Navigation Links
DNA abnormalities may contribute to cancer risk in people with type 2 diabetes
Date:7/14/2013

A type of genetic abnormality linked to cancer is more common in people with type 2 diabetes than the rest of the population, a new study has found.

People with type 2 diabetes are already known to have a higher risk of cancers, especially blood cancers like lymphoma and leukaemia. The new study, led by scientists at Imperial College London and CNRS in France, suggests that mutations called clonal mosaic events (CMEs) may partly explain why this is.

CMEs are defects that result in some cells having extra copies or missing copies of large chunks of DNA. They are very rare in young people but more common as we get older. Among those aged over 70, around one in 50 people have some of these mutations. Research published last year found that people with CMEs have a 10-fold higher risk of blood cancers.

In the new study, published in Nature Genetics, researchers looked for CMEs in blood samples from 7,437 participants in genetic studies in Europe, including 2,208 people with type 2 diabetes. They found that CMEs were four times more common in people with type 2 diabetes.

"Type 2 diabetes is a disease that accelerates ageing, so we wondered if it would make people more likely to have these genetic defects that are associated with ageing," said Professor Philippe Froguel, from the School of Public Health at Imperial College London, who led the study.

"This finding may partly explain why people with type 2 diabetes are more likely to get blood cancers. It could have profound clinical implications. It may be useful for doctors to test for CMEs in patients with type 2 diabetes to identify those who have the highest risk of cancers. These patients would be followed up closely to watch for early signs of leukaemia and could start having mild chemotherapy."

They also found that diabetes patients with CMEs had a much higher rate of complications such as kidney failure, eye disease or heart disease.


'/>"/>

Contact: Sam Wong
sam.wong@imperial.ac.uk
44-207-594-2198
Imperial College London
Source:Eurekalert

Page: 1

Related biology news :

1. Antiviral enzyme contributes to several forms of cancer, University of Minnesota researchers say
2. Study identifies protein that contributes to cognitive decline in Alzheimers
3. OGIs investment in cytognomix contributes to the Shannon Human Splicing Pipelines success
4. BUSM study reveals novel mechanism by which UVA contributes to photoaging of skin
5. CSHL neuroscientists show jumping genes may contribute to aging-related brain defects
6. Texas A&M research contributes to improved ultrasound imaging
7. Scientists identify genetic mechanism that contributed to Irish Famine
8. In beef production, cow-calf phase contributes most greenhouse gases
9. Japanese research organizations contribute to Human Brain Project
10. Study reveals that animals contribute to seagrass dispersal
11. Could poor sleep contribute to symptoms of schizophrenia?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the ... Business Report" report to their offering. This report ... Thousands by the following Segments: Face Biometrics, and Voice Biometrics. The ... , Japan , Europe ... & Africa , and Latin ...
(Date:3/23/2015)... , March 23, 2015 SoundView Technology Group ... NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView was one ... feedback on their experience with the Wocket in multiple scenarios ... CVS, Whole Foods and other retailers, making both debit and ... Tuttle also says, "If the company meets their plans ...
(Date:3/23/2015)... , Mar. 23, 2015 NXT-ID, Inc. (NASDAQ: ... focused on the growing mobile commerce market, announces its biometric ... advertising campaign on CNBC television starting March 30 th ... commence airing in New York markets. ... said: "We are excited about our new ad campaign following ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3
... Six scientists from the Department of Energy,s ... of the American Association for the Advancement of ... and apply it to real-world problems., The PNNL ... are: Leonard Bond, engineering; Liem Dang, chemistry; Csar ...
... eating vegetables gives you a healthy tan. The study, led by ... a healthy diet rich in fruit and vegetables gives you a ... showed that instead of heading for the sun the best way ... been published in the journal Evolution and Human Behaviour . ...
... Iowa Nine researchers from Iowa State University two ... Energy,s Ames Laboratory have been named fellows of the ... The new AAAS fellows and their award citations are: ... and Marylyne Munas Mehl Professor of Computer Engineering, "For distinguished ...
Cached Biology News:6 PNNL scientists elected 2010 AAAS Fellows 26 PNNL scientists elected 2010 AAAS Fellows 36 PNNL scientists elected 2010 AAAS Fellows 4Looking good on greens 2AAAS honors Iowa State, Ames Lab researchers for distinguished science 2
(Date:3/31/2015)... Campbell, California (PRWEB) March 31, 2015 ... management consulting firm with operations in California, Oregon, ... formal launch of its Merger and Acquisition (M&A) ... , Peter Adams, VP Client Services and M&A ... repeatedly shown that the vast majority of M&A ...
(Date:3/30/2015)... Calif. , March 30, 2015  NuGene ... its subsidiary corporation, NuGene BioPharma, Inc. has added ... Dr. Guan is an internationally recognized ... finishing his college education at Peking University, ... Ph.D. degree from the University of North Carolina, ...
(Date:3/30/2015)...    Intrexon Corporation (NYSE: XON ... Serono, the biopharmaceutical business of Merck KGaA, Darmstadt, ... exclusive strategic collaboration and license agreement to develop ... therapies. This collaboration advances Merck Serono,s comprehensive, science-driven ... immune system,s natural ability to fight tumors. ...
(Date:3/30/2015)... , March 30, 2015 ... auf    Richmond Pharmacology ist das erste ... Amyloidose-Zentrum am Royal Free Hospital in ... zur Untersuchung eines RNAi-Therapeutikums Studienversuche an einem Patienten ... von Transthyretin vermittelter Amyloidose entwickelt (ATTR), einer seltenen ...
Breaking Biology Technology:Lighthouse Information Systems, Inc., Announces Addition of M&A Integration Services 2UCI Professor Zhibin Guan Joins NuGene Advisory Board 2UCI Professor Zhibin Guan Joins NuGene Advisory Board 3Intrexon and Merck Serono Announce Agreement for the Development and Commercialization of CAR-T Therapy 2Intrexon and Merck Serono Announce Agreement for the Development and Commercialization of CAR-T Therapy 3Intrexon and Merck Serono Announce Agreement for the Development and Commercialization of CAR-T Therapy 4
... increasing evidence that, with best intent, current biological technology ... populations, with vaccines against emerging diseases at a rate ... change, e.g., before the disease has come and gone. ... synthesized vaccines produced in seven days can be effective, ...
... Acquisition Strengthens Gene Centric Product Portfolio , ROCKVILLE, Md., ... acquisition of Marligen Biosciences, Inc., a provider of cutting-edge ... protein and gene expression profiling assays and testing services, ... reinforces OriGene,s leading position in the bio-medical research industry ...
... , CLINTON, N.J., Oct. 19 Ikaria Holdings, Inc. today ... the board. Current Ikaria CEO Daniel Tasse has been ... as Chairman since 2007. , Shaw was a ... that was formed in 2005, and was instrumental in combining ...
Cached Biology Technology:New Non-Biological Synthetic Replikins(TM) Vaccines Shown to Be Effective and Fast; WorldVaccines(TM), Ltd Formed for Testing and Distribution 2New Non-Biological Synthetic Replikins(TM) Vaccines Shown to Be Effective and Fast; WorldVaccines(TM), Ltd Formed for Testing and Distribution 3OriGene Technologies Acquires Marligen Biosciences 2Ikaria(R) Names New Chairman 2
... The Finnpipette BioControl multichannel ... features as the single ... handle fits allseven multichannel ... tip cone modules. Both ...
cystatin A (N-18)...
...
Troponin I Immunogen: Full length native protein (purified) (Human). Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: