -- new drugs from an old source
11. Video-game technology may speed development of new drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... by academics in the University of Bristol,s Nutrition and ... liquid calories into account when planning meals. , The ... Study of Ingestive Behavior Conference (SSIB 2014) in Seattle, ... that we do. , The team was led by ... of Experimental Psychology. , As part of a Biotechnology ...
(Date:7/29/2014)... warms and sea ice retreats, the North is changing. ... open water which is predicted to extend across the ... Storms thus have the potential to create Arctic swell ... unpredictable element to the region. , A University of Washington ... middle of the Arctic Ocean, and detected house-sized waves ...
(Date:7/29/2014)... at a restaurant, don,t blame yourself; blame the menu. ... you want and more to do with a menu,s layout ... of over 300 diners, the Cornell study published this month ... that when it comes to what you order for dinner, ... and how you imagine it will taste. , First, any ...
Breaking Biology News(10 mins):Huge waves measured for first time in Arctic Ocean 2Huge waves measured for first time in Arctic Ocean 3Menu secrets that can make you slim by design 2
... Geneva and Lausanne, as well as the Swiss Institute ... project to sequence the bovine (cow) genome, a female ... is now complete, paving the way for research into ... of an increasing world population. The genome provides a ...
... world are alive because of him. His 40 ... use of life-saving devices such as prosthetic heart valves, ... systems almost commonplace. In the process, he has ... John Brash, P.Eng., director of the School of Biomedical ...
... The circadian clock coordinates physiological and behavioral processes on ... their environment and prepare accordingly. Scientists already know that ... turned on only one time during each 24-hour cycle. ... Medicine and the Salk Institute for Biological Studies found ...
Cached Biology News:Sequencing the cow's genetic code -- a new agricultural era dawns 2Canadian biomedical engineering pioneer receives international award 2A biological basis for the 8-hour workday? 2A biological basis for the 8-hour workday? 3
(Date:7/30/2014)... While administrative claims and other ... for a relatively long period of time, there ... use of these ‘big data’ for comparisons of ... today’s powerful computer technology with the plethora of ... holds significant promise for identifying optimal interventions for ...
(Date:7/30/2014)... , July 30, 2014   Wyle ... Fully Integrated Lifecycle Mission Support Services (FILMSS) contract ... (NASA). Under the terms of the contract, Wyle ... at Moffett Field, Calif. In particular, Wyle will ... flight development projects on the International Space Station ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 BCC Research ... Global Markets for Enzymes in Industrial Applications , the ... to nearly $7.1 billion by 2018, registering a five-year ... is estimated to be recorded in the detergent enzyme ... period. , Enzyme technology has influenced almost every sector ...
(Date:7/30/2014)... SAN DIEGO , July 30, 2014  Orexigen ... it has received the Day 180 List of Outstanding ... Medicinal Products for Human Use (CHMP) for the NB32 ... / bupropion SR) is an investigational drug candidate being ... of the earlier Day 120 time point were adequately ...
Breaking Biology Technology:Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks 2Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 3Orexigen Receives CHMP Day 180 List of Outstanding Issues 2Orexigen Receives CHMP Day 180 List of Outstanding Issues 3
... Contributed by John M. Sedivy, Department of Molecular Biophysics and,Biochemistry, ... , Introduction , ... kilobases in size. The need , to rapidly ... acute in conjunction with the Human Genome Project. Cosmid vectors are , ...
... , The Trans-Blot SD ... SD semi-dry electrophoretic transfer cell, allows blotting of DNA/RNA , ... pretreatments. , The Trans- Blot SD semi-dry electrophoretic ... (V/cm 2 ) which facilitates rapid transfers. The blotting , ...
... Genomic DNA Isolation Kit , Catalog #732-6340 , ... , Method , ... tissue (finely ground) or 6001,200 mg frozen , tissue (which may be ... 6001,200 mg fresh tissue to a 50 ml tube. Work quickly , ...
Cached Biology Technology:Efficient Cloning and Electro-transformation of Large Eukaryotic DNA Fragments 2Efficient Cloning and Electro-transformation of Large Eukaryotic DNA Fragments 3Efficient Cloning and Electro-transformation of Large Eukaryotic DNA Fragments 4Efficient Cloning and Electro-transformation of Large Eukaryotic DNA Fragments 5DNA/RNA Blotting With the Trans-Blot SD Semi-Dry Electrophoretic Transfer Cell 2DNA Isolation From 300 to 450 mg Dried or 600 to 1,200 mg Fresh Leaf Tissue 2
... The Luminex 100 IS System is ... using Upstate's Beadlyte reagents. This system contains ... software developed by Luminex. The user can ... multiplex kits. The system has fully integrated ...
Polyclonal Antibody to HADHB...
3T3 cells (RSV-transformed) Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
... Mutation Explorer processes up to 48 ... traces. Data input can be from either ... terminator or primer chemistries. The detection parameters ... analyst to analyst consistency. We have ...
Biology Products: