Navigation Links
Cortisol and fatty liver: Researchers find cause of severe metabolic disorders
Date:9/9/2008

A healthy body stores fat in the form of so-called triglycerides in specialized fatty tissue as an energy reserve. Under certain conditions the delicate balance of the lipid metabolism gets out of control and fat is accumulated in the liver, leading to the dreaded fatty liver. This increases the risk of many metabolic diseases, such as the metabolic syndrome known as "deadly quartet". This combination of fatty liver, obesity, diabetes and hypertension is regarded as the primary cause of life-threatening vascular events such as myocardial infarction and stroke.

It was still unknown which conditions cause the body to deposit fat in the liver. However, scientists knew that the body's own glucocorticoid hormones such as cortisol promote the development of fatty liver. This can be observed, for example, in a condition known as Cushing syndrome. Cortisol levels in affected patients are permanently raised often caused by malignant tumors. This, in turn, leads to high blood sugar levels and patients frequently develop fatty liver. Long-term cortisone therapies such as those used for treating chronic inflammatory diseases such as asthma also cause the triglyceride level in the liver to rise to dangerous levels. Dr. Stephan Herzig, head of the Junior Research Group "Molecular Metabolic Control" at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), and his team have now published the mechanism by which the body's own glucocorticoid hormones contribute to this disruption of the lipid metabolism.

The researchers in Herzig's team specifically switched off the cortisol receptor in the livers of mice, thus blocking the hormone's effect. As a result, the triglyceride level in the livers of the experimental animals dropped considerably. Investigations have revealed that, in the absence of the cortisol receptor, large amounts of the HES1 protein are produced in the livers of these animals. HES1 activates a number of enzymes that break
'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Omega-3 fatty acids protect against Parkinsons, study says
2. University of Alberta researchers report breakthrough in lowering bad cholesterol, fatty acid levels
3. Typical North American diet is deficient in omega-3 fatty acids
4. Trans-fatty acids and insulin sensitivity
5. Scientists suspect omega-3 fatty acids could slow acute wound healing
6. Atomic structure of the mammalian fatty acid factory determined
7. Researchers identify proteins involved in new neurodegenerative syndrome
8. Texas researchers and educators head for Antarctica
9. MGH researchers describe new way to identify, evolve novel enzymes
10. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
11. U of MN researchers discover noninvasive diagnostic tool for brain diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Wash. , Nov. 20, 2014 C-Labs ... for the Internet of Things (IoT), today announced the ... of chief operating officer. Previously a strategic advisor to ... finance, and operations. Mr. Traynor is based out of ... . He reports to Chris Muench , Chief ...
(Date:11/18/2014)... YORK , Nov. 18, 2014   ... identity authentication solutions, and MorphoTrust USA ... and services, today announced a strategic partnership to ... enterprise, motor vehicle administration (MVA), airport screening and ... in identity-related solutions, MorphoTrust serves consumers through a ...
(Date:11/7/2014)... associate professor, biomedical engineering, in the Grove School ... York, have identified a molecule that could lead ... aggressive forms of breast cancer. , Triple negative ... owing to aggressive proliferation and metastasis and a ... team, discovered the overexpression of intercellular adhesion molecule-1 ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3
... A new study by Indiana University-Purdue University Indianapolis (IUPUI) ... fast food outlet increases weight in children and that ... as well as so called junk food, lowers weight. ... and urban planning compared children,s weights over time before ...
... from the University of Cadiz has confirmed that zinc, copper and ... of the Huelva estuary, and have studied how some of these ... cadmium and copper accumulate in the body tissues of sole and ... some metals in the waters of the Huelva estuary and those ...
... of scientists has discovered extensive similarities between a strain ... linked to opportunistic infections in hospital patients. The findings ... for a range of biotech applications. The genetic analysis ... Energy,s (DOE) Brookhaven National Laboratory, and will be published ...
Cached Biology News:IUPUI study finds living near fast food outlet not a weighty problem for kids 2Study shows transfer of heavy metals from water to fish in Huelva estuary 2Plant microbe shares features with drug-resistant pathogen 2Plant microbe shares features with drug-resistant pathogen 3
(Date:11/22/2014)... 21, 2014 Prominent academics, leaders ... gather on December 3rd at Genetic Rx, a ... GeneticRx will take place at the Joseph B. ... will discuss the present and future of genetic ... and gene editing—as well as the treatment of ...
(Date:11/22/2014)... 22, 2014 The “Chiral Chromatography ... by Material (Metal, Glass, Plastic), by Application [GC, ... - Forecast to 2018” analyses and studies the ... North America, Europe, Asia, and Rest of the ... 15 figures spread through 135 pages and in-depth ...
(Date:11/21/2014)... November 21, 2014 , ...   Mariano Rodríguez es elegid vicepresidente senior ... KLOX está en marcha para comenzar de forma rápida ... heridas de reciente aprobación en Europa   , ... complace al anunciar los siguientes nombramientos: Todd ...
(Date:11/21/2014)... Author Matthew J. Pallamary’s second short ... Side” published as a tribute to his mentor ... Short Story” category of the 2014 USA Best ... of USA Book News, said this year’s contest yielded ... Simon & Schuster, Penguin, John Wiley & Sons, Houghton ...
Breaking Biology Technology:Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4
... 2011 The proposed rule for the Medicare Shared ... the Department of Health and Human Services on March ... sought by the health insurance lobby, a MedeAnalytics analysis ... "The proposed rule positively addresses many of the ...
... understanding the structure of proteins, polymers, minerals, and engineered ... of the journal Nature Materials . The discovery ... type of symmetry in the structure of materials, which ... or designing materials with desired properties. The research is ...
... WHITE PLAINS, N.Y., April 1, 2011 Once again, the ... Cancer shows a continued decline in diagnoses and deaths ... attributed primarily to preventive measures such as cessation of smoking ... http://photos.prnewswire.com/prnh/20110215/NY48642LOGO) But for many cancers, such as the ...
Cached Biology Technology:ACO Proposed Rule: Over 90 Percent of Commercial Payer RFI Suggestions Incorporated 2Search for advanced materials aided by discovery of hidden symmetries in nature 2Search for advanced materials aided by discovery of hidden symmetries in nature 3The Leukemia & Lymphoma Society: Accelerating Cures Must Be a Priority 2
UGT1A7 (E-15)...
... nucleofection of optimized cell lines in combination ... nucleofection parameters. Nucleofector Kits are only functional ... cell lines can be transfected with this ... given in brackets in percent (Efficiency [%] ...
... Fluorescein 6-Fam, Hex, Tet Cy3, Cy5, ... Tamra Black Hole Quenchers Molecular Beacons* ... Tamra, Joe 3 Dabcyl Dabcyl*Licensed ... York Double labelled probes are purified either ...
... Protein Phosphatase ( l-PPase) ... phosphatase with activity towards ... tyrosine residues. It is ... of the ORF221 open ...
Biology Products: