Navigation Links
Delivering drugs to the brain: New research into targeted treatment of Alzheimer's
Date:12/7/2010

Troy, N.Y. Pankaj Karande, a Rensselaer Polytechnic Institute assistant professor of chemical and biological engineering, is among a new generation of scientists and engineers developing exciting and novel new techniques to treat some of the most complex brain illnesses, including Alzheimer's disease, Parkinson's disease, traumatic brain injury, and brain cancer. His research has already attracted the interest of the Goldhirsh Foundation and now has garnered the support of the Alzheimer's Association with an additional $80,000 in research funding.

Karande's research seeks to open the natural and protective barriers that exist in the brain to allow for the targeted delivery of drugs into the brain. Such drug delivery systems could limit the side effects experienced by patients using existing drugs to treat brain illness, increase the effectiveness of current drug treatments, lead to the development of new drugs, and even allow drugs that previously failed in clinical trials to be reconsidered utilizing new delivery methods.

"You can have the best and most promising of drugs, but if it doesn't go where it is needed, then it won't be effective," Karande said. "There are a lot of new discoveries within the area of drug development, even related to treatment of Alzheimer's. There is not a drug discovery problem; drug delivery is really the challenge."

The problem with delivering drugs to the brain is that the brain is exceptionally good at keeping out foreign substances. The main obstacle to entry is called the blood-brain barrier. Blood vessels within the brain are lined with "Velcro-like" cells that interlock so tightly that very little is allowed to pass through into the system.

But entry is not impossible, according to Karande. "There are more blood vessels in the brain than anywhere else in the body. The supply lines are there, we simply need to understand how to open them."

Karande's hypothesis is that the key to
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-956-0701
Rensselaer Polytechnic Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Molecules delivering drugs as they walk
2. Conserving nature and dollars: Delivering cost-effective biodiversity protection
3. Study shows that delivering stem cells improves repair of major bone injuries in rats
4. Delivering medicine directly into a tumor
5. Synthetic cells shed biological insights while delivering battery power
6. Preventing ear infections in the future: Delivering vaccine through the skin
7. HIV drugs interfere with blood sugar, lead to insulin resistance
8. Multiple sclerosis drug serves as model for potential drugs to treat botulism poisoning
9. Scientists learn more about how kidneys fail and how new drugs may intervene
10. Drugstore of the future -- new drugs from an old source
11. Video-game technology may speed development of new drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2014)...  While we may still be a few years away ... Trek" to gain instant access to all that ailed his ... and tablets for monitoring and measuring our health are cropping ... seem a tad Orwellian to some, but a new survey ... technological opportunities into their healthcare regime. These are ...
(Date:11/11/2014)... -- Forensicon, Inc., a Chicago -based digital ... promotion of Yaniv Schiff from Senior Computer ... new role as Director, he will lead company efforts ... and provide leadership within the company,s digital forensics practice ... Schiff joined Forensicon in 2006 and ...
(Date:11/7/2014)... led by Dr. Debra Auguste, associate professor, biomedical ... The City College of New York, have identified ... for one of the most aggressive forms of ... have a high mortality rate owing to aggressive ... therapeutic options. However, Professor Auguste,s team, discovered the ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
... COLLEGE STATION The U.S. Department of Energy has granted more ... fuel source. And if that succeeds within 18 months, almost $2 million ... fast-growing grass species. , ... our country is the leader around the world in terms of energy ...
... fishermen would not give up their livelihood in the face ... University of East Anglia (UEA). A new report, published ... about poverty and adaptation by investigating why fishermen in developing ... Daw from UEA,s School of International Development and the Stockholm ...
... 2012 Aware, Inc. (NASDAQ: AWRE ), a ... today reported financial results for its fourth quarter and year ... fourth quarter of 2011 was $5.9 million, a decrease of ... year. Net income for the fourth quarter of 2011 was ...
Cached Biology News:US Energy Department grants $1.87 million for plant fuel project 2University of East Anglia research reveals why fishermen keep fishing despite dwindling catches 2University of East Anglia research reveals why fishermen keep fishing despite dwindling catches 3Aware, Inc. Reports Fourth Quarter and 2011 Financial Results 2Aware, Inc. Reports Fourth Quarter and 2011 Financial Results 3Aware, Inc. Reports Fourth Quarter and 2011 Financial Results 4Aware, Inc. Reports Fourth Quarter and 2011 Financial Results 5
(Date:11/24/2014)... , Nov. 24, 2014  Spherix Incorporated ... company committed to the fostering and monetization of ... v. VTech Telecommunications Ltd.,  Case No. 3:13-cv-03494-M and  ... No. 3:13-cv-03496-M, both in the United States District ... Texas . On November ...
(Date:11/22/2014)... 2014 Prominent academics, leaders of ... on December 3rd at Genetic Rx, a networking ... will take place at the Joseph B. Martin ... discuss the present and future of genetic medicines—including ... gene editing—as well as the treatment of patients ...
(Date:11/22/2014)... MI (PRWEB) November 22, 2014 ... to simulate the proper management of life-like respiratory ... test lung devices . Grand Rapids-based, Michigan Instruments ... to donate two of the respiratory simulation units ... $15,000 each. Grand Valley and Muskegon Community College ...
(Date:11/21/2014)... USA (PRWEB) November 19, 2014 The ... our lives was shared with more than 200 primary ... postgraduate students from the University of Otago Physics Department ... . The Otago students, members of the university’s OSA/SPIE ... Zealand in early September, giving children from small, rural ...
Breaking Biology Technology:Markman Hearing Held as Scheduled in VTech and Uniden Cases 2Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3
... BETHESDA, Md., Sept. 16 American Capital Ltd. ... 15, it completed the sale of its portfolio company Axygen ... Inc., to Corning Incorporated for approximately $400 million. The ... fee income, from the equity invested by American Capital,s affiliated ...
... , , COLUMBIA, Md., Sept. 16 Martek ... David M. Pernock to its Board of Directors. , ... extensive background in the commercialization of pharmaceutical products, having served from ... (GSK), one of the world,s leading healthcare companies. In his most ...
... HEIDELBERG, Germany, September 16 , ... Drug Targets in Wnt Pathway , ... antagonizes Wnt signalling"** is now available online in,Nature. , ... proteomics,platform was used to identify a small molecule which plays ...
Cached Biology Technology:American Capital Receives $182 Million In Proceeds From Sale of Axygen Bioscience 2American Capital Receives $182 Million In Proceeds From Sale of Axygen Bioscience 3American Capital Receives $182 Million In Proceeds From Sale of Axygen Bioscience 4Martek Announces Addition to Its Board of Directors 2Cellzome Technology Used to Unravel Novel Regulatory Mechanism in Cancer Signaling Pathway 2
... Low Speed Shaker ,Product Information ... shaker is a high quality, general purpose shaker ... after the other models in the line, the ... easy-access control panel. Electronic controls are utilized for ...
This modular benchtop laminar flow hood forces air through a 99.99% efficient HEPA filter to create a clean processing area. Options include a work bench, ionizaing bar, and air velocity gauge....
... Ligands\n\nReceptor-related research has long been enabled by ... selected to keep pace with new discoveries. ... and services for receptor research and drug ... you do not find exactly what you ...
... enables sensitive and specific detection of microRNAs ... probes have high binding affinity and discrimination, ... miRNAs. Due to the high binding affinity ... 1/10 the amount of sample is needed ...
Biology Products: