Navigation Links
Cyclin D1 governs microRNA processing in breast cancer
Date:11/29/2013

(PHILADELPHIA) Cyclin D1, a protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA (miRNA), according to new research publishing November 29 in Nature Communications. The research suggests that a protein strongly implicated in human cancer also governs the non-protein-coding genome. The non-coding genome, previously referred to as junk DNA, makes up most of the human genome, and unlike the coding genome, varies greatly between species.

"In addition to its role in regulating the cell cycle, cyclin D1 induces Dicer and thereby promotes the maturation of miRNA," says lead researcher Richard Pestell, M.D., Ph.D., Director of the Kimmel Cancer Center at Thomas Jefferson University and Chair of the Department of Cancer Biology. Dicer is a protein that converts inactive hairpin-structured microRNA precursors into their active single stranded form. "The work supports the idea that cancer-causing proteins like cyclin D1 may drive cancer progression in part via miRNA biogenesis."

Using antisense RNA, Dr. Pestell's group was the first to show that cyclin D1 drives mammary tumor growth in vivo. In prior work, they showed that cyclin D1 regulates the non coding genome, and that the non-coding genome, in turn, regulates expression of cyclin D1. Furthermore, the group showed that many cancer patients encode a form of cyclin D1 that evades negative feedback from the non coding genome. These attenuating feedback loops between the non coding and coding genome may be a common theme in cancer and other biological processes.

In the current study, the group sought to investigate the mechanism by which cyclin D1 regulates the biogenesis of non coding miRNA. Dr. Pestell and colleagues developed transgenic mice that could induce cyclin D1 expression in the breast and examined cells with cyclin D1 gene deleted
'/>"/>

Contact: Edyta Zielinska
edyta.zielinska@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New textbook tackles the sustainable recycling of manure
2. Historic blaze fueled a boom in tire recycling, advances in fire monitoring
3. Recycling valuable materials used in TVs, car batteries, cell phones
4. Gold nanoparticles give an edge in recycling CO2
5. More emphasis needed on recycling and reuse of Li-ion batteries
6. Blind flies without recycling
7. South Africas Capitec Bank Chooses Diebold Cash Recycling ATMs
8. Humans were already recycling 13,000 years ago
9. Alpine glaciers contribute to carbon cycling
10. ORNL researchers improve soil carbon cycling models
11. Polar And LOOK Launch The Worlds First Pedal-Based Power Cycling System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... of researchers led by the University of York has ... in the Western Indian Ocean. , The results, ... to a revolution in the management of marine protected ... than 11,000 km in the region now under ... zones of the seas and coasts designed to protect ...
(Date:7/24/2014)... Singapore have developed Asia,s first genetic test for identifying ... the cornea called corneal stromal dystrophy which can lead ... the POLARIS TGFBI (Transforming Growth Factor beta Induced) test, ... diagnosis and management of patients with corneal stromal dystrophies. ... mutation who may also be at risk of developing ...
(Date:7/23/2014)... new study of identical twins has found that early ... study, in the journal Child Development , was ... King,s College London. , "Since reading is an ability ... reading instruction," according to Stuart J. Ritchie, research fellow ... the study. "Early remediation of reading problems might aid ...
Breaking Biology News(10 mins):Western Indian Ocean communities play vital role in conservation 2Singapore team develops Asia's first genetic test that can prevent corneal blindness 2Singapore team develops Asia's first genetic test that can prevent corneal blindness 3Stronger early reading skills predict higher intelligence later 2
... may plead, cajole or entice their children to try new foods, ... University of North Carolina at Chapel Hill reveals that the reason ... on their plate and more to do with their genes. ... at UNC,s Gillings School of Global Public Health, adds to the ...
... scientists led by Dr Kate Sanders from the University of ... Museum, has uncovered how some sea snakes have developed ,shrunken ... Their research is published today in the journal ... "all the better to eat you with" - would ...
... DNA sequence data is growing exponentially", says Miami University ... the genes that we identify, we have no idea ... a foreign language, waiting to be deciphered." Understanding the ... at the forefront of molecular biology. Many groups develop ...
Cached Biology News:Genes may be reason some kids are picky about food 2Scientists discover reasons behind snakes' 'shrinking heads' 2Genomic data are growing, but what do we really know? 2
(Date:7/24/2014)... 2014 WIRB-Copernicus Group ® ("WCG")™, ... review services for clinical research, announced today that ... of Richmond, VA -based Alliance ... biosecurity consulting firm in the United ... division – WCG Biosafety™ – will be able ...
(Date:7/24/2014)... Canada (PRWEB) July 24, 2014 The ... Optimizing Dose Escalation in First in Human Studies” will ... make better go/no-go decisions. , With increasing R&D costs ... pharmaceutical companies need to maximize the knowledge collected in ... decisions and improve success in late stage development. , ...
(Date:7/24/2014)... 24, 2014  Spherix Incorporated (SPEX) -- an intellectual ... of intellectual property, today announced that the Company will ... 30, 2014 on Monday, August 18, 2014 for shareholders. ... ET on Monday, August 18, 2014 to discuss the ... company,s CEO, Anthony Hayes . Following ...
(Date:7/24/2014)... 24, 2014 As part of the ... in the MENA region during 2014 with potential global ... provider agreement with DZS to manage our clinical trials ... Global VP of R&D and President of SBI pharmaceuticals ... operational practices with a focus on utilizing eClinical software ...
Breaking Biology Technology:WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3Best Practices for Optimizing Dose Escalation in First in Human Studies, New Webinar August 6th Hosted by Xtalks 2Spherix Schedules Shareholder Update Call 2SBI Pharmaceuticals Co. Ltd. Enters into Preferred Provider Agreement with DZS Clinical Services 2
... Ohio, July 8 Knowledge Enterprises, Inc.,and ... release of The,2007-2008 Orthopaedic Industry Annual Report, ... industry data. The nearly 200,page Annual Report ... to Joint Replacement, Fracture Repair, Arthroscopy/Soft,Tissue Repair, ...
... July 8 RADI Medical Systems today,announced ... guide,wire, PressureWire(R) Certus, which will begin shipments ... The latest generation of the PressureWire(R) ... which provides three key,advantages for physicians. The ...
... July 8 Telik, Inc.,(Nasdaq: TELK ), ... &,Medicinal Chemistry Letters describing a novel class of ... new treatment for diabetes.,These unique compounds are the ... to optimize the original lead structure identified through,the ...
Cached Biology Technology:Knowledge Enterprises, Inc. and The Institute for Orthopaedics(TM) Release The 2007-2008 Orthopaedic Industry Annual Report 2RADI Medical Systems Launches Next Generation PressureWire(R) Certus 2Telik Announces Publication of Diabetes Research in Bioorganic & Medicinal Chemistry Letters 2
Human plasmacytoid dendritic cells, BDCA-4+, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Umbilical cord blood basophils, For immunohistochemistry (IHC)...
Human peripheral blood CD8+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Umbilical cord blood CD4+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood MNCs and T Cells...
Biology Products: