Navigation Links
Crystal structure of archael chromatin clarified in new study
Date:3/7/2012

Researchers at the RIKEN SPring-8 Center in Harima, Japan have clarified for the first time how chromatin in archaea, one of the three evolutionary branches of organisms in nature, binds to DNA. The results offer valuable clues into the evolution of chromatin structure in multi-cellular organisms and promise insights into how abnormalities in such structure can contribute to cancers and gene disorders.

Three distinct evolutionary branches of organisms make up all natural forms of life on the planet: bacteria, archaea and eukaryotes. Among these three, the domain known as archaea includes a variety of organisms that live in harsh environments similar to those of an early Earth, thus offering arguably the greatest glimpse of what life may have looked like 4 billion years ago.

One area of great interest is the process by which DNA bind to proteins to compact and regulate the availability of genetic material, a process which is essential in all cellular organisms. In eukaryotes, proteins known as "histones" package and order DNA into a compact protein-DNA structure called chromatin. Archaea, in contrast, have no such universal chromatin proteins, instead using two or more DNA-binding proteins to package DNA. Alba is the most widespread and abundant such archaeal chromatin protein, present in the genome sequence of every archaeal species that lives in high-temperature environments (thermophilic or hyperthermophilic).

While researchers know about the existence of Alba in archaea, the question of how these proteins bind to and compact DNA has remained a mystery. To answer this question, the researchers analyzed the crystal structure of the Alba2-DNA complex from the archaea A. pernix K1 at atomic-level resolution using synchrotron radiation from the RIKEN SPring-8 facility in Harima, Japan. Their results indicate that unlike the chromatin structure of eukaryotes, Alba2 in archaea forms a hollow pipe with the duplex DNA running through it, wi
'/>"/>

Contact: Thirumananseri Kumarevel
81-079-158-0802
RIKEN
Source:Eurekalert

Page: 1 2

Related biology news :

1. Crystal structure shows how motor protein works
2. Crystals detect threats to national security
3. Nano-diamond qubits and photonic crystals
4. Quartz crystal microbalances enable new microscale analytic technique
5. X-ray crystallography reveals structure of precursor to blood-clotting protein
6. New type of liquid crystal promises to improve performance of digital displays
7. How do your crystals grow?
8. A crystal ball for predicting the effects of global climate change
9. Cholesterol crystals incite inflammation in coronary arteries
10. Ancestral Eve crystal may explain origin of lifes left-handedness
11. Researchers envision high-tech applications for multiferroic crystals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... 2015 Synaptics Inc. (NASDAQ: ... solutions, today announced a new implementation of its ... rapid and secure transactions and reliable identification for ... a turnkey solution providing mouse and keyboard peripheral ... fingerprint ID solutions into their product offerings, bringing ...
(Date:2/24/2015)... YORK , Feb. 24, 2015 This report ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... . Annual estimates and forecasts are provided for the ... provided for these markets. Market data and analytics are derived ...
(Date:2/19/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kx9zp8/military ) ... Electro-Optical / Infrared Systems Market by Type, by ... to 2020" report to their offering. ... expected to reach $16.35 billion by 2020, to ... report segments the military electro-optical/infrared systems market on ...
Breaking Biology News(10 mins):Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3
... Energy Department,s National Renewable Energy Laboratory (NREL) have discovered that ... of Geysers on the Kamchatka Peninsula in Russia in 1990 ... leading component cellulase enzyme on the market. If the ... help drive down the price of making lignocellulosic fuels, from ...
... (land vertebrates) the fourth (ring) finger is the first to ... the outside of the hand (posterior, the pinky side) appears ... it can be shown that on the thumb side (anterior) ... this would have to be digit I. These data argue ...
... Staphylococcus aureus ), dubbed a ,superbug, due to its ... glycopeptide antibiotic Vancomycin being commonly prescribed for patients in ... to concerns of a ,creeping minimum, in the concentration ... nomograms are used to calculate the correct dosage of ...
Cached Biology News:NREL finds a new cellulose digestion mechanism by a fast-eating enzyme 2NREL finds a new cellulose digestion mechanism by a fast-eating enzyme 3The 5 fingers of our feathered friends: New research results on the evolution of bird wings 2
(Date:3/4/2015)... CALIFORNIA (PRWEB) March 04, 2015 ... firm in the life sciences industry, hired David ... leads the Cloud Compliance Services and Solutions at ... utilize cloud based applications while maintaining compliance with government ... Blewitt has been an accomplished life sciences regulatory and ...
(Date:3/4/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/jspg2c/global_biologics ) ... Biologics and Biosimilars Industry Report 2015" report ... Global Biologics and Biosimilars Industry Report 2015 is ... state of the biologics and biosimilars industry. ... the industry including definitions, classifications, applications and industry ...
(Date:3/4/2015)... CA. (PRWEB) March 04, 2015 ... headquartered in the San Francisco Bay Area, will exhibit ... (OCT) Israel Conference 2015 on March 25th and ... seeks to build relationships with Israeli life science companies ... clinical trials. The company’s services span all phases of ...
(Date:3/4/2015)... , March 4, 2015 AcelRx Pharmaceuticals, ... pharmaceutical company focused on the development and commercialization ... and breakthrough pain, today announced that it will ... after market close on Monday, March 9th, 2015. ... at 4:30 p.m. Eastern Time (1:30 p.m. Pacific ...
Breaking Biology Technology:USDM Life Sciences Names David Blewitt VP of Cloud Compliance for Regulated Life Sciences 2USDM Life Sciences Names David Blewitt VP of Cloud Compliance for Regulated Life Sciences 3Global Biologics and Biosimilars Industry Report 2015-2020 2PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 2PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 3PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 4AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 3
... SCOTTSDALE, Ariz. , Feb. 4 A ... cancer care in community oncology practices revealed that Medicare covers ... providing related infusion room services to seniors with cancer. The ... planning, care coordination, and follow-up care planning -- are not ...
... ... , ... (Vocus) February 4, 2010 -- Qteros, Inc. , a leading developer of second-generation ... announced today that Mick Sawka has joined the company as Vice President, Business Development, ...
... RESEARCH TRIANGLE PARK, N.C. , Feb. 4 ... orally available antiviral therapeutics, announced today that Gwendolyn Powell ... Medical Officer.   , Dr. Painter has more than 20 ... clinical development, clinical safety and pharmacovigilance, and occupational and environmental ...
Cached Biology Technology:Study: Medicare Covers Only Half the Cost of Administering Chemotherapy to Seniors with Cancer 2Study: Medicare Covers Only Half the Cost of Administering Chemotherapy to Seniors with Cancer 3Study: Medicare Covers Only Half the Cost of Administering Chemotherapy to Seniors with Cancer 4Biofuels Technology Leader Qteros Names Mick Sawka Vice President, Business Development 2Biofuels Technology Leader Qteros Names Mick Sawka Vice President, Business Development 3Chimerix Names Wendy Painter, M.D., M.P.H., as Chief Medical Officer 2Chimerix Names Wendy Painter, M.D., M.P.H., as Chief Medical Officer 3
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SSA (Sheep serum albumin) lysine through amide bonds. This product is homologous to NP-BSA....
...
Human Aminopeptidase P2/XPNPEP2 Affinity Purified PAb ENTREZ GeneID: 7512...
Collected from 8-12 week old sexually mature rats. Pricing: $100/unit for 1 - 10 units...
Biology Products: