Navigation Links
Countering brain chemical could prevent suicides
Date:12/14/2012

EAST LANSING, Mich. --- Researchers have found the first proof that a chemical in the brain called glutamate is linked to suicidal behavior, offering new hope for efforts to prevent people from taking their own lives.

Writing in the journal Neuropsychopharmacology, Michigan State University's Lena Brundin and an international team of co-investigators present the first evidence that glutamate is more active in the brains of people who attempt suicide. Glutamate is an amino acid that sends signals between nerve cells and has long been a suspect in the search for chemical causes of depression.

"The findings are important because they show a mechanism of disease in patients," said Brundin, an associate professor of experimental psychiatry in MSU's College of Human Medicine. "There's been a lot of focus on another neurotransmitter called serotonin for about 40 years now. The conclusion from our paper is that we need to turn some of that focus to glutamate."

Brundin and colleagues examined glutamate activity by measuring quinolinic acid -- which flips a chemical switch that makes glutamate send more signals to nearby cells -- in the spinal fluid of 100 patients in Sweden. About two-thirds of the participants were admitted to a hospital after attempting suicide and the rest were healthy.

They found that suicide attempters had more than twice as much quinolinic acid in their spinal fluid as the healthy people, which indicated increased glutamate signaling between nerve cells. Those who reported the strongest desire to kill themselves also had the highest levels of the acid.

The results also showed decreased quinolinic acid levels among a subset of patients who came back six months later, when their suicidal behavior had ended.

The findings explain why earlier research has pointed to inflammation in the brain as a risk factor for suicide. The body produces quinolinic acid as part of the immune response that
'/>"/>

Contact: Andy McGlashen
andy.mcglashen@cabs.msu.edu
517-355-5158
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
2. Pan-European organizations call for an advanced understanding of the human brain
3. Does the brain become unglued in autism?
4. How the common cat parasite gets into the brain
5. Research shows immune system response is detrimental to novel brain cancer therapy
6. Musical duets lock brains as well as rhythms
7. Double duty: Immune system regulator found to protect brain from effects of stroke
8. University of Maryland School of Medicine, NIH study pinpoints brain areas role in learning
9. Multiple sclerosis immune exchange between brain and blood is uncovered
10. A 3-D light switch for the brain
11. Neurons made from stem cells drive brain activity after transplantation in laboratory model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/7/2014)... Researchers led by Dr. Debra Auguste, associate professor, ... at The City College of New York, have ... treatment for one of the most aggressive forms ... (TNBCs) have a high mortality rate owing to ... effective therapeutic options. However, Professor Auguste,s team, discovered ...
(Date:11/6/2014)... team of Florida State University biologists could lead to ... and survive environmental swings such as droughts or floods. ... the journal The Plant Cell , sheds light ... is organized in a cell and how plants regulate ... and others are turned off. , "If you understand ...
(Date:11/6/2014)... - Insilico Medicine, Inc, a Baltimore-based bioinformatics company ... diseases announced a research collaboration with the international ... Inc (OTC: CSBR). , "There are many companies ... Champions Oncology,s TumorGraft technology is unique in a ... experimentally generating vast amounts of valuable data. Our ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2
... rapidly expanding their ranges northward, apparently in response to ... these historically southern species are replacing their northern counterparts. ... of Michigan, Michigan State University and Ohio,s Miami University, ... Global Change Biology . "When you read about ...
... costs of genome sequencing rapidly decreasing, and with the ... a computer to cheaply store, access, and analyze sequence ... apply genome data to real world problems, including reducing ... bioenergy, this may be accomplished through development of improved ...
... developed at North Carolina State University makes an animal ... has been removed from the animal,s body, allowing researchers ... for heart surgery. The machine saves researchers time and ... technologies in a realistic surgical environment, without the cost ...
Cached Biology News:Climate change driving Michigan mammals north 2Climate change driving Michigan mammals north 3Climate change driving Michigan mammals north 4A genome may reduce your carbon footprint 2'Beating' heart machine expedites research and development of new surgical tools, techniques 2
(Date:11/26/2014)... The report on the Global Smart Sensor ... market for revenue forecasts and market trends. It expects ... from 2013 to 2018. At the projected rate, the ... million by 2018. , Browse through the Global Smart ... about the market segmentation and in-depth analysis supported by ...
(Date:11/26/2014)... In keeping with the holiday spirit, DNA ... Thanksgiving savings. The company is offering up a variety ... this holiday weekend as well as a photo contest ... Monday are right around the corner, and DNA Spectrum ... and those looking to explore their ancestry, health, and ...
(Date:11/26/2014)... , Nov. 26, 2014 The ... from a survey of European physicians at the ... Innovation and Biological Therapies" at the Spanish Ministry ... hosted by EuropaBio and the Spanish Bioindustry Association ... Health, physicians from Spanish oncology and rheumatology societies, ...
(Date:11/26/2014)... PMG Research, Inc. announced today the ... network of sites that provide clinical research services to pharmaceutical ... lives through its partnerships with large physician practices and integrated ... locations in the Southeastern United States and spans over 60 ... board will be held by: Dr. Robert Holmes, MD, ...
Breaking Biology Technology:Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 2Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 3Global Smart Sensor Market in Building Automation is expected to reach a value of $1,415.6 million by 2018 - Report by MicroMarket Monitor 4DNA Spectrum Offers Last Minute Thanksgiving Coupons 2DNA Spectrum Offers Last Minute Thanksgiving Coupons 3ASBM Presents European Physicians Survey at Spanish Ministry of Health 2PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3
... 3SBio Inc. (Nasdaq:,SSRX), a leading China-based biotechnology company ... today,announced the results of the shareholder votes at ... September 12, 2008 (Friday) at 10:00 a.m.,(Beijing time)., ... Dr. Jing Lou,Liping Xu, Bin Huang, Lawrence S. ...
... in Routine Vaccination Program ... -, COLLEGEVILLE, Pa., Sept. 15 Wyeth,Pharmaceuticals, ... today announced that,South Africa has initiated an immunization ... Vaccine,Adsorbed), a vaccine which helps protect infants and ...
... Bulletin Board: CBPC) announced today that it has filed ... an amendment to its Certificate,of Incorporation to effect a ... ("Common Stock") will begin trading on a,reverse-split basis on ... By unanimous written consent dated July 3, 2008 the ...
Cached Biology Technology:South Africa Begins Introduction of PREVENAR into Childhood Immunization Program 2South Africa Begins Introduction of PREVENAR into Childhood Immunization Program 3South Africa Begins Introduction of PREVENAR into Childhood Immunization Program 4China Biopharma Effects 1 for 100 Reverse Stock Split 2China Biopharma Effects 1 for 100 Reverse Stock Split 3
Request Info...
Eliminate electrical interference from any analog signal, without filtering. Ideal for electrophysiology applications like EKG, EMG, and EEGs. Removes 50/60hz noise and harmonics caused by grounding ...
Buffer used for mitocapture assays....
... GFX Purification Kit, 50 purifications. Allows ... probesProvides efficient removal of unincorporated CyDye ... with superior yields of labeled cDNA ... of cDNA labeled by either direct ...
Biology Products: