Navigation Links
Cyclin D1 governs microRNA processing in breast cancer
Date:11/29/2013

(PHILADELPHIA) Cyclin D1, a protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA (miRNA), according to new research publishing November 29 in Nature Communications. The research suggests that a protein strongly implicated in human cancer also governs the non-protein-coding genome. The non-coding genome, previously referred to as junk DNA, makes up most of the human genome, and unlike the coding genome, varies greatly between species.

"In addition to its role in regulating the cell cycle, cyclin D1 induces Dicer and thereby promotes the maturation of miRNA," says lead researcher Richard Pestell, M.D., Ph.D., Director of the Kimmel Cancer Center at Thomas Jefferson University and Chair of the Department of Cancer Biology. Dicer is a protein that converts inactive hairpin-structured microRNA precursors into their active single stranded form. "The work supports the idea that cancer-causing proteins like cyclin D1 may drive cancer progression in part via miRNA biogenesis."

Using antisense RNA, Dr. Pestell's group was the first to show that cyclin D1 drives mammary tumor growth in vivo. In prior work, they showed that cyclin D1 regulates the non coding genome, and that the non-coding genome, in turn, regulates expression of cyclin D1. Furthermore, the group showed that many cancer patients encode a form of cyclin D1 that evades negative feedback from the non coding genome. These attenuating feedback loops between the non coding and coding genome may be a common theme in cancer and other biological processes.

In the current study, the group sought to investigate the mechanism by which cyclin D1 regulates the biogenesis of non coding miRNA. Dr. Pestell and colleagues developed transgenic mice that could induce cyclin D1 expression in the breast and examined cells with cyclin D1 gene deleted
'/>"/>

Contact: Edyta Zielinska
edyta.zielinska@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New textbook tackles the sustainable recycling of manure
2. Historic blaze fueled a boom in tire recycling, advances in fire monitoring
3. Recycling valuable materials used in TVs, car batteries, cell phones
4. Gold nanoparticles give an edge in recycling CO2
5. More emphasis needed on recycling and reuse of Li-ion batteries
6. Blind flies without recycling
7. South Africas Capitec Bank Chooses Diebold Cash Recycling ATMs
8. Humans were already recycling 13,000 years ago
9. Alpine glaciers contribute to carbon cycling
10. ORNL researchers improve soil carbon cycling models
11. Polar And LOOK Launch The Worlds First Pedal-Based Power Cycling System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... be cultivated efficiently, they are anything but sustainable: ... monoculture cultivation is becoming increasingly evident. Despite their ... and are regarded as the sole possibility of ... wrongfully, finds Bernhard Schmid, an ecology professor at ... form of agriculture and forestry. After all, a ...
(Date:10/15/2014)... from strains of influenza virus increases with the latest ... complacent that the most substantial threats have been identified, ... arise when a new virus strain – against which ... in the human population. There have been five such ... which – the 1918 Spanish Flu – cost 50 ...
(Date:10/15/2014)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" or ... commerce market releases photos and video of the recent opening bell ... th . Gino Pereira , CEO of ... Mr. Chad A. Verdi rang the bell.  ... and employees "for their work and dedication in bringing the world,s ...
Breaking Biology News(10 mins):Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3
... not help improve a person,s golf game, stream salamanders might ... in the near future, following a new University of Missouri ... the United States, and approximately 70 percent of that land ... of Biology in the MU College of Arts and Science. ...
... 2008 -- As the United States continues to develop ... ethanol has emerged as one of the most commercially ... available, but the loss of soil organic carbon (SOC) ... cellulosic ethanol feedstock is of agricultural and environmental concern. ...
... take their medication for a range of life-threatening illnesses ... university research project. The 21-month study involving health ... of Leicester will draw on the experiences of school ... to learn about the barriers that prevent them from ...
Cached Biology News:Golf course: Playing fields, wildlife sanctuaries or both 2Managing carbon loss 2A spoonful of sugar? 2A spoonful of sugar? 3
(Date:10/22/2014)... , Oct. 22, 2014 Nuvilex, Inc. ... approximately 400 million people worldwide are living with diabetes, ... people by 2030.  The global market for diabetes treatments ... approximately 330,000 people worldwide died from pancreatic cancer.  Pancreatic ... due to cancer in the United States ...
(Date:10/20/2014)... 2014 Mapp Biopharmaceutical,s valiant effort to ... to fight the Ebola outbreak will make the ... production of pharmaceuticals can be, according to Kalorama ... while some may be taken aback by the ... industry knowledge are well aware of the complex ...
(Date:10/20/2014)... 20, 2014 , A major ... and the delivery of care has revealed changing trends ... inequalities in the provision of healthcare services across the ... by United European Gastroenterology (UEG), have been announced today ... awareness of the burden of GI disorders across ...
(Date:10/20/2014)... Earle Martin , Chief ... that Ellen Teplitzky, an experienced attorney specializing in ... industry, has joined the firm as Director of ... practice. NDA Partners provides legal services, including ... to top law firms and their clients in ...
Breaking Biology Technology:Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2
... two guests on CNBCs Kudlow Show discuss the American workforce ... from the CATO Institute and the other was a Democratic ... CATO Institute director that there is a shortage of skilled ... is putting forth propaganda to justify the erosion of a ...
... StrandVision, which makes digital displays for lobbies and waiting rooms, ... to place a 42-inch plasma TV in its local dental ... news, office hours, treatments, and dental products and services, all ... displays through a web site. , ,Clinic manager Bobbi Potter ...
... a State of the State speech that is anything less ... ,Whether Republican or Democrat, riding high in the polls ... annual State of the State speech to inspire, cajole and ... Doyles fourth report to the state was no exception. , ...
Cached Biology Technology:Are guest worker programs causing backlash amid IT downsizing? 2Are guest worker programs causing backlash amid IT downsizing? 3Are guest worker programs causing backlash amid IT downsizing? 4How's the State of the State? It depends on what numbers are crunched 2How's the State of the State? It depends on what numbers are crunched 3
... product for cell-based kinetic assays and research ... of expensive HTS equipment, which lead to ... development stage. The NOVOstar offers the right ... as any other assay suitable for the ...
... kit measures mitochondria intactness and detects ... potential. Features and Benefits: ... staining isolated mitochondria and for assaying ... the reagents required for the detection ...
... handy dispensers save space and ... hats, and other garb. They ... bins for small parts used ... Clear acrylic. Open-slot design for ...
... These handy dispensers save space ... wipers, hats, and other garb. ... storage bins for small parts ... manufacturing. Clear acrylic. Many other ...
Biology Products: