Navigation Links
'Cornell Dots' that light up cancer cells go into clinical trials
Date:1/31/2011

ITHACA, N.Y. - "Cornell Dots" brightly glowing nanoparticles may soon be used to light up cancer cells to aid in diagnosing and treating cancer. The U.S. Food and Drug Administration (FDA) has approved the first clinical trial in humans of the new technology. It is the first time the FDA has approved using an inorganic material in the same fashion as a drug in humans.

"The FDA approval finally puts a federal approval stamp on all the assumptions we have been working under for years. This is really, really nice," said Ulrich Wiesner, the Spencer T. Olin Professor of Materials Science and Engineering, who has devoted eight years of research to developing the nanoparticles. "Cancer is a terrible disease, and my family has a long history of it. I, thus, have a particular personal motivation to work in this area."

The trial with five melanoma patients at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City will seek to verify that the dots, also known as C dots, are safe and effective in humans, and to provide data to guide future applications. "This is the first product of its kind. We want to make sure it does what we expect it to do," said Michelle Bradbury, M.D., radiologist at MSKCC and assistant professor of radiology at Weill Cornell Medical College.

C dots are silica spheres less than 8 nanometers in diameter that enclose several dye molecules. (A nanometer is one-billionth of a meter, about the length of three atoms in a row.) The silica shell, essentially glass, is chemically inert and small enough to pass through the body and out in the urine. For clinical applications, the dots are coated with polyethylene glycol so the body will not recognize them as foreign substances.

To make the dots stick to tumor cells, organic molecules that bind to tumor surfaces or even specific locations within tumors can be attached to the shell. When exposed to near-infrared light, the dots fluoresce much brighter than unenca
'/>"/>

Contact: Blaine Friedlander
bpf2@cornell.edu
607-254-8093
Cornell University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gates Foundation continues funding of tuberculosis research at Weill Cornell
2. Cornells regional sun grant energy conference is May 24-26
3. Cornell forges licensing agreement with new New York apple industry group
4. Weill Cornell researchers find that a single gene is responsible for OCD-like behaviors in mice
5. Weill Cornell science briefs: November 2009
6. Battling cancer with engineering: NCI funds new $13 million cancer research center led by Cornell
7. Genetic secrets of date palm unlocked by researchers at Weill Cornell Medical College in Qatar
8. NIST-Cornell team builds worlds first nanofluidic device with complex 3-D surfaces
9. Multicolor quantum dots aid in cancer biopsy diagnosis
10. Connecting the dots: How light receptors get their message across
11. Rice eyes risks of quantum dots
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... December 9, 2014   ... Platform   Jifflenow, ... scheduling solutions for business-to-business (B2B) events, today announced ... in mobile near-field communication (NFC), Bluetooth low energy ... (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will integrate ...
(Date:12/4/2014)... , Dec. 3, 2014  Crossmatch™, a leading ... that its DigitalPersona ® Pro Enterprise software ... been deployed throughout First Bank branch locations in ... South Carolina and Virginia. First Bank, a ... Southern Pines, North Carolina , selected the ...
(Date:11/21/2014)... 2014 According to a new ... (Video, RFID, Access Control, Intrusion Detection, Parking Management, Under ... Component Service Geography - Global Forecasts to 2020", published ... to be around $25 Billion in 2014 and is ... a CAGR of 8.69%. Browse 116 market ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... 2007, the United States Geological Survey (USGS) Coalition will ... important research, information, and services provided by the USGS ... for the Survey in the FY 2008 budget. ... to discuss the vital work the USGS conducts in ...
... the blueprint for life, has a lesser-known identity as ... in the most common model for DNA elasticity, a ... and perhaps pave the way for DNA to become ... difficult challenge. JILA is a joint venture of the ...
... in the field of HIV research through his rational approach ... vaccine. His method is based on gaining an understanding ... date, and the sites on the virus that the antibodies ... improvements to any molecules used in an HIV-1 vaccine. ...
Cached Biology News:USGS Coalition to host congressional reception 2JILA finds flaw in model describing DNA elasticity 2
(Date:12/19/2014)... , Dec. 19, 2014 Research and ... the addition of the "Technology Innovations in ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... in Smart Fabrics" offers a detailed assessment on ... Key Findings: 1. The ...
(Date:12/19/2014)... Ed Bilsky, Ph.D., vice president for Research ... in the Neurosciences (CEN), and professor of pharmacology at ... a member of the prestigious Dana Alliance for Brain ... to receive this honor. , The Dana Alliance ... Dana Foundation. Its mission is to advance public ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 The ... to the rising ageing population and technological innovations ... and nutraceutical industries are catalysing the growth of ... @ http://www.marketsandmarkets.com/Market-Reports/empty-capsules-market-218018190.html , Scope of Report ... as well as new entrants/smaller firms to gauge ...
(Date:12/19/2014)... DALLAS , Dec. 18, 2014   ISN ... Health & Safety Performance Indicators publication series. ... hours of activity reported in 2013 within its online ... health and safety key performance indicator (KPI) statistics. ... Hiring Clients, U.S. publication is available in ...
Breaking Biology Technology:Technology Innovations in Smart Fabrics (Technical Insights) 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3
... ... VA, will discuss practical approaches to President Obama’s challenges to "find the needle in ... ... connect the dots” on the Christmas bomber in his recent address to the Nation. ...
... , ABERDEEN PROVING GROUND, Md., Jan. 11 ... Biological Center (ECBC), the premier national resource for chemical and ... Development Canada (DRDC) Suffield -- a major Canadian military research ... to celebrate the delivery of two mobile laboratories during a ...
... ... consumers. , ... Moines, IA (Vocus) Jan. 11, 2010 – DuPont business Pioneer Hi-Bred ... Foundation for Agriculture’s My American Farm virtual education program. The donation from ...
Cached Biology Technology:NDIA's Biometrics Conference to Address Practical Approaches to the President's Challenge of 'Connecting the Dots' and Implementing $1B for New and Additional Security 2ECBC Delivers Mobile Labs to DRDC, Celebrates with Ribbon Cutting Ceremony 2ECBC Delivers Mobile Labs to DRDC, Celebrates with Ribbon Cutting Ceremony 3DuPont Pledges Support to My American Farm Initiative 2DuPont Pledges Support to My American Farm Initiative 3
Mouse monoclonal [SPM217] to Secretory Component Glycoprotein ( Abpromise for all tested applications)....
Rabbit polyclonal to FLIP ( Abpromise for all tested applications). entrezGeneID: 8837 SwissProtID: O15519...
... Rabbit monoclonal [EP282Y] to Asparagine ... all tested applications). ... corresponding to residues in the ... Entrez GeneID: ...
Fluorescein isothiocyanate (FITC) mouse anti-human IFN-alpha2 25 tests...
Biology Products: