Navigation Links
Crestor Delivers Latest LDL-C Targets in High-Risk Patients at Lower Doses than Other Statins
Date:3/26/2012

LONDON, March 26, 2012 /PRNewswire/ --

Results presented from new VOYAGER sub-analysis

This release is INTENDED EXCLUSIVELY FOR EUROPEAN media

AstraZeneca today announced the results of a sub-analysis from the VOYAGER individual patient data meta-analysis, which suggests that achieving an LDL-C goal of <70 mg/dL or >50% reduction in LDL-C levels in patients at high risk requires aggressive statin therapy. These goals reflect the latest European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) Guidelines for the Management of Dyslipidaemias. Results showed that a significantly greater percentage of patients achieved this goal with CRESTOR™ (rosuvastatin) than with equal or double doses of atorvastatin (Lipitor®) or simvastatin. These findings were presented at the 2012 International Symposium on Atherosclerosis in Sydney, Australia.

This sub-analysis was designed to determine the percentage of high-risk patients treated with rosuvastatin 10-40 mg, atorvastatin 10-80 mg or simvastatin 10-80 mg who achieved this recommended LDL-C goal. Additional findings from the VOYAGER sub-analysis included:

  • As statin dose increased, a higher percentage of patients achieved LDL-C <70 mg/dL or >50% LDL-C reduction.
  • Statistically significant differences (all p<0.001)were observed across a range of statin therapy comparisons, including:
  • Rosuvastatin 10mg vs atorvastatin 10-20mg and simvastatin 10-20mg
  • Rosuvastatin 20mg vs atorvastatin 20-40mg and simvastatin 20-80mg
  • Rosuvastatin 40mg vs atorvastatin 40-80mg and simvastatin 40-80mg

Percentage of high-risk patients achieving LDL-C goal

 

     (Photo: http://www.newscom.com/cgi-bin/prnh/20120326/521032 )

 

"These data reinforce CRESTOR a
'/>"/>

SOURCE AstraZeneca
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology news :

1. Global commission delivers food security policy recommendations
2. Partnership delivers asthma care to children whose care centers were flooded by Katrina
3. Three-part handoff delivers proteins to membrane surface
4. Cell Press delivers the news
5. Global Rainmakers Delivers World Class Iris Capability for Portoss
6. DigitalPersona Delivers New Centrally-Managed Solution for Notebook Data Protection and Remote Access Security
7. Homex Delivers Solid Q-1 2010 Revenue Growth of 12.2 Percent
8. BIO-key(R) Delivers FBI-Compliant 2 Factor Authentication Solution for First Responders
9. ESAs ice mission delivers first data
10. Self-assembling nano-fiber gel delivers high concentrations of clinically approved drugs
11. Toxicologists annual meeting in San Francisco to showcase the latest scientific achievements
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... channels are implicated in many serious conditions such as ... potential target for drug therapies. Unfortunately, there is still ... Cambridge research provides fresh and unexpected insight into the ... components - β-subunit molecules - which are responsible for ... published in the most recent edition of the ...
(Date:4/17/2014)... whereby the genetic information of DNA is used ... have numerous different functions in living organisms. Messenger ... gene expression, by relating the genetic information of ... proteins. , By examining the different types ... organism at a given time, researchers can determine ...
(Date:4/17/2014)... researchers, led by the Australian National University (ANU), ... changes and deep-sea temperature variability over the past ... better understand the climate surrounding ice ages over ... determine the relationship between carbon dioxide levels, global ... the University of Southampton (UoS) and the National ...
Breaking Biology News(10 mins):Structure of sodium channels different than previously believed 2Rapid and accurate mRNA detection in plant tissues 2Ancient sea-levels give new clues on ice ages 2
... team of scientists led by Dr Kate Sanders from the ... South Australian Museum, has uncovered how some sea snakes have ... related species. Their research is published today in ... large head "all the better to eat you with" ...
... Ohio An obesity intervention taught by teen mentors ... blood pressure and healthy lifestyle changes among the younger ... In contrast, children taught the same lessons by ... their health outcomes. The results of the eight-week ...
... March 20, 2013 - Philanthropist, businessman and community leader ... approximately $2 million to fund the development of a ... parasitic infection that affects tens of millions of people ... "We are grateful for John,s generosity and foresight," said ...
Cached Biology News:Scientists discover reasons behind snakes' 'shrinking heads' 2Teen mentors inspire healthier choices in younger children 2Teen mentors inspire healthier choices in younger children 3Teen mentors inspire healthier choices in younger children 4John Moores gives $2 million to Scripps Research to develop river blindness field test 2
(Date:1/14/2014)... (PRWEB) January 14, 2014 Histogen, Inc., ... products of cells grown under simulated embryonic conditions, today ... agreement with Suneva Medical, Inc. for physician-dispensed aesthetic products ... , This agreement is an amendment to the ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... of Alliqua, Inc. (OTCQB: ALQA). Alliqua is an emerging ... to serve the wound care market. , Free report ... was restructured with a seasoned management team and Board, ...
(Date:1/14/2014)... 14, 2014 iLab Solutions, the leader in ... new Director of Product Strategy. In this role, Michelle will ... sub-teams to guide in the development of iLab products. Her ... maximum possible benefit to the scientific community by offering the ...
(Date:1/14/2014)... 14, 2014 Global Record Systems, ... information technology solutions for patients, physicians, the biopharmaceutical ... announced today the signing of a three-year Research ... Drug Administration (FDA). This initiative is designed ...
Breaking Biology Technology:Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... protects cellular RNA , within specimens ... Whether you are in the lab, in the OR, or out in the field, , ... Stabilization Solution from ambient temperatures down to , ... Characterization of disease mechanisms using , ...
... RNAs (siRNAs) are , short, double-stranded ... mRNAs for degradation via a cellular process termed RNA interference , ... the use of vectors expressing functional siRNAs ... (for a review, see Tuschl, 2002). Two different , ...
... Now it's easy to make your RNA free of genomic DNA , ... & Removal Reagents contain RNase-free DNase, and an optimized ... complete removal of , contaminating DNA from ... DNase Removal Reagent which, after digestion, eliminates DNase in , ...
Cached Biology Technology:Preserve Samples for RNA Expression Microarrays RNAlater Around the World 2Preserve Samples for RNA Expression Microarrays RNAlater Around the World 3Preserve Samples for RNA Expression Microarrays RNAlater Around the World 4Preserve Samples for RNA Expression Microarrays RNAlater Around the World 5More siRNA Vectors for RNA Interference 2More siRNA Vectors for RNA Interference 3More siRNA Vectors for RNA Interference 4More siRNA Vectors for RNA Interference 5More siRNA Vectors for RNA Interference 6More siRNA Vectors for RNA Interference 7DNA-free A NEW Method to Remove DNA 2DNA-free A NEW Method to Remove DNA 3DNA-free A NEW Method to Remove DNA 4DNA-free A NEW Method to Remove DNA 5DNA-free A NEW Method to Remove DNA 6DNA-free A NEW Method to Remove DNA 7DNA-free A NEW Method to Remove DNA 8
... Exonuclease III digests duplex DNA in ... end, 5'-overhang or nick, producing stretches of ... degradation by Exonuclease III proceeds at a ... Because the rate of exonucleolytic excision of ...
... Klenow fragment is a proteolytic ... DNA Polymerase I which ... 5 exonuclease activity, but has ... Klenow retains the polymerization fidelity ...
... RNase H degrades, as an endoribonuclease, ... DNA hybrids of natural origin, e.g. ... synthetic complexes, e.g. poly(A) x poly(dT). ... and 3-OH termini. Nearly no activity ...
... Source: E. coli strain containing an overproducing ... Ligase catalyzes the formation of a phosphodiester bond ... in duplex DNA or RNA. It repairs single-stranded ... and will join both blunt-end and cohesive-end fragments ...
Biology Products: