Navigation Links
DNA variants may influence COPD patients' response to inhaled bronchodilators
Date:10/25/2013

Several novel gene variants may help explain the response of patients with chronic obstructive pulmonary disease (COPD) to inhaled bronchodilators, according to a meta-analysis reported today (Oct. 25) at the American Society of Human Genetics 2013 meeting in Boston.

The meta-analysis used statistical methods to combine results from four individual studies with a total of 5,789 Caucasian patients with moderate to severe COPD.

Over 6.3 million unique single nucleotide polymorphisms (SNPs) were identified in the genotypes of the patients with COPD, which is a progressive breathing disorder that limits airflow in the lungs. The genotypes of over 700 African Americans with COPD also were analyzed.

"Identifying single nucleotide polymorphisms associated with bronchodilator responsiveness may reveal genetic pathways associated with the pathogenesis of COPD and may identify novel treatment methods," said Megan Hardin, M.D., Instructor of Medicine at Harvard Medical School and researcher in the Channing Division of Network Medicine at Brigham and Women's Hospital, Boston.

Dr. Hardin, who presented the research, added that multiple genetic determinants likely influence bronchodilator responsiveness. Functional analysis of the SNPs will be conducted, she added.

"As we continue to analyze the data, we expect to identify other important SNPs," said Craig P. Hersh, M.D., who headed the study and is Assistant Professor, Harvard Medical School, and faculty member in the Channing Division of Network Medicine at Brigham and Women's Hospital.

All of the subjects studied had significant histories of smoking, with most (4,561), over 10 pack-years. All patients were genotyped, and their lung function was tested by spirometry before and after they used the bronchodilator medication albuterol, which relaxes muscles in the airways and increases airflow to the lungs. Spirometry measures the volume and flow of air that is exhaled.<
'/>"/>

Contact: Cathy Yarbrough
press@ashg.org
858-243-1814
American Society of Human Genetics
Source:Eurekalert

Page: 1 2

Related biology news :

1. Common genetic variants identify autism risk in high risk siblings of children with ASD
2. Study examines effects of genetic variants for infants with neonatal abstinence syndrome
3. Gene variants may predict who will benefit from breast cancer prevention drugs
4. Penn: New variants at gene linked to kidney disease, sleeping sickness resistance
5. African-American study identifies 4 genetic variants associated with blood pressure
6. New NIH-funded resource focuses on use of genomic variants in medical care
7. Genetic variants associated with bronchodilator responsiveness
8. Circadian rhythms have profound influence on metabolic output, UCI study reveals
9. BUSM researchers identify genes that influence hippocampal volume
10. Fat outside of arteries may influence onset of coronary artery disease
11. New evidence that many genes of small effect influence economic decisions and political attitudes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... 2015 Huntington Memorial Hospital is the first ... new miniaturized, wireless monitoring sensor to manage heart failure ... only FDA-approved heart failure monitoring device that has been ... physicians to manage heart failure. The CardioMEMS ... the pulmonary artery (PA) during a non-surgical procedure to ...
(Date:4/20/2015)... 20, 2015 The announcement comes ... Glenbeigh Records Management (GRM), Ireland,s foremost ... Bank. Having built up an impressive track record of clients ... player within the records management sector in Dubai ... is GCC staffbase and employ a further eight staff members ...
(Date:4/17/2015)... , April 17, 2015 ... concerns, and technological advancement to drive biometric systems ... until 2020   According to a ... Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems market in ... to register growth at CAGR of over 22% ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... a room in the intensive care unit (ICU) ... may increase the odds of acquiring such bacteria, ... issue of Archives of Internal Medicine, one of ... significant illness and death in hospitals: methicillin-resistant Staphylococcus ...
... cold seeps--strange clams, mussels and sea snails that thrive in ... marine mollusk community as a whole, according to a new ... published by AAAS, the nonprofit science society. , On average, ... geological record is a full epoch earlier than that of ...
... Boston have demonstrated that it may be possible to ... the heart from scarring. Working with rats, they combined ... division with a naturally occurring growth factor that encourages ... heart-muscle cells to multiply and the heart to regain ...
Cached Biology News:Transmission of antibiotic-resistant bacteria linked to previous intensive care unit room occupants 2Ocean seep mollusks may share evolutionary history with other deep-sea creatures 2Ocean seep mollusks may share evolutionary history with other deep-sea creatures 3Rescuing injured hearts by enhancing regeneration 2Rescuing injured hearts by enhancing regeneration 3
(Date:4/21/2015)... April 21, 2015  Novogen Limited (ASX:NRT; NASDAQ: ... advises that it has entered into definitive agreements ... shares plus one attaching 6-month option and half ... share issued, to institutional investors in ... placement for aggregate gross proceeds of approximately AU$15,500,000 ...
(Date:4/21/2015)... PRC Clinical, a Clinical ... the ACRP 2015 Global Conference and Exhibition on April ... of Clinical Research Professionals (ACRP) Global Conference and Exhibition ... on the conduct of clinical trials. ACRP supports clinical ... recognized industry certifications. , The ACRP 2015 Global ...
(Date:4/21/2015)... RESEARCH TRIANGLE PARK, N.C. , April 21, 2015 ... announced today that it will release its first quarter ... 28, 2015. United Therapeutics will host a ... a.m. Eastern Time.  The teleconference is accessible by dialing ... the teleconference will be available for one week and ...
(Date:4/21/2015)... New York (PRWEB) April 21, 2015 ... and Fertility Authority, LLC, announced that it has secured ... Byers (KPCB), TPG Biotech, SR One and Merck Serono ... efforts to provide patients the best fertility outcomes by ... is the largest online marketplace for families seeking fertility ...
Breaking Biology Technology:Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 2Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 3Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 4Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 5Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 6PRC Clinical Sponsors The ACRP 2015 Global Conference And Meets Biotech Companies in the Salt Lake City Area. 2Announcing Progyny: Combining Best-in-Class Clinical Solutions with Consumer Expertise 2
... Holdings, Inc. (Nasdaq: NHWK ), the leading ... United States, today announced that,Tim Mayleben, NightHawk,s President ... for personal reasons. Mayleben will remain with,NightHawk in ... and is,expected to resign from the board of ...
... Martek Biosciences,(Nasdaq: MATK ) announced today that ... eye and heart health, is now available in,two new ... Grapefruit Lychee and Marionberry Guava, join 10 existing flavors ... line is,available at natural food stores nationwide., "We ...
... Board of Directors, Ron ... Vice President Legal Affairs -, SEATTLE, Feb. 13 ... development of therapeutics for,autoimmune and inflammatory disorders, today announced ... of Dendreon Corporation,(Nasdaq: DNDN ), to the Company,s ...
Cached Biology Technology:NightHawk Radiology Holdings, Inc. Announces Senior Executive Departures 2NightHawk Radiology Holdings, Inc. Announces Senior Executive Departures 3Martek's life'sDHA(TM) Now Featured in Two New Flavors of Rachel's(R) Wickedly Delicious Yogurt from WhiteWave Foods 2Martek's life'sDHA(TM) Now Featured in Two New Flavors of Rachel's(R) Wickedly Delicious Yogurt from WhiteWave Foods 3VLST Corporation Announces Board and Executive Management Appointments 2VLST Corporation Announces Board and Executive Management Appointments 3