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Crestor Delivers Latest LDL-C Targets in High-Risk Patients at Lower Doses than Other Statins
Date:3/26/2012

LONDON, March 26, 2012 /PRNewswire/ --

Results presented from new VOYAGER sub-analysis

This release is INTENDED EXCLUSIVELY FOR EUROPEAN media

AstraZeneca today announced the results of a sub-analysis from the VOYAGER individual patient data meta-analysis, which suggests that achieving an LDL-C goal of <70 mg/dL or >50% reduction in LDL-C levels in patients at high risk requires aggressive statin therapy. These goals reflect the latest European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) Guidelines for the Management of Dyslipidaemias. Results showed that a significantly greater percentage of patients achieved this goal with CRESTOR™ (rosuvastatin) than with equal or double doses of atorvastatin (Lipitor®) or simvastatin. These findings were presented at the 2012 International Symposium on Atherosclerosis in Sydney, Australia.

This sub-analysis was designed to determine the percentage of high-risk patients treated with rosuvastatin 10-40 mg, atorvastatin 10-80 mg or simvastatin 10-80 mg who achieved this recommended LDL-C goal. Additional findings from the VOYAGER sub-analysis included:

  • As statin dose increased, a higher percentage of patients achieved LDL-C <70 mg/dL or >50% LDL-C reduction.
  • Statistically significant differences (all p<0.001)were observed across a range of statin therapy comparisons, including:
  • Rosuvastatin 10mg vs atorvastatin 10-20mg and simvastatin 10-20mg
  • Rosuvastatin 20mg vs atorvastatin 20-40mg and simvastatin 20-80mg
  • Rosuvastatin 40mg vs atorvastatin 40-80mg and simvastatin 40-80mg

Percentage of high-risk patients achieving LDL-C goal

 

     (Photo: http://www.newscom.com/cgi-bin/prnh/20120326/521032 )

 

"These data reinforce CRESTOR a
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SOURCE AstraZeneca
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