Shruti Naik, PhD, with her sponsor Elaine V. Fuchs, PhD, at The Rockefeller University, New York, New York, is studying the interactions between immune cells and adult skin tissue stem cells in an effort to understand the how this crosstalk drives epithelial disorders, including chronic inflammation and cancer. Because adult tissue stem cells are long-lived cells that continually replenish tissues throughout an organism's lifetime, they represent ideal points of therapeutic intervention. Identification of inflammation-induced molecular changes in skin stem cells that drive epithelial dysfunction will facilitate the development of therapies for various epithelial inflammatory diseases and cancer.
Hanjing Peng, PhD, with her sponsor Jun O. Liu, PhD, at The Johns Hopkins University School of Medicine, Baltimore, Maryland, seeks to identify compounds that inhibit the proteasome, the protein degradation machinery in the cell that maintains the balance of cell growth and death. Inhibitors that regulate proteasome function are potential anticancer drugs. She has designed and constructed a synthetic library of compounds in search of potent proteasome inhibitors. She hopes to discover new anticancer drug candidates with lower toxicity or side effects than current drugs.
Erin F. Simonds, PhD, with his sponsor William A. Weiss, MD, PhD, at University of California, San Francisc
|Contact: Yung S. Lie, Ph.D.|
Damon Runyon Cancer Research Foundation