Navigation Links
Crystal structure of archael chromatin clarified in new study
Date:3/7/2012

Researchers at the RIKEN SPring-8 Center in Harima, Japan have clarified for the first time how chromatin in archaea, one of the three evolutionary branches of organisms in nature, binds to DNA. The results offer valuable clues into the evolution of chromatin structure in multi-cellular organisms and promise insights into how abnormalities in such structure can contribute to cancers and gene disorders.

Three distinct evolutionary branches of organisms make up all natural forms of life on the planet: bacteria, archaea and eukaryotes. Among these three, the domain known as archaea includes a variety of organisms that live in harsh environments similar to those of an early Earth, thus offering arguably the greatest glimpse of what life may have looked like 4 billion years ago.

One area of great interest is the process by which DNA bind to proteins to compact and regulate the availability of genetic material, a process which is essential in all cellular organisms. In eukaryotes, proteins known as "histones" package and order DNA into a compact protein-DNA structure called chromatin. Archaea, in contrast, have no such universal chromatin proteins, instead using two or more DNA-binding proteins to package DNA. Alba is the most widespread and abundant such archaeal chromatin protein, present in the genome sequence of every archaeal species that lives in high-temperature environments (thermophilic or hyperthermophilic).

While researchers know about the existence of Alba in archaea, the question of how these proteins bind to and compact DNA has remained a mystery. To answer this question, the researchers analyzed the crystal structure of the Alba2-DNA complex from the archaea A. pernix K1 at atomic-level resolution using synchrotron radiation from the RIKEN SPring-8 facility in Harima, Japan. Their results indicate that unlike the chromatin structure of eukaryotes, Alba2 in archaea forms a hollow pipe with the duplex DNA running through it, wi
'/>"/>

Contact: Thirumananseri Kumarevel
81-079-158-0802
RIKEN
Source:Eurekalert

Page: 1 2

Related biology news :

1. Crystal structure shows how motor protein works
2. Crystals detect threats to national security
3. Nano-diamond qubits and photonic crystals
4. Quartz crystal microbalances enable new microscale analytic technique
5. X-ray crystallography reveals structure of precursor to blood-clotting protein
6. New type of liquid crystal promises to improve performance of digital displays
7. How do your crystals grow?
8. A crystal ball for predicting the effects of global climate change
9. Cholesterol crystals incite inflammation in coronary arteries
10. Ancestral Eve crystal may explain origin of lifes left-handedness
11. Researchers envision high-tech applications for multiferroic crystals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... -- higi, a leading cloud-based consumer engagement platform that provides ... their communities around health and wellness, announced today the ... ... convenient vehicle to receive validated health information from consumers. ... API will allow higi,s trusted partners, on a user ...
(Date:4/6/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market, announced today ... MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND SYSTEM FOR ... introduces a new revolutionary method and system to ... of miniature antenna modules for multiple purposes including ...
(Date:4/2/2015)... Fingerprint Cards (FPC) has received ... the distributor World Peace Industrial Group (WPI), part of ... the major part of the shipments will take place ... smartphone manufacturers in China . The ... communicated revenue guidance of + 1 000 MSEK for 2015.  ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... becomes higher, the hair at the back of the man's ... greater or lesser hair loss. There are hardly any successful ... , It has long been suspected that hereditary factors are ... was unclear which genes are involved. The researchers in the ...
... team from Yale School of Medicine has glimpsed one ... work, performed in collaboration with English and French scientists, ... internalize cell surface receptors. , All cells traffic protein ... most important routes for cargo internalization is clathrin mediated ...
... brain cells less than half the size of a pencil eraser ... when it's time to go to sleep. The same cells also ... zones. , The human circadian clock, comprised of about 20,000 time-keeping ... about 30 years ago. Now, a researcher at the University of ...
Cached Biology News:Tendency to hair loss inherited from the mother 2Researchers develop assay that could be applied to drug screening 2The circadian clock: Understanding nature's timepiece 2
(Date:5/4/2015)... 4, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) announced ... Form 20-F for the fiscal year ended December 31, ... The annual report on Form 20-F contains information regarding ... the area of cancer immune checkpoints. This project aims ... specificity and binding in targeting certain identified immune checkpoints. ...
(Date:5/4/2015)... Boston, MA (PRWEB) May 04, 2015 ... solutions for drug discovery and life science research, ... 5.0 , the latest version of its enterprise ... for biopharma R&D enables more efficient discovery and ... holistic approach to integrate and address protein optimization ...
(Date:5/4/2015)...   Tocagen Inc. , a clinical-stage immuno-oncology ... ongoing investigational studies were presented at the 11 th ... of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) ... Washington, D.C. In addition, ... FDA and continues to advance towards initiation of ...
(Date:5/1/2015)... N.C. (PRWEB) May 01, 2015 ... Charlotte (UNC Charlotte) spin-out company, announced that Pinku Mukherjee, ... the UNC Board of Governors’ highest faculty honor. ... to humanity’s welfare , for her innovative research and ... Max Gardner Award represents a crowning moment in my ...
Breaking Biology Technology:Tikcro Technologies Files Annual Report on Form 20-F for the Year Ended December 31, 2014 2Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 2Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 3Genedata Biologics 5.0 – Antibody Engineering and Developability Assessment Advances 4Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 2Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 3Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 4Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 5OncoTAb CSO Awarded the University of North Carolina’s O. Max Gardner Award 2
... , Agencourts RNAClean ... method for purifying nucleic acid products generated in common enzymatic , ... The kit is formatted for microarray , gene ... automated formats. RNAClean eliminates the need for vacuum filtration or ...
... , , RNA later is a ... that stabilizes and protects cellular RNA in fresh , ... specifically for use with frozen tissues - see "<A , ... Grinding Frozen Tissue " for more information.) ...
... Gene arrays are solid ... collection of gene-specific nucleic acids have been placed at , ... array analysis, a nucleic acid-containing sample is labeled , ... targets , on the array. ...
Cached Biology Technology:RNAClean - RNA & cDNA in vitro Reaction Purification 2RNArticles: Keeping RNA Intact Prior to RNA Isolation - RNAlater 2RNArticles: Keeping RNA Intact Prior to RNA Isolation - RNAlater 3RNArticles: Keeping RNA Intact Prior to RNA Isolation - RNAlater 4RNArticles: Keeping RNA Intact Prior to RNA Isolation - RNAlater 5RNArticles: Keeping RNA Intact Prior to RNA Isolation - RNAlater 6RNArticles: Keeping RNA Intact Prior to RNA Isolation - RNAlater 7Array Analysis: The Basics 2Array Analysis: The Basics 3Array Analysis: The Basics 4Array Analysis: The Basics 5
Rabbit polyclonal to Peptide E ( Abpromise for all tested applications)....
Mouse monoclonal [6911] to E. coli K99 pilus ( Abpromise for all tested applications)....
...
...
Biology Products: