Navigation Links
DNA variants may influence COPD patients' response to inhaled bronchodilators
Date:10/25/2013

Several novel gene variants may help explain the response of patients with chronic obstructive pulmonary disease (COPD) to inhaled bronchodilators, according to a meta-analysis reported today (Oct. 25) at the American Society of Human Genetics 2013 meeting in Boston.

The meta-analysis used statistical methods to combine results from four individual studies with a total of 5,789 Caucasian patients with moderate to severe COPD.

Over 6.3 million unique single nucleotide polymorphisms (SNPs) were identified in the genotypes of the patients with COPD, which is a progressive breathing disorder that limits airflow in the lungs. The genotypes of over 700 African Americans with COPD also were analyzed.

"Identifying single nucleotide polymorphisms associated with bronchodilator responsiveness may reveal genetic pathways associated with the pathogenesis of COPD and may identify novel treatment methods," said Megan Hardin, M.D., Instructor of Medicine at Harvard Medical School and researcher in the Channing Division of Network Medicine at Brigham and Women's Hospital, Boston.

Dr. Hardin, who presented the research, added that multiple genetic determinants likely influence bronchodilator responsiveness. Functional analysis of the SNPs will be conducted, she added.

"As we continue to analyze the data, we expect to identify other important SNPs," said Craig P. Hersh, M.D., who headed the study and is Assistant Professor, Harvard Medical School, and faculty member in the Channing Division of Network Medicine at Brigham and Women's Hospital.

All of the subjects studied had significant histories of smoking, with most (4,561), over 10 pack-years. All patients were genotyped, and their lung function was tested by spirometry before and after they used the bronchodilator medication albuterol, which relaxes muscles in the airways and increases airflow to the lungs. Spirometry measures the volume and flow of air that is exhaled.<
'/>"/>

Contact: Cathy Yarbrough
press@ashg.org
858-243-1814
American Society of Human Genetics
Source:Eurekalert

Page: 1 2

Related biology news :

1. Common genetic variants identify autism risk in high risk siblings of children with ASD
2. Study examines effects of genetic variants for infants with neonatal abstinence syndrome
3. Gene variants may predict who will benefit from breast cancer prevention drugs
4. Penn: New variants at gene linked to kidney disease, sleeping sickness resistance
5. African-American study identifies 4 genetic variants associated with blood pressure
6. New NIH-funded resource focuses on use of genomic variants in medical care
7. Genetic variants associated with bronchodilator responsiveness
8. Circadian rhythms have profound influence on metabolic output, UCI study reveals
9. BUSM researchers identify genes that influence hippocampal volume
10. Fat outside of arteries may influence onset of coronary artery disease
11. New evidence that many genes of small effect influence economic decisions and political attitudes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... 2015 The Granite Club, ... athletic club, today announced it has implemented a state-of-the-art ... movement for members and staff, while restricting access to ... we selected FST,s IMID Access system because it has ... members and staff, in addition to unparalleled security," said ...
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ... of the "Global Iris Recognition Market 2015-2019" ... the Global Iris Recognition market to grow at a ... This report covers the present scenario and the ... the period 2015-2019. To calculate the market size, the ...
(Date:3/24/2015)... ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of the ... report to their offering. This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ...
Breaking Biology News(10 mins):Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... 27 After a disastrous 2009, the market for CMP slurry and ... to a new report from Linx Consulting, the foremost electronic materials consultant to ... The new report, ... forecasts the 2010 market for CMP consumables will be $1.3 billion ...
... 27 From international jetsetter to model to entrepreneur, Melania Trump ... unveils her debut collection for QVC. The Slovenian beauty is scheduled to appear on ... to debut the Melania™ Timepieces & Fashion Jewelry line and give viewers ... , , ...
... MDStarting Saturday, May 1, in Nassau, Bahamas, the Khaled ... partnership with the Harvard Medical School Center for Health ... Educational Foundation (BREEF), will conduct an intensive four-day education ... All funding for this program will be provided ...
Cached Biology News:CMP Consumables Market to Show Complete Recovery by 2011 2CMP Consumables Market to Show Complete Recovery by 2011 3Melania Trump Takes 'Time' To Shine With New QVC(R) Collection 2Melania Trump Takes 'Time' To Shine With New QVC(R) Collection 3Melania Trump Takes 'Time' To Shine With New QVC(R) Collection 4Unique coral reef education pilot program to be conducted in the Bahamas 2
(Date:3/29/2015)... As a symbol of its commitment to ... manufacturing clients, Whitehouse Laboratories is excited to announce that ... Team for the 2015 race season. Success on the ... strong sense of precision and attention to detail. These ... the quality control testing laboratory. Sponsorship of the race ...
(Date:3/27/2015)... , 27. März 2015  Peter ... in Biomedical Science für seine bahnbrechende Arbeit ... zwischen Zellkompartimenten transportiert werden, sowie für die ... zur Reaktion auf Stress nutzen, der mit ... Walter ist Professor für Biochemie an der ...
(Date:3/27/2015)... 27, 2015  Peter Walter was chosen as winner ... pioneering work on how proteins are transported between cellular ... mechanism that cells use to handle stress tied to ... professor of biochemistry at the University of California, San ... range of human diseases related to defective protein folding ...
(Date:3/27/2015)... ROCKVILLE, Md. , March 27, 2015  CASI ... dedicated to the acquisition, development and commercialization of innovative ... the global market with a commercial focus on ... the three and 12 months ended December 31, 2014.  ... of ($1.6 million), or ($0.05) per share, for the ...
Breaking Biology Technology:Whitehouse Laboratories Reaffirms Commitment to Speedy Results – Renews Sponsorship of Berkenstock Racing Team 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 2Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 3Deutschstämmiger Zellbiologe Peter Walter gewinnt den Vilcek Prize in Biomedical Science 2015 4German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 2German-born cell biologist Peter Walter wins the 2015 Vilcek Prize in Biomedical Science 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 2CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 3CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 4CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 5CASI Pharmaceuticals Reports 2014 Fourth Quarter And Full Year Financial Results 6
... Authors to Discuss Issue at International AIDS Conference, August ... exposure to or,transmission of HIV does nothing to reduce ... drives people away from accessing care,while disproportionately burdening women ... HIV status to partners for fear of violence,according to ...
... Aug. 4 ( http://www.amdl.com ),AMDL, Inc. (Amex: ... with major operations in China and the US, ... a second quarter FY2008 corporate,update for AMDL, Inc. ... includes a 12 month target price of $23 ...
... Keynote Presentations, Four Pre-Conference Summits, Six, Therapeutics Conference ... ... Seventy Exhibitors, WESTBOROUGH, Mass., Aug. 4 Today ... & Development of Innovative,Therapeutics (DDT) World Congress in Boston, ...
Cached Biology Technology:JAMA Commentary Opposes Criminal Punishment for HIV Exposure/Transmission 2JAMA Commentary Opposes Criminal Punishment for HIV Exposure/Transmission 3Rudd Report Highlights AMDL, Inc.'s Latest Business Achievements; Supports 2008 Financial Guidance 2IBC Life Sciences Kicks Off the 13th Annual Drug Discovery & Development of Innovative Therapeutics World Congress in Boston, Massachusetts 2
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (E6027) or contact customer s...
... index chromatography system, uses the highly sensitive ... processing is provided by the CE 4900 interface ... pressure CE 4100 dual piston pump. A ... The system can be upgraded to provide binary ...
capacity 250 mL...
Rabbit polyclonal to YANK2 ( Abpromise for all tested applications). Antigen: A KLH conjugated synthetic peptide selected within aa 300~400 (C terminal region) of human YANK2. Entrez Gene ID:...
Biology Products: