Navigation Links
Dark Ages scourge enlightens modern struggle between man and microbes
Date:12/13/2012

The plague-causing bacteria Yersinia pestis evades detection and establishes a stronghold without setting off the body's early alarms.

New discoveries reported this week help explain how the stealthy agent of Black Death avoids tripping a self-destruct mechanism inside germ-destroying cells.

The authors of the study, appearing in the Dec. 13 issue of Cell Host & Microbe, are Dr. Christopher N. LaRock of the University of Washington Department of Microbiology and Dr. Brad Cookson, UW professor of microbiology and laboratory medicine.

Normally, certain defender cells are programmed to burst if they are either invaded by or detect the presence of pathogens, Cookson explained. This host defense mechanism called pyroptosis ("going up in flames") eliminates places for the germs to reproduce. As it splits open, the cell spills a cauldron of antimicrobial chemicals and emits signals to alert of an attack and its precise location. Tissues become inflamed as more cells arrive to fight the infection.

The bacteria are widely believed to be behind the great pestilences of the Middle Ages in the 1300s. The pathogen had evolved a tactic to delay provoking people's protective inflammatory response until it was too late. Plague claimed an estimated 30 percent to 50 percent of Europe's 14th century population.

"People and pathogens have been in an eternal struggle since the dawn of humanity," Cookson said. With a hand over hand gesture he explained, "Humans continuously ratchet up their defenses, and germs repeatedly find a way around them."

During several medieval epidemics, the plague started in rats. High-jumping fleas transmitted it to and between humans. It commonly caused lymph nodes to rupture. Respiratory forms were more deadly. They damaged the lungs and were spread by sneezing. Plague bacteria in the blood stream ended lives through sepsis, in which the burden of infection overwhelms the body
'/>"/>

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
2. Drug could reverse scourge of cerebral malaria for survivors
3. Modern Mobility Aids, Inc. Announces a Revised Agreement for the Acquisition of Lumigene
4. Ancient whale species sheds new light on its modern relatives
5. Has modern science become dysfunctional?
6. Crime and punishment: The neurobiological roots of modern justice
7. Modern hybrid corn makes better use of nitrogen, study shows
8. Research: Modern Portfolio Theory optimizes conservation practices
9. Squid ink from Jurassic period identical to modern squid ink, U.Va. study shows
10. Woolly mammoth extinction has lessons for modern climate change
11. Fossil egg discovered in Lleida (Spain) links dinosaurs to modern birds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Dark Ages scourge enlightens modern struggle between man and microbes
(Date:4/24/2014)... April 24, 2014D-ribose is a commercially important sugar ... as a starting compound for synthesizing riboflavin and ... coli to increase the bacteria,s ability to ... more efficient industrial-scale production of this valuable chemical, ... Biotechnology , a peer-reviewed journal from Mary Ann ...
(Date:4/24/2014)... Society of America (ESA) is very pleased to announce ... of Insect Science from the University of Wisconsin. ... is an international, open-access, peer-reviewed journal that publishes ... and other arthropods -- from the molecular to the ... impacts. It is freely available to individuals and institutions, ...
(Date:4/24/2014)... and the University of North Carolina at Chapel Hill ... identify arterial plaque that is at high risk of ... At issue is the plaque that builds up in ... deemed "vulnerable," meaning that they are more likely to ... or stroke. , "Existing state-of-the-art technologies are capable of ...
Breaking Biology News(10 mins):ESA to publish the Journal of Insect Science 2New ultrasound device may add in detecting risk for heart attack, stroke 2
... in how organisms grow and flourish, but studying their ... difficult. Now, a team of chemists and neurobiologists led ... Erin M. Schuman at the California Institute of Technology ... protein synthesis in specific locations. , The new method, ...
... at the University of Chicago show how the bacteria that ... how, by slightly altering one of the microbe's tools, the ... vaccine. , Both papers -- one published online July 28 ... Infection and Immunity -- focus on aspects of the type-III ...
... greatly benefit crop plants, scientists have deciphered the genome ... from diseases. , The research provides clues to better ... safeguards roots and seeds from infection by harmful microbes ... published in Nature Biotechnology and was scheduled to be ...
Cached Biology News:Protein synthesis can be controlled by light, opening way for new scientific, medical applications 2Protein synthesis can be controlled by light, opening way for new scientific, medical applications 3Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine 2Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine 3Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine 4Genome study of beneficial microbe may help boost plant health 2
(Date:1/15/2014)... Niagara Thermal Products is proud to announce that ... ("B3") as the critical thermal component supplier in support ... Corps of Engineers.  B3 has developed the only comprehensive ... destroys VOCs and other chemical pollutants, allergens and organic ...
(Date:1/15/2014)... Calif. (PRWEB) January 15, 2014 Cynvenio, ... and management through the genomic analysis of tumor cells ... Therapy Finder™, a web-based cancer decision support application powered ... option with Cynvenio’s ClearID™ genomic test, Therapy Finder will ...
(Date:1/15/2014)... ­ RedBrick Health , a fast-growing leader in ... that EmblemHealth , the New York ... providing the RedBrick Compass health assessment, combined with the ... its members. EmblemHealth is among the first health plans ...
(Date:1/15/2014)... A study has been launched to test whether technology ... help to tackle the problem of obesity.  This unique healthcare ... based in Stowmarket) and academics at University Campus Suffolk is ... which is inspired by equipment used to collect data about ...
Breaking Biology Technology:Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4
... ... firm today announced that LI-COR is moving its B2B sales into the Cloud with the ... ... Consulting , a leading technology services firm today announced that LI-COR is moving its B2B ...
... The University of Georgia Research Foundation, Inc. (UGARF) and ... non-exclusive license for a portfolio of glow-in-the-dark pigments that ... of the visible spectrum for nearly a day. ... Phosphorescence is a process in which energy ...
... , BETHESDA, Md., Aug. 17 Spherix Incorporated (Nasdaq: ... of technical and regulatory consulting services to food, supplement, biotechnology and pharmaceutical companies, ... , Recent and Upcoming Company Highlights , ... , Clinical trials on Naturlose ...
Cached Biology Technology:Biosciences Firm Chooses CloudCraze for eCommerce Business Solution -- LI-COR and EDL Consulting Take Expertise into the "Cloud" 2Biosciences Firm Chooses CloudCraze for eCommerce Business Solution -- LI-COR and EDL Consulting Take Expertise into the "Cloud" 3UGA, UPR grant license for long-persistence glow materials, in any color 2UGA, UPR grant license for long-persistence glow materials, in any color 3UGA, UPR grant license for long-persistence glow materials, in any color 4Spherix Reports Second Quarter 2009 Earnings 2Spherix Reports Second Quarter 2009 Earnings 3Spherix Reports Second Quarter 2009 Earnings 4Spherix Reports Second Quarter 2009 Earnings 5Spherix Reports Second Quarter 2009 Earnings 6Spherix Reports Second Quarter 2009 Earnings 7Spherix Reports Second Quarter 2009 Earnings 8
One bottle containing 30 ml of protein solution and 0.1% sodium azide....
...
Sheep polyclonal to Quinolone ( Abpromise for all tested applications). Antigen: Norfloxacin(N)conjugated to BSA...
Certified U.S. origin. Bovine Serum:, *Certified U.S. origin. Available raw, nonsterile filtered, or sterile filtered. , , *Sterility tested , , *Low Hemoglobin levels , , *Mycoplasma testing upon...
Biology Products: