Navigation Links
Defensive measures: Toward a vaccine for Ebola
Date:12/5/2011

protection of the vaccinated mice was equivalent to that seen in prior experiments with the best, previously available experimental vaccine.

The advantages of using tobacco to manufacture a vaccine are significant. The initial costs for plant growth are much cheaper than design of traditional pharmaceutical facilities. In addition, the material extracted from tobacco leaves can be easily purified, and then might be spray dried or freeze-dried, yielding a highly stable compound, storable at ambient temperatures for extended periods. This will be essential for an Ebola vaccine, since it will primarily be stockpiled to use only if there is a disease outbreak.

Vaccines typically contain adjuvantsimmune modulating factors that improve a vaccine's protective qualities. Most vaccines contain alum (or aluminum hydroxide), which is an FDA approved adjuvant. In the case of the plant-derived Ebola vaccine, alum did not improve the survival rates in mice when it was co-administered with EIC. Instead, the group found that a Toll-like receptor (TLR) agonist known as PIC, when delivered in tandem with EIC, dramatically improved survival.

Toll-like receptors are part of the body's innate immune systeminvolved in processes of inflammation, where defensive cells like macrophages and dendritic cells are attracted to the site of infection. Arntzen explains that the TLR agonist PIC acts to mimic a site of inflammation, amplifying the immune response, without causing tissue damage. In experiments using a combination of PIC and EIC, mice achieved an 80 percent survival rate against a lethal challenge of Ebolacommensurate with the best existing vaccine candidates.

The road ahead

In their companion PNAS paper, Arnzen's collaborators at Mapp Biopharmaceuticals outline the process for creating the monoclonal antibodies used for this research. Treatment for an Ebola infection, Arntzen says, would likely involve the injection of fast act
'/>"/>

Contact: Joseph Caspermeyer
Joseph.Caspermeyer@asu.edu
Arizona State University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Cells die so defensive organs can live
2. Rapid venom evolution in pit vipers may be defensive
3. Toward more cost-effective production of biofuels from plant lignocellulosic biomass
4. Leicester leads the way towards a sustainable lake in Africa
5. Advance toward a breath test to diagnose multiple sclerosis
6. Progress towards developing plants that accommodate climate change
7. Wildlife Conservation Society study uncovers a predictable sequence toward coral reef collapse
8. Award-winning research points toward Alzheimer’s vaccine
9. Another step toward resisting breast cancer
10. Toward new medications for chronic brain diseases
11. Toward a more efficient use of solar energy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Defensive measures: Toward a vaccine for Ebola  
(Date:11/3/2014)... Research and Markets has announced the addition of a ... to their offering. This report describes ... started to play an important role in the practice of ... bone marrow transplants. Role of cells in drug discovery is ... of medical practice. Stem cells are discussed in ...
(Date:11/3/2014)... , Nov. 3, 2014  NeuroSigma ® ... -based life sciences company focused on commercialization of ... for the treatment of neurological and neuropsychiatric ... Industrial Property has issued a Notice of Allowance ... application is co-owned by NeuroSigma and the Regents ...
(Date:11/2/2014)... , James Dacey explores the ways in which physicists ... innovations from the lab into the commercial market. , ... companies as they move from prototype to product is ... physics-based inventions are usually far from market-ready when initially ... lot more complicated than had been originally thought. , ...
Breaking Biology News(10 mins):Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 2NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 3The 'valley of death' facing physics start-ups 2
... the Max Planck Institute for Polymer Research (MPI-P) in ... a mineral content of almost 90 percent, yet extremely ... sea sponges and recreated the sponge spicules using the ... sponge. Natural minerals are usually very hard and prickly, ...
... termites, bed bugs and Argentine ants be effectively controlled? What ... And what are some ways to address the rodent ... for both the public interested in these questions and professionals ... University of California, Riverside on March 26, from 7:15 a.m. ...
... Biologists since Aristotle have puzzled over the reasons for ... of up to several hundred individuals drive themselves up ... shed some light on whether family relationships play a ... otherwise healthy whales. One hypothesis regarding the ...
Cached Biology News:Inspired by deep sea sponges: Creating flexible minerals 2Annual Urban Pest Management Conference set for March 26 2Oh mother, where art thou? 2Oh mother, where art thou? 3
(Date:11/21/2014)... York, NY (PRWEB) November 20, 2014 ... is now available as an open access journal featuring ... with infrared fluorescent proteins to preserve photoresponsiveness in the ... Two-color fluorescent in situ hybridization using chromogenic substrates ... chips for DNA, RNA, and protein electrophoresis , ...
(Date:11/21/2014)... 21, 2014 2014 Deep Research ... is a professional and in-depth research report on ... information, like its definition, classification, application, and ... This report covers the international market analysis, including ... as the US, Europe, Asia, China, Japan etc. ...
(Date:11/21/2014)... Nov. 20, 2014 /CNW/ - Aequus Pharmaceuticals Inc. ... that it has closed a brokered private placement ... approximately C$3.7 million.  Cormark Securities Inc. and Clarus ... Brokered Offering for a syndicate of agents that ... Corp. (collectively the "Agents"). Concurrently with the Brokered ...
(Date:11/18/2014)... Nov. 18, 2014 Cord Blood Registry® (CBR®) ... the 10th Annual World Stem Cell Summit, the largest global ... 2014 World Stem Cell Summit will be held December 3-5 ... . The World Stem Cell ... lifesaving cures and therapies, convening the most prominent figures in ...
Breaking Biology Technology:BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3
... Critical step in determining cardiac safety of new drugs, ... the completion of its 100th Thorough QT Study.,QT has ... prolongation of QTc is a known surrogate for assessing ... Thorough QT Studies as one of the,centralized ECG services ...
... to Debut at NASS, GREENVILLE, N.C. and WOBURN, ... the U.S. market release of their,FortrOss bone graft substitute. ... 23rd Annual Meeting of the North American Spine Society ... the power of,nanotechnology for orthopaedic applications, is a scaffold ...
... Neb., Oct. 14 LI-COR Biosciences introduces a,new, ... the Odyssey(R),Infrared Imaging system. The Odyssey Two-Color Protein ... 700 and 800 nm channels of the,Odyssey System. ... gels,and can be used to visualize the progress ...
Cached Biology Technology:eRT Completes Milestone 100th Thorough QT Study 2eRT Completes Milestone 100th Thorough QT Study 3Pioneer(R) Surgical Technology Announces Market Release of FortrOss(TM), a Next Generation Bone Void Filler 2LI-COR Introduces the Odyssey(R) Two-Color NIR Fluorescent Protein Molecular Weight Marker 2
... a simple and efficient means for isolation ... using annexin V magnetic beads (MagBeads). Annexin ... with high affinity for phosphatidylseri The ... and efficient means for isolation of apoptotic ...
... A tracking dye for nucleic acid ... including DNA sequencing. Preparation Quantity Equivalency: ... recommended. A 2% stock solution can ... Chem comp: Dye content ~ ...
... The VSOS-4 Orbital Shaker is designed to be ... a uniform motion that is both mixing and ... Orbital Shaker provides a smooth, quiet, reproducible and ... wide range of laboratory applications such as cell/tissue ...
... Biometra TProfessional Thermocycler combines top performance with ... achieves high speed and unparalleled temperature uniformity. ... providing programming in a spreadsheet or alternatively ... Smart Lid opens on the push of ...
Biology Products: