Dr. Trapnell studies the vast complexity underlying cell identity and fate. He will use genomic and computational biology approaches to analyze individual tumor cells and understand how a variety of genetic mutations give rise to aggressive tumor cell behavior. He aims to map the key pathways controlling cell fate, ultimately leading to information that may aid the development of more effective targeted therapies.
November 2013 Damon Runyon Fellows
Brittany Adamson, PhD [HHMI Fellow] with her sponsor Jonathan S. Weissman, PhD, at University of California, San Francisco, California, is using large-scale genetic approaches to map the regulatory networks responsible for maintaining molecular equilibria inside human cells. An important question in cancer research is how cancer cells adapt to abnormal growth environments and proliferate under stress. Systematic characterization of the processes that maintain these equilibria will be critical for better understanding cancer formation and growth.
Ryan D. Baldridge, PhD, with his sponsor Thomas A. Rapaport, PhD, at Harvard Medical School, Boston, Massachusetts, focuses on a cellular process called endoplasmic reticulum associated degradation (ERAD), a system involved in recognition, transport and degradation of regulated and misfolded proteins. ERAD plays a role in cancer processes, in some instances by regulating the levels of proteins involved in tumor growth and metastasis. His goal is to understand the mechanism and specificity of the ERAD system.
Liron Bar-Peled, PhD, with his sponsor Benjamin F. Cravatt, PhD, at The Scripps Research Institute, La Jolla, California, is exploring how the protease Caspase-8 regulates T cell activation, which represents a critical step in the adaptive immune response to cancer. While Caspase-8 is known to be essential for T cell activation, the molecular mechanisms underlying its role in this process remain poorly understood. His
|Contact: Yung S. Lie, Ph.D.|
Damon Runyon Cancer Research Foundation