Navigation Links
Countering brain chemical could prevent suicides
Date:12/14/2012

EAST LANSING, Mich. --- Researchers have found the first proof that a chemical in the brain called glutamate is linked to suicidal behavior, offering new hope for efforts to prevent people from taking their own lives.

Writing in the journal Neuropsychopharmacology, Michigan State University's Lena Brundin and an international team of co-investigators present the first evidence that glutamate is more active in the brains of people who attempt suicide. Glutamate is an amino acid that sends signals between nerve cells and has long been a suspect in the search for chemical causes of depression.

"The findings are important because they show a mechanism of disease in patients," said Brundin, an associate professor of experimental psychiatry in MSU's College of Human Medicine. "There's been a lot of focus on another neurotransmitter called serotonin for about 40 years now. The conclusion from our paper is that we need to turn some of that focus to glutamate."

Brundin and colleagues examined glutamate activity by measuring quinolinic acid -- which flips a chemical switch that makes glutamate send more signals to nearby cells -- in the spinal fluid of 100 patients in Sweden. About two-thirds of the participants were admitted to a hospital after attempting suicide and the rest were healthy.

They found that suicide attempters had more than twice as much quinolinic acid in their spinal fluid as the healthy people, which indicated increased glutamate signaling between nerve cells. Those who reported the strongest desire to kill themselves also had the highest levels of the acid.

The results also showed decreased quinolinic acid levels among a subset of patients who came back six months later, when their suicidal behavior had ended.

The findings explain why earlier research has pointed to inflammation in the brain as a risk factor for suicide. The body produces quinolinic acid as part of the immune response that
'/>"/>

Contact: Andy McGlashen
andy.mcglashen@cabs.msu.edu
517-355-5158
Michigan State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. MicroRNA-218 targets medulloblastoma, most aggressive childhood brain cancer
2. Pan-European organizations call for an advanced understanding of the human brain
3. Does the brain become unglued in autism?
4. How the common cat parasite gets into the brain
5. Research shows immune system response is detrimental to novel brain cancer therapy
6. Musical duets lock brains as well as rhythms
7. Double duty: Immune system regulator found to protect brain from effects of stroke
8. University of Maryland School of Medicine, NIH study pinpoints brain areas role in learning
9. Multiple sclerosis immune exchange between brain and blood is uncovered
10. A 3-D light switch for the brain
11. Neurons made from stem cells drive brain activity after transplantation in laboratory model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2015)... June 16, 2015 /CNW Telbec/ - handyem Inc. ... around the incorporation of handyem,s HPC-150 portable flow ... the Mo-POD™. This unprecedented model of mobile laboratory ... at the Pennsylvania Convention ... 15 th to 18 th 2015. ...
(Date:6/15/2015)... According to a new market research report ... Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) ... Natural Language Processing Market is expected to grow to ... forecast period 2015-2020. Browse 65 market ...   through 155 P ages and in-depth TOC ...
(Date:6/11/2015)... June 11, 2015 Daon, a global ... that its IdentityX Mobile Authentication Platform v4.0 has ... Alliance is an industry consortium launched in 2013 ... simpler, stronger authentication.  In order to receive certification, ... rigorous series of tests that measure compliance and ...
Breaking Biology News(10 mins):handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3Natural Language Processing Market Worth $13.4 Billion by 2020 2Natural Language Processing Market Worth $13.4 Billion by 2020 3Natural Language Processing Market Worth $13.4 Billion by 2020 4Natural Language Processing Market Worth $13.4 Billion by 2020 5Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2
... Regular as clockwork, the flu arrives every year. And, according to ... percent of the U.S. population on average will come down with ... a bigger concern than the seasonal flu is an outright flu ... say it is not a question of if such a health ...
... the body must prevent the immune system from launching ... identity of a nutrient "floodgate" that serves to protect ... in the May 4, 2007 issue of the journal ... found that animals lacking a protein enriched in fat ...
... in your tank." Fuel companies aren't touting that slogan. At ... part by Bruce Dale, Michigan State University professor of chemical ... corn stalks is becoming more efficient and cost-effective. , ... on making ethanol from plant biomass ?the stems, leaves, stalks ...
Cached Biology News:US control strategies may make flu epidemics worse, UCLA study shows 2Keeping the immune system from starting a 'food fight' 2
(Date:7/2/2015)... BETHESDA, Md. , July 2, 2015  Spherix ... committed to the fostering and monetization of intellectual property, ... matter of Spherix Incorporated v. Verizon Services Corp. ... States District Court for the Eastern District of ... Order on July 1, 2015 interpreting certain key claims ...
(Date:7/1/2015)... ... 01, 2015 , ... It is now possible to separate two common disorders: ... computed tomography (SPECT) according to researchers from Amen Clinics, UCLA, Thomas Jefferson University, ... and is believed to be the largest brain imaging study ever, will be published ...
(Date:7/1/2015)... India , July 1, 2015  Strand Life ... generation sequencing technology to empower cancer care, today announced ... chief executive officer. In his expanded role as now ... strategy, business expansion and worldwide operations effective immediately.  Dr. ... chairman and CEO since its founding in 2000, will ...
(Date:7/1/2015)... , ... July 01, 2015 , ... A newly launched ... ideas to lower the barriers to innovation in life sciences R&D. The Pistoia Alliance ... two cash prizes of US$15,000 and a period of expert mentorship from a senior ...
Breaking Biology Technology:Spherix Issues A Litigation Update 2Spherix Issues A Litigation Update 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3
... Development Corp. has purchased the remaining interest in ... , and plans to open a OneProspect office in ... of the Potawatomi Business Development Corp., is now completely ... of 2006, the corporation had purchased a 49 percent ...
... - TomoTherapy, Inc. has filed a registration statement ... public offering of common stock. , ,The Madison-based medical device manufacturer ... the NASDAQ Global Market . , ,The number of shares ... yet to be determined. According to the statement filed with the ...
... Wis. - Expect the face of small business to ... class diversifies to an even greater degree, according to a ... of small business sponsored by Intuit , the California-based ... authored by the Institute for the Future , paints ...
Cached Biology Technology:TomoTherapy files registration statement for IPO 2Small-business trends: Intuit sees more mom-preneurs 2Small-business trends: Intuit sees more mom-preneurs 3Small-business trends: Intuit sees more mom-preneurs 4
...
Collected from sexually mature mice....
Sterile concentration of Dithiothreitol (DTT) solution in phosphate buffer (pH 7.0). Dilute contents in one vial (10- fold) to 100 ml. For use in liquefying sputum samples....
5 minutes from gel band to purified DNA...
Biology Products: