Navigation Links
Could metabolism play a role in epilepsy?
Date:2/19/2014

February 19Researchers from the Franciscan University of Steubenville, Ohio are exploring a possible link between metabolic defects and seizures. They determined that diet could influence susceptibility to seizures, and they have identified a common diabetes drug that could be useful in treating disorders such as epilepsy.

Dr. Daniel Kuebler, the principal investigator behind the experiment, and his lab made the connection by measuring fruit fly movement with inexpensive web-cams. They have published a peer-reviewed, video demonstration of their method in JoVE, the Journal of Visualized Experiments, to assist others in reproducing and further applying the method.

"This technique has allowed us to identify a number of metabolism-altering drugs that affect seizure susceptibility," said Dr. Kuebler, "It has opened up a new line of research looking at the effect dietary modifications have on seizure susceptibility." As published in the article, his lab team determined that metformin, a drug commonly used to treat type II diabetes, reduces the intensity of seizures.

The drug-screening model system is especially ideal for labs on a tight budget, said Dr. Kuebler. According to the article, "Video tracking systems have been used widely to analyze Drosophila melanogaster movement and detect various abnormalities in locomotive behavior. [But] while these systems can provide a wealth of behavioral information, the cost and complexity of these systems can be prohibitive for many labs." Unlike similar experiments, which study the behavior of these flies in aggregate, Dr. Kuebler and his team's approach studies fly behavior one at a time. This is beneficial in that it can determine subtle differences in behavior and seizure alterations, he said.

While there is no known trigger behind seizures in people with epilepsy, Dr. Kuebler and his lab are using their drug-screening technique to investigate potential metabolic causesusing genetically modified, seizure-prone flies (a family of Drosophila flies called Bang-sensitive paralytic mutants). "It is well known that certain diets, such as the ketogenic diet, have effects on seizures, but there is little agreement on the mechanism behind this diet," said Dr. Kuebler, "This technique allows us to better address this question."

Dr. Kuebler chose to publish his method in a video format because of its capacity to communicate scientific procedures better than text. "The ability to show the seizure behavior visually, [showing] exactly how the recording is done, made the journal a much more attractive option than print only journals," said Dr. Kuebler, "This low cost system is simple enough to set up in an undergraduate teaching lab and can allow for students to do some inquiry based learning labs on a budget."


'/>"/>

Contact: Rachel Greene
rachel.greene@jove.com
617-250-8451
The Journal of Visualized Experiments
Source:Eurekalert  

Related biology news :

1. Why tackling appetite could hold the key to preventing childhood obesity
2. First biological marker for major depression could enable better diagnosis and treatment
3. Small non-coding RNAs could be warning signs of cancer
4. A role of glucose tolerance could make the adaptor protein p66Shc a new target for cancer and diabetes
5. Asian longhorned beetles pheromone could be used to manage pest
6. Electronically controlled drugs could minimize side effects
7. Cell division finding could boost understanding of cancer
8. Newly discovered signaling pathway could impact a variety of autoinflammatory diseases
9. Genetic function discovered that could offer new avenue to cancer therapies
10. Secrets of potato blight evolution could help farmers fight back
11. Long-lived breast stem cells could retain cancer legacy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Could metabolism play a role in epilepsy?
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... grow at a CAGR of 30.37% during the period 2017-2021. ... prepared based on an in-depth market analysis with inputs from industry ... over the coming years. The report also includes a discussion of ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... (PRWEB) , ... June 22, 2017 , ... ... provider, announced the release of Limfinity® version 6.5, a content-packed update to the ... continue to gain a larger and more diverse base of customers among labs ...
(Date:6/20/2017)... ... June 20, 2017 , ... Biologist Dawn Maslar MS has found ... latest book, Men Chase, Women Choose: The Neuroscience of Meeting, Dating, Losing Your Mind, ... effect on men. ”The logical next step, in my estimation, was to scientifically track ...
(Date:6/20/2017)... ... June 20, 2017 , ... National ... well-versed leader with extensive assay development and biomarker expertise, as VP of Scientific ... Boston CRO specializing in bio-analytical assay development and sample testing services. The organization ...
(Date:6/19/2017)... NJ (PRWEB) , ... June 19, 2017 , ... ... for overseeing all service activities supporting EDETEK’s products including training, implementation, support, and ... experience to his new role. He has previously held leadership roles for service ...
Breaking Biology Technology: