Navigation Links
Defining gene's role may lead to prevention of dangerous corn toxin
Date:3/25/2008

WEST LAFAYETTE, Ind. - Discovery that a specific gene is integral to both fungal invasion of corn and development of a potentially deadly toxin in the kernels may lead to ways to control the pathogen and the poison.

Purdue University researchers evaluated the fungal gene ZFR1 and found that it is vital to the process of the fungus growing on corn kernels. Production of the toxin decreased when the scientists disabled the gene.

At certain levels, the toxin can cause illness in humans and most domestic livestock. Horses and pigs are at particular risk and can develop fatal diseases by ingesting feed containing one of a group of toxins called fumonisins (few-mahn-ah-sins). About $40 million of the U.S. corn crop is lost annually due to presence of these toxins, according to experts.

"Our main research question has been what triggers toxin production when the fungus attacks the corn kernel; it appears that kernel starch plays an important role," said Charles Woloshuk, a Purdue plant pathologist. "When ZFR1 is deleted, the resulting mutant fungus has a problem transporting sugars that are produced from the degradation of kernel starch."

The resulting sugars must be transported to cells as fuel for other biochemical processes.

"The pathogen - the fungus Fusarium verticillioides - has a number of putative sugar transporter genes that are expressed during its growth on kernels and toxin production," Woloshuk said. "Disruption of ZFR1 also affects expression of the sugar transporter genes."

Woloshuk and his colleague, Bert Bluhm, now at the University of Arkansas, report in the current issue of Molecular Plant Pathology that when the gene ZFR1 is turned off, it reduces manifestation of genes involved in production of the most prevalent and dangerous fumonisin, FB1.

The researchers studied ZFR1 regulation of fungal growth and toxin production in the starch-rich areas of corn kernels and the conversion
'/>"/>

Contact: Susan A. Steeves
ssteeves@purdue.edu
765-496-7481
Purdue University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Gene regulation, not just genes, is what sets humans apart
2. Interaction of just 2 genes governs coloration patterns in mice
3. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
4. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
5. Smoking turns on genes -- permanently
6. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
7. Hebrew SeniorLife researchers search for aging, osteoporosis genes
8. UT Southwestern researchers identify hundreds of genes controlling female fertility
9. Genes and environment grant funds close look at nature-nurture overlap in common diseases
10. Jumping genes could make for safer gene delivery system
11. Genes from the father facilitate the formation of new species
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Defining gene's role may lead to prevention of dangerous corn toxin
(Date:8/4/2015)... , Aug. 04, 2015 ... http://www.researchandmarkets.com/research/nvh7k2/digital_forensics ) has announced the addition of ... (Hardware, Software, and Service), Sub-Segment (Computer Forensics, ... Forensics), Tool Types, Service, Vertical and Region ... to their offering. By Component ...
(Date:7/31/2015)... -- Den 10. internationale konference om Genomik (ICG-10, ... 25. oktober i Shenzhen , Kina. ... år. Siden starten i 2006 er ICB blevet en ... er en af de mest dynamiske, entusiastiske og sjove ... gennembrud og fremskridt inden for ,omik,-forskning, som yderligere vil ...
(Date:7/31/2015)... La 10e Conférence internationale sur la ... le BGI du 22 au 25 octobre 2015 ... La conférence célèbre son 10e anniversaire ... est devenue l,une des réunions annuelles mondiales les ... c,est aussi la plus dynamique, la plus enthousiaste ...
Breaking Biology News(10 mins):Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3
... May 9, 2013, New York, NY and San Diego, CA ... Epigenome Roadmap Project has published a sweeping analysis in the ... genes are turned on and off to direct early human ... Cancer Research, Joseph Ecker of The Salk Institute for Biological ...
... WASHINGTON , May 9, 2013 ... a solution that automates forensic   bulk-processing of media ... proven with US Federal agencies to provide an "Order ... of suspects. Allevate Limited and Tygart ...
... The Howard Hughes Medical Institute (HHMI) has announced the ... of HHMI Investigators.The appointment ranks as one of the ... research scientist. Dr. Nudler, the Julie Wilson Anderson Professor ... Pharmacology at NYU Langone Medical Center, was selected among ...
Cached Biology News:Mapping the embryonic epigenome 2Mapping the embryonic epigenome 3Revolutionary Face Recognition Media Exploitation System Now Available to Enhance Public Safety in Europe 2Revolutionary Face Recognition Media Exploitation System Now Available to Enhance Public Safety in Europe 3Revolutionary Face Recognition Media Exploitation System Now Available to Enhance Public Safety in Europe 4NYU Langone Medical Center researcher named Howard Hughes Investigator 2
(Date:9/1/2015)... ... September 01, 2015 , ... ... Confocal High-Content Imaging System. This transformative system fits a broad range of ... such as spheroids, tissues, and organisms. , The ImageXpress Micro Confocal ...
(Date:9/1/2015)... ... September 01, 2015 , ... VetStem Biopharma ... Equine cervical facet joint problems can be caused by injuries and abnormalities of ... of nerve roots or of the spinal cord itself. This can manifest itself ...
(Date:9/1/2015)... ... ... Knowledgent , the data and analytics firm, today announced a new ... the healthcare industry. , As the Internet of Things (IoT) continues to grab headlines ... years as more entities become technology enabled through Electronic Medical Records (EMRs). , With ...
(Date:9/1/2015)... ... September 01, 2015 , ... A new host-based ... researchers at the Keck Graduate Institute and its collaborators. The discovery has the ... were published online on August 27 by Scientific Reports, an open access research ...
Breaking Biology Technology:ImageXpress Micro Confocal High-Content Imaging System Expands the Boundaries of Research 2ImageXpress Micro Confocal High-Content Imaging System Expands the Boundaries of Research 3VetStem Biopharma Announces New Clinical Research Program for Equine Cervical Facet Joint Disease 2VetStem Biopharma Announces New Clinical Research Program for Equine Cervical Facet Joint Disease 3New White Paper Explores Data Lake Opportunities in the Healthcare Industry 2Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 2Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 3Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 4
... 8 Edwards Lifesciences,Corporation (NYSE: EW ), the ... the company will celebrate a number of cardiac surgery,milestones ... the American,Association for Thoracic Surgery (AATS), May 10-14 in ... -- which this year celebrates,its 50th anniversary of partnering ...
... Listing and Attract Additional Investors ... as Company Enters Next Growth Phase, SAN DIEGO, May 8 ... (ICG),technology, today announced the reverse split of 1 for 7 shares ... Company,s,Annual Shareholders Meeting earlier today., The record date for the ...
... ... U.S. ThermaCool NXT System Sales ... THRM ), a leader in non-invasive tissue tightening in the ... 31, 2008., Revenue for the first quarter of 2008 was ...
Cached Biology Technology:Edwards Lifesciences Celebrates One Million Heart Valve Patients and More at AATS 2008 2Edwards Lifesciences Celebrates One Million Heart Valve Patients and More at AATS 2008 3Edwards Lifesciences Celebrates One Million Heart Valve Patients and More at AATS 2008 4CardioDynamics Shareholders Approve One-for-Seven Reverse Split of Company's Common Stock and Trading in Post-split Shares Begins May 9, 2008 2CardioDynamics Shareholders Approve One-for-Seven Reverse Split of Company's Common Stock and Trading in Post-split Shares Begins May 9, 2008 3Thermage Announces First Quarter 2008 Financial Results 2Thermage Announces First Quarter 2008 Financial Results 3Thermage Announces First Quarter 2008 Financial Results 4Thermage Announces First Quarter 2008 Financial Results 5Thermage Announces First Quarter 2008 Financial Results 6Thermage Announces First Quarter 2008 Financial Results 7Thermage Announces First Quarter 2008 Financial Results 8Thermage Announces First Quarter 2008 Financial Results 9
... Hybaid's unique Electro-4 design allows "4 gels ... it is possible to run 200,samples or ... stacking up to four,horizontal gels. To ensure ... to the number of gels being run. ...
... Continuing a tradition of progressive centrifuge design ... series. The Centra-CL3 and Centra-CL3R (refrigerated) general ... laboratory., Quality Control Over Sample Preparation ... lock up to 99 protocols and has ...
... DNA Polymerase I Large (Klenow) Fragment, Exonuclease ... lacks both the 5´→3´ and the 3´→5´ ... DNA Polymerase I (1,2). It is used ... strand displacement amplification (5). Klenow Fragment, Exonuclease ...
DNA Polymerase I Large (Klenow) Fragment is a DNA polymerase that lacks the 5'Cut Site3' exodeoxyribonuclease activity of intact DNA Polymerase I but it contains the 3'Cut Site5' exodeoxyribonuclease...
Biology Products: