Navigation Links
Cyclin D1 governs microRNA processing in breast cancer
Date:11/29/2013

(PHILADELPHIA) Cyclin D1, a protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA (miRNA), according to new research publishing November 29 in Nature Communications. The research suggests that a protein strongly implicated in human cancer also governs the non-protein-coding genome. The non-coding genome, previously referred to as junk DNA, makes up most of the human genome, and unlike the coding genome, varies greatly between species.

"In addition to its role in regulating the cell cycle, cyclin D1 induces Dicer and thereby promotes the maturation of miRNA," says lead researcher Richard Pestell, M.D., Ph.D., Director of the Kimmel Cancer Center at Thomas Jefferson University and Chair of the Department of Cancer Biology. Dicer is a protein that converts inactive hairpin-structured microRNA precursors into their active single stranded form. "The work supports the idea that cancer-causing proteins like cyclin D1 may drive cancer progression in part via miRNA biogenesis."

Using antisense RNA, Dr. Pestell's group was the first to show that cyclin D1 drives mammary tumor growth in vivo. In prior work, they showed that cyclin D1 regulates the non coding genome, and that the non-coding genome, in turn, regulates expression of cyclin D1. Furthermore, the group showed that many cancer patients encode a form of cyclin D1 that evades negative feedback from the non coding genome. These attenuating feedback loops between the non coding and coding genome may be a common theme in cancer and other biological processes.

In the current study, the group sought to investigate the mechanism by which cyclin D1 regulates the biogenesis of non coding miRNA. Dr. Pestell and colleagues developed transgenic mice that could induce cyclin D1 expression in the breast and examined cells with cyclin D1 gene deleted
'/>"/>

Contact: Edyta Zielinska
edyta.zielinska@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New textbook tackles the sustainable recycling of manure
2. Historic blaze fueled a boom in tire recycling, advances in fire monitoring
3. Recycling valuable materials used in TVs, car batteries, cell phones
4. Gold nanoparticles give an edge in recycling CO2
5. More emphasis needed on recycling and reuse of Li-ion batteries
6. Blind flies without recycling
7. South Africas Capitec Bank Chooses Diebold Cash Recycling ATMs
8. Humans were already recycling 13,000 years ago
9. Alpine glaciers contribute to carbon cycling
10. ORNL researchers improve soil carbon cycling models
11. Polar And LOOK Launch The Worlds First Pedal-Based Power Cycling System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2015)... 12, 2015   MedNet Solutions , an innovative ... of clinical research, is proud to announce that ... SaaS-based eClinical technology platform, has led the way to ... quarters of 2015.   Q2 2015 and Q1 2015 ... by contract value sold in the company,s 15 year ...
(Date:8/12/2015)... , Aug. 12, 2015  New research ... can attack Android phones to steal users, fingerprints. ... increasing availability of fingerprint scanners on mobile devices, ... concern. To secure biometrics on mobile devices, HYPR ... augment these convenient authentication systems with strong cryptographic ...
(Date:8/11/2015)... Sweden , August 11, 2015 Today, ... FPC1155. Already received as well as expected revenues in 2015 that ... in FPC,s communicated revenue guidance of approximately 2,200 MSEK for 2015. ... is a prominent smartphone manufacturer in ... ZUK selected FPC1 155 for ...
Breaking Biology News(10 mins):MedNet Solutions Experiences Explosive Corporate Growth 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2
... agree that vitamin D promotes bone health, but a belief ... causes of death has been a major health controversy. Consistent ... a new study finds that vitamin D did not confer ... health factors such as abdominal obesity. "What we have ...
... Southern California (USC) professor Mary Ann Pentz, Ph.D., shows that ... more likely to drink alcohol in high school than their ... 2011 issue of the journal Alcohol and Alcoholism , ... may benefit from special prevention programs. "As you age, ...
... ALAMOS, New Mexico, October 31, 2011 A National Institutes of ... could help unravel the gnarly secrets of how many human ... the approximately 20,000 genes of the human body have been ... best tools for exposing a gene,s function is to take ...
Cached Biology News:Vitamin D study suggests no mortality benefit for older women 2Underage drinking among close friends high indicator of future alcohol use by black teens 2Antibody library project could unlock mysteries of human gene function 2
(Date:8/27/2015)... ... 2015 , ... Proove Biosciences, a commercial and research ... genetics and hypertension at the International Academy of Cardiology Annual Scientific ... The event, which boasts an extensive overview of the latest research developments in ...
(Date:8/26/2015)... 26, 2015  The Diabetes Research Institute (DRI), ... Miami Miller School of Medicine, announced today that ... test for the first time a novel transplant ... FDA approved Phase I/II study builds upon decades ... an important first step toward the development of ...
(Date:8/26/2015)... After litigating and negotiating patent infringement claims brought ... United States patent RE43,651 (the ,651 patent), ... United States without any admission or concession of ... a result of the parties, settlement, the US District Court ... dismissed the case without prejudice. Under the terms ...
(Date:8/25/2015)... ... August 25, 2015 , ... A ... are cancerous is described by University of Illinois researchers in the Journal ... photonics. , In “ Breast cancer diagnosis using spatial light interference microscopy ,” ...
Breaking Biology Technology:Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 2Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4P2i Settles United States Litigation 2New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 2New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 3New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 4
... N.C., May 5 ASG, Inc., saw continued ... of neighboring Ockham Development Group. The February merger ... expand the breadth and value of services that ... outsourcing and staffing services or the opportunity to ...
... May 5 /PRNewswire-FirstCall/ - Neptune Technologies & Bioressources Inc. ("Neptune") ... its product portfolio., Worldwide Sales and Distribution ... marketing team through the hiring of two, ... recognized backgrounds in the nutraceutical ...
... Uveitis, or inflammation within the eye, is a ... loss roughly comparable to that caused by diabetes. ... program in uveitis, the LUMINATE trials sponsored by ... voclosporin oral capsule) to significantly improve this chronic ...
Cached Biology Technology:CRO Acquisition Seen Boosting Activity, Positioning ASG, Inc., for New Growth in Q2 2Neptune Product and Distribution Update 2Neptune Product and Distribution Update 3Neptune Product and Distribution Update 4First oral uveitis drug reduces both inflammation and recurrence in potentially blinding eye disease 2First oral uveitis drug reduces both inflammation and recurrence in potentially blinding eye disease 3First oral uveitis drug reduces both inflammation and recurrence in potentially blinding eye disease 4