Each patient's bronchodilator responsiveness (BDR) was determined by three measures: absolute change in the volume of air exhaled during a forced breath in one second (FEV1); change as a percentage of predicted FEV1; and change as percentage of baseline FEV1.
In the presentation today, Dr. Hardin reported the top SNPs that thus far have been associated with each BDR outcome, but emphasized that additional analysis may reveal other SNPs with equally or greater influence on COPD patients' response.
SNPs in HS6ST3 were associated with the baseline measure while SNPs in XKR4 were associated with baseline and predicted measures. SNPs in the CUBN were associated with absolute and predicted measures. Among African American subjects, SNPs in CDH13 were significantly associated with the absolute measure.
|Contact: Cathy Yarbrough|
American Society of Human Genetics