Navigation Links
Defining gene's role may lead to prevention of dangerous corn toxin
Date:3/25/2008

WEST LAFAYETTE, Ind. - Discovery that a specific gene is integral to both fungal invasion of corn and development of a potentially deadly toxin in the kernels may lead to ways to control the pathogen and the poison.

Purdue University researchers evaluated the fungal gene ZFR1 and found that it is vital to the process of the fungus growing on corn kernels. Production of the toxin decreased when the scientists disabled the gene.

At certain levels, the toxin can cause illness in humans and most domestic livestock. Horses and pigs are at particular risk and can develop fatal diseases by ingesting feed containing one of a group of toxins called fumonisins (few-mahn-ah-sins). About $40 million of the U.S. corn crop is lost annually due to presence of these toxins, according to experts.

"Our main research question has been what triggers toxin production when the fungus attacks the corn kernel; it appears that kernel starch plays an important role," said Charles Woloshuk, a Purdue plant pathologist. "When ZFR1 is deleted, the resulting mutant fungus has a problem transporting sugars that are produced from the degradation of kernel starch."

The resulting sugars must be transported to cells as fuel for other biochemical processes.

"The pathogen - the fungus Fusarium verticillioides - has a number of putative sugar transporter genes that are expressed during its growth on kernels and toxin production," Woloshuk said. "Disruption of ZFR1 also affects expression of the sugar transporter genes."

Woloshuk and his colleague, Bert Bluhm, now at the University of Arkansas, report in the current issue of Molecular Plant Pathology that when the gene ZFR1 is turned off, it reduces manifestation of genes involved in production of the most prevalent and dangerous fumonisin, FB1.

The researchers studied ZFR1 regulation of fungal growth and toxin production in the starch-rich areas of corn kernels and the conversion
'/>"/>

Contact: Susan A. Steeves
ssteeves@purdue.edu
765-496-7481
Purdue University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Gene regulation, not just genes, is what sets humans apart
2. Interaction of just 2 genes governs coloration patterns in mice
3. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
4. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
5. Smoking turns on genes -- permanently
6. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
7. Hebrew SeniorLife researchers search for aging, osteoporosis genes
8. UT Southwestern researchers identify hundreds of genes controlling female fertility
9. Genes and environment grant funds close look at nature-nurture overlap in common diseases
10. Jumping genes could make for safer gene delivery system
11. Genes from the father facilitate the formation of new species
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Defining gene's role may lead to prevention of dangerous corn toxin
(Date:4/24/2014)... very pleased to announce that it has assumed ownership ... the University of Wisconsin. , The Journal ... peer-reviewed journal that publishes papers on all aspects of ... the molecular to the ecological -- as well as ... to individuals and institutions, and it provides a reasonably ...
(Date:4/24/2014)... study of animal intelligence to-date finds that animals with bigger ... week in the journal Proceedings of the National Academy ... history of research aimed at understanding the animal mind. Specifically, ... and use tools, read social cues, or even understand basic ... of animal intelligence have focused on only one or a ...
(Date:4/24/2014)... returning home from Iraq and Afghanistan, post-traumatic stress disorder ... institutions and the culture at-large. Estimates indicate that as ... and Afghanistan suffer from PTSD. New research from the ... light on how PTSD is linked to other diseases ... PTSD has implications beyond the impact of the psychiatric ...
Breaking Biology News(10 mins):ESA to publish the Journal of Insect Science 2Animals with bigger brains, broader diets have better self control 2Animals with bigger brains, broader diets have better self control 3New study links inflammation in those with PTSD to changes in microRNA 2New study links inflammation in those with PTSD to changes in microRNA 3
... Researchers at Washington University in St. Louis and Arizona State University ... energy by making an even rarer form of chlorophyll, chlorophyll d. ... invisible to the naked eye. , ... competes with virtually no other plant or bacterium in the world ...
... Disclosure Project (CDP) a collaboration of 385 institutional investors, ... its 2008 information request to the worlds largest corporations. ... gas emissions and report on their strategy for dealing ... The resulting information will be held on the ...
... of the most important metabolic processes in our bodies, ... intermediates have been produced in multigram quantitieswith one exception, ... University of Leipzig have finally done it. As they ... combination of one biotechnological and one chemical step, starts ...
Cached Biology News:Bacterium sequenced makes rare form of chlorophyll 2Bacterium sequenced makes rare form of chlorophyll 3World's largest investor coalition seeks further disclosure on climate change and shareholder value 2World's largest investor coalition seeks further disclosure on climate change and shareholder value 3Kilogram quantities at last! 2
(Date:1/15/2014)... Look inside the new Preferred Solutions® catalog ... from fluid handling to instruments to supplies. Many items ... order. , Preferred Solutions features a full selection ... model for precise flow control and dispensing to I/P® ...
(Date:1/15/2014)... England , January 15, 2014 A ... win races on the Formula 1 track could help to ... McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based in ... by healthcare provider Simplyhealth. Telemetry technology, which is ...
(Date:1/15/2014)... 2013 was a banner year of ... They saw continued independent research led by the team ... a $1 million grant from the Susanne Marcus Collins ... a peer reviewed journal, Amy Grant highlighted Brainwave Optimization® ...
(Date:1/14/2014)... 14, 2014 Carahsoft and CDS Federal ... 23, 2014 at 2pm EST (11am PST), “Natural Language ... focuses on how technology can turn raw, heterogeneous data ... government agencies. The online webinar will last approximately one ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... Jan. 6, 2011 Cellular Dynamics International, Inc. (CDI), ... (iPS) cell lines and tissue cells for drug discovery ... to present at the 29th Annual JPMorgan Healthcare Conference ... Westin St. Francis Hotel in San Francisco. Robert Palay, ...
...  MacroGenics, Inc., a privately held biotechnology company that ... infectious diseases, today announced that it had administered ... a Phase I clinical trial of MGAH22.  MGAH22 ... which has been shown, in pre-clinical studies, to ...
... This release is available in Spanish . ... leading in Spain the European project within the VII Framework ... buildings which host large numbers of people, such as sports ... by the management and optimisation of energy in its three ...
Cached Biology Technology:MacroGenics Initiates Phase I Clinical Trial of MGAH22 for Patients With HER2-Expressing Solid Tumors 2MacroGenics Initiates Phase I Clinical Trial of MGAH22 for Patients With HER2-Expressing Solid Tumors 3MacroGenics Initiates Phase I Clinical Trial of MGAH22 for Patients With HER2-Expressing Solid Tumors 4Tecnalia leads the integration of energy efficiency in sports facilities 2
... single use spatulas have been designed to ... are for those interested in eliminating the ... Each spatula is individually packaged, RNase/DNase free, ... is a new product number, created to ...
... Alkaline Phosphatase Detection Kit (Catalog number SCR004) ... the phenotypic assessment of ES cell differentiation ... Available separately from CHEMICON are the monoclonal ... (Catalog Number MAB4354), which permit the detection ...
... complete, flexible system designed specifically for ... is frequently required in biological research. ... miniature Clark-style polarographic electrode. Measuring only ... (3.2 mm), it is ideal for ...
Yellow oily liquid. Contains 85% Drakeol 5NF, 15% Arlacel A (mannide monooleate emulsifier). Heat sterilized. Contains zero colony forming units/ml. ...
Biology Products: