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Damon Runyon Cancer Research Foundation grants prestigious awards to 20 top young scientists
Date:1/13/2014

tts Institute of Technology, Cambridge, Massachusetts, studies pancreatic ductal adenocarcinoma (PDAC). PDAC is characterized by an extremely stiff texture, which is caused by accumulation of excessive extracellular matrix (ECM). The compositions of ECM, known to have major effects on tumor progression, are not well understood in PDAC disease. She aims to identify global ECM changes during PDAC progression by proteomic approaches, and to investigate how these changes impact cancer progression. This research will provide novel insights into diagnosis, prognosis and treatments of this very difficult disease.

Thomas S. Vierbuchen, PhD [HHMI Fellow] with his sponsor Michael E. Greenberg, PhD, at Harvard Medical School, Boston, Massachusetts, aims to understand how neurons adapt to experience by modifying the complement of genes they express. He is using high-throughput sequencing-based approaches to identify and characterize the function of genomic regulatory elements that control neuronal activity-regulated gene transcription.

Eric M. Woerly, PhD, with his sponsor Eric N. Jacobsen, PhD, at Harvard University, Cambridge, Massachusetts, aims to develop new chemical synthetic methods for the preparation of cancer therapeutics. The introduction of fluorine into pharmaceutical targets is an important element of drug design. The controlled, selective synthesis of fluorinated compounds, however, can be a great synthetic challenge. He plans to enable access to such targets by developing a method for the asymmetric synthesis of fluorinated small molecules, potentially leading to improved cancer therapies.


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Contact: Yung S. Lie, Ph.D.
yung.lie@damonrunyon.org
212-455-0521
Damon Runyon Cancer Research Foundation
Source:Eurekalert

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