Navigation Links
Delivering drugs to the brain: New research into targeted treatment of Alzheimer's
Date:12/7/2010

Troy, N.Y. Pankaj Karande, a Rensselaer Polytechnic Institute assistant professor of chemical and biological engineering, is among a new generation of scientists and engineers developing exciting and novel new techniques to treat some of the most complex brain illnesses, including Alzheimer's disease, Parkinson's disease, traumatic brain injury, and brain cancer. His research has already attracted the interest of the Goldhirsh Foundation and now has garnered the support of the Alzheimer's Association with an additional $80,000 in research funding.

Karande's research seeks to open the natural and protective barriers that exist in the brain to allow for the targeted delivery of drugs into the brain. Such drug delivery systems could limit the side effects experienced by patients using existing drugs to treat brain illness, increase the effectiveness of current drug treatments, lead to the development of new drugs, and even allow drugs that previously failed in clinical trials to be reconsidered utilizing new delivery methods.

"You can have the best and most promising of drugs, but if it doesn't go where it is needed, then it won't be effective," Karande said. "There are a lot of new discoveries within the area of drug development, even related to treatment of Alzheimer's. There is not a drug discovery problem; drug delivery is really the challenge."

The problem with delivering drugs to the brain is that the brain is exceptionally good at keeping out foreign substances. The main obstacle to entry is called the blood-brain barrier. Blood vessels within the brain are lined with "Velcro-like" cells that interlock so tightly that very little is allowed to pass through into the system.

But entry is not impossible, according to Karande. "There are more blood vessels in the brain than anywhere else in the body. The supply lines are there, we simply need to understand how to open them."

Karande's hypothesis is that the key to
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-956-0701
Rensselaer Polytechnic Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Molecules delivering drugs as they walk
2. Conserving nature and dollars: Delivering cost-effective biodiversity protection
3. Study shows that delivering stem cells improves repair of major bone injuries in rats
4. Delivering medicine directly into a tumor
5. Synthetic cells shed biological insights while delivering battery power
6. Preventing ear infections in the future: Delivering vaccine through the skin
7. HIV drugs interfere with blood sugar, lead to insulin resistance
8. Multiple sclerosis drug serves as model for potential drugs to treat botulism poisoning
9. Scientists learn more about how kidneys fail and how new drugs may intervene
10. Drugstore of the future -- new drugs from an old source
11. Video-game technology may speed development of new drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 18, 2014   LaunchKey , the first decentralized mobile ... Internet of Things era, today announced the close of ... was led by Metamorphic Ventures with participation from ENIAC ... and others.  LaunchKey has raised $4 million to date, ...
(Date:12/17/2014)... FORT BELVOIR, Va. , Dec. 15, 2014 ... make it easier to detect and prevent counterfeit microcircuits ... the agency started performing an in-house microcircuit anti-counterfeit initiative ... of purchased microcircuits while increasing their reliability throughout the ...
(Date:12/17/2014)... Dec. 16, 2014 Valencell, a leader in performance ... technology to industry leaders such as Intel, Jabra, Atlas, ... biometric wearable products. These products will be showcased at ... Las Vegas . "Our partners ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... , , ... analysis of the automated optical inspection (AOI) equipment market, Frost ... Sullivan Award for Product Innovation of the Year for its ... combines high-speed inspection with superior performance, accuracy, quality, and repeatability. ...
... of a new and environmentally friendly process for producing ... 11 billion pounds of poultry industry waste that accumulate ... scheduled for the July 22 issue of ACS, ... publication. In the study Mano Misra, Susanta Mohapatra, ...
... rather than electromechanical valves, can drive experimental samples through ... University of Michigan. This development could significantly simplify the ... paper on the research will be published online in ... the week of July 20. A ...
Cached Biology News:Frost & Sullivan Recognizes MIRTEC With the 2009 Award for Automated Optical Inspection Product Innovation of the Year 2Frost & Sullivan Recognizes MIRTEC With the 2009 Award for Automated Optical Inspection Product Innovation of the Year 3Music is the engine of new U-M lab-on-a-chip device 2
(Date:1/22/2015)... COLUMBIA, Md. (PRWEB) January 22, 2015 ... of its new UV-1280 multipurpose UV-visible spectrophotometer. Offering ... compact, high-quality instrument is ideal for applications in ... and life science. , The user-friendly UV-1280 enables ...
(Date:1/22/2015)... (PRWEB) January 21, 2015 Cambridge Semantics, the ... technology, today announced that 2014 was a record-breaking year across ... capabilities of the Anzo Smart Data Platform and our Smart ... utilize insights from diverse data which led to record growth ...
(Date:1/22/2015)... California (PRWEB) January 22, 2015 Pipette.com ... Offer to their comprehensive portfolio of Eppendorf products. ... customers to purchase a Centrifuge 5424/5424 R and receive ... of either Eppendorf Research plus or Eppendorf Reference 2 ...
(Date:1/22/2015)... January 22, 2015 Selexis SA, a ... Research Cell Banks (RCBs) used for drug discovery to ... Banks will include Next-Generation Sequencing (NGS) data ... de-risks biologic manufacturing by ensuring the integrity of the ...
Breaking Biology Technology:Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2Cambridge Semantics Announces Record Results for 2014 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2
... Mersana, a cancer therapeutics,company, announced today the appointment ... Board of Directors. Mr. Clarke is a senior ... accomplishment over a,30-year industry career., "It is ... Chairman of our Board,of Directors," said Julie A. ...
... SGP ) today announced that the U.S. ... status to the company,s,New Drug Application (NDA) for ... the effects of certain,muscle relaxants, marketed in the ... Muscle relaxants are used as part of,general anesthesia ...
... Nektar,Therapeutics, (Nasdaq: NKTR ) President and CEO ... upcoming JPMorgan 26th Annual Healthcare,Conference at the Westin St. ... 2008, at 4:30 p.m. Pacific Time., The presentation ... through a link posted on the Investor Relations, Events ...
Cached Biology Technology:Mersana Therapeutics Appoints C. Boyd Clarke Chairman of the Board of Directors 2Schering-Plough Announces New Drug Application for Sugammadex Assigned Priority Review Status by U.S. FDA 2Schering-Plough Announces New Drug Application for Sugammadex Assigned Priority Review Status by U.S. FDA 3Schering-Plough Announces New Drug Application for Sugammadex Assigned Priority Review Status by U.S. FDA 4