Navigation Links
Counting duplicated genome segments now possible
Date:8/30/2009

A newly designed computational method has proven its usefulness in counting copies of duplicated genome sequences and in doing initial assessments of their contents, according to a study to be published Aug. 30 in Nature Genetics. The number of copies of particular DNA segments can differ from one person to the next.

The researchers named their method mrFAST, an acronym for micro-read Fast Alignment Search Tool. The study is titled, "Personalized Copy Number and Segmental Duplication Maps Using Next Generation Sequencing." The lead authors are Dr. Can Alkan, a senior fellow, and Jeffrey M. Kidd, a graduate student, both in the Department of Genome Sciences at the University of Washington (UW). Dr. Evan E. Eichler, UW professor of genome sciences, is the senior author.

Segmental duplications in the human genome have been associated with susceptibility and resistance to disease. Duplicated segments have been linked to such disorders as lupus, Crohn's disease, mental retardation, schizophrenia, color blindness, psoriasis, and age-related macular degeneration. Segmental duplications often contain duplicated genes, many of which have an unknown function. Individuals have different numbers of copies of some of these duplications. Determining the number, content, and location of segmental duplications is an important step in understanding the health significance of gene copy-number variation.

"New computational methods, combined with next-generation DNA sequencing technology, has provided for the first time an accurate census of specific genes that exist in varying number of copies," Alkan said.

"This is a way to deal with some of the most complex regions of the human genome and do what might appear to be a simple thing: Count whether a person has one, two, three or more copies of a gene," explained Kidd. "In fact, such counting is surprisingly difficult." Many standard genome analyses exclude duplication-rich or repeat-ri
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The straight poop on counting tigers
2. Counting sheep in climate change predictions
3. Carbon accounting from atmospheric measurements -- the aircraft perspective
4. Study shows Californias autism increase not due to better counting, diagnosis
5. Counting tumor cells in blood predicts treatment benefit in prostate cancer
6. When accounting for the global nitrogen budget, dont forget fish
7. Mars Express -- 5000 orbits and counting
8. Faster, cheaper way to find disease genes in human genome passes initial test
9. Genome duplication responsible for more plant species than previously thought
10. After dinosaurs, mammals rise but their genomes get smaller
11. Springer to collaborate with the Human Genome Organization
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... first week of May, 2015 and will be fulfilling ... Gino Pereira , Chief Executive Officer ... as Wocket® enters the consumer market. We would like ...
(Date:4/20/2015)... PASADENA, Calif. , April 20, 2015 ... San Gabriel Valley to implant a new miniaturized, wireless ... HF System is the first and only FDA-approved heart ... reduce hospital admissions when used by physicians to manage ... a sensor that is implanted in the pulmonary artery ...
(Date:4/14/2015)... 2015  HYPR Corp. today announced it has ... Alliance tm , an industry consortium transforming online ... share technology and collaborate to deliver open specifications ... secure and private, and easier to use. ... protects sensitive user information and eliminates the dependency ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3
... neonatal illness in piglets is coccidiosis, a parasitic disease ... Isospora suis . There are many reasons ... welfare considerations to pure financial concerns. Unfortunately, however, ... should be done. Sulfonamides are frequently suggested as ...
... of the measurements will be used to evaluate the effect ... the environmental impact on the air and soil. The initiative ... BATFARM European project.. The mobile laboratory is equipped with ... A photoacoustic gas analyser will be used to monitor in ...
... and mosquitoes share similar sensory receptors that allow them to ... chemical odors as they search for food or try ... report in the current electronic edition of the journal ... found on the surfaces of neurons that give the fruit ...
Cached Biology News:Healthy piglets? Not with sulfonamides! 2Neiker-Tecnalia sets up a mobile laboratory to reduce the environmental impact of farms 2Senses of sophistication: Mosquitoes detect subtle cues finding food, spreading diseases 2
(Date:5/21/2015)... , May 21, 2015  The EveryLife Foundation ... (R-UT) and Amy Klobuchar (D-MN) ... Accelerating Cures & Treatments, or OPEN ACT. ... patient advocacy organizations, this bipartisan legislation promises to ... medicines to rare disease patients by incentivizing drug ...
(Date:5/21/2015)... W. R. Grace & Co. (NYSE: ... Germany has received good manufacturing practice (GMP) certification ... Pharmaceutical Excipient Council (IPEC) Foundation. , ... FP brand of pharmaceutical grade excipient silica gels ... Bay, Maryland (USA) and Sorocaba, Brazil locations. The ...
(Date:5/21/2015)... , May 21, 2015  CytRx Corporation (NASDAQ: ... company specializing in oncology, today announced positive updated ... with aldoxorubicin for the treatment of unresectable glioblastoma ...  The open-label, multisite trial is designed to investigate ... patients whose tumors have progressed following prior treatment ...
(Date:5/21/2015)... May 20, 2015 Research and Markets ... of the "2015 Global Survey on Flow ... The primary goal of this research ... instruments and reagents. Key information the survey seeks ... of flow cytometers, predominantly used applications for flow ...
Breaking Biology Technology:Advocates Cheer Senate Leaders for Introducing Bipartisan Bill to Increase Number of Rare Disease Treatments 2Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7Global Survey on Flow Cytometry Adoption Trends 2015 2
, , , , back to top...
... Faye Boeckman, Marni Brisson, and Larissa Tan, Bio-Rad Laboratories, Inc.,Hercules CA 94547 USA ... , General Information , ... a versatile tool , in molecular biology. The ... advances in gene discovery, diagnostics, and gene expression analysis. , ...
... Psychiatry Research, , 130 West Kingsbridge Road, ... Introduction , ... population (Strange 1992). Patients experience a variety of ... of positive symptoms (e.g., thought disorder, , abnormal ...
Cached Biology Technology:Real-Time PCR: General Considerations, Rev A 2Real-Time PCR: General Considerations, Rev A 3Real-Time PCR: General Considerations, Rev A 4Real-Time PCR: General Considerations, Rev A 5Real-Time PCR: General Considerations, Rev A 6Real-Time PCR: General Considerations, Rev A 7Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A 2Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A 3Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A 4Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A 5Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A 6Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A 7Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A 8Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A 9Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A 10
... plastic tray. Ideal for staining westerns and ... for multipurposes. Pour spouts in each corner ... label may be used for identification. Lid ... or shakers for staining several gels simultaneously. ...
... Vivaclear centrifugal filters are disposable microfiltration devices ... samples in the range 100 l to 500 ... rotors accepting 2.2 ml centrifuge tubes. Product Features: ... pore size Low hold up volume ...
... The ClearSpin Filter is a novel ... aid the clarification of bacterial lysates in ... Filter is a novel, disposable spin filtration ... of bacterial lysates in plasmid purification procedures. ...
... fixed-angle microcentrifuge rotor at RCF up ... filters consist of a membrane-containing filter ... filter by centrifugation for bacteria removal, ... of cells from media and DNA ...
Biology Products: